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Aliases for RPRML Gene

Aliases for RPRML Gene

  • Reprimo Like 2 3 5
  • Reprimo-Like 2

External Ids for RPRML Gene

Previous GeneCards Identifiers for RPRML Gene

  • GC17M042411
  • GC17M045055
  • GC17M040433

Summaries for RPRML Gene

GeneCards Summary for RPRML Gene

RPRML (Reprimo Like) is a Protein Coding gene. An important paralog of this gene is RPRM.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRML Gene

Genomics for RPRML Gene

Regulatory Elements for RPRML Gene

Enhancers for RPRML Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPRML on UCSC Golden Path with GeneCards custom track

Promoters for RPRML Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPRML Gene

46,978,156 bp from pter
46,979,248 bp from pter
1,093 bases
Minus strand

Genomic View for RPRML Gene

Genes around RPRML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRML Gene

Proteins for RPRML Gene

  • Protein details for RPRML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Reprimo-like protein
    Protein Accession:

    Protein attributes for RPRML Gene

    120 amino acids
    Molecular mass:
    12312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPRML Gene

Post-translational modifications for RPRML Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPRML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRML Gene

Domains & Families for RPRML Gene

Protein Domains for RPRML Gene


Suggested Antigen Peptide Sequences for RPRML Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the reprimo family.
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRML: view

No data available for Gene Families for RPRML Gene

Function for RPRML Gene

genes like me logo Genes that share phenotypes with RPRML: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPRML Gene

Localization for RPRML Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRML Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RPRML Gene COMPARTMENTS Subcellular localization image for RPRML gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPRML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRML: view

Pathways & Interactions for RPRML Gene

SuperPathways for RPRML Gene

No Data Available

Interacting Proteins for RPRML Gene

Gene Ontology (GO) - Biological Process for RPRML Gene


No data available for Pathways by source and SIGNOR curated interactions for RPRML Gene

Drugs & Compounds for RPRML Gene

No Compound Related Data Available

Transcripts for RPRML Gene

mRNA/cDNA for RPRML Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPRML Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRML Gene

No ASD Table

Relevant External Links for RPRML Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPRML Gene

mRNA expression in normal human tissues for RPRML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRML Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x10.4), Brain - Putamen (basal ganglia) (x9.0), Brain - Caudate (basal ganglia) (x6.8), Brain - Cortex (x4.6), and Brain - Frontal Cortex (BA9) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of RPRML Gene:


SOURCE GeneReport for Unigene cluster for RPRML Gene:

genes like me logo Genes that share expression patterns with RPRML: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RPRML Gene

Orthologs for RPRML Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRML Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPRML 34
  • 90.56 (n)
  • 90 (a)
  • 92 (a)
(Canis familiaris)
Mammalia RPRML 34
  • 92.22 (n)
  • 92.5 (a)
  • 94 (a)
(Mus musculus)
Mammalia Rprml 34
  • 88.6 (n)
  • 88.03 (a)
Rprml 16
Rprml 35
  • 92 (a)
(Pan troglodytes)
Mammalia RPRML 34
  • 98.89 (n)
  • 99.17 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rprml 34
  • 89.17 (n)
  • 88.03 (a)
(Monodelphis domestica)
Mammalia RPRML 35
  • 82 (a)
(Gallus gallus)
Aves RPRML 34
  • 72.67 (n)
  • 71.17 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia RPRML 35
  • 64 (a)
(Danio rerio)
Actinopterygii rprml 34
  • 68.79 (n)
  • 62.73 (a)
rprml 35
  • 58 (a)
Species where no ortholog for RPRML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRML Gene

Gene Tree for RPRML (if available)
Gene Tree for RPRML (if available)

Paralogs for RPRML Gene

Paralogs for RPRML Gene

(1) SIMAP similar genes for RPRML Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPRML: view

Variants for RPRML Gene

Sequence variations from dbSNP and Humsavar for RPRML Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3048484 -- 46,978,401(+) AAAAA(-/A/AA)CTGGT utr-variant-3-prime
rs3072527 -- 46,978,394(-) TTTTT(-/TT)GTTTG utr-variant-3-prime
rs6146075 -- 46,980,683(+) AAAAA(-/A/AA)TTAGC upstream-variant-2KB
rs6504635 -- 46,980,460(+) AGGAG(A/C)CTTGT upstream-variant-2KB
rs7212161 -- 46,980,419(+) tctgt(C/T)ttctt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPRML Gene

Variant ID Type Subtype PubMed ID
dgv41n68 CNV loss 17160897
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv953917 CNV deletion 24416366

Variation tolerance for RPRML Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPRML Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRML Gene

Disorders for RPRML Gene

Relevant External Links for RPRML

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPRML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPRML Gene

Publications for RPRML Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for RPRML Gene

Sources for RPRML Gene

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