Aliases for RPRD1B Gene
- Regulation Of Nuclear Pre-MRNA Domain Containing 1B 2 3
- CREPT 3 4 6
- Cell-Cycle Related And Expression-Elevated Protein In Tumor 2 3
- Cell Cycle-Related And Expression-Elevated Protein In Tumor 3 4
- C20orf77 3 4
- Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 1B 3
- Chromosome 20 Open Reading Frame 77 2
- DJ1057B20.2 3
- NET60 3
External Ids for RPRD1B Gene
Previous Symbols for RPRD1B Gene
GeneCards Summary for RPRD1B Gene
RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core binding. An important paralog of this gene is RPRD2.
UniProtKB/Swiss-Prot for RPRD1B Gene
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3 end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.