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RPRM Gene

protein-coding   GIFtS: 50
GCID: GC02M154333

Reprimo, TP53 Dependent G2 Arrest Mediator Candidate

(Previous names: reprimo, TP53 dependant G2 arrest mediator candidate)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reprimo, TP53 Dependent G2 Arrest Mediator Candidate1 2
Reprimo, TP53 Dependant G2 Arrest Mediator Candidate1 2
REPRIMO1 2
Candidate Mediator Of The P53 Dependent G2 Arrest1 2
Candidate Mediator Of The P53-Dependent G2 Arrest2
Protein Reprimo2

External Ids:    HGNC: 242011   Entrez Gene: 564752   Ensembl: ENSG000001775197   OMIM: 6121715   UniProtKB: Q9NS643   

Export aliases for RPRM gene to outside databases

Previous GC identifers: GC02M154159 GC02M154042 GC02M146220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RPRM Gene:
RPRM (reprimo, TP53 dependent G2 arrest mediator candidate) is a protein-coding gene. Diseases associated with RPRM include pancreatic ductal adenocarcinoma, and pituitary tumors. An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64
Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell
cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPRM gene promoter:
         STAT1   STAT1beta   E47   IRF-2   POU2F1   POU2F1a   STAT2   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPRM promoter sequence
   Search Chromatin IP Primers for RPRM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPRM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q24.1

RPRM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPRM gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M154333:  view genomic region     (about GC identifiers)

Start:
154,333,852 bp from pter      End:
154,335,322 bp from pter
Size:
1,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64 (See protein sequence)
Recommended Name: Protein reprimo  
Size: 109 amino acids; 11774 Da
Miscellaneous: 'Reprimo' signifies stop/repress
Secondary accessions: B2R4V1

Explore the universe of human proteins at neXtProt for RPRM: NX_Q9NS64

Explore proteomics data for RPRM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn18
  • Modification sites at PhosphoSitePlus

  • See RPRM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062819.1  
    ENSEMBL proteins: 
     ENSP00000314946  

    RPRM Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RPRM

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    Cloud-Clone Corp. Antibodies for RPRM
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    RPRM Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPRM
    Cloud-Clone Corp. CLIAs for RPRM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026786 Reprimo

    Graphical View of Domain Structure for InterPro Entry Q9NS64

    ProtoNet protein and cluster: Q9NS64

    UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64
    Similarity: Belongs to the reprimo family


    RPRM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPRM_HUMAN, Q9NS64
    Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell
    cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)
    Induction: By p53/TP53, following X-ray irradiation

    Phenotypes:
         1 GenomeRNAi human phenotype for RPRM:

     Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPRM
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPRM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPRM

    miRNA
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    Block miRNA regulation of human, mouse, rat RPRM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPRM (see all 15):
    hsa-miR-498 hsa-miR-148b* hsa-miR-26a-2* hsa-miR-1224-3p hsa-miR-597 hsa-miR-548o hsa-miR-335 hsa-miR-3667-5p
    SwitchGear 3'UTR luciferase reporter plasmidRPRM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPRM
    Predesigned siRNA for gene silencing in human, mouse, rat RPRM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPRM

    Clone
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    OriGene clones in human, mouse for RPRM (see all 6)
    OriGene ORF clones in mouse, rat for RPRM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPRM (NM_019845)
    Sino Biological Human cDNA Clone for RPRM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPRM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPRM

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RPRM 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPRM_HUMAN, Q9NS64: Cytoplasm (By similarity). Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral component of membrane IEA--

    RPRM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPRM About    
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RPRM):
        p53 signaling pathway


    RPRM for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPRM: 
              p53 Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RPRM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RPRM (Q9NS641, 3 ENSP000003149464) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 3, ENSP000002579044EBI-1052363,EBI-295644 I2D: score=2 STRING: ENSP00000257904
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    FBXW11Q9UKB13, ENSP000002650944I2D: score=2 STRING: ENSP00000265094
    STK32CQ86UX63, ENSP000002986304I2D: score=1 STRING: ENSP00000298630
    MEN1O002553, ENSP000003370884I2D: score=2 STRING: ENSP00000337088
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--
    GO:0007346regulation of mitotic cell cycle IEA--

    RPRM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPRM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPRM gene: 
    NM_019845.2  

    Unigene Cluster for RPRM:

    Reprimo, TP53 dependent G2 arrest mediator candidate
    Hs.100890  [show with all ESTs]
    Unigene Representative Sequence: AB043585
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000325926(uc002tyq.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPRM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPRM (see all 15):
    hsa-miR-498 hsa-miR-148b* hsa-miR-26a-2* hsa-miR-1224-3p hsa-miR-597 hsa-miR-548o hsa-miR-335 hsa-miR-3667-5p
    SwitchGear 3'UTR luciferase reporter plasmidRPRM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPRM
    Predesigned siRNA for gene silencing in human, mouse, rat RPRM
    Clone
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    OriGene ORF clones in mouse, rat for RPRM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPRM (NM_019845)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPRM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPRM
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPRM
    OriGene qSTAR qPCR primer pairs in human, mouse for RPRM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPRM
      QuantiTect SYBR Green Assays in human, mouse, rat RPRM
      QuantiFast Probe-based Assays in human, mouse, rat RPRM

    Additional mRNA sequence: 

    AB043585.1 AK074808.1 AK311958.1 BC002908.2 

    3 DOTS entries:

    DT.210481  DT.75102615  DT.86848952 

    Selected AceView cDNA sequences (see all 65):

    AA808632 CA450192 AW160419 CR596780 BC002908 BQ109534 BX451528 BM683004 
    CR610159 AK074808 AI879171 CR609982 CB241600 AI937878 BE220755 BE467507 
    AW291108 BI917372 BM719022 CD105873 AW134954 BQ573917 AI565634 BP376280 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPRM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RPRM Expression
    About this image


    RPRM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS1
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
    RPRM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPRM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.100890
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPRM: 
              p53 Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RPRM
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    QuantiFast Probe-based Assays in human, mouse, rat RPRM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RPRM gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rprm1 , 5 reprimo, TP53 dependent G2 arrest mediator candidate1, 5 90.52(n)1
    97.25(a)1
      2 (30.69 cM)5
    678741  NM_023396.51  NP_075885.11 
     540840935 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.265142 Xenopus laevis cDNA clone IMAGE6877591, partial cds 79.59(n)    BC054197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733612 hypothetical protein MGC73361 81.25(n)   393779  BC059672.1 


    ENSEMBL Gene Tree for RPRM (if available)
    TreeFam Gene Tree for RPRM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPRM gene
    RPRML2  
    1 SIMAP similar gene for RPRM using alignment to 1 protein entry:     RPRM_HUMAN:
    RPRML

    RPRM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPRM (see all 76)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764995521,2
    C,F--154333389(+) TCCCTC/TCGCCC 1 -- ds50011Minor allele frequency- T:0.12WA 118
    rs37703021,2
    C,F,H--154333531(+) GCCTGG/ACACGG 1 -- ds500110Minor allele frequency- A:0.00EA NS NA 2628
    rs37703031,2
    C,F,A--154333563(+) GCCCTT/CCTGTC 1 -- ds500116Minor allele frequency- C:0.41EA NA WA CSA 2039
    rs1161088941,2
    C,F--154333680(+) CCTTCT/CCAGTC 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1911204801,2
    --154333838(+) CACCAA/GGAGGC 1 -- ds50010--------
    rs803390621,2
    F--154333930(+) ATGTCA/CAGAGC 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1153367311,2
    F--154334050(+) CACTAA/CAAGAA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs751308741,2
    C--154334066(+) TCACCC/TCGTTC 1 -- ut310--------
    rs10525811,2
    C,F,H--154334106(-) TGTGGG/AAGAAG 1 -- ut3117Minor allele frequency- A:0.09MN NS EA WA NA 2522
    rs1828999381,2
    --154334147(+) AACAGG/TCCACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RPRM (154333852 - 154335322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPRM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875301CNV Loss21882294
    nsv7331OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPRM
    DNA2.0 Custom Variant and Variant Library Synthesis for RPRM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612171    OMIM disorders: --

    9 diseases for RPRM:    
    About MalaCards
    pancreatic ductal adenocarcinoma    pituitary tumors    gastric adenocarcinoma    adenocarcinoma
    colorectal cancer    pancreatitis    cerebritis    endotheliitis
    neuronitis


    RPRM for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPRM
    Human Genome Epidemiology (HuGE) Navigator: RPRM (1 document)

    Export disorders for RPRM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPRM gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RPRM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PubMed id 10930422)1, 2, 3 Ohki R....Taniguchi T. (J. Biol. Chem. 2000)
    2. Reprimo 824 G&gt;C and p53R2 4696 C&gt;G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PubMed id 18197409)1, 4 Beasley W.D....Parry J.M. (Int J Colorectal Dis 2008)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    5. Reprimo (RPRM) is a novel tumor suppressor in pituitary tumors and regulates survival, proliferation, and tumorigenicity. (PubMed id 22562171)1 Xu M....Wierman M.E. (Endocrinology 2012)
    6. Epstein-Barr virus-encoded latent membrane protein-1 upregulates 14-3-3I8 and Reprimo to confer G(2)/M phase cell cycle arrest. (PubMed id 23312294)1 Yeo K.S....Ng C.C. (C. R. Biol. 2012)
    7. Loss of Reprimo and S100A2 expression in human gastric adenocarcinoma. (PubMed id 20949468)1 Luo J....Liu H. (Diagn. Cytopathol. 2011)
    8. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. (PubMed id 19917725)1 Malik S.... Oesterreich S. (Mol. Cell. Biol. 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Reprimo as a potential biomarker for early detection in gastric cancer. (PubMed id 18829507)1 Bernal C....Corvalan A.H. (Clin. Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56475 HGNC: 24201 AceView: RPRM Ensembl:ENSG00000177519 euGenes: HUgn56475
    ECgene: RPRM Kegg: 56475 H-InvDB: RPRM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPRM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPRM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPRM gene:
    Search GeneIP for patents involving RPRM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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