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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS10 Gene

protein-coding   GIFtS: 64
GCID: GC06M034898

ribosomal protein S10
 Explore 12 diseases affiliated with
RPS10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPS10    

Aliases
for RPS10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S101 2
S101 2
DBA92 5
MGC888191
40S Ribosomal Protein S102

External Ids:    HGNC: 103831   Entrez Gene: 62042   Ensembl: ENSG000001246147   OMIM: 6036325   UniProtKB: P467833   

Export aliases for RPS10 gene to outside databases

Previous GC identifers: GC06M034383 GC06M034432 GC06M034493 GC06M034107 GC06M034514


Summaries
for RPS10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS10:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of
ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to
adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of
the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that
encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring
locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: RS10_HUMAN, P46783
Function: Component of the 40S ribosomal subunit

Gene Wiki entry for RPS10


Genomic Views
for RPS10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS10 gene promoter:
         SREBP-1c   Olf-1   GATA-1   SREBP-1b   Evi-1   AREB6   CREB   SREBP-1a   deltaCREB   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS10 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

RPS10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M034898:  view genomic region     (about GC identifiers)

Start:
 34,385,231 bp from pter      End:
 34,393,902 bp from pter
Size:
 8,672 bases      Orientation:
 minus strand

Proteins
for RPS10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RS10_HUMAN, P46783 (See protein sequence)
Recommended Name: 40S ribosomal protein S10  
Size: 165 amino acids; 18898 Da
Subunit: Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=Localized in the granular component (GC) region of the
nucleolus. Methylation is required for its localization in the GC region. Co-localizes with NPS1 in the GC region of
the nucleolus
Secondary accessions: B2R4E3 Q5TZC0

Explore the universe of human proteins at neXtProt for RPS10: NX_P46783

Post-translational modifications:

  • Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component
    • (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46783

    • RPS10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005.1  NP_001190174.1  NP_001191020.1  

    ENSEMBL proteins: 
     ENSP00000347271   ENSP00000363169  
    Reactome Protein details: P46783
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPS10

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS7772601
    GO:0022627cytosolic small ribosomal subunit IDA8706699


    RPS10 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RPS10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS10 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005326 S10_plectin_N

    Graphical View of Domain Structure for InterPro Entry P46783

    ProtoNet protein and cluster: P46783

    1 Blocks protein family: IPB005326 Plectin/S10

    UniProtKB/Swiss-Prot: RS10_HUMAN, P46783
    Similarity: Belongs to the ribosomal protein S10e family


    Function
    for RPS10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RS10_HUMAN, P46783
    Function: Component of the 40S ribosomal subunit

         Genatlas biochemistry entry for RPS10:
    40S ribosomal protein S10

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RPS10:
    hsa-miR-4272
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    RPS10 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RPS10:
     Cytoplasmic 40S maturation def  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 
     Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 


    Pathways & Interactions
    for RPS10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Disease
    		Disease1.00
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS10
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS10 
        Cytoplasmic Ribosomal Proteins

    5/32        Reactome Pathways for RPS10 (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPS10):
        Ribosome


    RPS10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/361 Interacting proteins for RPS10 (P467832, 3 ENSP000003472714) via UniProtKB, MINT, STRING, and/or I2D (see all 361)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPS10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS10
    Search CenterWatch for drugs/clinical trials and news about RPS10 / RS10 

    Transcripts
    for RPS10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS10 gene (3 alternative transcripts): 
    NM_001014.4  NM_001203245.2  NM_001204091.1  

    Unigene Clusters for RPS10:

    Ribosomal protein S10
    Hs.406620  [show with all ESTs], Hs.645317  [show with all ESTs]
    Unigene Representative Sequences: AK025353, BF570090
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326199(uc003ojn.3 uc021yyu.1) ENST00000494077(uc003ojm.3)
    ENST00000467531 ENST00000464218 ENST00000344700 ENST00000480942

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RPS10:
    hsa-miR-4272
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS10 (see all 7)
    OriGene shRNA RFP: RPS10
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS10
    Clone
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    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS10

    Additional cDNA sequence: 

    AB209165.1 AK311797.1 BC001032.2 BC070235.1 BC071946.1 BC073799.1 U14972.1 

    24/87 DOTS entries (see all 87):

    DT.100741961  DT.95148488  DT.102845466  DT.100060228  DT.100741966  DT.87009604  DT.100741994  DT.100060233 
    DT.100742007  DT.100851413  DT.97861563  DT.100741977  DT.97863460  DT.97863822  DT.100741970  DT.91727229 
    DT.97863804  DT.100874268  DT.97862802  DT.100741964  DT.91894836  DT.121358906  DT.100741997  DT.91780040 

    1 AceView cDNA sequence:

    BC073799 

    GeneLoc Exon Structure


    Expression
    for RPS10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTCTCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPS10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)

    See RPS10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS10

    SOURCE GeneReport for Unigene clusters: Hs.406620 Hs.645317
        SABiosciences Custom PCR Arrays for RPS10
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    In Situ
    Assay Products:     
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    Orthologs
    for RPS10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS10 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rps105 ribosomal protein S10   --   17 (14.59 cM) 27630422 
    chicken
    (Gallus gallus)    		 Aves RPS106
    		 Uncharacterized protein
    		 98(a)
    		 1 ↔ 1
    		 26(4209930-4216176)
    lizard
    (Anolis carolinensis)    		 Reptilia RPS106
    		 --
    		 88(a)
    		 1 ↔ 1
    		 4(121435423-121441380)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC055985.12   -- 80.63(n)    BC055985.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659362 ribosomal protein S10 78.54(n)   394121  BC055098.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG142063
    RpS10b1    		 structural constituent of ribosome3
    Ribosomal protein S10b1    		 65(a)
    (best of 2)3
    63.03(n)1
    65.38(a)1    		   18D33
    329531  NM_134480.31  NP_608324.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rps-101 , 3 40S ribosomal protein S103
    Protein RPS-101    		 48(a)3
    61.49(n)1
    54.73(a)1    		   I(4583936-4584795)3
    1720611  NM_058997.31  NP_491398.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G415201 40S ribosomal protein S10-2 58.33(n)
    53.21(a)    		   834154  NM_123516.3  NP_198967.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.201822 Transcribed sequence with weak similarity to protein more 72.92(n)    AU174824.1 


    ENSEMBL Gene Tree for RPS10 (if available)
    TreeFam Gene Tree for RPS10 (if available) 

    Paralogs
    for RPS10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS10 gene
    2 SIMAP similar genes for RPS10 using alignment to 2 protein entries:     RS10_HUMAN (see all proteins):
    RPS10P5    PLEC

    RPS10 for paralogs           About GeneDecksing


    5/35 Pseudogenes.org Pseudogenes for RPS10 (see all 35)
    PGOHUM00000238646 PGOHUM00000242221 PGOHUM00000239764 PGOHUM00000249948 PGOHUM00000247139


    Genomic Variants
    for RPS10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 NCBI SNPs in RPS10 are shown (see all 219)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1155509111,2
    		C,F,--34107532(+) TGAGCC/ATTGAA 3 -- ds50011Minor allele frequency- A:0.02WA 118
    rs752592391,2
    		F,--34108175(+) GTAAAC/GAGCTG 3 -- int11Minor allele frequency- G:0.04EA 120
    rs760121331,2
    		F,--34108181(+) AGCTGG/AGAGAG 3 -- int11Minor allele frequency- A:0.04EA 120
    rs1165008411,2
    		C,F,--34108239(+) GGGCCA/GTATCT 3 -- int12Minor allele frequency- G:0.02WA NS 264
    rs93942131,2
    		C,H--34109031(+) TTGCAG/AGAAAA 3 -- int15Minor allele frequency- A:0.00NS EA 598
    rs737448971,2
    		C,F,--34109144(+) ATGTCA/TCCCTT 3 -- int13Minor allele frequency- T:0.10WA CSA 122
    rs1128308221,2
    		C,--34109606(+) ATCTCG/AGCTCA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs766622131,2
    		C,--34110071(+) TTTTTT/AAAACC 3 -- int11Minor allele frequency- A:0.50WA 2
    rs756595701,2
    		C,--34110416(+) GGTGCG/AGGGGG 3 -- int12Minor allele frequency- A:0.09WA 120
    rs779148491,2
    		F,--34110464(+) ACAAGA/GTCATA 3 -- int11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for RPS10 (34385231 - 34393902 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPS10
         1 CNV: 3605
    Human Gene Mutation Database (HGMD): RPS10

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RPS10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS10 for disorders           About GeneDecksing

    OMIM gene information: 603632   
    OMIM disorders: 613308  
    UniProtKB/Swiss-Prot: RS10_HUMAN, P46783
  • Defects in RPS10 are the cause of Diamond-Blackfan anemia type 9 (DBA9) [MIM:613308]. It is a form of
    • Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy.
    Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an
    increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital
    anomalies, the most frequent being craniofacial (Pierre- Robin syndrome and cleft palate), thumb and urogenital
    anomalies

    12 diseases for RPS10:    About MalaCards
    diamond-blackfan anemia    macrocytic anemia    colorectal cancer    short stature
    systemic lupus erythematosus    lupus erythematosus    anemia    pituitary tumor
    hepatocellular carcinoma    schizophrenia    carcinoma    malaria

    1 disease from the University of Copenhagen DISEASES database for RPS10:
    Diamond-Blackfan anemia

    Export disorders for RPS10 gene to outside databases

    Publications
    for RPS10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS10 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with RPS10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PubMed id 7772601)1, 2, 3 Frigerio J.-M.... Iovanna J.L. (1995)
    3. Methylation of ribosomal protein S10 by protein-argin ine methyltransferase 5 regulates ribosome biogenesis. (PubMed id 20159986)1, 2, 9 Ren J....Xu Z. (2010)
    4. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (PubMed id 20116044)1, 2 Doherty L....Gazda H.T. (2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    8. Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. (PubMed id 9915854)1, 9 Pei L. (1999)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    External Searches for RPS10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RPS10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6204 HGNC: 10383 AceView: RPS10.2 Ensembl:ENSG00000124614 euGenes: HUgn6204
    ECgene: RPS10 Kegg: 6204 H-InvDB: RPS10

    Other Databases showing RPS10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS10 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RPS10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS10 gene:
    Search GeneIP for patents involving RPS10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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