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RPS12 Gene

protein-coding   GIFtS: 65
GCID: GC06P133136

Ribosomal Protein S12

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Ribosomal Protein S121 2
40S Ribosomal Protein S122
S122

External Ids:    HGNC: 103851   Entrez Gene: 62062   Ensembl: ENSG000001123067   OMIM: 6036605   UniProtKB: P253983   
ORGUL members:    fRNAdb10:FR349989      
H-InvDB12:HIT000101207    
NCBI13:D28378    
RNAdb15:HIV1922    

Export aliases for RPS12 gene to outside databases

Previous GC identifers: GC06P132758 GC06P132982 GC06P133116 GC06P133177 GC06P130710


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS12 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family
of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers
compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins,
there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul
2008)

GeneCards Summary for RPS12 Gene:
RPS12 (ribosomal protein S12) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS12 Gene

fRNAdb sequence ontology for RPS12:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for RPS12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS12 gene promoter:
         GR   Brachyury   FOXO3   FOXO3b   YY1   PPAR-gamma1   FOXO3a   c-Myb   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS12 promoter sequence
   Search Chromatin IP Primers for RPS12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.2   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23

RPS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS12 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P133136:  view genomic region     (about GC identifiers)

Start:
133,135,580 bp from pter      End:
133,138,703 bp from pter
Size:
3,124 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RS12_HUMAN, P25398 (See protein sequence)
Recommended Name: 40S ribosomal protein S12  
Size: 132 amino acids; 14515 Da
1 PDB 3D structure from and Proteopedia for RPS12:
3J3A (3D)    
Secondary accessions: Q76M58

Explore the universe of human proteins at neXtProt for RPS12: NX_P25398

Explore proteomics data for RPS12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys93, Lys112, Lys129
  • Modification sites at PhosphoSitePlus

  • See RPS12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001007.2  
    ENSEMBL proteins: 
     ENSP00000230050  
    Reactome Protein details: P25398

    RPS12 Human Recombinant Protein Products:

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    antibodies-online peptides for RPS12

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    2 InterPro protein domains:
     IPR000530 Ribosomal_S12e
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

    Graphical View of Domain Structure for InterPro Entry P25398

    ProtoNet protein and cluster: P25398

    2 Blocks protein domains:
    IPB000530 Ribosomal protein S12E
    IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45


    UniProtKB/Swiss-Prot: RS12_HUMAN, P25398
    Similarity: Belongs to the ribosomal protein S12e family


    Find genes that share domains with RPS12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS12:
    60S ribosomal protein S12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003735structural constituent of ribosome IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPS12           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for RPS12:
     Cytoplasmic 40S maturation def  Decreased Hepatitis C virus re  Decreased cell number  Decreased viability of wild-ty 
     Nucleolar pre-40S maturation d  S arrest  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    hsa-mir-181b-5p (MIRT047275), hsa-mir-125b-5p (MIRT046000), hsa-mir-16-5p (MIRT031756), hsa-mir-331-3p (MIRT043516), hsa-mir-320a (MIRT044716), hsa-mir-30c-5p (MIRT047983), hsa-mir-615-3p (MIRT039793), hsa-mir-18a-3p (MIRT040779)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS12_HUMAN, P25398: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0022627cytosolic small ribosomal subunit NAS1861993

    Find genes that share ontologies with RPS12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS12 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with RPS12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS12
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS12
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPS12 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS12):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS12
    Interactions:

        Search GeneGlobe Interaction Network for RPS12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS12 (P253982, 3 ENSP000002300504) via UniProtKB, MINT, STRING, and/or I2D (see all 377)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS17P087082, 3, ENSP000003460454MINT-8044024 I2D: score=2 STRING: ENSP00000346045
    MAP3K14Q995582, 3MINT-48843 I2D: score=2 
    ENSG00000096150P622692, 3, ENSP000002113724MINT-8395092 I2D: score=1 STRING: ENSP00000211372
    ENSG00000223367P622692, 3, ENSP000004125834MINT-8395092 I2D: score=1 STRING: ENSP00000412583
    ENSG00000226225P622692, 3, ENSP000004031754MINT-8395092 I2D: score=1 STRING: ENSP00000403175
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPS12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS12 (RS12)

    4 Novoseek inferred chemical compound relationships for RPS12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    streptomycin 73.2 8 1725261 (1), 17238915 (1), 9634793 (1), 10645439 (1) (see all 6)
    kanamycin 52.2 1 17052696 (1)
    nadh 49.7 6 11920594 (2), 1865874 (1), 10355121 (1), 7476853 (1) (see all 5)
    glucose 0 1 9747975 (1)



    Find genes that share compounds with RPS12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for RPS12 gene: 
    NM_001016.3  

    Unigene Cluster for RPS12:

    Ribosomal protein S12
    Hs.546289  [show with all ESTs]
    Unigene Representative Sequence: BC002550
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230050(uc003qdx.3) ENST00000484616
    miRNA
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    Additional mRNA sequence: 

    AK311826.1 BC002550.1 BC017321.2 BC071930.1 BC095424.1 X53505.1 

    Selected DOTS entries (see all 61):

    DT.220499  DT.100711172  DT.100711162  DT.100711165  DT.92325986  DT.95156505  DT.100060132  DT.121388367 
    DT.95156600  DT.121388343  DT.121388399  DT.121388364  DT.40291319  DT.101987342  DT.91650205  DT.100061025 
    DT.100711164  DT.121388401  DT.121388332  DT.87017203  DT.121406732  DT.121388337  DT.91692616  DT.121388349 

    Selected AceView cDNA sequences (see all 1384):

    BQ652075 BU509048 CF129435 BM845655 BF055927 CB110244 AA974080 BQ709806 
    CB109349 BM742041 AI460288 CA407382 AA493388 BG036435 BQ648066 BF058003 
    AA194821 AW592401 AW272427 BF942220 BM841380 CD512883 AA552713 N68232 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
    SP1:                                      -                           
    SP2:                          -     -     -                           
    SP3:                                                                  
    SP4:                                      -     -     -     -         
    SP5:                          -     -     -                           


    ECgene alternative splicing isoforms for RPS12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGAGGAAG
    RPS12 Expression
    About this image


    RPS12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RPS12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546289
        Custom PCR Arrays for RPS12
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS12 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps121 , 5 ribosomal protein S121, 5 91.41(n)1
    100(a)1
      10 (11.10 cM)5
    200421  NM_011295.61  NP_035425.21 
     237852115 
    chicken
    (Gallus gallus)
    Aves RPS121 ribosomal protein S12 83.2(n)
    100(a)
      421698  NM_001277911.1  NP_001264840.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS126
    ribosomal protein S12
    98(a)
    1 ↔ 1
    GL343200.1(4366532-4375672)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685292 hypothetical protein MGC68529 84.49(n)    BC056655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa95a022 wufa95a02 81.64(n)   337007  BC059433.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS123 protein biosynthesis structural
    constituent of more
    67(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea rps-121 , 3 rps-121 65(a)3
    58.06(n)1
    61.29(a)1
      III(5751105-5751923)3
    1757861  NM_065820.51  NP_498221.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS12(YOR369C)4
    RPS121
    Protein component of the small (40S) ribosomal subunit; more4
    RPS121
    55.46(n)1
    56.64(a)1
      15(1028625-1028194)4
    8545511, 4  NP_015014.31  NP_015014.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G159301 AT1G15930 58.69(n)
    52.99(a)
      838163  NM_101461.4  NP_173045.1 
    rice
    (Oryza sativa)
    Liliopsida Os.229932 Transcribed sequence with weak similarity to protein more 71.1(n)    CA755296.1 


    ENSEMBL Gene Tree for RPS12 (if available)
    TreeFam Gene Tree for RPS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS12 gene

    Find genes that share paralogs with RPS12           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPS12 (see all 33)
    PGOHUM00000238405 PGOHUM00000238514 PGOHUM00000238561 PGOHUM00000238852 PGOHUM00000242381


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS12 (see all 46)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823978991,2
    --133133828(+) GTCTTC/TAGATA 1 -- us2k10--------
    rs1466622561,2
    --133133847(+) TGCGCG/TGAAAG 1 -- us2k10--------
    rs737729611,2
    C,F--133133906(+) CTCCAA/GAAAAG 1 -- us2k13Minor allele frequency- G:0.12WA CSA 122
    rs793338411,2
    C,F--133133938(+) TGCCCC/GTACAC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1403121041,2
    --133133949(+) TTTCAC/TCCATT 1 -- us2k10--------
    rs1501381651,2
    F--133133963(+) AATACC/ACTCCT 1 -- us2k11Minor allele frequency- A:0.03NS 140
    rs1161059471,2
    C,F--133134001(+) CTCTTA/CGTTTT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1440293501,2
    --133134041(+) AAGCCC/TGAGGT 1 -- us2k10--------
    rs104575941,2
    C,F,A--133134100(+) GTATCT/GCCTCT 1 -- us2k112Minor allele frequency- G:0.35NA WA CSA EA NS 592
    rs1464975721,2
    C--133134136(+) GTCTAA/CAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS12 (133135580 - 133138703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPS12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886676CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS12
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603660OMIM information: 122550 143400 604519 608545    

    Find genes that share disorders with RPS12           About GenesLikeMe

    3 Novoseek inferred disease relationships for RPS12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterility male 63.8 2 1865874 (1), 10355121 (1)
    tuberculosis 31.4 2 17238915 (1), 19519851 (1)
    cervical cancer 15.1 1 11920594 (1)

    Human Genome Epidemiology (HuGE) Navigator: RPS12 (2 documents)

    Export disorders for RPS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS12 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with RPS12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PubMed id 1861993)1, 2, 3 Herault Y.... Brun G. (Nucleic Acids Res. 1991)
    3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    5. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PubMed id 11870519)1, 9 Cheng Q....Hui K.M. (Br. J. Cancer 2002)
    6. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    7. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    8. RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector. (PubMed id 23546393)1 Chen D....Sun X. (Int. J. Oncol. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6206 HGNC: 10385 AceView: RPS12 Ensembl:ENSG00000112306 euGenes: HUgn6206
    ECgene: RPS12 Kegg: 6206 H-InvDB: RPS12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS12 gene:
    Search GeneIP for patents involving RPS12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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