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Aliases for RPRD1B Gene

Aliases for RPRD1B Gene

  • Regulation Of Nuclear Pre-MRNA Domain Containing 1B 2 3
  • CREPT 3 4 6
  • Cell-Cycle Related And Expression-Elevated Protein In Tumor 2 3
  • Cell Cycle-Related And Expression-Elevated Protein In Tumor 3 4
  • C20orf77 3 4
  • Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 1B 3
  • Chromosome 20 Open Reading Frame 77 2
  • DJ1057B20.2 3
  • NET60 3

External Ids for RPRD1B Gene

Previous HGNC Symbols for RPRD1B Gene

  • C20orf77

Previous GeneCards Identifiers for RPRD1B Gene

  • GC20P036096
  • GC20P036662
  • GC20P033397

Summaries for RPRD1B Gene

GeneCards Summary for RPRD1B Gene

RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core binding. An important paralog of this gene is RPRD2.

UniProtKB/Swiss-Prot for RPRD1B Gene

  • Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3 end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRD1B Gene

Genomics for RPRD1B Gene

Regulatory Elements for RPRD1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPRD1B Gene

Start:
38,033,462 bp from pter
End:
38,127,780 bp from pter
Size:
94,319 bases
Orientation:
Plus strand

Genomic View for RPRD1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPRD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRD1B Gene

Proteins for RPRD1B Gene

  • Protein details for RPRD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQG5-RPR1B_HUMAN
    Recommended name:
    Regulation of nuclear pre-mRNA domain-containing protein 1B
    Protein Accession:
    Q9NQG5
    Secondary Accessions:
    • Q1WDE7
    • Q6PKF4

    Protein attributes for RPRD1B Gene

    Size:
    326 amino acids
    Molecular mass:
    36900 Da
    Quaternary structure:
    • Associates with the RNA polymerase II complex.
    SequenceCaution:
    • Sequence=AAH01696.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPRD1B Gene

neXtProt entry for RPRD1B Gene

Proteomics data for RPRD1B Gene at MOPED

Post-translational modifications for RPRD1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPRD1B Gene

Antibody Products

No data available for DME Specific Peptides for RPRD1B Gene

Domains for RPRD1B Gene

Protein Domains for RPRD1B Gene

Suggested Antigen Peptide Sequences for RPRD1B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQG5

UniProtKB/Swiss-Prot:

RPR1B_HUMAN :
  • Q9NQG5
Domain:
  • Contains 1 CID domain.
Family:
  • Belongs to the UPF0400 (RTT103) family.
genes like me logo Genes that share domains with RPRD1B: view

No data available for Gene Families for RPRD1B Gene

Function for RPRD1B Gene

Molecular function for RPRD1B Gene

UniProtKB/Swiss-Prot Function:
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3 end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for RPRD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 22264791
GO:0005515 protein binding IPI 22264791
genes like me logo Genes that share ontologies with RPRD1B: view
genes like me logo Genes that share phenotypes with RPRD1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPRD1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPRD1B Gene

Localization for RPRD1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPRD1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPRD1B Gene COMPARTMENTS Subcellular localization image for RPRD1B gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPRD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22264791
GO:0016591 DNA-directed RNA polymerase II, holoenzyme IDA 22231121
genes like me logo Genes that share ontologies with RPRD1B: view

Pathways for RPRD1B Gene

SuperPathways for RPRD1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPRD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IDA 22264791
GO:0010564 regulation of cell cycle process IDA 22264791
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 22264791
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain IMP 22231121
genes like me logo Genes that share ontologies with RPRD1B: view

No data available for Pathways by source for RPRD1B Gene

Transcripts for RPRD1B Gene

Unigene Clusters for RPRD1B Gene

Regulation of nuclear pre-mRNA domain containing 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPRD1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPRD1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for RPRD1B Gene

GeneLoc Exon Structure for
RPRD1B
ECgene alternative splicing isoforms for
RPRD1B

Expression for RPRD1B Gene

mRNA expression in normal human tissues for RPRD1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPRD1B Gene

This gene is overexpressed in Liver (6.1).

Protein differential expression in normal tissues for RPRD1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.7) and Lymph node (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPRD1B Gene

SOURCE GeneReport for Unigene cluster for RPRD1B Gene Hs.278839

mRNA Expression by UniProt/SwissProt for RPRD1B Gene

Q9NQG5-RPR1B_HUMAN
Tissue specificity: Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level).
genes like me logo Genes that share expressions with RPRD1B: view

Expression partners for RPRD1B Gene

In Situ Assay Products

Orthologs for RPRD1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPRD1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPRD1B 35
  • 93.66 (n)
  • 100 (a)
RPRD1B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPRD1B 35
  • 94.89 (n)
  • 100 (a)
RPRD1B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rprd1b 35
  • 92.41 (n)
  • 99.69 (a)
Rprd1b 16
Rprd1b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPRD1B 35
  • 99.9 (n)
  • 100 (a)
RPRD1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rprd1b 35
  • 93.46 (n)
  • 99.39 (a)
oppossum
(Monodelphis domestica)
Mammalia RPRD1B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPRD1B 35
  • 83.69 (n)
  • 96.62 (a)
CREPT 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPRD1B 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rprd1a 35
  • 74.36 (n)
  • 86.15 (a)
Str.4805 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29308 35
zebrafish
(Danio rerio)
Actinopterygii rprd1b 35
  • 71.37 (n)
  • 81.29 (a)
wufb23h08 35
rprd1b 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005331 35
  • 53.21 (n)
  • 49.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9018 35
  • 52.92 (n)
  • 49.85 (a)
CG9018 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cids-1 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT103 36
  • 15 (a)
OneToMany
RTT103 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4640 36
  • 54 (a)
OneToMany
Species with no ortholog for RPRD1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPRD1B Gene

ENSEMBL:
Gene Tree for RPRD1B (if available)
TreeFam:
Gene Tree for RPRD1B (if available)

Paralogs for RPRD1B Gene

Paralogs for RPRD1B Gene

Selected SIMAP similar genes for RPRD1B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RPRD1B Gene

genes like me logo Genes that share paralogs with RPRD1B: view

Variants for RPRD1B Gene

Sequence variations from dbSNP and Humsavar for RPRD1B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs751230 -- 38,075,666(-) TCAGA(A/G)ATTAA intron-variant
rs910664 -- 38,053,899(+) AATAC(C/T)ATGCC intron-variant
rs958034 -- 38,051,217(+) aaata(C/T)ataca intron-variant
rs990792 -- 38,043,068(+) GACAC(G/T)GGGGG intron-variant
rs990793 -- 38,043,380(+) atgca(C/G)cagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPRD1B Gene

Variant ID Type Subtype PubMed ID
nsv833971 CNV Gain 17160897
nsv833972 CNV Loss 17160897
esv2670839 CNV Deletion 23128226

Relevant External Links for RPRD1B Gene

HapMap Linkage Disequilibrium report
RPRD1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPRD1B Gene

Disorders for RPRD1B Gene

Relevant External Links for RPRD1B

Genetic Association Database (GAD)
RPRD1B

No disorders were found for RPRD1B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RPRD1B Gene

Publications for RPRD1B Gene

  1. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. (PMID: 22231121) Ni Z. … Greenblatt J.F. (Transcription 2011) 2 3 4
  2. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes. (PMID: 22264791) Lu D. … Chang Z. (Cancer Cell 2012) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPRD1B Gene

Sources for RPRD1B Gene

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