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Aliases for RPS10 Gene

Aliases for RPS10 Gene

  • Ribosomal Protein S10 2 3 5
  • 40S Ribosomal Protein S10 3
  • DBA9 3
  • S10 3

External Ids for RPS10 Gene

Previous GeneCards Identifiers for RPS10 Gene

  • GC06M034383
  • GC06M034432
  • GC06M034493
  • GC06M034107
  • GC06M034514
  • GC06M034898
  • GC06M035236
  • GC06M035731
  • GC06M034633
  • GC06M035569
  • GC06M036282

Summaries for RPS10 Gene

Entrez Gene Summary for RPS10 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]

GeneCards Summary for RPS10 Gene

RPS10 (Ribosomal Protein S10) is a Protein Coding gene. Diseases associated with RPS10 include Diamond-Blackfan Anemia 9 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RPS10-NUDT3.

UniProtKB/Swiss-Prot for RPS10 Gene

  • Component of the 40S ribosomal subunit.

Gene Wiki entry for RPS10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS10 Gene

Genomics for RPS10 Gene

Regulatory Elements for RPS10 Gene

Enhancers for RPS10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS10 on UCSC Golden Path with GeneCards custom track

Promoters for RPS10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS10 Gene

34,417,454 bp from pter
34,426,125 bp from pter
8,672 bases
Minus strand

Genomic View for RPS10 Gene

Genes around RPS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS10 Gene

Proteins for RPS10 Gene

  • Protein details for RPS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S10
    Protein Accession:
    Secondary Accessions:
    • B2R4E3
    • Q5TZC0

    Protein attributes for RPS10 Gene

    165 amino acids
    Molecular mass:
    18898 Da
    Quaternary structure:
    • Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.

    Three dimensional structures from OCA and Proteopedia for RPS10 Gene

neXtProt entry for RPS10 Gene

Post-translational modifications for RPS10 Gene

  • Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.
  • Ubiquitination at Lys 59, Lys 107, Lys 138, and Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS10 Gene

No data available for DME Specific Peptides for RPS10 Gene

Domains & Families for RPS10 Gene

Gene Families for RPS10 Gene

Protein Domains for RPS10 Gene


Suggested Antigen Peptide Sequences for RPS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S10e family.
  • Belongs to the ribosomal protein S10e family.
genes like me logo Genes that share domains with RPS10: view

Function for RPS10 Gene

Molecular function for RPS10 Gene

GENATLAS Biochemistry:
40S ribosomal protein S10
UniProtKB/Swiss-Prot Function:
Component of the 40S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for RPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 20159986
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS10: view
genes like me logo Genes that share phenotypes with RPS10: view

Human Phenotype Ontology for RPS10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS10 Gene

Localization for RPS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS10 Gene

Cytoplasm. Nucleus, nucleolus. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus.

Subcellular locations from

Jensen Localization Image for RPS10 Gene COMPARTMENTS Subcellular localization image for RPS10 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 20159986
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 7772601
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPS10: view

Pathways & Interactions for RPS10 Gene

SuperPathways for RPS10 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS10: view

Gene Ontology (GO) - Biological Process for RPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IC 8706699
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS10: view

No data available for SIGNOR curated interactions for RPS10 Gene

Drugs & Compounds for RPS10 Gene

No Compound Related Data Available

Transcripts for RPS10 Gene

mRNA/cDNA for RPS10 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS10 Gene

Ribosomal protein S10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS10 Gene

No ASD Table

Relevant External Links for RPS10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS10 Gene

mRNA expression in normal human tissues for RPS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS10 Gene

Protein tissue co-expression partners for RPS10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS10 Gene:


SOURCE GeneReport for Unigene cluster for RPS10 Gene:

genes like me logo Genes that share expression patterns with RPS10: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS10 Gene

Orthologs for RPS10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS10 34
  • 92.73 (n)
  • 100 (a)
RPS10 35
  • 91 (a)
(Canis familiaris)
Mammalia RPS10 34
  • 91.11 (n)
  • 100 (a)
-- 35
  • 99 (a)
-- 35
  • 99 (a)
RPS10 35
  • 100 (a)
(Mus musculus)
Mammalia Rps10 34
  • 91.11 (n)
  • 98.79 (a)
Rps10 16
Rps10-ps1 35
  • 97 (a)
(Pan troglodytes)
Mammalia LOC742827 34
  • 98.99 (n)
  • 97.58 (a)
(Rattus norvegicus)
Mammalia Rps10 34
  • 89.09 (n)
  • 98.79 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
(Gallus gallus)
Aves RPS10 34
  • 85.05 (n)
  • 98.79 (a)
RPS10 35
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
(Danio rerio)
Actinopterygii zgc65936 34
rps10 35
  • 91 (a)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD32148 36
  • 56 (a)
CG14206 36
  • 65 (a)
RpS10a 35
  • 57 (a)
RpS10b 35
  • 64 (a)
RpS10a 34
  • 64.14 (n)
  • 60.69 (a)
(Caenorhabditis elegans)
Secernentea rps-10 36
  • 48 (a)
rps-10 35
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR569W 34
  • 56.54 (n)
  • 51.96 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08173g 34
  • 55.66 (n)
  • 55.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS10A 34
  • 54.9 (n)
  • 55.88 (a)
RPS10A 35
  • 53 (a)
RPS10B 35
  • 52 (a)
RPS10A 37
(Hordeum vulgare)
Liliopsida Hv.2081 34
(Oryza sativa)
Liliopsida Os.20182 34
(Triticum aestivum)
Liliopsida Ta.14409 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06743 34
  • 55.3 (n)
  • 52.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1001 34
  • 64.1 (n)
  • 61.54 (a)
Species where no ortholog for RPS10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for RPS10 Gene

Gene Tree for RPS10 (if available)
Gene Tree for RPS10 (if available)

Paralogs for RPS10 Gene

Paralogs for RPS10 Gene

(3) SIMAP similar genes for RPS10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS10: view

Variants for RPS10 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS10 Gene

Variant ID Type Subtype PubMed ID
esv2759418 CNV gain 17122850
nsv981133 CNV duplication 23825009

Variation tolerance for RPS10 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPS10 Gene

Disorders for RPS10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPS10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 9
  • dba9
diamond-blackfan anemia
  • diamond-blackfan anemia 1
rps10-related diamond-blackfan anemia
  • dba9
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPS10 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 9 (DBA9) [MIM:613308]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS10: view

No data available for Genatlas for RPS10 Gene

Publications for RPS10 Gene

  1. Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. (PMID: 20159986) Ren J. … Xu Z. (J. Biol. Chem. 2010) 3 4 22 65
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 65
  3. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 65
  4. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (PMID: 20116044) Doherty L. … Gazda H.T. (Am. J. Hum. Genet. 2010) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for RPS10 Gene

Sources for RPS10 Gene

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