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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPRML Gene

protein-coding GIFtS: 37
GCID: GC17M045055

reprimo-like

Search for RPRML
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reprimo-Like¹
MGC43894¹
Reprimo-Like Protein²

External Ids:	HGNC: 32422¹	Entrez Gene: 388394²	Ensembl: ENSG00000179673⁷	UniProtKB: Q8N4K4³

Export aliases for RPRML gene to outside databases

Previous GC identifers: GC17M042411 GC17M040433

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPRML gene promoter:
AhR AML1a Pax-5 MEF-2 GATA-1 E47 AREB6 MEF-2A Hand1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPRML promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPRML

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32

RPRML Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPRML gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M045055: view genomic region (about GC identifiers)

Start:	45,055,522 bp from pter	End:	45,056,614 bp from pter
Size:	1,093 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPRML_HUMAN, Q8N4K4 (See protein sequence)

Recommended Name: Reprimo-like protein

Size: 120 amino acids; 12312 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for RPRML: NX_Q8N4K4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N4K4

RPRML Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_981945.1

ENSEMBL proteins:

ENSP00000318032

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

RPRML for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N4K4

UniProtKB/Swiss-Prot: RPRML_HUMAN, Q8N4K4

Similarity: Belongs to the reprimo family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPRML

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RPRML gene:

NM_203400.4

Unigene Cluster for RPRML:

Reprimo-like

Hs.367999 [show with all ESTs]

Unigene Representative Sequence: BC033942

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000322329(uc002ilb.3)

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Additional cDNA sequence:

BC033942.1 BC108690.1

1 DOTS entry:

DT.75166873

8 AceView cDNA sequences:

BC033942 AI939613 NM_203400 AI651498 AI468052 BI831481 BI552140 AA173148

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPRML expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAACTTTC

About this image

RPRML expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPRML Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPRML

SOURCE GeneReport for Unigene cluster: Hs.367999

SABiosciences Custom PCR Arrays for RPRML

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RPRML gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rprml^{1 , 5}	reprimo-like^{1, 5}	90.88(n)¹ 92.31(a)¹		11 (67.41 cM)⁵ 104582¹ NM_001033212.2¹ NP_001028384.1¹ 103649570⁵
chicken (Gallus gallus)	Aves	RPRML¹	reprimo-like	72.67(n) 71.17(a)		419946 XM_418067.2 XP_418067.1
lizard (Anolis carolinensis)	Reptilia	RPRML⁶	--	65(a)	1 ↔ 1	6(65769675-65770013)
zebrafish (Danio rerio)	Actinopterygii	rprml¹	reprimo-like	65.77(n) 60.36(a)		100073335 NM_001098771.1 NP_001092241.1

ENSEMBL Gene Tree for RPRML (if available)
TreeFam Gene Tree for RPRML (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPRML gene

RPRM²

1 SIMAP similar gene for RPRML using alignment to 1 protein entry: RPRML_HUMAN:

RPRM

RPRML for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77287979^1,2	C,	--	45055036(+)	`GCCAAC/TCCCCA`	1	--	int¹		3		NA WA	240
rs80335285^1,2	F,	--	45055107(+)	`GGGACA/GAAGCA`	1	--	int¹		1		NA	120
rs185817414^1,2		--	45055280(+)	`AATCTC/TACCAG`	1	--	int¹		0	--	--	--	--
rs141477228^1,2		--	45055494(+)	`CCGCA-/ACACACA`	1	--	int¹		0	--	--	--	--
rs72628342^1,2		--	45055601(+)	`AGCTCA/GGCGAC`	1	--	ut3¹		0	--	--	--	--
rs199695818^1,2		--	45055747(+)	`TTAAA-/AAAC AAACA`	1	--	ut3¹		0	--	--	--	--
rs3072527^1,2	C,	--	45055756(-)	`TTTTTTT/-GTTTG`	1	--	ut3¹		1		CSA	2
rs201863464^1,2		--	45056204(+)	`CGTCGA/GGCGCC`	2	P L	mis¹		0	--	--	--	--
rs200971595^1,2		--	45056215(+)	`AGCCCC/TGCGGG`	2	A	syn¹		0	--	--	--	--
rs79497126^1,2	C,F,	--	45056301(+)	`TCCCAG/TGGCGG`	2	M L	mis¹		2		NA EA	240

HapMap Linkage Disequilibrium report for RPRML (45055522 - 45056614 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPRML
1 CNV: 4038

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPRML gene integrated from 9 sources:
(articles sorted by number of sources associating them with RPRML)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388394	HGNC: 32422	AceView: LOC388394	Ensembl:ENSG00000179673	euGenes: HUgn388394
ECgene: RPRML	H-InvDB: RPRML

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPRML	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPRML gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPRML gene:
Search GeneIP for patents involving RPRML

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section


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RPRML Gene

reprimo-like

Aliasesfor RPRML gene

Summariesfor RPRML gene

Genomic Viewsfor RPRML gene

Proteinsfor RPRML gene

Protein Domains /Familiesfor RPRML gene

Functionfor RPRML gene

Pathways & Interactionsfor RPRML gene

Drugs & Compoundsfor RPRML gene

Transcriptsfor RPRML gene

Expression for RPRML gene

Orthologsfor RPRML gene

Paralogsfor RPRML gene

Genomic Variantsfor RPRML gene

Disorders / Diseasesfor RPRML gene

Publicationsfor RPRML gene

External Searches for RPRML gene

Genome Databases showing RPRML gene

Other Databases showing RPRML gene

Specialized Databases showing RPRML gene

Intellectual Propertyfor RPRML gene

Productsfor RPRML gene

View Random Gene

Aliases
for RPRML gene

Summaries
for RPRML gene

Genomic Views
for RPRML gene

Proteins
for RPRML gene

Protein Domains /
Families
for RPRML gene

Function
for RPRML gene

Pathways & Interactions
for RPRML gene

Drugs & Compounds
for RPRML gene

Transcripts
for RPRML gene

Expression
for RPRML gene

Orthologs
for RPRML gene

Paralogs
for RPRML gene

Genomic Variants
for RPRML gene

Disorders / Diseases
for RPRML gene

Publications
for RPRML gene

Intellectual Property
for RPRML gene

Products
for RPRML gene