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Aliases for RPRM Gene

Aliases for RPRM Gene

  • Reprimo, TP53 Dependent G2 Arrest Mediator Candidate 2 3 5
  • Reprimo, TP53 Dependant G2 Arrest Mediator Candidate 2 3
  • Candidate Mediator Of The P53 Dependent G2 Arrest 2 3
  • REPRIMO 2 3
  • Candidate Mediator Of The P53-Dependent G2 Arrest 3

External Ids for RPRM Gene

Previous GeneCards Identifiers for RPRM Gene

  • GC02M154159
  • GC02M154042
  • GC02M154333
  • GC02M146220

Summaries for RPRM Gene

GeneCards Summary for RPRM Gene

RPRM (Reprimo, TP53 Dependent G2 Arrest Mediator Candidate) is a Protein Coding gene. Among its related pathways are p53 Pathway (RnD) and p53 signaling pathway. An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot for RPRM Gene

  • May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRM Gene

Genomics for RPRM Gene

Regulatory Elements for RPRM Gene

Promoters for RPRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPRM on UCSC Golden Path with GeneCards custom track

Genomic Location for RPRM Gene

Chromosome:
2
Start:
153,477,338 bp from pter
End:
153,478,808 bp from pter
Size:
1,471 bases
Orientation:
Minus strand

Genomic View for RPRM Gene

Genes around RPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRM Gene

Proteins for RPRM Gene

  • Protein details for RPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS64-RPRM_HUMAN
    Recommended name:
    Protein reprimo
    Protein Accession:
    Q9NS64
    Secondary Accessions:
    • B2R4V1

    Protein attributes for RPRM Gene

    Size:
    109 amino acids
    Molecular mass:
    11774 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Reprimo signifies stop/repress.

neXtProt entry for RPRM Gene

Proteomics data for RPRM Gene at MOPED

Post-translational modifications for RPRM Gene

  • Glycosylation at Asn 7 and Asn 18
  • Modification sites at PhosphoSitePlus

Other Protein References for RPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRM Gene

Domains & Families for RPRM Gene

Protein Domains for RPRM Gene

ProtoNet:

Suggested Antigen Peptide Sequences for RPRM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS64

UniProtKB/Swiss-Prot:

RPRM_HUMAN :
  • Belongs to the reprimo family.
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRM: view

No data available for Gene Families for RPRM Gene

Function for RPRM Gene

Molecular function for RPRM Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53, following X-ray irradiation.
genes like me logo Genes that share phenotypes with RPRM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPRM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPRM Gene

Localization for RPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRM Gene

Cytoplasm. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPRM Gene COMPARTMENTS Subcellular localization image for RPRM gene
Compartment Confidence
plasma membrane 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RPRM Gene

Pathways & Interactions for RPRM Gene

SuperPathways for RPRM Gene

genes like me logo Genes that share pathways with RPRM: view

Pathways by source for RPRM Gene

1 KEGG pathway for RPRM Gene
1 R&D Systems pathway for RPRM Gene

Gene Ontology (GO) - Biological Process for RPRM Gene

None

No data available for SIGNOR curated interactions for RPRM Gene

Drugs & Compounds for RPRM Gene

No Compound Related Data Available

Transcripts for RPRM Gene

mRNA/cDNA for RPRM Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPRM Gene

Reprimo, TP53 dependent G2 arrest mediator candidate:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPRM Gene

No ASD Table

Relevant External Links for RPRM Gene

GeneLoc Exon Structure for
RPRM
ECgene alternative splicing isoforms for
RPRM

Expression for RPRM Gene

mRNA expression in normal human tissues for RPRM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRM Gene

This gene is overexpressed in Uterus (x4.8).

SOURCE GeneReport for Unigene cluster for RPRM Gene Hs.100890

genes like me logo Genes that share expression patterns with RPRM: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RPRM Gene

Orthologs for RPRM Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPRM 36
  • 100 (a)
OneToOne
RPRM 35
  • 99.08 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPRM 35
  • 94.19 (n)
  • 99.08 (a)
RPRM 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rprm 16
Rprm 35
  • 90.52 (n)
  • 97.25 (a)
Rprm 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPRM 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rprm 35
  • 90.83 (n)
  • 98.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26514 35
zebrafish
(Danio rerio)
Actinopterygii rprma 35
  • 72.82 (n)
  • 76.7 (a)
zgc73361 35
rprma 36
  • 75 (a)
OneToMany
rprmb 36
  • 70 (a)
OneToMany
Species with no ortholog for RPRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRM Gene

ENSEMBL:
Gene Tree for RPRM (if available)
TreeFam:
Gene Tree for RPRM (if available)

Paralogs for RPRM Gene

Paralogs for RPRM Gene

(1) SIMAP similar genes for RPRM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPRM: view

Variants for RPRM Gene

Sequence variations from dbSNP and Humsavar for RPRM Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs14924 -- 153,477,539(+) TAAAA(A/G)AAACA utr-variant-3-prime
rs1052581 -- 153,477,592(-) TGTGG(A/G)AGAAG utr-variant-3-prime
rs1063728 -- 153,477,985(-) GCGCA(C/G)AACTT utr-variant-3-prime
rs2033764 -- 153,479,455(-) TCACG(A/G)TAAAA upstream-variant-2KB
rs11575891 -- 153,477,970(-) AGCTG(C/G)TACTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPRM Gene

Variant ID Type Subtype PubMed ID
nsv7331 OTHER Inversion 18451855
nsv875301 CNV Loss 21882294

Variation tolerance for RPRM Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPRM Gene

HapMap Linkage Disequilibrium report
RPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRM Gene

Disorders for RPRM Gene

Relevant External Links for RPRM

Genetic Association Database (GAD)
RPRM
Human Genome Epidemiology (HuGE) Navigator
RPRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPRM

No disorders were found for RPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPRM Gene

Publications for RPRM Gene

  1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PMID: 10930422) Ohki R. … Taniguchi T. (J. Biol. Chem. 2000) 2 3 4 67
  2. Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. (PMID: 25954972) Saavedra K. … CorvalA!n A.H. (PLoS ONE 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  5. DNA damage-inducible gene, reprimo functions as a tumor suppressor and is suppressed by promoter methylation in gastric cancer. (PMID: 23982217) Ooki A. … Watanabe M. (Mol. Cancer Res. 2013) 3

Products for RPRM Gene

Sources for RPRM Gene

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