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Aliases for RPS12 Gene

Aliases for RPS12 Gene

  • Ribosomal Protein S12 2 3
  • 40S Ribosomal Protein S12 3
  • S12 3

External Ids for RPS12 Gene

Previous GeneCards Identifiers for RPS12 Gene

  • GC06P132758
  • GC06P132982
  • GC06P133116
  • GC06P133177
  • GC06P130710
  • GC06P133136

Summaries for RPS12 Gene

Entrez Gene Summary for RPS12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS12 Gene

RPS12 (Ribosomal Protein S12) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS12 Gene

Genomics for RPS12 Gene

Regulatory Elements for RPS12 Gene

Genomic Location for RPS12 Gene

Start:
132,814,441 bp from pter
End:
132,817,564 bp from pter
Size:
3,124 bases
Orientation:
Plus strand

Genomic View for RPS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS12 Gene

Proteins for RPS12 Gene

  • Protein details for RPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25398-RS12_HUMAN
    Recommended name:
    40S ribosomal protein S12
    Protein Accession:
    P25398
    Secondary Accessions:
    • Q76M58

    Protein attributes for RPS12 Gene

    Size:
    132 amino acids
    Molecular mass:
    14515 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS12 Gene

neXtProt entry for RPS12 Gene

Proteomics data for RPS12 Gene at MOPED

Post-translational modifications for RPS12 Gene

  • Ubiquitination at Lys93, Lys112, and Lys129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS12 Gene

Domains for RPS12 Gene

Gene Families for RPS12 Gene

HGNC:
  • RPS :S ribosomal proteins

Suggested Antigen Peptide Sequences for RPS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25398

UniProtKB/Swiss-Prot:

RS12_HUMAN :
  • P25398
Family:
  • Belongs to the ribosomal protein S12e family.
genes like me logo Genes that share domains with RPS12: view

Function for RPS12 Gene

Molecular function for RPS12 Gene

GENATLAS Biochemistry: 60S ribosomal protein S12

Gene Ontology (GO) - Molecular Function for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS12: view
genes like me logo Genes that share phenotypes with RPS12: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS12 Gene

Localization for RPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS12 Gene COMPARTMENTS Subcellular localization image for RPS12 gene
Compartment Confidence
cytosol 5
chloroplast 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0022627 cytosolic small ribosomal subunit NAS 1861993
genes like me logo Genes that share ontologies with RPS12: view

Pathways for RPS12 Gene

SuperPathways for RPS12 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS12: view

Pathways by source for RPS12 Gene

1 KEGG pathway for RPS12 Gene
1 GeneGo (Thomson Reuters) pathway for RPS12 Gene

Gene Ontology (GO) - Biological Process for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS12: view

Compounds for RPS12 Gene

(4) Novoseek inferred chemical compound relationships for RPS12 Gene

Compound -log(P) Hits PubMed IDs
streptomycin 73.2 6
kanamycin 52.2 1
nadh 49.7 6
glucose 0 1
genes like me logo Genes that share compounds with RPS12: view

Transcripts for RPS12 Gene

mRNA/cDNA for RPS12 Gene

(1384) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS12 Gene

Ribosomal protein S12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for RPS12 Gene

GeneLoc Exon Structure for
RPS12
ECgene alternative splicing isoforms for
RPS12

Expression for RPS12 Gene

mRNA expression in normal human tissues for RPS12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS12 Gene

SOURCE GeneReport for Unigene cluster for RPS12 Gene Hs.546289

genes like me logo Genes that share expressions with RPS12: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS12 Gene

Orthologs for RPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS12 35
  • 99.49 (n)
  • 100 (a)
RPS12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
OneToMany
RPS12 35
  • 94.44 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RPS12 35
  • 95.71 (n)
  • 100 (a)
RPS12 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps12 35
  • 91.41 (n)
  • 100 (a)
Rps12 16
Rps12 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS12 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps12 35
  • 91.41 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS12 35
  • 83.2 (n)
  • 100 (a)
RPS12 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS12 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68529 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rps12 35
  • 86.87 (n)
  • 98.48 (a)
Str.17155 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8526 35
zebrafish
(Danio rerio)
Actinopterygii rps12 35
  • 81.31 (n)
  • 96.97 (a)
rps12 36
  • 97 (a)
OneToOne
wufa95a02 35
fruit fly
(Drosophila melanogaster)
Insecta RpS12 36
  • 58 (a)
OneToOne
RpS12 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-12 35
  • 58.06 (n)
  • 61.29 (a)
rps-12 36
  • 55 (a)
OneToOne
rps-12 37
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR412C 35
  • 55.07 (n)
  • 54.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS12 35
  • 55.46 (n)
  • 56.64 (a)
RPS12 36
  • 46 (a)
OneToOne
RPS12 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00352g 35
  • 53.85 (n)
  • 50.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15930 35
  • 58.69 (n)
  • 52.99 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7997 35
corn
(Zea mays)
Liliopsida Zm.6239 35
rice
(Oryza sativa)
Liliopsida Os.22993 35
Os07g0150200 35
  • 62.81 (n)
  • 62.81 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22961 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06432 35
  • 56.35 (n)
  • 58.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1201 35
  • 62.06 (n)
  • 65.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
CSA.4620 36
  • 66 (a)
OneToMany
Species with no ortholog for RPS12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS12 Gene

ENSEMBL:
Gene Tree for RPS12 (if available)
TreeFam:
Gene Tree for RPS12 (if available)

Paralogs for RPS12 Gene

genes like me logo Genes that share paralogs with RPS12: view

No data available for Paralogs for RPS12 Gene

Variants for RPS12 Gene

Sequence variations from dbSNP and Humsavar for RPS12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9483503 -- 132,813,043(+) GAATC(A/G)TCTTT upstream-variant-2KB
rs10457594 -- 132,812,961(+) GTATC(G/T)CCTCT upstream-variant-2KB
rs34048476 -- 132,813,061(+) CCTCG(-/TT)TTTTT upstream-variant-2KB
rs62425119 -- 132,813,079(+) TTTAA(A/T)TCAAA upstream-variant-2KB
rs67074708 -- 132,817,982(+) TTTGA(-/CTT)CTTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPS12 Gene

Variant ID Type Subtype PubMed ID
nsv886676 CNV Loss 21882294

Relevant External Links for RPS12 Gene

HapMap Linkage Disequilibrium report
RPS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS12 Gene

Disorders for RPS12 Gene

(3) Novoseek inferred disease relationships for RPS12 Gene

Disease -log(P) Hits PubMed IDs
sterility male 63.8 2
tuberculosis 31.4 2
cervical cancer 15.1 1

Relevant External Links for RPS12

Human Genome Epidemiology (HuGE) Navigator
RPS12
genes like me logo Genes that share disorders with RPS12: view

No data available for UniProtKB/Swiss-Prot for RPS12 Gene

Publications for RPS12 Gene

  1. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Herault Y. … Brun G. (Nucleic Acids Res. 1991) 2 3 4
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  3. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  4. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PMID: 11870519) Cheng Q. … Hui K.M. (Br. J. Cancer 2002) 3 23
  5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4

Products for RPS12 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPS12
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPS12
    • Block miRNA regulation of RPS12 using miScript Target Protectors

    Sources for RPS12 Gene

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