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Aliases for RPS12 Gene

Aliases for RPS12 Gene

  • Ribosomal Protein S12 2 3 5
  • Small Ribosomal Subunit Protein ES12 3 4
  • 40S Ribosomal Protein S12 3
  • S12 3

External Ids for RPS12 Gene

Previous GeneCards Identifiers for RPS12 Gene

  • GC06P132758
  • GC06P132982
  • GC06P133116
  • GC06P133177
  • GC06P130710
  • GC06P133136

Summaries for RPS12 Gene

Entrez Gene Summary for RPS12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS12 Gene

RPS12 (Ribosomal Protein S12) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS12 Gene

Genomics for RPS12 Gene

Regulatory Elements for RPS12 Gene

Enhancers for RPS12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G132812 1.5 FANTOM5 ENCODE 10.9 +0.1 140 4.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D SLC18B1 RPS12 SNORA33 VNN1 GC06P132818
GH06G132669 1 Ensembl ENCODE 11.3 -142.5 -142502 4.2 CTCF ESRRA FOXA2 ZNF133 MAX RAD21 POLR2A ZNF366 HNF4G SMC3 ENSG00000234484 VNN2 VNN3 RPS12 SNORD100 SNORD101 SNORA33 SLC18B1 VNN1 HLFP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS12 on UCSC Golden Path with GeneCards custom track

Promoters for RPS12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000203019 -241 3201 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for RPS12 Gene

132,814,441 bp from pter
132,817,564 bp from pter
3,124 bases
Plus strand

Genomic View for RPS12 Gene

Genes around RPS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS12 Gene

Proteins for RPS12 Gene

  • Protein details for RPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S12
    Protein Accession:
    Secondary Accessions:
    • Q76M58

    Protein attributes for RPS12 Gene

    132 amino acids
    Molecular mass:
    14515 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS12 Gene

neXtProt entry for RPS12 Gene

Post-translational modifications for RPS12 Gene

  • Ubiquitination at Lys93, isoforms=112, and isoforms=129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS12 Gene

Domains & Families for RPS12 Gene

Gene Families for RPS12 Gene

Suggested Antigen Peptide Sequences for RPS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS12 family.
  • Belongs to the eukaryotic ribosomal protein eS12 family.
genes like me logo Genes that share domains with RPS12: view

Function for RPS12 Gene

Molecular function for RPS12 Gene

GENATLAS Biochemistry:
60S ribosomal protein S12

Gene Ontology (GO) - Molecular Function for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with RPS12: view
genes like me logo Genes that share phenotypes with RPS12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS12 Gene

Localization for RPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS12 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS12 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS12: view

Pathways & Interactions for RPS12 Gene

SuperPathways for RPS12 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS12: view

Gene Ontology (GO) - Biological Process for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 1861993
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS12: view

No data available for SIGNOR curated interactions for RPS12 Gene

Drugs & Compounds for RPS12 Gene

(4) Drugs for RPS12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPS12: view

Transcripts for RPS12 Gene

mRNA/cDNA for RPS12 Gene

Unigene Clusters for RPS12 Gene

Ribosomal protein S12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - - -
SP4: - - - -
SP5: - - -

Relevant External Links for RPS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS12 Gene

Protein differential expression in normal tissues from HIPED for RPS12 Gene

This gene is overexpressed in Amniocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS12 Gene

Protein tissue co-expression partners for RPS12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS12 Gene:


SOURCE GeneReport for Unigene cluster for RPS12 Gene:


Evidence on tissue expression from TISSUES for RPS12 Gene

  • Liver(4.9)
  • Skin(4.7)
  • Nervous system(4.3)
  • Intestine(3.2)
  • Heart(2.9)
  • Pancreas(2.8)
  • Muscle(2.7)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Lung(2.5)
  • Stomach(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RPS12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS12 Gene

Orthologs for RPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia RPS12 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS12 35
  • 100 (a)
(Pan troglodytes)
Mammalia RPS12 34 35
  • 99.49 (n)
(Canis familiaris)
Mammalia RPS12 34 35
  • 95.71 (n)
(Bos Taurus)
Mammalia RPS12 34
  • 94.44 (n)
-- 35
  • 85 (a)
(Mus musculus)
Mammalia Rps12 34 16 35
  • 91.41 (n)
(Rattus norvegicus)
Mammalia Rps12 34
  • 91.41 (n)
(Gallus gallus)
Aves RPS12 34 35
  • 83.2 (n)
(Anolis carolinensis)
Reptilia RPS12 35
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps12 34
  • 86.87 (n)
Str.17155 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68529 34
(Danio rerio)
Actinopterygii rps12 34 35
  • 81.31 (n)
wufa95a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8526 34
fruit fly
(Drosophila melanogaster)
Insecta RpS12 36 35
  • 67 (a)
(Caenorhabditis elegans)
Secernentea rps-12 36 34 35
  • 58.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS12 34 35 37
  • 55.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR412C 34
  • 55.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00352g 34
  • 53.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15930 34
  • 58.69 (n)
(Oryza sativa)
Liliopsida Os07g0150200 34
  • 62.81 (n)
Os.22993 34
(Hordeum vulgare)
Liliopsida Hv.7997 34
(Triticum aestivum)
Liliopsida Ta.22961 34
(Zea mays)
Liliopsida Zm.6239 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4620 35
  • 66 (a)
-- 35
  • 53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1201 34
  • 62.06 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06432 34
  • 56.35 (n)
Species where no ortholog for RPS12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS12 Gene

Gene Tree for RPS12 (if available)
Gene Tree for RPS12 (if available)

Paralogs for RPS12 Gene

No data available for Paralogs for RPS12 Gene

Variants for RPS12 Gene

Sequence variations from dbSNP and Humsavar for RPS12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000421697 -- 132,814,751(+) AACTT(C/T)ACCCG upstream-variant-2KB, utr-variant-5-prime
rs1000519286 -- 132,814,207(+) TGGTG(G/T)GGAAA upstream-variant-2KB
rs1001612348 -- 132,813,329(+) AGCGC(C/T)GGCAC nc-transcript-variant, upstream-variant-2KB
rs1002374186 -- 132,815,044(+) CACGA(G/T)GGCCT upstream-variant-2KB, reference, missense
rs1002516999 -- 132,814,168(+) GGAGG(C/G)TGGGT nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS12 Gene

Variant ID Type Subtype PubMed ID
dgv1830e212 CNV loss 25503493
nsv970166 CNV duplication 23825009
nsv970167 CNV duplication 23825009

Variation tolerance for RPS12 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS12 Gene

Disorders for RPS12 Gene

Relevant External Links for RPS12

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS12 Gene

Publications for RPS12 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Herault Y. … Brun G. (Nucleic Acids Res. 1991) 2 3 4 64
  3. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PMID: 11870519) Cheng Q. … Hui K.M. (Br. J. Cancer 2002) 3 22 64
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4 64

Products for RPS12 Gene

Sources for RPS12 Gene

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