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Aliases for RPS13 Gene

Aliases for RPS13 Gene

  • Ribosomal Protein S13 2 3 5
  • 40S Ribosomal Protein S13 2 3
  • S13 3

External Ids for RPS13 Gene

Previous GeneCards Identifiers for RPS13 Gene

  • GC11M018166
  • GC11M018039
  • GC11M017135
  • GC11M017060
  • GC11M017054
  • GC11M017055
  • GC11M016780
  • GC11M017095
  • GC11M017080
  • GC11M017085
  • GC11M017091

Summaries for RPS13 Gene

Entrez Gene Summary for RPS13 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS13 Gene

RPS13 (Ribosomal Protein S13) is a Protein Coding gene. Diseases associated with RPS13 include Malignant Giant Cell Tumor and Autonomic Nervous System Neoplasm. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

Gene Wiki entry for RPS13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS13 Gene

Genomics for RPS13 Gene

Regulatory Elements for RPS13 Gene

Enhancers for RPS13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS13 on UCSC Golden Path with GeneCards custom track

Promoters for RPS13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS13 Gene

17,074,389 bp from pter
17,077,787 bp from pter
3,399 bases
Minus strand

Genomic View for RPS13 Gene

Genes around RPS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS13 Gene

Proteins for RPS13 Gene

  • Protein details for RPS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S13
    Protein Accession:
    Secondary Accessions:
    • B2R549
    • P19116
    • Q02546
    • Q29200
    • Q498Y0

    Protein attributes for RPS13 Gene

    151 amino acids
    Molecular mass:
    17222 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS13 Gene

neXtProt entry for RPS13 Gene

Post-translational modifications for RPS13 Gene

  • Ubiquitination at Lys 9, Lys 27, Lys 34, Lys 39, Lys 43, Lys 70, and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS13 Gene

Domains & Families for RPS13 Gene

Gene Families for RPS13 Gene

Protein Domains for RPS13 Gene

Suggested Antigen Peptide Sequences for RPS13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S15P family.
  • Belongs to the ribosomal protein S15P family.
genes like me logo Genes that share domains with RPS13: view

Function for RPS13 Gene

Molecular function for RPS13 Gene

GENATLAS Biochemistry:
60S ribosomal protein S13

Gene Ontology (GO) - Molecular Function for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 17881366
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 12054647
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with RPS13: view
genes like me logo Genes that share phenotypes with RPS13: view

Animal Model Products

CRISPR Products

miRNA for RPS13 Gene

miRTarBase miRNAs that target RPS13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS13 Gene

Localization for RPS13 Gene

Subcellular locations from

Jensen Localization Image for RPS13 Gene COMPARTMENTS Subcellular localization image for RPS13 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17881366
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 17881366
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8332508
genes like me logo Genes that share ontologies with RPS13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS13 Gene

Pathways & Interactions for RPS13 Gene

SuperPathways for RPS13 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS13: view

Gene Ontology (GO) - Biological Process for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS13: view

No data available for SIGNOR curated interactions for RPS13 Gene

Drugs & Compounds for RPS13 Gene

No Compound Related Data Available

Transcripts for RPS13 Gene

Unigene Clusters for RPS13 Gene

Ribosomal protein S13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6
SP2: - - -

Relevant External Links for RPS13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS13 Gene

mRNA expression in normal human tissues for RPS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS13 Gene

This gene is overexpressed in Nasal epithelium (11.8) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS13 Gene

Protein tissue co-expression partners for RPS13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS13 Gene:


SOURCE GeneReport for Unigene cluster for RPS13 Gene:

genes like me logo Genes that share expression patterns with RPS13: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS13 Gene

Orthologs for RPS13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS13 34
  • 90.51 (n)
  • 100 (a)
-- 35
  • 98 (a)
RPS13 35
  • 100 (a)
(Canis familiaris)
Mammalia RPS13 34
  • 91.39 (n)
  • 100 (a)
(Mus musculus)
Mammalia Rps13 34
  • 86.98 (n)
  • 100 (a)
Rps13 16
Rps13 35
  • 100 (a)
(Pan troglodytes)
Mammalia RPS13 34
  • 99.78 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS13 35
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia RPS13 35
  • 99 (a)
(Gallus gallus)
Aves RPS13 34
  • 81.68 (n)
  • 100 (a)
RPS13 35
  • 100 (a)
(Anolis carolinensis)
Reptilia RPS13 35
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps13 34
  • 80.79 (n)
  • 99.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia rps13-prov 34
(Danio rerio)
Actinopterygii rps13 34
  • 78.15 (n)
  • 97.35 (a)
rps13 35
  • 97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13839 34
fruit fly
(Drosophila melanogaster)
Insecta RpS13 36
  • 87 (a)
RpS13 34
  • 71.08 (n)
  • 87.42 (a)
RpS13 35
  • 87 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RS13_ANOGA 34
  • 68.21 (n)
  • 84.11 (a)
(Caenorhabditis elegans)
Secernentea rps-13 36
  • 76 (a)
rps-13 34
  • 68.43 (n)
  • 76.16 (a)
rps-13 35
  • 76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL030W 34
  • 66.44 (n)
  • 78.67 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18040g 34
  • 67.11 (n)
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS13 34
  • 66.22 (n)
  • 78 (a)
RPS13 35
  • 77 (a)
RPS13 37
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS13A 34
  • 66 (n)
  • 78.81 (a)
(Oryza sativa)
Liliopsida Os.15168 34
Os08g0117300 34
  • 62.69 (n)
  • 72.85 (a)
(Triticum aestivum)
Liliopsida Ta.14203 34
(Zea mays)
Liliopsida Zm.3223 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14352 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03038 34
  • 68.21 (n)
  • 80.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps13 34
  • 65.56 (n)
  • 74.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11176 35
  • 88 (a)
Species where no ortholog for RPS13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS13 Gene

Gene Tree for RPS13 (if available)
Gene Tree for RPS13 (if available)

Paralogs for RPS13 Gene

genes like me logo Genes that share paralogs with RPS13: view

No data available for Paralogs for RPS13 Gene

Variants for RPS13 Gene

Sequence variations from dbSNP and Humsavar for RPS13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs76993169 -- 17,078,997(+) AAAAA(-/AAAA)GGAAA upstream-variant-2KB
rs139312128 -- 17,078,043(+) TTGTC(C/T)TGGCA upstream-variant-2KB
rs150137457 -- 17,079,510(+) CAGAG(C/T)GAGAC upstream-variant-2KB
rs11024147 -- 17,074,018(+) ATTAC(G/T)TTTGC downstream-variant-500B
rs11024150 -- 17,078,718(+) CGCCT(C/G)GGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS13 Gene

Variant ID Type Subtype PubMed ID
nsv467711 CNV gain 19166990
nsv553567 CNV gain 21841781
nsv553568 CNV gain 21841781

Variation tolerance for RPS13 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS13 Gene

Disorders for RPS13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant giant cell tumor
  • malignant giant cell neoplasm
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
- elite association - COSMIC cancer census association via MalaCards
Search RPS13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS13 Gene

Publications for RPS13 Gene

  1. Cloning and analysis of the human S13 ribosomal protein cDNA. (PMID: 8332508) Chadeneau C. … Denis M.G. (Nucleic Acids Res. 1993) 2 3 4 65
  2. Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. (PMID: 17881366) Malygin A.A. … Karpova G.G. (Nucleic Acids Res. 2007) 3 22 65
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 65
  4. Human ribosomal protein S13: cloning, expression, refolding, and structural stability. (PMID: 15680243) Malygin A. … Karpova G. (Biochim. Biophys. Acta 2005) 3 22 65
  5. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. (PMID: 15149863) Shi Y. … Fan D. (Exp. Cell Res. 2004) 3 22 65

Products for RPS13 Gene

Sources for RPS13 Gene

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