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Aliases for RPS13 Gene

Aliases for RPS13 Gene

  • Ribosomal Protein S13 2 3 5
  • 40S Ribosomal Protein S13 2
  • S13 3

External Ids for RPS13 Gene

Previous GeneCards Identifiers for RPS13 Gene

  • GC11M018166
  • GC11M018039
  • GC11M017135
  • GC11M017060
  • GC11M017054
  • GC11M017055
  • GC11M016780
  • GC11M017095
  • GC11M017080
  • GC11M017085

Summaries for RPS13 Gene

Entrez Gene Summary for RPS13 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS13 Gene

RPS13 (Ribosomal Protein S13) is a Protein Coding gene. Diseases associated with RPS13 include malignant giant cell tumor and giant axonal neuropathy. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

Gene Wiki entry for RPS13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS13 Gene

Genomics for RPS13 Gene

Regulatory Elements for RPS13 Gene

Enhancers for RPS13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS13 on UCSC Golden Path with GeneCards custom track

Promoters for RPS13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS13 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS13 Gene

Chromosome:
11
Start:
17,074,389 bp from pter
End:
17,077,787 bp from pter
Size:
3,399 bases
Orientation:
Minus strand

Genomic View for RPS13 Gene

Genes around RPS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS13 Gene

Proteins for RPS13 Gene

  • Protein details for RPS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62277-RS13_HUMAN
    Recommended name:
    40S ribosomal protein S13
    Protein Accession:
    P62277
    Secondary Accessions:
    • B2R549
    • P19116
    • Q02546
    • Q29200
    • Q498Y0

    Protein attributes for RPS13 Gene

    Size:
    151 amino acids
    Molecular mass:
    17222 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS13 Gene

neXtProt entry for RPS13 Gene

Proteomics data for RPS13 Gene at MOPED

Post-translational modifications for RPS13 Gene

  • Ubiquitination at Lys 9, Lys 27, Lys 34, Lys 39, Lys 43, Lys 70, and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS13 Gene

Domains & Families for RPS13 Gene

Gene Families for RPS13 Gene

Protein Domains for RPS13 Gene

Suggested Antigen Peptide Sequences for RPS13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62277

UniProtKB/Swiss-Prot:

RS13_HUMAN :
  • Belongs to the ribosomal protein S15P family.
Family:
  • Belongs to the ribosomal protein S15P family.
genes like me logo Genes that share domains with RPS13: view

Function for RPS13 Gene

Molecular function for RPS13 Gene

GENATLAS Biochemistry:
60S ribosomal protein S13

Gene Ontology (GO) - Molecular Function for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12054647
genes like me logo Genes that share ontologies with RPS13: view
genes like me logo Genes that share phenotypes with RPS13: view

Animal Model Products

miRNA for RPS13 Gene

miRTarBase miRNAs that target RPS13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS13 Gene

Localization for RPS13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS13 Gene COMPARTMENTS Subcellular localization image for RPS13 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,NAS 8332508
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS13 Gene

Pathways & Interactions for RPS13 Gene

SuperPathways for RPS13 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS13: view

Gene Ontology (GO) - Biological Process for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPS13: view

No data available for SIGNOR curated interactions for RPS13 Gene

Drugs & Compounds for RPS13 Gene

No Compound Related Data Available

Transcripts for RPS13 Gene

Unigene Clusters for RPS13 Gene

Ribosomal protein S13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6
SP1:
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for RPS13 Gene

GeneLoc Exon Structure for
RPS13
ECgene alternative splicing isoforms for
RPS13

Expression for RPS13 Gene

mRNA expression in normal human tissues for RPS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS13 Gene

This gene is overexpressed in Nasal epithelium (11.8) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS13 Gene



SOURCE GeneReport for Unigene cluster for RPS13 Gene Hs.446588

genes like me logo Genes that share expression patterns with RPS13: view

Protein tissue co-expression partners for RPS13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS13 Gene

Orthologs for RPS13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS13 35
  • 90.51 (n)
  • 100 (a)
-- 36
  • 98 (a)
OneToMany
RPS13 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS13 35
  • 91.39 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rps13 35
  • 86.98 (n)
  • 100 (a)
Rps13 16
Rps13 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS13 35
  • 99.78 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS13 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS13 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS13 35
  • 81.68 (n)
  • 100 (a)
RPS13 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS13 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps13 35
  • 80.79 (n)
  • 99.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia rps13-prov 35
zebrafish
(Danio rerio)
Actinopterygii rps13 35
  • 78.15 (n)
  • 97.35 (a)
rps13 36
  • 97 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13839 35
fruit fly
(Drosophila melanogaster)
Insecta RpS13 37
  • 87 (a)
RpS13 35
  • 71.08 (n)
  • 87.42 (a)
RpS13 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RS13_ANOGA 35
  • 68.21 (n)
  • 84.11 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-13 37
  • 76 (a)
rps-13 35
  • 68.43 (n)
  • 76.16 (a)
rps-13 36
  • 76 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL030W 35
  • 66.44 (n)
  • 78.67 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18040g 35
  • 67.11 (n)
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS13 35
  • 66.22 (n)
  • 78 (a)
RPS13 36
  • 77 (a)
OneToOne
RPS13 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS13A 35
  • 66 (n)
  • 78.81 (a)
rice
(Oryza sativa)
Liliopsida Os.15168 35
Os08g0117300 35
  • 62.69 (n)
  • 72.85 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14203 35
corn
(Zea mays)
Liliopsida Zm.3223 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14352 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03038 35
  • 68.21 (n)
  • 80.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps13 35
  • 65.56 (n)
  • 74.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11176 36
  • 88 (a)
OneToOne
Species with no ortholog for RPS13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS13 Gene

ENSEMBL:
Gene Tree for RPS13 (if available)
TreeFam:
Gene Tree for RPS13 (if available)

Paralogs for RPS13 Gene

genes like me logo Genes that share paralogs with RPS13: view

No data available for Paralogs for RPS13 Gene

Variants for RPS13 Gene

Sequence variations from dbSNP and Humsavar for RPS13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112773343 -- 17,078,980(+) TCTGT(C/G)TTAAA upstream-variant-2KB
rs72870889 -- 17,078,053(+) ACTAG(A/T)TCCCT upstream-variant-2KB
rs12420958 -- 17,078,885(+) AGGAG(G/T)CTGAG upstream-variant-2KB
rs73433220 -- 17,078,863(+) GTGCC(G/T)TTGGT upstream-variant-2KB
rs12577388 -- 17,079,608(+) CCCCC(A/C/T)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS13 Gene

Variant ID Type Subtype PubMed ID
nsv467711 CNV Gain 19166990

Variation tolerance for RPS13 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS13 Gene

HapMap Linkage Disequilibrium report
RPS13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS13 Gene

Disorders for RPS13 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malignant giant cell tumor
  • malignant giant cell neoplasm
giant axonal neuropathy
  • gan
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
- elite association - COSMIC cancer census association via MalaCards
Search RPS13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS13
genes like me logo Genes that share disorders with RPS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS13 Gene

Publications for RPS13 Gene

  1. Cloning and analysis of the human S13 ribosomal protein cDNA. (PMID: 8332508) Chadeneau C. … Denis M.G. (Nucleic Acids Res. 1993) 2 3 4 67
  2. Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. (PMID: 17881366) Malygin A.A. … Karpova G.G. (Nucleic Acids Res. 2007) 3 23
  3. Human ribosomal protein S13: cloning, expression, refolding, and structural stability. (PMID: 15680243) Malygin A. … Karpova G. (Biochim. Biophys. Acta 2005) 3 23
  4. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. (PMID: 15149863) Shi Y. … Fan D. (Exp. Cell Res. 2004) 3 23
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3

Products for RPS13 Gene

Sources for RPS13 Gene

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