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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPRM Gene

protein-coding   GIFtS: 49
GCID: GC02M154333

Reprimo, TP53 Dependent G2 Arrest Mediator Candidate

(Previous names: reprimo, TP53 dependant G2 arrest mediator candidate)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reprimo, TP53 Dependent G2 Arrest Mediator Candidate1 2
Reprimo, TP53 Dependant G2 Arrest Mediator Candidate1 2
REPRIMO1 2
Candidate Mediator Of The P53 Dependent G2 Arrest1 2
Candidate Mediator Of The P53-Dependent G2 Arrest2
Protein Reprimo2

External Ids:    HGNC: 242011   Entrez Gene: 564752   Ensembl: ENSG000001775197   OMIM: 6121715   UniProtKB: Q9NS643   

Export aliases for RPRM gene to outside databases

Previous GC identifers: GC02M154159 GC02M154042 GC02M146220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RPRM Gene: 
RPRM (reprimo, TP53 dependent G2 arrest mediator candidate) is a protein-coding gene. Diseases associated with RPRM include pancreatic ductal adenocarcinoma, and gastric cancer, and among its related super-pathways are DNA damage response. An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64
Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell
cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPRM gene promoter:
         STAT1   STAT1beta   E47   IRF-2   POU2F1   POU2F1a   STAT2   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPRM promoter sequence
   Search SABiosciences Chromatin IP Primers for RPRM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPRM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q24.1

RPRM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPRM gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M154333:  view genomic region     (about GC identifiers)

Start:
154,333,852 bp from pter      End:
154,335,322 bp from pter
Size:
1,471 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64 (See protein sequence)
Recommended Name: Protein reprimo  
Size: 109 amino acids; 11774 Da
Subcellular location: Cytoplasm (By similarity). Membrane; Single-pass membrane protein (Potential)
Miscellaneous: 'Reprimo' signifies stop/repress
Secondary accessions: B2R4V1

Explore the universe of human proteins at neXtProt for RPRM: NX_Q9NS64

Explore proteomics data for RPRM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NS64

  • RPRM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPRM Protein Expression
    REFSEQ proteins: NP_062819.1  
    ENSEMBL proteins: 
     ENSP00000314946  

    Human Recombinant Protein Products for RPRM: 
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    Novus Biologicals RPRM Protein
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for RPRM 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral to membrane IEA--

    RPRM for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026786 Reprimo

    Graphical View of Domain Structure for InterPro Entry Q9NS64

    ProtoNet protein and cluster: Q9NS64

    UniProtKB/Swiss-Prot: RPRM_HUMAN, Q9NS64
    Similarity: Belongs to the reprimo family


    RPRM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPRM_HUMAN, Q9NS64
    Function: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell
    cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)
    Induction: By p53/TP53, following X-ray irradiation

    Phenotypes:
         1 GenomeRNAi human phenotype for RPRM:

     Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPRM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPRM

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    SwitchGear 3'UTR luciferase reporter plasmidRPRM 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPRM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for RPRM):
        p53 signaling pathway


    RPRM for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPRM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for RPRM (Q9NS641, 3 ENSP000003149464) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 3, ENSP000002579044EBI-1052363,EBI-295644 I2D: score=2 STRING: ENSP00000257904
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    FBXW11Q9UKB13, ENSP000002650944I2D: score=2 STRING: ENSP00000265094
    STK32CQ86UX63, ENSP000002986304I2D: score=1 STRING: ENSP00000298630
    MEN1O002553, ENSP000003370884I2D: score=2 STRING: ENSP00000337088
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--
    GO:0007346regulation of mitotic cell cycle IEA--

    RPRM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPRM

    Search CenterWatch for drugs/clinical trials and news about RPRM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPRM gene: 
    NM_019845.2  

    Unigene Cluster for RPRM:

    Reprimo, TP53 dependent G2 arrest mediator candidate
    Hs.100890  [show with all ESTs]
    Unigene Representative Sequence: AB043585
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000325926(uc002tyq.1)
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    hsa-miR-498 hsa-miR-148b* hsa-miR-26a-2* hsa-miR-1224-3p hsa-miR-597 hsa-miR-548o hsa-miR-335 hsa-miR-3667-5p
    SwitchGear 3'UTR luciferase reporter plasmidRPRM 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB043585.1 AK074808.1 AK311958.1 BC002908.2 

    3 DOTS entries:

    DT.210481  DT.75102615  DT.86848952 

    24/65 AceView cDNA sequences (see all 65):

    CR596780 AI879171 AK074808 AA808632 AW160419 BC002908 BQ109534 CR610159 
    CA450192 BX451528 AI937878 CB241600 BM683004 BE220755 BE467507 CR609982 
    D81532 BI757241 AW162035 AI591000 AW134954 BE797198 AL534122 BX440997 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPRM expression in normal human tissues (normalized intensities)      RPRM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RPRM Expression
    About this image


    RPRM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 31 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Human Astrocytes   
             Vomeronasal organ   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
             limb/hindlimb/hind-paw   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
             visceral organ/metanephros/renal cortex   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   

    See RPRM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPRM

    SOURCE GeneReport for Unigene cluster: Hs.100890
        SABiosciences Expression via Pathway-Focused PCR Arrays including RPRM: 
              p53 Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RPRM gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rprm1 , 5 reprimo, TP53 dependent G2 arrest mediator candidate1, 5 90.52(n)1
    97.25(a)1
      2 (30.69 cM)5
    678741  NM_023396.51  NP_075885.11 
     540840935 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.265142 Xenopus laevis cDNA clone IMAGE6877591, partial cds 79.59(n)    BC054197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733612 hypothetical protein MGC73361 81.25(n)   393779  BC059672.1 


    ENSEMBL Gene Tree for RPRM (if available)
    TreeFam Gene Tree for RPRM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPRM gene
    RPRML2  
    1 SIMAP similar gene for RPRM using alignment to 1 protein entry:     RPRM_HUMAN:
    RPRML

    RPRM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/76 SNPs in RPRM are shown (see all 76)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764995521,2
    C,F--154333389(+) TCCCTC/TCGCCC 1 -- ds50011Minor allele frequency- T:0.12WA 118
    rs37703021,2
    C,F,H--154333531(+) GCCTGG/ACACGG 1 -- ds500110Minor allele frequency- A:0.00EA NS NA 2628
    rs37703031,2
    C,F,A--154333563(+) GCCCTT/CCTGTC 1 -- ds500116Minor allele frequency- C:0.41EA NA WA CSA 2039
    rs1161088941,2
    C,F--154333680(+) CCTTCT/CCAGTC 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1911204801,2
    --154333838(+) CACCAA/GGAGGC 1 -- ds50010--------
    rs803390621,2
    F--154333930(+) ATGTCA/CAGAGC 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1153367311,2
    F--154334050(+) CACTAA/CAAGAA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs751308741,2
    C--154334066(+) TCACCC/TCGTTC 1 -- ut310--------
    rs10525811,2
    C,F,H--154334106(-) TGTGGG/AAGAAG 1 -- ut3117Minor allele frequency- A:0.09MN NS EA WA NA 2522
    rs1828999381,2
    --154334147(+) AACAGG/TCCACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RPRM (154333852 - 154335322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPRM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875301CNV Loss21882294
    nsv7331OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612171    OMIM disorders: --

    5 diseases for RPRM:    About MalaCards
    pancreatic ductal adenocarcinoma    gastric cancer    adenocarcinoma    colorectal cancer
    pancreatitis


    RPRM for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPRM
    Human Genome Epidemiology (HuGE) Navigator: RPRM (1 document)

    Export disorders for RPRM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPRM gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RPRM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PubMed id 10930422)1, 2, 3 Ohki R....Taniguchi T. (2000)
    2. Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PubMed id 18197409)1, 4 Beasley W.D....Parry J.M. (2008)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Reprimo (RPRM) is a novel tumor suppressor in pituitar y tumors and regulates survival, proliferation, and tumorigenicity. (PubMed id 22562171)1 Xu M....Wierman M.E. (2012)
    5. Epstein-Barr virus-encoded latent membrane protein-1 u pregulates 14-3-3s and Reprimo to confer G(2)/M phase cell cycle arrest. (PubMed id 23312294)1 Yeo K.S....Ng C.C. (2012)
    6. Loss of Reprimo and S100A2 expression in human gastri c adenocarcinoma. (PubMed id 20949468)1 Luo J....Liu H. (2011)
    7. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. (PubMed id 19917725)1 Malik S.... Oesterreich S. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Reprimo as a potential biomarker for early detection in gastric cancer. (PubMed id 18829507)1 Bernal C....Corvalan A.H. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56475 HGNC: 24201 AceView: RPRM Ensembl:ENSG00000177519 euGenes: HUgn56475
    ECgene: RPRM Kegg: 56475 H-InvDB: RPRM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPRM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPRM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPRM gene:
    Search GeneIP for patents involving RPRM

    GeneCards and IP:
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