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Aliases for RPS11 Gene

Aliases for RPS11 Gene

  • Ribosomal Protein S11 2 3 5
  • Small Ribosomal Subunit Protein US17 3 4
  • 40S Ribosomal Protein S11 2 3
  • S11 3

External Ids for RPS11 Gene

Previous GeneCards Identifiers for RPS11 Gene

  • GC19P050657
  • GC19P050367
  • GC19P054675
  • GC19P054692
  • GC19P054693
  • GC19P054695
  • GC19P054710
  • GC19P054719
  • GC19P054720
  • GC19P054728
  • GC19P054735
  • GC19P054742
  • GC19P054749
  • GC19P054755
  • GC19P054767
  • GC19P054779
  • GC19P049999
  • GC19P046377

Summaries for RPS11 Gene

Entrez Gene Summary for RPS11 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

GeneCards Summary for RPS11 Gene

RPS11 (Ribosomal Protein S11) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and rRNA binding.

Gene Wiki entry for RPS11 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS11 Gene

Genomics for RPS11 Gene

Regulatory Elements for RPS11 Gene

Enhancers for RPS11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049494 2 FANTOM5 Ensembl ENCODE dbSUPER 36.3 +2.7 2679 9.7 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPS11 ALDH16A1 SNORD35A PIH1D1 SNORD35B RPL18 FLT3LG PRR12 CD37 POLD1
GH19G049486 1.7 Ensembl ENCODE dbSUPER 23.4 -6.1 -6126 7.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 SP3 NFYC RPS11 NUP62 PRR12 ALDH16A1 SNORD35B FLT3LG SNORD35A PIH1D1 POLD1 RPL18
GH19G048632 1.7 Ensembl ENCODE dbSUPER 23.1 -859.9 -859889 7.8 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PRR12 ENSG00000268093 GRWD1 RPS11 SNORD35A PIH1D1 RPL18 NOP53-AS1 SNORD35B ALDH16A1
GH19G048612 1.7 Ensembl ENCODE dbSUPER 21.6 -879.6 -879603 7.8 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC PRR12 SNORD35A KDELR1 SNORD35B ALDH16A1 GRWD1 SEC1P NOP53-AS1 RPS11 PIH1D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS11 on UCSC Golden Path with GeneCards custom track

Promoters for RPS11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110906 135 1801 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D

Genomic Location for RPS11 Gene

49,496,365 bp from pter
49,499,712 bp from pter
3,348 bases
Plus strand

Genomic View for RPS11 Gene

Genes around RPS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS11 Gene

Proteins for RPS11 Gene

  • Protein details for RPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S11
    Protein Accession:
    Secondary Accessions:
    • B2R4F5
    • P04643
    • Q498Y6
    • Q6IRY0

    Protein attributes for RPS11 Gene

    158 amino acids
    Molecular mass:
    18431 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS11 Gene

neXtProt entry for RPS11 Gene

Post-translational modifications for RPS11 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys12, isoforms=32, isoforms=38, Lys59, and Lys136
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS11 Gene

No data available for DME Specific Peptides for RPS11 Gene

Domains & Families for RPS11 Gene

Gene Families for RPS11 Gene

Suggested Antigen Peptide Sequences for RPS11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS17 family.
  • Belongs to the universal ribosomal protein uS17 family.
genes like me logo Genes that share domains with RPS11: view

Function for RPS11 Gene

Molecular function for RPS11 Gene

GENATLAS Biochemistry:
40S ribosomal protein S11,18kDa

Gene Ontology (GO) - Molecular Function for RPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 24725412
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS11: view
genes like me logo Genes that share phenotypes with RPS11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS11 Gene

Localization for RPS11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS11 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS11 Gene

Pathways & Interactions for RPS11 Gene

SuperPathways for RPS11 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS11: view

Gene Ontology (GO) - Biological Process for RPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001649 osteoblast differentiation IEA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 1577483
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS11: view

No data available for SIGNOR curated interactions for RPS11 Gene

Drugs & Compounds for RPS11 Gene

No Compound Related Data Available

Transcripts for RPS11 Gene

mRNA/cDNA for RPS11 Gene

Unigene Clusters for RPS11 Gene

Ribosomal protein S11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for RPS11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS11 Gene

This gene is overexpressed in Tlymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS11 Gene

Protein tissue co-expression partners for RPS11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS11 Gene:


SOURCE GeneReport for Unigene cluster for RPS11 Gene:


Evidence on tissue expression from TISSUES for RPS11 Gene

  • Eye(4.9)
  • Liver(4.9)
  • Lung(4.9)
  • Blood(4.8)
  • Nervous system(4.8)
  • Intestine(4.4)
  • Pancreas(4.4)
  • Stomach(4.4)
  • Bone(4.2)
  • Muscle(4.2)
  • Skin(3.9)
  • Heart(3.3)
  • Kidney(3.2)
  • Bone marrow(3)
  • Lymph node(3)
  • Spleen(2.9)
  • Adrenal gland(2.8)
  • Thyroid gland(2.8)
  • Gall bladder(2.7)
genes like me logo Genes that share expression patterns with RPS11: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS11 Gene

Orthologs for RPS11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS11 35
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS11 35
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia RPS11 35
  • 97 (a)
(Bos Taurus)
Mammalia RPS11 34 35
  • 91.98 (n)
(Canis familiaris)
Mammalia RPS11 34 35
  • 90.72 (n)
(Rattus norvegicus)
Mammalia Rps11 34
  • 90.3 (n)
(Mus musculus)
Mammalia Rps11 34 16 35
  • 90.08 (n)
(Gallus gallus)
Aves RPS11 34 35
  • 86.71 (n)
(Anolis carolinensis)
Reptilia RPS11 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps11 34
  • 85.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia rps11-prov 34
(Danio rerio)
Actinopterygii rps11 34 35
  • 81.86 (n)
RPS11 (2 of 2) 35
  • 72 (a)
Dr.1339 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8696 34
African malaria mosquito
(Anopheles gambiae)
Insecta RS11_ANOGA 34
  • 71.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8857 36
  • 71 (a)
RpS11 34 35
  • 69.68 (n)
(Caenorhabditis elegans)
Secernentea rps-11 36 34 35
  • 66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS11B 35 37
  • 69 (a)
RPS11A 34 35
  • 66.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL091C 34
  • 66.89 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10483g 34
  • 65.1 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS11-BETA 34
  • 62.5 (n)
(Glycine max)
eudicotyledons Gma.13177 34
(Oryza sativa)
Liliopsida Os04g0502300 34
  • 63.49 (n)
Os.9405 34
(Hordeum vulgare)
Liliopsida Hv.837 34
(Triticum aestivum)
Liliopsida Ta.1289 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7869 35
  • 74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1102 34
  • 65.98 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03102 34
  • 65.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7405 34
Species where no ortholog for RPS11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS11 Gene

Gene Tree for RPS11 (if available)
Gene Tree for RPS11 (if available)

Paralogs for RPS11 Gene

No data available for Paralogs for RPS11 Gene

Variants for RPS11 Gene

Sequence variations from dbSNP and Humsavar for RPS11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000106134 -- 49,499,294(+) GTCCT(C/T)GGAGG intron-variant
rs1000428049 -- 49,498,401(+) GAAAC(A/G)AAGTT intron-variant
rs1000878761 -- 49,498,269(+) ATGTT(C/T)TCGCA intron-variant, downstream-variant-500B
rs1001270349 -- 49,497,009(+) TATGA(A/G)TTACA intron-variant, upstream-variant-2KB
rs1002649887 -- 49,496,802(+) CCTGC(C/T)GTCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS11 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for RPS11 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS11 Gene

Disorders for RPS11 Gene

Relevant External Links for RPS11

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS11 Gene

Publications for RPS11 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim Y.J. … Cho Y.S. (Nat. Genet. 2011) 3 46 64
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome. (PMID: 10580157) Higa S. … Kenmochi N. (Gene 1999) 3 4 64

Products for RPS11 Gene

Sources for RPS11 Gene

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