Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS12 Gene

protein-coding   GIFtS: 61
GCID: GC06P133136

ribosomal protein S12
 Explore 11 diseases affiliated with
RPS12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPS12    

Aliases
for RPS12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S121 2
S121 2
40S Ribosomal Protein S122

External Ids:    HGNC: 103851   Entrez Gene: 62062   Ensembl: ENSG000001123067   OMIM: 6036605   UniProtKB: P253983   

Export aliases for RPS12 gene to outside databases

Previous GC identifers: GC06P132758 GC06P132982 GC06P133116 GC06P133177 GC06P130710


Summaries
for RPS12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS12:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of
ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared
to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPS12


Genomic Views
for RPS12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS12 gene promoter:
         GR   Brachyury   FOXO3   FOXO3b   YY1   PPAR-gamma1   FOXO3a   c-Myb   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS12 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.2   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23

RPS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS12 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P133136:  view genomic region     (about GC identifiers)

Start:
 133,135,580 bp from pter      End:
 133,138,703 bp from pter
Size:
 3,124 bases      Orientation:
 plus strand

Proteins
for RPS12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RS12_HUMAN, P25398 (See protein sequence)
Recommended Name: 40S ribosomal protein S12  
Size: 132 amino acids; 14515 Da
Subcellular location: Cytoplasm
Secondary accessions: Q76M58

Explore the universe of human proteins at neXtProt for RPS12: NX_P25398

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25398

    • RPS12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001007.2  
    ENSEMBL proteins: 
     ENSP00000230050  
    Reactome Protein details: P25398
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RPS12
    OriGene Custom Protein Services for RPS12 
    GenScript Custom Purified and Recombinant Proteins Services for RPS12
    Novus Biologicals RPS12 Protein
    Novus Biologicals RPS12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPS12

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0022627cytosolic small ribosomal subunit NAS1861993


    RPS12 for ontologies           About GeneDecksing



    RPS12 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RPS12 
    GenScript Custom Superior Antibodies Services for RPS12
    Novus Biologicals RPS12 Antibodies
    Abcam antibodies for RPS12 
    Uscn Antibodies for RPS12
    Search ThermoFisher Antibodies for RPS12

    Assay Products for RPS12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPS12
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RPS12

    Protein Domains /
    Families
    for RPS12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS12 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000530 Ribosomal_S12e
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

    Graphical View of Domain Structure for InterPro Entry P25398

    ProtoNet protein and cluster: P25398

    2 Blocks protein families:
    IPB000530 Ribosomal protein S12E
    IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45


    UniProtKB/Swiss-Prot: RS12_HUMAN, P25398
    Similarity: Belongs to the ribosomal protein S12e family


    Function
    for RPS12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for RPS12:
    60S ribosomal protein S12

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RPS12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS12
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS12 (see all 7)
    OriGene shRNA RFP: RPS12
    OriGene siRNA: RPS12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS12

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPS12

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS12
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): RPS12 (NM_021107)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS12 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RPS12
    Search LifeMap BioReagents cell lines for RPS12

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS12

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003735structural constituent of ribosome IEA--


    RPS12 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for RPS12:
     Cytoplasmic 40S maturation def  Decreased Hepatitis C virus re  Decreased cell number  Decreased viability of wild-ty 
     Nucleolar pre-40S maturation d  S arrest  Synthetic lethal with Ras 


    Pathways & Interactions
    for RPS12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Disease
    		Disease1.00
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS12
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS12 
        Cytoplasmic Ribosomal Proteins

    5/32        Reactome Pathways for RPS12 (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPS12):
        Ribosome


    RPS12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/199 Interacting proteins for RPS12 (P253982, 3 ENSP000002300504) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS17P087082, 3, ENSP000003460454MINT-8044024 I2D: score=2 STRING: ENSP00000346045
    MAP3K14Q995582, 3MINT-48843 I2D: score=2 
    RPS19P390192, 3, ENSP000002219754MINT-8044024 MINT-8395092 I2D: score=1 STRING: ENSP00000221975
    RPS5P467822, 3, ENSP000001965514MINT-8395092 I2D: score=1 STRING: ENSP00000196551
    RPS20P608662, 3, ENSP000000095894MINT-8044024 I2D: score=1 STRING: ENSP00000009589
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPS12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS12
    4 Novoseek chemical compound relationships for RPS12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    streptomycin 73.2 8 1725261 (1), 17238915 (1), 9634793 (1), 10645439 (1) (see all 6)
    kanamycin 52.2 1 17052696 (1)
    nadh 49.7 6 11920594 (2), 1865874 (1), 10355121 (1), 7476853 (1) (see all 5)
    glucose 0 1 9747975 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS12 / RS12 

    Transcripts
    for RPS12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS12 gene: 
    NM_001016.3  

    Unigene Cluster for RPS12:

    Ribosomal protein S12
    Hs.546289  [show with all ESTs]
    Unigene Representative Sequence: BC002550
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230050(uc003qdx.3) ENST00000484616

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RPS12
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS12
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS12 (see all 7)
    OriGene shRNA RFP: RPS12
    OriGene siRNA: RPS12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS12
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS12
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): RPS12 (NM_021107)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS12 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS12
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS12

    Additional cDNA sequence: 

    AK311826.1 BC002550.1 BC017321.2 BC071930.1 BC095424.1 X53505.1 

    24/61 DOTS entries (see all 61):

    DT.220499  DT.100711172  DT.100711162  DT.100711165  DT.92325986  DT.95156505  DT.100060132  DT.121388367 
    DT.95156600  DT.121388343  DT.121388399  DT.121388364  DT.40291319  DT.101987342  DT.91650205  DT.100061025 
    DT.100711164  DT.121388401  DT.121388332  DT.87017203  DT.121406732  DT.121388337  DT.91692616  DT.121388349 

    24/1384 AceView cDNA sequences (see all 1384):

    AA508683 BM752961 BQ059147 BQ428168 AA911050 AI207641 BQ643165 BU183610 
    BF718310 BQ066962 CB107852 CB110683 AA595084 CB151480 CF129326 AI066445 
    CB125681 CB149864 BQ669647 N68232 BF058003 AW172641 BM742041 AI000333 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
    SP1:                                      -                           
    SP2:                          -     -     -                           
    SP3:                                                                  
    SP4:                                      -     -     -     -         
    SP5:                          -     -     -                           


    ECgene alternative splicing isoforms for RPS12

    Expression
    for RPS12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCGAGGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPS12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPS12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS12

    SOURCE GeneReport for Unigene cluster: Hs.546289
        SABiosciences Custom PCR Arrays for RPS12
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS12
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS12
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS12
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS12
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS12

    Orthologs
    for RPS12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS12 gene from 10/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rps121 , 5 ribosomal protein S121, 5 91.41(n)1
    100(a)1    		   10 (11.10 cM)5
    200421  NM_011295.61  NP_035425.21 
     237852115 
    chicken
    (Gallus gallus)    		 Aves RPS121 ribosomal protein S12 84.34(n)
    99.24(a)    		   421698  XM_419736.3  XP_419736.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPS126
    		 --
    		 94(a)
    		 1 ↔ 1
    		 GL343200.1(4366556-4369981)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685292 hypothetical protein MGC68529 84.49(n)    BC056655.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa95a022 wufa95a02 81.64(n)   337007  BC059433.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpS123 protein biosynthesis structural constituent
    of more    		 67(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea rps-121 , 3 Protein RPS-121 65(a)3
    58.06(n)1
    61.29(a)1    		   III(5751105-5751923)3
    1757861  NM_065820.41  NP_498221.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPS12(YOR369C)4
    RPS121    		 Protein component of the small (40S) ribosomal subunit; more4
    Rps12p1    		 55.36(n)1
    55.65(a)1    		   15(1028625-1028194)4
    8545511, 4  NP_015014.31  NP_015014.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G159306
    AT2G320606
    		 40S ribosomal protein S12-2
    		 44(a)
    43(a)
    		 many → 1
    many → 1
    		 1(5471400-5473014)
    2(13639016-13640370)
    rice
    (Oryza sativa)    		 Liliopsida Os.229932 Transcribed sequence with weak similarity to protein more 71.1(n)    CA755296.1 


    ENSEMBL Gene Tree for RPS12 (if available)
    TreeFam Gene Tree for RPS12 (if available) 

    Paralogs
    for RPS12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS12 gene

    RPS12 for paralogs           About GeneDecksing


    5/33 Pseudogenes.org Pseudogenes for RPS12 (see all 33)
    PGOHUM00000238405 PGOHUM00000238514 PGOHUM00000238561 PGOHUM00000238852 PGOHUM00000242381


    Genomic Variants
    for RPS12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/238 NCBI SNPs in RPS12 are shown (see all 238)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1823978991,2
    		--133133828(+) GTCTTC/TAGATA 1 -- us2k10--------
    rs1466622561,2
    		--133133847(+) TGCGCG/TGAAAG 1 -- us2k10--------
    rs737729611,2
    		C,--133133906(+) CTCCAA/GAAAAG 1 -- us2k13Minor allele frequency- G:0.12WA CSA 122
    rs793338411,2
    		C,F,--133133938(+) TGCCCC/GTACAC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1403121041,2
    		--133133949(+) TTTCAC/TCCATT 1 -- us2k10--------
    rs1501381651,2
    		F--133133963(+) AATACC/ACTCCT 1 -- us2k11Minor allele frequency- A:0.03NS 140
    rs1161059471,2
    		C,F,--133134001(+) CTCTTA/CGTTTT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1440293501,2
    		--133134041(+) AAGCCC/TGAGGT 1 -- us2k10--------
    rs104575941,2
    		C,F,A,--133134100(+) GTATCT/GCCTCT 1 -- us2k112Minor allele frequency- G:0.35NA WA CSA EA NS 592
    rs1464975721,2
    		--133134136(+) GTCTAA/CAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS12 (133135580 - 133138703 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPS12: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS12
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS12

    Disorders / Diseases
    for RPS12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS12 for disorders           About GeneDecksing

    OMIM gene information: 603660    OMIM disorders: --

    11 diseases for RPS12:    About MalaCards
    colorectal cancer    squamous cell carcinoma    diphtheria    cervicitis
    cervical carcinoma    tuberculosis    breast carcinoma    carcinoma
    retinitis    malaria    mycobacterium tuberculosis

    3 Novoseek disease relationships for RPS12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterility male 63.8 2 1865874 (1), 10355121 (1)
    tuberculosis 31.4 2 17238915 (1), 19519851 (1)
    cervical cancer 15.1 1 11920594 (1)

    Human Genome Epidemiology (HuGE) Navigator: RPS12 (2 documents)

    Export disorders for RPS12 gene to outside databases

    Publications
    for RPS12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS12 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with RPS12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    2. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PubMed id 1861993)1, 2, 3 Herault Y.... Brun G. (1991)
    3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    5. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PubMed id 11870519)1, 9 Cheng Q....Hui K.M. (2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)

    External Searches for RPS12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPS12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6206 HGNC: 10385 AceView: RPS12 Ensembl:ENSG00000112306 euGenes: HUgn6206
    ECgene: RPS12 Kegg: 6206 H-InvDB: RPS12

    Other Databases showing RPS12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RPS12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS12 gene:
    Search GeneIP for patents involving RPS12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RPS12 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RPS12  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS12   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS12  
     OriGene Protein Over-expression Lysate for RPS12   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RPS12   OriGene 3'-UTR Clone for RPS12  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS12   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS12  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS12   OriGene Custom Protein Services for RPS12  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS12
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS12
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS12
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS12
     GenScript Custom Purified and Recombinant Proteins Services for RPS12 GenScript cDNA clones with any tag delivered in your preferred vector for RPS12
     GenScript Custom Assay Services for RPS12 GenScript Custom Superior Antibodies Services for RPS12
     GenScript Custom overexpressing Cell Line Services for RPS12 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPS12 promoter
     Search Chromatin IP Primers for RPS12
     RT2 qPCR Primer Assay in human, mouse, rat RPS12
     Search GNC Networks for RPS12
     SABiosciences Custom PCR Arrays for RPS12
     Search Tocris compounds for RPS12
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS12 antibodies
     RPS12 proteins
     RPS12 lysates
     Antibodies for RPS12
     See all of Abcam's Antibodies, Kits and Proteins for RPS12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RPS12 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RPS12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS12
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPS12
     SwitchGear Promoter luciferase reporter plasmids for RPS12
     Search ThermoFisher Antibodies for RPS12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS12
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RPS12 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4