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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPRM Gene

protein-coding GIFtS: 49
GCID: GC02M154333

reprimo, TP53 dependent G2 arrest mediator candidate

(Previous names: reprimo, TP53 dependant G2 arrest mediator candidate )

Explore 5 diseases affiliated with
RPRM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reprimo, TP53 Dependent G2 Arrest Mediator Candidate¹ ²		Candidate Mediator Of The P53 Dependent G2 Arrest²
REPRIMO¹ ²		Candidate Mediator Of The P53-Dependent G2 Arrest²
Reprimo, TP53 Dependant G2 Arrest Mediator Candidate¹ ²		Protein Reprimo²
FLJ90327¹

External Ids:	HGNC: 24201¹	Entrez Gene: 56475²	Ensembl: ENSG00000177519⁷	OMIM: 612171⁵	UniProtKB: Q9NS64³

Export aliases for RPRM gene to outside databases

Previous GC identifers: GC02M154159 GC02M154042 GC02M146220

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64

Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle

arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPRM gene promoter:
STAT1 STAT1beta E47 IRF-2 POU2F1 POU2F1a STAT2 Hand1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPRM promoter sequence

Search SABiosciences Chromatin IP Primers for RPRM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPRM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q24.1

RPRM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPRM gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M154333: view genomic region (about GC identifiers)

Start:	154,333,852 bp from pter	End:	154,335,322 bp from pter
Size:	1,471 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64 (See protein sequence)

Recommended Name: Protein reprimo

Size: 109 amino acids; 11774 Da

Subcellular location: Cytoplasm (By similarity). Membrane; Single-pass membrane protein (Potential)

Miscellaneous: 'Reprimo' signifies stop/repress

Secondary accessions: B2R4V1

Explore the universe of human proteins at neXtProt for RPRM: NX_Q9NS64

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NS64

RPRM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_062819.1

ENSEMBL proteins:

ENSP00000314946

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016021	integral to membrane	IEA	--

RPRM for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPRM for domains About GeneDecksing

1 InterPro domain/family:

IPR026786 Reprimo

Graphical View of Domain Structure for InterPro Entry Q9NS64

ProtoNet protein and cluster: Q9NS64

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64

Similarity: Belongs to the reprimo family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64

Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle

arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)

Induction: By p53/TP53, following X-ray irradiation

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In Situ Assay
Products:

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1 GenomeRNAi human phenotype for RPRM:

Increased cell death in breast

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

p53 signaling pathway

p53 signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for RPRM):

p53 signaling pathway

RPRM for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPRM

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/10 Interacting proteins for RPRM (Q9NS64^{1, 3} ENSP00000314946⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK4	P11802¹^,³, ENSP00000257904⁴	EBI-1052363,EBI-295644 I2D: score=2 STRING: ENSP00000257904
CUL1	Q13616³, ENSP00000326804⁴	I2D: score=2 STRING: ENSP00000326804
FBXW11	Q9UKB1³, ENSP00000265094⁴	I2D: score=2 STRING: ENSP00000265094
STK32C	Q86UX6³, ENSP00000298630⁴	I2D: score=1 STRING: ENSP00000298630
MEN1	O00255³, ENSP00000337088⁴	I2D: score=2 STRING: ENSP00000337088

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007050	cell cycle arrest	IEA	--
GO:0007346	regulation of mitotic cell cycle	IEA	--

RPRM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPRM
Search CenterWatch for drugs/clinical trials and news about RPRM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPRM gene:

NM_019845.2

Unigene Cluster for RPRM:

Reprimo, TP53 dependent G2 arrest mediator candidate

Hs.100890 [show with all ESTs]

Unigene Representative Sequence: AB043585

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000325926(uc002tyq.1)

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		hsa-miR-498 hsa-miR-148b* hsa-miR-26a-2* hsa-miR-1224-3p hsa-miR-597 hsa-miR-548o hsa-miR-335 hsa-miR-3667-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RPRM 3' UTR sequence

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Additional cDNA sequence:

AB043585.1 AK074808.1 AK311958.1 BC002908.2

3 DOTS entries:

DT.210481 DT.75102615 DT.86848952

24/65 AceView cDNA sequences (see all 65):

AI879171 CR610159 AW160419 CR596780 AK074808 CB241600 CR609982 BC002908

BX451528 BE220755 BQ109534 CA450192 AA808632 AI937878 BM683004 BE467507

NM_019845 BQ573917 D81532 AI565634 AA779892 BE797198 AI350916 AW078586

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPRM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RPRM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Kidney

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Brain

Brain

Eye

Kidney

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Midbrain dopaminergic-like neurons (Generation of midbra...)

Nkx2-1 GFP+ cells (Efficient derivation...)

Definitive endoderm-like cells (A scalable, suspensi...)

See RPRM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPRM

SOURCE GeneReport for Unigene cluster: Hs.100890

SABiosciences Expression via Pathway-Focused PCR Arrays including RPRM:

p53 Signaling Pathway in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RPRM gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
African clawed frog (Xenopus laevis)	Amphibia	Xl.26514²	Xenopus laevis cDNA clone IMAGE6877591, partial cds	79.59(n)		BC054197.1
zebrafish (Danio rerio)	Actinopterygii	zgc73361²	hypothetical protein MGC73361	81.25(n)		393779 BC059672.1

ENSEMBL Gene Tree for RPRM (if available)
TreeFam Gene Tree for RPRM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPRM gene

RPRML²

1 SIMAP similar gene for RPRM using alignment to 1 protein entry: RPRM_HUMAN:

RPRML

RPRM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76499552^1,2	C,F,	--	154333389(+)	`TCCCTC/TCGCCC`	1	--	ds500¹		1		WA	118
rs3770302^1,2	C,F,H,	--	154333531(+)	`GCCTGG/ACACGG`	1	--	ds500¹		10		EA NS NA	2628
rs3770303^1,2	C,F,A,	--	154333563(+)	`GCCCTT/CCTGTC`	1	--	ds500¹		16		EA NA WA CSA	2039
rs116108894^1,2	C,F,	--	154333680(+)	`CCTTCT/CCAGTC`	1	--	ds500¹		1		NA	120
rs191120480^1,2		--	154333838(+)	`CACCAA/GGAGGC`	1	--	ds500¹		0	--	--	--	--
rs80339062^1,2		--	154333930(+)	`ATGTCA/CAGAGC`	1	--	ut3¹		1		NA	120
rs115336731^1,2		--	154334050(+)	`CACTAA/CAAGAA`	1	--	ut3¹		1		NA	120
rs75130874^1,2	C	--	154334066(+)	`TCACCC/TCGTTC`	1	--	ut3¹		0	--	--	--	--
rs1052581^1,2	C,F,H,	--	154334106(-)	`TGTGGG/AAGAAG`	1	--	ut3¹		17		MN NS EA WA NA	2522
rs182899938^1,2		--	154334147(+)	`AACAGG/TCCACT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RPRM (154333852 - 154335322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPRM: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPRM for disorders           About GeneDecksing

OMIM gene information: 612171    OMIM disorders: --

5 diseases for RPRM:    About MalaCards

pancreatic ductal adenocarcinoma gastric cancer colorectal cancer adenocarcinoma

pancreatitis

Human Genome Epidemiology (HuGE) Navigator: RPRM (1 document)

Export disorders for RPRM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPRM gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with RPRM)

Utopia: connect your pdf to the dynamic
world of online information

Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PubMed id 10930422)^{1, 2, 3} Ohki R....Taniguchi T. (2000)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Reprimo (RPRM) is a novel tumor suppressor in pituitar y tumors and regulates survival, proliferation, and tumorigenicity. (PubMed id 22562171)¹ Xu M....Wierman M.E. (2012)
Loss of Reprimo and S100A2 expression in human gastri c adenocarcinoma. (PubMed id 20949468)¹ Luo J....Liu H. (2011)
Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. (PubMed id 19917725)¹ Malik S.... Oesterreich S. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PubMed id 18197409)¹ Beasley W.D....Parry J.M. (2008)
Reprimo as a potential biomarker for early detection in gastric cancer. (PubMed id 18829507)¹ Bernal C....Corvalan A.H. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56475	HGNC: 24201	AceView: RPRM	Ensembl:ENSG00000177519	euGenes: HUgn56475
ECgene: RPRM	Kegg: 56475	H-InvDB: RPRM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPRM	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RPRM	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RPRM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPRM gene:
Search GeneIP for patents involving RPRM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPRM
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	GenScript Custom Purified and Recombinant Proteins Services for RPRM		GenScript cDNA clones with any tag delivered in your preferred vector for RPRM
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPRM

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RPRM gene at Home site.

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RPRM Gene

reprimo, TP53 dependent G2 arrest mediator candidate

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RPRM Gene

reprimo, TP53 dependent G2 arrest mediator candidate

Aliasesfor RPRM gene

Summariesfor RPRM gene

Genomic Viewsfor RPRM gene

Proteinsfor RPRM gene

Protein Domains /Familiesfor RPRM gene

Functionfor RPRM gene

Pathways & Interactionsfor RPRM gene

Drugs & Compoundsfor RPRM gene

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Expression for RPRM gene

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Genome Databases showing RPRM gene

Other Databases showing RPRM gene

Specialized Databases showing RPRM gene

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Summaries
for RPRM gene

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for RPRM gene

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Families
for RPRM gene

Function
for RPRM gene

Pathways & Interactions
for RPRM gene

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for RPRM gene

Transcripts
for RPRM gene

Expression
for RPRM gene

Orthologs
for RPRM gene

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for RPRM gene

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