Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPRML Gene

Aliases for RPRML Gene

  • Reprimo Like 2 3 5
  • Reprimo-Like 2

External Ids for RPRML Gene

Previous GeneCards Identifiers for RPRML Gene

  • GC17M042411
  • GC17M045055
  • GC17M040433

Summaries for RPRML Gene

GeneCards Summary for RPRML Gene

RPRML (Reprimo Like) is a Protein Coding gene. An important paralog of this gene is RPRM.

Additional gene information for RPRML Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRML Gene

Genomics for RPRML Gene

GeneHancer (GH) Regulatory Elements for RPRML Gene

Promoters and enhancers for RPRML Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I046978 Promoter/Enhancer 1.3 EPDnew Ensembl 559.9 +0.3 291 1.1 SIN3A ZNF76 ZNF2 ZNF335 GLIS2 SCRT2 ZNF391 EGR2 SP3 ZNF398 RPRML LRRC37A17P MYL4 ENSG00000262633
GH17I046977 Enhancer 0.6 ENCODE 550.8 +1.7 1708 0.2 SMARCA5 CTCF HLF SP2 SIN3A REST ZBTB8A RAD21 SP1 GLIS1 RPRML LRRC37A17P MYL4 CDC27 PIR62352 ENSG00000262633
GH17I047002 Enhancer 1.1 Ensembl ENCODE 27.4 -22.1 -22053 0.6 ARID4B ZNF2 IRF4 ZNF48 SLC30A9 ELK1 ZNF143 RUNX3 KLF13 NCOA1 RPRML GOSR2 LOC101927060 PIR35727 GC17M046992 PIR54173 LRRC37A17P ENSG00000262633
GH17I047098 Promoter/Enhancer 1.5 Ensembl ENCODE 10.8 -120.6 -120591 2.5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B POLR2B ZNF143 LOC101927060 KANSL1 ARL17A ARL17B MRPL45P2 SP2 EFCAB13 ENSG00000264701 ENSG00000266601 CDC27
GH17I046922 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.8 +52.3 52256 9.6 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GOSR2 MRPL45P2 LOC101927060 ARL17B ARL17A EFCAB13 ENSG00000262372 CDC27 RPS7P11 MYL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPRML on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPRML gene promoter:

Genomic Locations for RPRML Gene

Genomic Locations for RPRML Gene
chr17:46,978,156-46,979,248
(GRCh38/hg38)
Size:
1,093 bases
Orientation:
Minus strand
chr17:45,055,522-45,056,614
(GRCh37/hg19)

Genomic View for RPRML Gene

Genes around RPRML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRML Gene

Proteins for RPRML Gene

  • Protein details for RPRML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4K4-RPRML_HUMAN
    Recommended name:
    Reprimo-like protein
    Protein Accession:
    Q8N4K4

    Protein attributes for RPRML Gene

    Size:
    120 amino acids
    Molecular mass:
    12312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPRML Gene

Post-translational modifications for RPRML Gene

No Post-translational modifications

Other Protein References for RPRML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRML Gene

Domains & Families for RPRML Gene

Gene Families for RPRML Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RPRML Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPRML Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4K4

UniProtKB/Swiss-Prot:

RPRML_HUMAN :
  • Belongs to the reprimo family.
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRML: view

Function for RPRML Gene

Phenotypes From GWAS Catalog for RPRML Gene

genes like me logo Genes that share phenotypes with RPRML: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPRML Gene

Localization for RPRML Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRML Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPRML gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RPRML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRML: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPRML Gene

Pathways & Interactions for RPRML Gene

SuperPathways for RPRML Gene

No Data Available

Interacting Proteins for RPRML Gene

Gene Ontology (GO) - Biological Process for RPRML Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RPRML Gene

Drugs & Compounds for RPRML Gene

No Compound Related Data Available

Transcripts for RPRML Gene

mRNA/cDNA for RPRML Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPRML Gene

Reprimo-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRML Gene

No ASD Table

Relevant External Links for RPRML Gene

GeneLoc Exon Structure for
RPRML
ECgene alternative splicing isoforms for
RPRML

Expression for RPRML Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPRML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRML Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x10.4), Brain - Putamen (basal ganglia) (x9.0), Brain - Caudate (basal ganglia) (x6.8), Brain - Cortex (x4.6), and Brain - Frontal Cortex (BA9) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of RPRML Gene:

RPRML

SOURCE GeneReport for Unigene cluster for RPRML Gene:

Hs.367999

Evidence on tissue expression from TISSUES for RPRML Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with RPRML: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPRML Gene

Orthologs for RPRML Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRML Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPRML 33 34
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia RPRML 33 34
  • 92.22 (n)
cow
(Bos Taurus)
Mammalia RPRML 33 34
  • 90.56 (n)
rat
(Rattus norvegicus)
Mammalia Rprml 33
  • 89.17 (n)
mouse
(Mus musculus)
Mammalia Rprml 33 16 34
  • 88.6 (n)
oppossum
(Monodelphis domestica)
Mammalia RPRML 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPRML 33 34
  • 72.67 (n)
lizard
(Anolis carolinensis)
Reptilia RPRML 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rprml 33 34
  • 68.79 (n)
Species where no ortholog for RPRML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRML Gene

ENSEMBL:
Gene Tree for RPRML (if available)
TreeFam:
Gene Tree for RPRML (if available)

Paralogs for RPRML Gene

Paralogs for RPRML Gene

(1) SIMAP similar genes for RPRML Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPRML: view

Variants for RPRML Gene

Sequence variations from dbSNP and Humsavar for RPRML Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1002579657 -- 46,980,757(-) C/T upstream_transcript_variant
rs1002936054 -- 46,980,848(-) A/G upstream_transcript_variant
rs1003120786 -- 46,979,760(-) T/G upstream_transcript_variant
rs1003487112 -- 46,980,865(-) AAAAAAA/AAAAAA/AAAAAAAA upstream_transcript_variant
rs1003561501 -- 46,979,514(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPRML Gene

Variant ID Type Subtype PubMed ID
dgv41n68 CNV loss 17160897
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv953917 CNV deletion 24416366

Variation tolerance for RPRML Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPRML Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPRML

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRML Gene

Disorders for RPRML Gene

Additional Disease Information for RPRML

No disorders were found for RPRML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPRML Gene

Publications for RPRML Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for RPRML Gene

Sources for RPRML Gene

Content
Loading form....