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Aliases for RPS10-NUDT3 Gene

Aliases for RPS10-NUDT3 Gene

  • RPS10-NUDT3 Readthrough 2 3 5

External Ids for RPS10-NUDT3 Gene

Previous GeneCards Identifiers for RPS10-NUDT3 Gene

  • GC06U902178
  • GC06M035243
  • GC06M035740
  • GC06M034554
  • GC06M035577
  • GC06M036317
  • GC06M036686
  • GC06M037041

Summaries for RPS10-NUDT3 Gene

Entrez Gene Summary for RPS10-NUDT3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RPS10 (ribosomal protein S10) and NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) genes on chromosome 6. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for RPS10-NUDT3 Gene

RPS10-NUDT3 (RPS10-NUDT3 Readthrough) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is RPS10.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS10-NUDT3 Gene

Genomics for RPS10-NUDT3 Gene

Regulatory Elements for RPS10-NUDT3 Gene

Enhancers for RPS10-NUDT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G034424 1.2 ENCODE 0.7 +0.8 831 2.9 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 RPS10 ENSG00000272374 LEMD2 RPL35P2 NUDT3 RPS10-NUDT3
GH06G034423 1 ENCODE 0.7 +2.8 2767 0.2 HDGF HNRNPUL1 PKNOX1 ARID4B FEZF1 ZNF2 YY1 FOS ZNF263 PAF1 RPS10-NUDT3 RPS10 NUDT3
GH06G034414 1.3 Ensembl ENCODE 0.4 +10.9 10944 1.7 PKNOX1 FOXA2 ARNT ARID4B DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP5 RPS10 RPS10-NUDT3 NUDT3
GH06G034462 1.1 Ensembl ENCODE 0.3 -36.6 -36607 0.7 HDGF PKNOX1 KLF17 NFXL1 ZNF2 RAD21 ZNF121 ZNF391 EGR2 ZNF263 PACSIN1 RPS10 RPS10-NUDT3
GH06G034416 0.8 ENCODE 0.4 +9.9 9865 0.2 PKNOX1 NFIB ZNF792 RAD21 EGR1 POLR2A NFE2 ZNF600 ZNF652 PAF1 RPS10 RPS10-NUDT3 NUDT3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS10-NUDT3 on UCSC Golden Path with GeneCards custom track

Promoters for RPS10-NUDT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195950 325 1601 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for RPS10-NUDT3 Gene

Chromosome:
6
Start:
34,284,887 bp from pter
End:
34,426,125 bp from pter
Size:
141,239 bases
Orientation:
Minus strand

Genomic View for RPS10-NUDT3 Gene

Genes around RPS10-NUDT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS10-NUDT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS10-NUDT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS10-NUDT3 Gene

Proteins for RPS10-NUDT3 Gene

  • Protein details for RPS10-NUDT3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R435
    Recommended name:
    RPS10-NUDT3 readthrough
    Protein Accession:
    S4R435

    Protein attributes for RPS10-NUDT3 Gene

    Size:
    286 amino acids
    Molecular mass:
    32596 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPS10-NUDT3 Gene

Post-translational modifications for RPS10-NUDT3 Gene

No Post-translational modifications

Other Protein References for RPS10-NUDT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS10-NUDT3 Gene

Domains & Families for RPS10-NUDT3 Gene

Protein Domains for RPS10-NUDT3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPS10-NUDT3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RPS10-NUDT3 Gene

Function for RPS10-NUDT3 Gene

Gene Ontology (GO) - Molecular Function for RPS10-NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPS10-NUDT3: view

Phenotypes for RPS10-NUDT3 Gene

genes like me logo Genes that share phenotypes with RPS10-NUDT3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPS10-NUDT3 Gene

Localization for RPS10-NUDT3 Gene

Gene Ontology (GO) - Cellular Components for RPS10-NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0022627 cytosolic small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with RPS10-NUDT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RPS10-NUDT3 Gene

Pathways & Interactions for RPS10-NUDT3 Gene

SuperPathways for RPS10-NUDT3 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.56
genes like me logo Genes that share pathways with RPS10-NUDT3: view

Pathways by source for RPS10-NUDT3 Gene

1 KEGG pathway for RPS10-NUDT3 Gene

Interacting Proteins for RPS10-NUDT3 Gene

Gene Ontology (GO) - Biological Process for RPS10-NUDT3 Gene

None

No data available for SIGNOR curated interactions for RPS10-NUDT3 Gene

Drugs & Compounds for RPS10-NUDT3 Gene

No Compound Related Data Available

Transcripts for RPS10-NUDT3 Gene

mRNA/cDNA for RPS10-NUDT3 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RPS10-NUDT3 Gene

No ASD Table

Relevant External Links for RPS10-NUDT3 Gene

GeneLoc Exon Structure for
RPS10-NUDT3
ECgene alternative splicing isoforms for
RPS10-NUDT3

Expression for RPS10-NUDT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS10-NUDT3 Gene

Protein differential expression in normal tissues from HIPED for RPS10-NUDT3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for RPS10-NUDT3 Gene



Protein tissue co-expression partners for RPS10-NUDT3 Gene

genes like me logo Genes that share expression patterns with RPS10-NUDT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS10-NUDT3 Gene

Orthologs for RPS10-NUDT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS10-NUDT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS10 34
  • 100 (n)
RPS10-NUDT3 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps10 35
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100361240 34
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RPS10 35
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps10 34
  • 80.48 (n)
zebrafish
(Danio rerio)
Actinopterygii rps10 34 35
  • 78.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000739 34
  • 63.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS10b 34 35
  • 62.42 (n)
RpS10a 35
  • 55 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rps-10 34 35
  • 61.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS10A 35
  • 53 (a)
ManyToMany
RPS10B 35
  • 52 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G52650 34
  • 57.45 (n)
rice
(Oryza sativa)
Liliopsida Os04g0430100 34
  • 57.26 (n)
Species where no ortholog for RPS10-NUDT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS10-NUDT3 Gene

ENSEMBL:
Gene Tree for RPS10-NUDT3 (if available)
TreeFam:
Gene Tree for RPS10-NUDT3 (if available)

Paralogs for RPS10-NUDT3 Gene

Paralogs for RPS10-NUDT3 Gene

(6) SIMAP similar genes for RPS10-NUDT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPS10-NUDT3: view

Variants for RPS10-NUDT3 Gene

Sequence variations from dbSNP and Humsavar for RPS10-NUDT3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs267607021 Pathogenic 34,425,219(-) CAGAT(A/G)TTGAT reference, missense
rs267607022 Pathogenic 34,421,793(-) GTGAG(C/T)GACCT reference, stop-gained
rs111597547 Likely benign 34,426,074(+) GAAGG(A/C)GCATG upstream-variant-2KB, utr-variant-5-prime
rs113071821 Likely benign 34,426,129(+) CCAGG(A/G)CCCGC upstream-variant-2KB
rs140822093 Likely benign 34,426,060(+) CCGGG(A/G)CTGGA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS10-NUDT3 Gene

Variant ID Type Subtype PubMed ID
dgv10618n54 CNV loss 21841781
dgv10619n54 CNV loss 21841781
dgv10620n54 CNV loss 21841781
dgv10621n54 CNV loss 21841781
dgv10622n54 CNV loss 21841781
dgv10623n54 CNV loss 21841781
dgv1115e199 CNV deletion 23128226
esv1159599 CNV insertion 17803354
esv2674771 CNV deletion 23128226
esv2731907 CNV deletion 23290073
esv2759418 CNV gain 17122850
esv29044 CNV loss 19812545
esv33496 CNV loss 17666407
esv3425871 CNV insertion 20981092
esv3567619 CNV deletion 23714750
esv3608655 CNV loss 21293372
esv3608656 CNV loss 21293372
esv3608657 CNV loss 21293372
nsv1034978 CNV gain 25217958
nsv473801 CNV novel sequence insertion 20440878
nsv5253 CNV insertion 18451855
nsv602863 CNV loss 21841781
nsv602886 CNV loss 21841781
nsv981133 CNV duplication 23825009

Variation tolerance for RPS10-NUDT3 Gene

Gene Damage Index Score: 0.25; 5.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS10-NUDT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS10-NUDT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS10-NUDT3 Gene

Disorders for RPS10-NUDT3 Gene

Relevant External Links for RPS10-NUDT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS10-NUDT3

No disorders were found for RPS10-NUDT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS10-NUDT3 Gene

Publications for RPS10-NUDT3 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 64
  2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 64
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  5. Construction of a human full-length cDNA bank. (PMID: 7821789) Kato S. … Aoki T. (Gene 1994) 3 64

Products for RPS10-NUDT3 Gene

Sources for RPS10-NUDT3 Gene

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