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Aliases for RPRM Gene

Aliases for RPRM Gene

  • Reprimo, TP53 Dependent G2 Arrest Mediator Candidate 2 3
  • Reprimo, TP53 Dependant G2 Arrest Mediator Candidate 2 3
  • Candidate Mediator Of The P53 Dependent G2 Arrest 2 3
  • REPRIMO 2 3
  • Candidate Mediator Of The P53-Dependent G2 Arrest 3
  • Protein Reprimo 3

External Ids for RPRM Gene

Previous GeneCards Identifiers for RPRM Gene

  • GC02M154159
  • GC02M154042
  • GC02M154333
  • GC02M146220

Summaries for RPRM Gene

GeneCards Summary for RPRM Gene

RPRM (Reprimo, TP53 Dependent G2 Arrest Mediator Candidate) is a Protein Coding gene. Diseases associated with RPRM include pancreatic ductal adenocarcinoma and gastric adenocarcinoma. Among its related pathways are p53 signaling pathway. An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot for RPRM Gene

  • May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRM Gene

Genomics for RPRM Gene

Regulatory Elements for RPRM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPRM Gene

Start:
153,477,338 bp from pter
End:
153,478,808 bp from pter
Size:
1,471 bases
Orientation:
Minus strand

Genomic View for RPRM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRM Gene

Proteins for RPRM Gene

  • Protein details for RPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS64-RPRM_HUMAN
    Recommended name:
    Protein reprimo
    Protein Accession:
    Q9NS64
    Secondary Accessions:
    • B2R4V1

    Protein attributes for RPRM Gene

    Size:
    109 amino acids
    Molecular mass:
    11774 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Reprimo signifies stop/repress

neXtProt entry for RPRM Gene

Proteomics data for RPRM Gene at MOPED

Post-translational modifications for RPRM Gene

  • Glycosylation at Asn7 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for RPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRM Gene

Domains for RPRM Gene

Protein Domains for RPRM Gene

ProtoNet:

Suggested Antigen Peptide Sequences for RPRM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS64

UniProtKB/Swiss-Prot:

RPRM_HUMAN :
  • Q9NS64
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRM: view

No data available for Gene Families for RPRM Gene

Function for RPRM Gene

Molecular function for RPRM Gene

UniProtKB/Swiss-Prot Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
UniProtKB/Swiss-Prot Induction: By p53/TP53, following X-ray irradiation.

Gene Ontology (GO) - Molecular Function for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPRM: view

Phenotypes for RPRM Gene

genes like me logo Genes that share phenotypes with RPRM: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPRM Gene

Localization for RPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRM Gene

Cytoplasm. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPRM Gene COMPARTMENTS Subcellular localization image for RPRM gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRM: view

Pathways for RPRM Gene

SuperPathways for RPRM Gene

Superpath Contained pathways
1 p53 signaling pathway
genes like me logo Genes that share pathways with RPRM: view

Pathways by source for RPRM Gene

1 KEGG pathway for RPRM Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0007346 regulation of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with RPRM: view

Transcripts for RPRM Gene

mRNA/cDNA for RPRM Gene

(65) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPRM Gene

Reprimo, TP53 dependent G2 arrest mediator candidate:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPRM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRM Gene

No ASD Table

Relevant External Links for RPRM Gene

GeneLoc Exon Structure for
RPRM
ECgene alternative splicing isoforms for
RPRM

Expression for RPRM Gene

mRNA expression in normal human tissues for RPRM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRM Gene

This gene is overexpressed in Uterus (4.8).

SOURCE GeneReport for Unigene cluster for RPRM Gene Hs.100890

genes like me logo Genes that share expressions with RPRM: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for RPRM Gene

Orthologs for RPRM Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPRM 35
  • 99.08 (n)
  • 100 (a)
RPRM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPRM 35
  • 94.19 (n)
  • 99.08 (a)
RPRM 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rprm 35
  • 90.52 (n)
  • 97.25 (a)
Rprm 16
Rprm 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPRM 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rprm 35
  • 90.83 (n)
  • 98.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26514 35
zebrafish
(Danio rerio)
Actinopterygii rprma 35
  • 72.82 (n)
  • 76.7 (a)
rprma 36
  • 75 (a)
OneToMany
rprmb 36
  • 70 (a)
OneToMany
zgc73361 35
Species with no ortholog for RPRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRM Gene

ENSEMBL:
Gene Tree for RPRM (if available)
TreeFam:
Gene Tree for RPRM (if available)

Paralogs for RPRM Gene

Paralogs for RPRM Gene

Selected SIMAP similar genes for RPRM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPRM: view

Variants for RPRM Gene

Sequence variations from dbSNP and Humsavar for RPRM Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14924 -- 153,477,539(+) TAAAA(A/G)AAACA utr-variant-3-prime
rs1052581 -- 153,477,592(-) TGTGG(A/G)AGAAG utr-variant-3-prime
rs1063728 -- 153,477,985(-) GCGCA(C/G)AACTT utr-variant-3-prime
rs2033764 -- 153,479,455(-) TCACG(A/G)TAAAA upstream-variant-2KB
rs3770302 -- 153,477,017(+) GCCTG(A/G)CACGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPRM Gene

Variant ID Type Subtype PubMed ID
nsv7331 OTHER Inversion 18451855
nsv875301 CNV Loss 21882294

Relevant External Links for RPRM Gene

HapMap Linkage Disequilibrium report
RPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRM Gene

Disorders for RPRM Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RPRM Gene including...

Search for RPRM Gene in MalaCards »

Relevant External Links for RPRM

Genetic Association Database (GAD)
RPRM
Human Genome Epidemiology (HuGE) Navigator
RPRM
genes like me logo Genes that share disorders with RPRM: view

No data available for UniProtKB/Swiss-Prot for RPRM Gene

Publications for RPRM Gene

  1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PMID: 10930422) Ohki R. … Taniguchi T. (J. Biol. Chem. 2000) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PMID: 18197409) Beasley W.D. … Parry J.M. (Int J Colorectal Dis 2008) 3 48
  4. Reprimo as a potential biomarker for early detection in gastric cancer. (PMID: 18829507) Bernal C. … Corvalan A.H. (Clin. Cancer Res. 2008) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RPRM Gene

Sources for RPRM Gene

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