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Aliases for RPS10 Gene

Aliases for RPS10 Gene

  • Ribosomal Protein S10 2 3 5
  • Small Ribosomal Subunit Protein ES10 3 4
  • 40S Ribosomal Protein S10 3
  • DBA9 3
  • S10 3

External Ids for RPS10 Gene

Previous GeneCards Identifiers for RPS10 Gene

  • GC06M034383
  • GC06M034432
  • GC06M034493
  • GC06M034107
  • GC06M034514
  • GC06M034898
  • GC06M035236
  • GC06M035731
  • GC06M034633
  • GC06M035569
  • GC06M036282
  • GC06M036656
  • GC06M037009
  • GC06M037359

Summaries for RPS10 Gene

Entrez Gene Summary for RPS10 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]

GeneCards Summary for RPS10 Gene

RPS10 (Ribosomal Protein S10) is a Protein Coding gene. Diseases associated with RPS10 include Diamond-Blackfan Anemia 9 and Rps10-Related Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RPS10-NUDT3.

UniProtKB/Swiss-Prot for RPS10 Gene

  • Component of the 40S ribosomal subunit.

Gene Wiki entry for RPS10 Gene

Additional gene information for RPS10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS10 Gene

Genomics for RPS10 Gene

Regulatory Elements for RPS10 Gene

Enhancers for RPS10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H034223 2 FANTOM5 Ensembl ENCODE dbSUPER 38.8 +201.7 201688 2 HDGF ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF766 ZNF207 FOS VPS52 TAF11 RPS10 WDR46 LEMD2 DAXX RGL2 HCG25 ITPR3 RPL35P2
GH06H034390 1.4 ENCODE dbSUPER 48.1 +34.0 33989 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 RPS10 TAF11 ENSG00000272374 LEMD2 PHF1 ITPR3 ZNF76 NUDT3 SYNGAP1 ANKS1A
GH06H034233 1.7 Ensembl ENCODE dbSUPER 30 +183.9 183869 17 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D LEMD2 VPS52 TAF11 WDR46 HCG25 DAXX RPS10 RGL2 ITPR3 ZBTB22
GH06H033743 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +680.3 680327 5 HDGF ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 SLC30A9 LEMD2 BRD2 DAXX WDR46 RPS18 VPS52 RPS10 RXRB IP6K3 UQCC2
GH06H034424 1.1 ENCODE 31.3 +0.8 831 2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SLC30A9 CBX5 ZNF143 SP3 RPS10 LEMD2 RPS10-NUDT3 NUDT3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS10 on UCSC Golden Path with GeneCards custom track

Promoters for RPS10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195950 325 1601 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SLC30A9 CBX5 ZNF143 SP3

Genomic Location for RPS10 Gene

Chromosome:
6
Start:
34,417,454 bp from pter
End:
34,426,125 bp from pter
Size:
8,672 bases
Orientation:
Minus strand

Genomic View for RPS10 Gene

Genes around RPS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS10 Gene

Proteins for RPS10 Gene

  • Protein details for RPS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46783-RS10_HUMAN
    Recommended name:
    40S ribosomal protein S10
    Protein Accession:
    P46783
    Secondary Accessions:
    • B2R4E3
    • Q5TZC0

    Protein attributes for RPS10 Gene

    Size:
    165 amino acids
    Molecular mass:
    18898 Da
    Quaternary structure:
    • Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.

    Three dimensional structures from OCA and Proteopedia for RPS10 Gene

neXtProt entry for RPS10 Gene

Post-translational modifications for RPS10 Gene

  • Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.
  • Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).
  • Ubiquitination at Lys59, Lys107, isoforms=138, and isoforms=139
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS10 Gene

No data available for DME Specific Peptides for RPS10 Gene

Domains & Families for RPS10 Gene

Gene Families for RPS10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46783

UniProtKB/Swiss-Prot:

RS10_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS10 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS10 family.
genes like me logo Genes that share domains with RPS10: view

Function for RPS10 Gene

Molecular function for RPS10 Gene

GENATLAS Biochemistry:
40S ribosomal protein S10
UniProtKB/Swiss-Prot Function:
Component of the 40S ribosomal subunit.

Phenotypes From GWAS Catalog for RPS10 Gene

Gene Ontology (GO) - Molecular Function for RPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA,IDA 22658674
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 20159986
genes like me logo Genes that share ontologies with RPS10: view
genes like me logo Genes that share phenotypes with RPS10: view

Human Phenotype Ontology for RPS10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS10 Gene

Localization for RPS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS10 Gene

Cytoplasm. Nucleus, nucleolus. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS10 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA,IEA 20159986
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS10: view

Pathways & Interactions for RPS10 Gene

SuperPathways for RPS10 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS10: view

Gene Ontology (GO) - Biological Process for RPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IC 8706699
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS10: view

No data available for SIGNOR curated interactions for RPS10 Gene

Drugs & Compounds for RPS10 Gene

No Compound Related Data Available

Transcripts for RPS10 Gene

Unigene Clusters for RPS10 Gene

Ribosomal protein S10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPS10 Gene

No ASD Table

Relevant External Links for RPS10 Gene

GeneLoc Exon Structure for
RPS10
ECgene alternative splicing isoforms for
RPS10

Expression for RPS10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS10 Gene



Protein tissue co-expression partners for RPS10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS10 Gene:

RPS10

SOURCE GeneReport for Unigene cluster for RPS10 Gene:

Hs.406620

Evidence on tissue expression from TISSUES for RPS10 Gene

  • Skin(5)
  • Intestine(4.8)
  • Lung(4.8)
  • Nervous system(4.8)
  • Liver(4.5)
  • Bone(4.4)
  • Pancreas(4.4)
  • Eye(4.3)
  • Blood(4.2)
  • Kidney(3.9)
  • Muscle(3.6)
  • Stomach(3.6)
  • Heart(2.7)
  • Lymph node(2.2)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
Thorax:
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
Pelvis:
  • pelvis
  • penis
  • ureter
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RPS10: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS10 Gene

Orthologs for RPS10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToMany
-- 34
  • 99 (a)
OneToMany
RPS10 33 34
  • 91.11 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC742827 33
  • 98.99 (n)
mouse
(Mus musculus)
Mammalia Rps10-ps1 34
  • 97 (a)
OneToMany
Rps10 33 16
  • 91.11 (n)
cow
(Bos Taurus)
Mammalia RPS10 33 34
  • 92.73 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rps10 33
  • 89.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPS10 33 34
  • 85.05 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rps10 34
  • 91 (a)
OneToMany
zgc65936 33
fruit fly
(Drosophila melanogaster)
Insecta CG14206 35
  • 65 (a)
RpS10a 33 34
  • 64.14 (n)
RpS10b 34
  • 64 (a)
ManyToMany
BcDNA:LD32148 35
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-10 35 34
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR569W 33
  • 56.54 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08173g 33
  • 55.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS10A 33 34 36
  • 54.9 (n)
RPS10B 34
  • 52 (a)
ManyToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2081 33
rice
(Oryza sativa)
Liliopsida Os.20182 33
wheat
(Triticum aestivum)
Liliopsida Ta.14409 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1001 33
  • 64.1 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06743 33
  • 55.3 (n)
Species where no ortholog for RPS10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for RPS10 Gene

ENSEMBL:
Gene Tree for RPS10 (if available)
TreeFam:
Gene Tree for RPS10 (if available)

Paralogs for RPS10 Gene

Paralogs for RPS10 Gene

(3) SIMAP similar genes for RPS10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS10: view

Variants for RPS10 Gene

Sequence variations from dbSNP and Humsavar for RPS10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs267607021 Pathogenic 34,425,219(-) CAGAT(A/G)TTGAT reference, missense
rs267607022 Pathogenic 34,421,793(-) GTGAG(C/T)GACCT reference, stop-gained
rs111597547 Likely benign 34,426,074(+) GAAGG(A/C)GCATG upstream-variant-2KB, utr-variant-5-prime
rs113071821 Likely benign 34,426,129(+) CCAGG(A/G)CCCGC upstream-variant-2KB
rs140822093 Likely benign 34,426,060(+) CCGGG(A/G)CTGGA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS10 Gene

Variant ID Type Subtype PubMed ID
esv2759418 CNV gain 17122850
nsv981133 CNV duplication 23825009

Variation tolerance for RPS10 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS10 Gene

Human Gene Mutation Database (HGMD)
RPS10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS10 Gene

Disorders for RPS10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPS10 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 9
  • dba9
rps10-related diamond-blackfan anemia
  • diamond-blackfan anemia 9
diamond-blackfan anemia
  • diamond-blackfan anemia 1
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPS10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RS10_HUMAN
  • Diamond-Blackfan anemia 9 (DBA9) [MIM:613308]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS10
genes like me logo Genes that share disorders with RPS10: view

No data available for Genatlas for RPS10 Gene

Publications for RPS10 Gene

  1. Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. (PMID: 20159986) Ren J … Xu Z (The Journal of biological chemistry 2010) 3 4 22 60
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 60
  3. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4 60
  4. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. (PMID: 28132843) Sundaramoorthy E … Bennett EJ (Molecular cell 2017) 3 4 60
  5. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. (PMID: 28065601) Juszkiewicz S … Hegde RS (Molecular cell 2016) 3 4 60

Products for RPS10 Gene

Sources for RPS10 Gene

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