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Aliases for RPRM Gene

Aliases for RPRM Gene

  • Reprimo, TP53 Dependent G2 Arrest Mediator Candidate 2 3 5
  • Reprimo, TP53 Dependant G2 Arrest Mediator Candidate 2 3
  • Candidate Mediator Of The P53 Dependent G2 Arrest 2 3
  • REPRIMO 2 3
  • Protein Reprimo 3

External Ids for RPRM Gene

Previous GeneCards Identifiers for RPRM Gene

  • GC02M154159
  • GC02M154042
  • GC02M154333
  • GC02M146220

Summaries for RPRM Gene

GeneCards Summary for RPRM Gene

RPRM (Reprimo, TP53 Dependent G2 Arrest Mediator Candidate) is a Protein Coding gene. Among its related pathways are DNA damage response and p53 Pathway (RnD). An important paralog of this gene is RPRML.

UniProtKB/Swiss-Prot for RPRM Gene

  • May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRM Gene

Genomics for RPRM Gene

Regulatory Elements for RPRM Gene

Enhancers for RPRM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F153533 0.6 ENCODE 15.8 -55.8 -55782 1.2 MNT RPRM PIR41575 GC02P153569
GH02F152729 1.3 Ensembl ENCODE 13.4 +748.2 748208 2.0 SOX13 MAX CEBPG RAD21 GATA3 MTA3 CTBP1 RCOR1 GATAD2A FOXA3 RPRM PRPF40A ARL6IP6 GC02P152749
GH02F153476 1.2 FANTOM5 ENCODE 7.3 +1.2 1211 2.2 KLF17 FEZF1 ZNF2 GLIS2 SCRT2 KLF7 EGR2 THAP11 ZNF263 REST RPRM ENSG00000200377 GC02M153447
GH02F153479 0.3 FANTOM5 2.1 -0.7 -738 0.2 PKNOX1 MAZ STAT1 ZNF366 ZNF223 GALNT13 RPRM PIR41575
GH02F153478 0.5 ENCODE 0.8 -0.2 -174 0.5 ZNF76 FEZF1 ZNF48 RAD21 GLIS2 ZNF366 SCRT2 ZNF143 THAP11 ZNF263 RPRM PIR41575
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPRM on UCSC Golden Path with GeneCards custom track

Genomic Location for RPRM Gene

Chromosome:
2
Start:
153,477,338 bp from pter
End:
153,478,808 bp from pter
Size:
1,471 bases
Orientation:
Minus strand

Genomic View for RPRM Gene

Genes around RPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRM Gene

Proteins for RPRM Gene

  • Protein details for RPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS64-RPRM_HUMAN
    Recommended name:
    Protein reprimo
    Protein Accession:
    Q9NS64
    Secondary Accessions:
    • B2R4V1

    Protein attributes for RPRM Gene

    Size:
    109 amino acids
    Molecular mass:
    11774 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Reprimo signifies stop/repress.

neXtProt entry for RPRM Gene

Post-translational modifications for RPRM Gene

  • Glycosylation at Asn 7 and Asn 18
  • Modification sites at PhosphoSitePlus

Other Protein References for RPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPRM Gene

Domains & Families for RPRM Gene

Protein Domains for RPRM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPRM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS64

UniProtKB/Swiss-Prot:

RPRM_HUMAN :
  • Belongs to the reprimo family.
Family:
  • Belongs to the reprimo family.
genes like me logo Genes that share domains with RPRM: view

No data available for Gene Families for RPRM Gene

Function for RPRM Gene

Molecular function for RPRM Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53, following X-ray irradiation.

Gene Ontology (GO) - Molecular Function for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPRM: view
genes like me logo Genes that share phenotypes with RPRM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPRM

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPRM Gene

Localization for RPRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRM Gene

Cytoplasm. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPRM Gene COMPARTMENTS Subcellular localization image for RPRM gene
Compartment Confidence
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPRM: view

Pathways & Interactions for RPRM Gene

SuperPathways for RPRM Gene

SuperPathway Contained pathways
1 DNA damage response
2 p53 Pathway (RnD)
genes like me logo Genes that share pathways with RPRM: view

Pathways by source for RPRM Gene

1 KEGG pathway for RPRM Gene
1 R&D Systems pathway for RPRM Gene

Gene Ontology (GO) - Biological Process for RPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA,TAS --
GO:0007346 regulation of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with RPRM: view

No data available for SIGNOR curated interactions for RPRM Gene

Transcripts for RPRM Gene

mRNA/cDNA for RPRM Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPRM Gene

Reprimo, TP53 dependent G2 arrest mediator candidate:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRM Gene

No ASD Table

Relevant External Links for RPRM Gene

GeneLoc Exon Structure for
RPRM
ECgene alternative splicing isoforms for
RPRM

Expression for RPRM Gene

mRNA expression in normal human tissues for RPRM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRM Gene

This gene is overexpressed in Uterus (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of RPRM Gene:

RPRM

SOURCE GeneReport for Unigene cluster for RPRM Gene:

Hs.100890
genes like me logo Genes that share expression patterns with RPRM: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RPRM Gene

Orthologs for RPRM Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPRM 34 35
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia RPRM 34 35
  • 94.19 (n)
rat
(Rattus norvegicus)
Mammalia Rprm 34
  • 90.83 (n)
mouse
(Mus musculus)
Mammalia Rprm 34 16 35
  • 90.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPRM 35
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26514 34
zebrafish
(Danio rerio)
Actinopterygii rprma 34 35
  • 72.82 (n)
rprmb 35
  • 70 (a)
OneToMany
zgc73361 34
Species where no ortholog for RPRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRM Gene

ENSEMBL:
Gene Tree for RPRM (if available)
TreeFam:
Gene Tree for RPRM (if available)

Paralogs for RPRM Gene

Paralogs for RPRM Gene

(1) SIMAP similar genes for RPRM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPRM: view

Variants for RPRM Gene

Sequence variations from dbSNP and Humsavar for RPRM Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1052581 -- 153,477,592(-) TGTGG(A/G)AGAAG utr-variant-3-prime
rs1063728 -- 153,477,985(-) GCGCA(C/G)AACTT utr-variant-3-prime
rs111984662 -- 153,477,506(+) GACGC(C/T)TCCCA utr-variant-3-prime
rs112664753 -- 153,478,885(+) GCAGC(G/T)GCGGG upstream-variant-2KB
rs114585190 -- 153,479,761(+) TTAAA(C/T)TAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPRM Gene

Variant ID Type Subtype PubMed ID
esv3592922 CNV loss 21293372
nsv7331 OTHER inversion 18451855

Variation tolerance for RPRM Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRM Gene

Disorders for RPRM Gene

Relevant External Links for RPRM

Genetic Association Database (GAD)
RPRM
Human Genome Epidemiology (HuGE) Navigator
RPRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPRM

No disorders were found for RPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPRM Gene

Publications for RPRM Gene

  1. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. (PMID: 10930422) Ohki R. … Taniguchi T. (J. Biol. Chem. 2000) 2 3 4 64
  2. Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study. (PMID: 18197409) Beasley W.D. … Parry J.M. (Int J Colorectal Dis 2008) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. tp53-dependent G2 arrest mediator candidate gene, Reprimo, is down-regulated by promoter hypermethylation in pediatric acute myeloid leukemia. (PMID: 25629980) Tao Y.F. … Pan J. (Leuk. Lymphoma 2015) 3 64
  5. Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. (PMID: 25954972) Saavedra K. … CorvalA!n A.H. (PLoS ONE 2015) 3 64

Products for RPRM Gene

Sources for RPRM Gene

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