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Aliases for RPRD2 Gene

Aliases for RPRD2 Gene

  • Regulation Of Nuclear Pre-MRNA Domain Containing 2 2 3
  • KIAA0460 2 3 4
  • Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 2 3
  • HSPC099 3

External Ids for RPRD2 Gene

Previous HGNC Symbols for RPRD2 Gene

  • KIAA0460

Previous GeneCards Identifiers for RPRD2 Gene

  • GC01P148604
  • GC01P121715

Summaries for RPRD2 Gene

GeneCards Summary for RPRD2 Gene

RPRD2 (Regulation Of Nuclear Pre-MRNA Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is RPRD1B.

Gene Wiki entry for RPRD2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRD2 Gene

Genomics for RPRD2 Gene

Regulatory Elements for RPRD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPRD2 Gene

150,363,091 bp from pter
150,476,566 bp from pter
113,476 bases
Plus strand

Genomic View for RPRD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRD2 Gene

Proteins for RPRD2 Gene

  • Protein details for RPRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulation of nuclear pre-mRNA domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K6N8
    • B3KPT1
    • B4E2Q6
    • O75048
    • Q5VT51
    • Q5VT53
    • Q6MZL4
    • Q86XD2
    • Q9P0D7

    Protein attributes for RPRD2 Gene

    1461 amino acids
    Molecular mass:
    156020 Da
    Quaternary structure:
    • Associates with the RNA polymerase II complex.
    • Sequence=AAF28922.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH45623.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPRD2 Gene

    Alternative splice isoforms for RPRD2 Gene


neXtProt entry for RPRD2 Gene

Proteomics data for RPRD2 Gene at MOPED

Post-translational modifications for RPRD2 Gene

  • Ubiquitination at Lys293
  • Modification sites at PhosphoSitePlus

Other Protein References for RPRD2 Gene

No data available for DME Specific Peptides for RPRD2 Gene

Domains for RPRD2 Gene

Protein Domains for RPRD2 Gene

Suggested Antigen Peptide Sequences for RPRD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CID domain.
  • Contains 1 CID domain.
genes like me logo Genes that share domains with RPRD2: view

No data available for Gene Families for RPRD2 Gene

Function for RPRD2 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPRD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPRD2 Gene

Localization for RPRD2 Gene

Subcellular locations from

Jensen Localization Image for RPRD2 Gene COMPARTMENTS Subcellular localization image for RPRD2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RPRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016591 DNA-directed RNA polymerase II, holoenzyme IDA 22231121
genes like me logo Genes that share ontologies with RPRD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPRD2 Gene

Pathways for RPRD2 Gene

SuperPathways for RPRD2 Gene

No Data Available

Interacting Proteins for RPRD2 Gene

Gene Ontology (GO) - Biological Process for RPRD2 Gene


No data available for Pathways by source for RPRD2 Gene

Transcripts for RPRD2 Gene

Unigene Clusters for RPRD2 Gene

Regulation of nuclear pre-mRNA domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPRD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: -

Relevant External Links for RPRD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPRD2 Gene

mRNA expression in normal human tissues for RPRD2 Gene

Protein differential expression in normal tissues for RPRD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.4), Testis (8.4), and Serum (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPRD2 Gene

SOURCE GeneReport for Unigene cluster for RPRD2 Gene Hs.213666

genes like me logo Genes that share expressions with RPRD2: view

Expression partners for RPRD2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPRD2 Gene

Orthologs for RPRD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPRD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPRD2 35
  • 93.18 (n)
  • 95.13 (a)
RPRD2 36
  • 93 (a)
(Canis familiaris)
Mammalia RPRD2 35
  • 94.43 (n)
  • 96.03 (a)
RPRD2 36
  • 96 (a)
(Mus musculus)
Mammalia Rprd2 35
  • 90.24 (n)
  • 91.22 (a)
Rprd2 16
Rprd2 36
  • 90 (a)
(Monodelphis domestica)
Mammalia RPRD2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RPRD2 36
  • 64 (a)
(Pan troglodytes)
Mammalia RPRD2 36
  • 100 (a)
(Gallus gallus)
Aves RPRD2 35
  • 71.69 (n)
  • 74.89 (a)
-- 36
  • 85 (a)
-- 36
  • 73 (a)
RPRD2 36
  • 72 (a)
(Anolis carolinensis)
Reptilia RPRD2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rprd2 35
  • 61.78 (n)
  • 60.51 (a)
Str.19358 35
(Danio rerio)
Actinopterygii wufk52b12 35
rprd2a 36
  • 37 (a)
rprd2b 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15160 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT103 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for RPRD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPRD2 Gene

Gene Tree for RPRD2 (if available)
Gene Tree for RPRD2 (if available)

Paralogs for RPRD2 Gene

Paralogs for RPRD2 Gene

genes like me logo Genes that share paralogs with RPRD2: view

Variants for RPRD2 Gene

Sequence variations from dbSNP and Humsavar for RPRD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7002 -- 150,473,343(+) AAACC(A/G)AGGGA utr-variant-3-prime
rs9357 -- 150,473,251(+) TTCAC(A/G)GTTTA utr-variant-3-prime, reference, missense
rs13057 -- 150,476,212(-) TTATT(A/C)CTGGT utr-variant-3-prime
rs696615 -- 150,366,512(+) ATATG(A/C)TAACA intron-variant
rs696616 -- 150,363,697(+) TTTGT(A/G)GTGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPRD2 Gene

Variant ID Type Subtype PubMed ID
nsv831548 CNV Loss 17160897
nsv872416 CNV Loss 21882294
esv2717773 CNV Deletion 23290073
esv2717784 CNV Deletion 23290073
esv2717795 CNV Deletion 23290073
esv2540817 CNV Deletion 19546169
esv989789 CNV Deletion 20482838
esv2670951 CNV Deletion 23128226
esv274946 CNV Loss 21479260
esv999047 CNV Insertion 20482838
esv2658303 CNV Deletion 23128226

Relevant External Links for RPRD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRD2 Gene

Disorders for RPRD2 Gene

Relevant External Links for RPRD2

Genetic Association Database (GAD)

No disorders were found for RPRD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RPRD2 Gene

Publications for RPRD2 Gene

  1. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. (PMID: 22231121) Ni Z. … Greenblatt J.F. (Transcription 2011) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4

Products for RPRD2 Gene

  • Addgene plasmids for RPRD2

Sources for RPRD2 Gene

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