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Aliases for RPS12 Gene

Aliases for RPS12 Gene

  • Ribosomal Protein S12 2 3 5
  • S12 3

External Ids for RPS12 Gene

Previous GeneCards Identifiers for RPS12 Gene

  • GC06P132758
  • GC06P132982
  • GC06P133116
  • GC06P133177
  • GC06P130710
  • GC06P133136

Summaries for RPS12 Gene

Entrez Gene Summary for RPS12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS12 Gene

RPS12 (Ribosomal Protein S12) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS12 Gene

Genomics for RPS12 Gene

Regulatory Elements for RPS12 Gene

Enhancers for RPS12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS12 on UCSC Golden Path with GeneCards custom track

Promoters for RPS12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS12 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS12 Gene

132,814,441 bp from pter
132,817,564 bp from pter
3,124 bases
Plus strand

Genomic View for RPS12 Gene

Genes around RPS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS12 Gene

Proteins for RPS12 Gene

  • Protein details for RPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S12
    Protein Accession:
    Secondary Accessions:
    • Q76M58

    Protein attributes for RPS12 Gene

    132 amino acids
    Molecular mass:
    14515 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS12 Gene

neXtProt entry for RPS12 Gene

Proteomics data for RPS12 Gene at MOPED

Post-translational modifications for RPS12 Gene

  • Ubiquitination at Lys 93, Lys 112, and Lys 129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS12 Gene

Domains & Families for RPS12 Gene

Gene Families for RPS12 Gene

Suggested Antigen Peptide Sequences for RPS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S12e family.
  • Belongs to the ribosomal protein S12e family.
genes like me logo Genes that share domains with RPS12: view

Function for RPS12 Gene

Molecular function for RPS12 Gene

GENATLAS Biochemistry:
60S ribosomal protein S12
genes like me logo Genes that share phenotypes with RPS12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS12 Gene

Localization for RPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS12 Gene


Subcellular locations from

Jensen Localization Image for RPS12 Gene COMPARTMENTS Subcellular localization image for RPS12 gene
Compartment Confidence
cytosol 5
chloroplast 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPS12: view

Pathways & Interactions for RPS12 Gene

SuperPathways for RPS12 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS12: view

Gene Ontology (GO) - Biological Process for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPS12: view

No data available for SIGNOR curated interactions for RPS12 Gene

Drugs & Compounds for RPS12 Gene

(3) Drugs for RPS12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RPS12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS12: view

Transcripts for RPS12 Gene

mRNA/cDNA for RPS12 Gene

Unigene Clusters for RPS12 Gene

Ribosomal protein S12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - - -
SP4: - - - -
SP5: - - -

Relevant External Links for RPS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS12 Gene

mRNA expression in normal human tissues for RPS12 Gene

Protein differential expression in normal tissues from HIPED for RPS12 Gene

This gene is overexpressed in Amniocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS12 Gene

SOURCE GeneReport for Unigene cluster for RPS12 Gene Hs.546289

genes like me logo Genes that share expression patterns with RPS12: view

Protein tissue co-expression partners for RPS12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS12 Gene

Orthologs for RPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS12 35
  • 94.44 (n)
  • 100 (a)
-- 36
  • 85 (a)
(Canis familiaris)
Mammalia RPS12 35
  • 95.71 (n)
  • 100 (a)
RPS12 36
  • 100 (a)
(Mus musculus)
Mammalia Rps12 35
  • 91.41 (n)
  • 100 (a)
Rps12 16
Rps12 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS12 35
  • 99.49 (n)
  • 100 (a)
RPS12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps12 35
  • 91.41 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS12 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS12 36
  • 100 (a)
(Gallus gallus)
Aves RPS12 35
  • 83.2 (n)
  • 100 (a)
RPS12 36
  • 99 (a)
(Anolis carolinensis)
Reptilia RPS12 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps12 35
  • 86.87 (n)
  • 98.48 (a)
Str.17155 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68529 35
(Danio rerio)
Actinopterygii rps12 35
  • 81.31 (n)
  • 96.97 (a)
wufa95a02 35
rps12 36
  • 97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8526 35
fruit fly
(Drosophila melanogaster)
Insecta RpS12 37
  • 67 (a)
RpS12 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea rps-12 37
  • 65 (a)
rps-12 35
  • 58.06 (n)
  • 61.29 (a)
rps-12 36
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR412C 35
  • 55.07 (n)
  • 54.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00352g 35
  • 53.85 (n)
  • 50.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS12 35
  • 55.46 (n)
  • 56.64 (a)
RPS12 36
  • 46 (a)
RPS12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15930 35
  • 58.69 (n)
  • 52.99 (a)
(Hordeum vulgare)
Liliopsida Hv.7997 35
(Oryza sativa)
Liliopsida Os.22993 35
Os07g0150200 35
  • 62.81 (n)
  • 62.81 (a)
(Triticum aestivum)
Liliopsida Ta.22961 35
(Zea mays)
Liliopsida Zm.6239 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06432 35
  • 56.35 (n)
  • 58.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1201 35
  • 62.06 (n)
  • 65.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
CSA.4620 36
  • 66 (a)
Species with no ortholog for RPS12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS12 Gene

Gene Tree for RPS12 (if available)
Gene Tree for RPS12 (if available)

Paralogs for RPS12 Gene

genes like me logo Genes that share paralogs with RPS12: view

No data available for Paralogs for RPS12 Gene

Variants for RPS12 Gene

Sequence variations from dbSNP and Humsavar for RPS12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9483503 -- 132,813,043(+) GAATC(A/G)TCTTT upstream-variant-2KB
rs10457594 -- 132,812,961(+) GTATC(G/T)CCTCT upstream-variant-2KB
rs62425119 -- 132,813,079(+) TTTAA(A/T)TCAAA upstream-variant-2KB
rs67074708 -- 132,817,982(+) TTTGA(-/CTT)CTTTG downstream-variant-500B
rs143811673 -- 132,813,126(+) AGCAG(C/T)TTCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS12 Gene

Variant ID Type Subtype PubMed ID
nsv886676 CNV Loss 21882294

Variation tolerance for RPS12 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS12 Gene

Disorders for RPS12 Gene

Relevant External Links for RPS12

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS12 Gene

Publications for RPS12 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PMID: 11870519) Cheng Q. … Hui K.M. (Br. J. Cancer 2002) 3 23
  3. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Herault Y. … Brun G. (Nucleic Acids Res. 1991) 2 3
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for RPS12 Gene

Sources for RPS12 Gene