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RPRD1B Gene

protein-coding   GIFtS: 54
GCID: GC20P036662

Regulation Of Nuclear Pre-MRNA Domain Containing 1B

(Previous name: chromosome 20 open reading frame 77)
(Previous symbol: C20orf77)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulation Of Nuclear Pre-MRNA Domain Containing 1B1 2     NET602
C20orf771 2 3     Cell-Cycle Related And Expression-Elevated Protein In Tumor2
CREPT2 3 5     dJ1057B20.22
Cell Cycle-Related And Expression-Elevated Protein In Tumor2 3     Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 1B2
Chromosome 20 Open Reading Frame 771     

External Ids:    HGNC: 162091   Entrez Gene: 584902   Ensembl: ENSG000001014137   OMIM: 6146945   UniProtKB: Q9NQG53   

Export aliases for RPRD1B gene to outside databases

Previous GC identifers: GC20P036096 GC20P033397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RPRD1B Gene:
RPRD1B (regulation of nuclear pre-mRNA domain containing 1B) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II core binding. An important paralog of this gene is RPRD1A.

UniProtKB/Swiss-Prot: RPR1B_HUMAN, Q9NQG5
Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase
II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances
expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region
before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading
through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of
the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes
including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPRD1B gene promoter:
         GR   E2F   E2F-1   GR-beta   Sox9   GR-alpha   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPRD1B promoter sequence
   Search Chromatin IP Primers for RPRD1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPRD1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21-q12   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.21-q12

RPRD1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPRD1B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P036662:  view genomic region     (about GC identifiers)

Start:
36,661,948 bp from pter      End:
36,720,768 bp from pter
Size:
58,821 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RPR1B_HUMAN, Q9NQG5 (See protein sequence)
Recommended Name: Regulation of nuclear pre-mRNA domain-containing protein 1B  
Size: 326 amino acids; 36900 Da
Subunit: Associates with the RNA polymerase II complex
Sequence caution: Sequence=AAH01696.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
4 PDB 3D structures from and Proteopedia for RPRD1B:
4FLA (3D)        4FU3 (3D)        4HFG (3D)        4NAD (3D)    
Secondary accessions: Q1WDE7 Q6PKF4

Explore the universe of human proteins at neXtProt for RPRD1B: NX_Q9NQG5

Explore proteomics data for RPRD1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RPRD1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067038.1  
    ENSEMBL proteins: 
     ENSP00000362532   ENSP00000436816   ENSP00000433947   ENSP00000416420  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006903 RNA_pol_II-bd
     IPR006569 CID_dom
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry Q9NQG5

    ProtoNet protein and cluster: Q9NQG5

    1 Blocks protein domain: IPB006569 Regulation of nuclear pre-mRNA protein

    UniProtKB/Swiss-Prot: RPR1B_HUMAN, Q9NQG5
    Similarity: Belongs to the UPF0400 (RTT103) family
    Similarity: Contains 1 CID domain


    Find genes that share domains with RPRD1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPR1B_HUMAN, Q9NQG5
    Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase
    II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances
    expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region
    before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading
    through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of
    the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes
    including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RPRD1B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPRD1B:
     Increased G2M DNA content, inc  Increased cell number in G1, s 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rprd1b):
     behavior/neurological  hematopoietic system  homeostasis/metabolism 

    Find genes that share phenotypes with RPRD1B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPRD1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPRD1B
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    hsa-mir-16-5p (MIRT031629), hsa-mir-30a-5p (MIRT028504), hsa-mir-103a-3p (MIRT027086), hsa-mir-124-3p (MIRT022922), hsa-mir-130b-3p (MIRT020154), hsa-mir-33a-5p (MIRT049853)

    Block miRNA regulation of human, mouse, rat RPRD1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPRD1B (see all 43):
    hsa-miR-21* hsa-miR-579 hsa-miR-100* hsa-miR-300 hsa-miR-4272 hsa-miR-513a-5p hsa-miR-628-3p hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidRPRD1B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRD1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPR1B_HUMAN, Q9NQG5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016591DNA-directed RNA polymerase II, holoenzyme IDA--

    Find genes that share ontologies with RPRD1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPRD1B
    Interactions:

        Search GeneGlobe Interaction Network for RPRD1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPRD1B (Q9NQG51, 2, 3 ENSP000003625324) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUBGCP4Q9UGJ12, 3, ENSP000002603834MINT-67164 I2D: score=4 STRING: ENSP00000260383
    POLR2AP249281, ENSP000003149494EBI-747925,EBI-295301 STRING: ENSP00000314949
    CCND1ENSP000002275074STRING: ENSP00000227507
    XRN2ENSP000003663964STRING: ENSP00000366396
    CDC73ENSP000003564054STRING: ENSP00000356405
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0008284positive regulation of cell proliferation IDA--
    GO:0010564regulation of cell cycle process IDA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--
    GO:0070940dephosphorylation of RNA polymerase II C-terminal domain IMP--

    Find genes that share ontologies with RPRD1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPRD1B (RPR1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPRD1B gene: 
    NM_021215.3  

    Unigene Cluster for RPRD1B:

    Regulation of nuclear pre-mRNA domain containing 1B
    Hs.278839  [show with all ESTs]
    Unigene Representative Sequence: NM_021215
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373433(uc002xho.4 uc002xhp.4) ENST00000462548 ENST00000495457
    ENST00000449186 ENST00000471511 ENST00000484683
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RPRD1B (see all 43):
    hsa-miR-21* hsa-miR-579 hsa-miR-100* hsa-miR-300 hsa-miR-4272 hsa-miR-513a-5p hsa-miR-628-3p hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidRPRD1B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RPRD1B
      QuantiFast Probe-based Assays in human, mouse, rat RPRD1B

    Additional mRNA sequence: 

    AK092567.1 AK312468.1 AL080224.1 AL117521.1 BC001696.2 BC020939.1 BC033629.1 DQ372938.1 

    12 DOTS entries:

    DT.100747183  DT.120818839  DT.97773885  DT.446745  DT.95122094  DT.120818916  DT.120818888  DT.40129132 
    DT.91753847  DT.95141814  DT.99985840  DT.75167381 

    Selected AceView cDNA sequences (see all 198):

    AI280965 BC020939 AW193438 H59904 F05898 AI276073 BP357464 BM545387 
    AI346125 BM454427 BQ574251 AA708590 BP359144 AI346404 AI678621 BX325298 
    BU180788 N70934 F02145 NM_021215 AI309230 BM722305 AK126484 AI085611 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPRD1B (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                -                             -     -           -     -                     
    SP2:                                                              -     -           -     -                     
    SP3:                          -     -                                                                           
    SP4:                    -           -                                                                           
    SP5:                                                                    -                                       


    ECgene alternative splicing isoforms for RPRD1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPRD1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGAGAAC
    RPRD1B Expression
    About this image


    RPRD1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Eye (Sensory Organs)
             Retina
    RPRD1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPRD1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278839

    UniProtKB/Swiss-Prot: RPR1B_HUMAN, Q9NQG5
    Tissue specificity: Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast,
    prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent
    non-tumor tissue (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat RPRD1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRD1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPRD1B gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rprd1b1 , 5 regulation of nuclear pre-mRNA domain containing 1B1, 5 92.41(n)1
    99.69(a)1
      2 (78.72 cM)5
    704701  NM_027434.21  NP_081710.11 
     1580284975 
    chicken
    (Gallus gallus)
    Aves RPRD1B1 regulation of nuclear pre-mRNA domain containing 1B 83.69(n)
    96.62(a)
      419295  NM_001030862.1  NP_001026033.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPRD1B6
    regulation of nuclear pre-mRNA domain containing 1...
    95(a)
    1 ↔ 1
    GL343572.1(122060-192775)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.293082 Xenopus laevis transcribed sequence with weak similarity more 76.48(n)    BU912672.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb23h082 wufb23h08 74.92(n)   321636  BC048885.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90181 CG9018 52.92(n)
    49.85(a)
      38283  NM_139444.2  NP_647701.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cids-16
    Protein CIDS-1 (cids-1) mRNA, complete cds
    23(a)
    1 → many
    III(8244443-8245794) WBGene00015347
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTT103(YDR289C)4 Protein that interacts with exonuclease Rat1p and Rai1p more   --   4(1039509-1038280) 851884  NP_010575.1 


    ENSEMBL Gene Tree for RPRD1B (if available)
    TreeFam Gene Tree for RPRD1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPRD1B gene
    RPRD1A2  RPRD22  
    1 SIMAP similar gene for RPRD1B using alignment to 4 protein entries:     RPR1B_HUMAN (see all proteins):
    RPRD1A

    Find genes that share paralogs with RPRD1B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RPRD1B
    PGOHUM00000258034


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPRD1B (see all 1202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741798851,2
    C--36639039(+) GTTCA-/T/TTT 
            
    TTTTT
    2 -- int1 cds11NA 2
    rs1921281371,2
    --36663873(+) CTACAA/GCAGGC 1 -- int10--------
    rs1480307971,2
    C--36663944(+) GGACTC/GCCCCC 1 -- int10--------
    rs1417505051,2
    --36663956(+) AATATC/TGCGTA 1 -- int10--------
    rs1827230831,2
    --36663957(+) ATATCC/GCGTAC 1 -- int10--------
    rs1859079291,2
    --36663981(+) GGATCC/TCCTCA 1 -- int10--------
    rs1899833101,2
    --36663983(+) ATCCCC/GTCAGC 1 -- int10--------
    rs1459600881,2
    --36663999(+) GGGCAG/TTTCCG 1 -- int10--------
    rs1398724611,2
    C--36664003(+) AGTTCC/TGGGAA 1 -- int10--------
    rs761972121,2
    F--36664104(+) CCACTG/CTACAG 1 -- int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for RPRD1B (36661948 - 36720768 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RPRD1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670839CNV Deletion23128226
    nsv833972CNV Loss17160897
    nsv833971CNV Gain17160897

    Human Gene Mutation Database (HGMD): RPRD1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPRD1B
    DNA2.0 Custom Variant and Variant Library Synthesis for RPRD1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614694    OMIM disorders: --


    Find genes that share disorders with RPRD1B           About GenesLikeMe

    Genetic Association Database (GAD): RPRD1B

    Export disorders for RPRD1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPRD1B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RPRD1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. (PubMed id 22231121)1, 2, 3 Ni Z.... Greenblatt J.F. (Transcription 2011)
    2. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes. (PubMed id 22264791)1, 2 Lu D.... Chang Z. (Cancer Cell 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58490 HGNC: 16209 AceView: C20orf77 Ensembl:ENSG00000101413 euGenes: HUgn58490
    ECgene: RPRD1B H-InvDB: RPRD1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPRD1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPRD1B gene:
    Search GeneIP for patents involving RPRD1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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