Aliases for RPRD1A Gene
- Regulation Of Nuclear Pre-MRNA Domain Containing 1A 2 3 5
- Cyclin-Dependent Kinase Inhibitor 2B-Related Protein (P15INK4B-Related Protein) 2 3
- Cyclin-Dependent Kinase 2B-Inhibitor-Related Protein 2 3
- P15INK4B-Related Protein 3 4
- P15RS 3 4
- Cyclin-Dependent Kinase Inhibitor 2B-Related Protein 4
- CDKN2B-Related Protein 3
- HsT3101 3
External Ids for RPRD1A Gene
Previous GeneCards Identifiers for RPRD1A Gene
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
GeneCards Summary for RPRD1A Gene
RPRD1A (Regulation Of Nuclear Pre-MRNA Domain Containing 1A) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. An important paralog of this gene is RPRD2.
UniProtKB/Swiss-Prot for RPRD1A Gene
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.