RPRD1A Gene
protein-coding GIFtS: 49
GCID: GC18M033569
|
|
regulation of nuclear pre-mRNA domain containing 1A
| |
Aliases
for RPRD1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulation Of Nuclear Pre-MRNA Domain Containing 1A1 2 | | Cyclin-Dependent Kinase 2B-Inhibitor-Related Protein2 | | P15RS1 2 3 | | Cyclin-Dependent Kinase Inhibitor 2B-Related Protein (P15INK4B-Related Protein)2 | | HsT31011 2 | | Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 1A2 | | P15INK4B-Related Protein2 3 | | Cyclin-Dependent Kinase Inhibitor 2B-Related Protein3 | | FLJ106561 | | |
Export aliases for RPRD1A gene to outside databasesPrevious GC identifers: GC18M031824 GC18M030428 |
Summaries
for RPRD1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPRD1A:
P15RS is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) (CDKN2B; MIM 600431) and mayhave a role in cell cycle regulation (Liu et al., 2002 (PubMed 12470661)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: RPR1A_HUMAN, Q96P16Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase IIsubunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1)and cyclin-E (CCNE1) in the cell cycle
|
Genomic Views
for RPRD1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPRD1A gene promoter:
AhR Sp1 HTF Arnt Pax-3 POU2F1 POU2F1b POU2F1a POU2F1c ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPRD1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPRD1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12.2 Ensembl cytogenetic band: 18q12.2 HGNC cytogenetic band: 18q12.2RPRD1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M033569: view genomic region
(about GC identifiers)
Start:
|
33,564,350 bp from pter |
End:
|
33,647,539 bp from pter |
Size:
|
83,190 bases |
Orientation:
|
minus strand |
|
Proteins
for RPRD1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RPR1A_HUMAN, Q96P16 (See
protein sequence)Recommended Name: Regulation of nuclear pre-mRNA domain-containing protein 1A Size: 312 amino acids; 35720 Da
Subunit: Associates with the RNA polymerase II complex
Sequence caution: Sequence=AAH10136.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A8KA42 B2RBA3 Q7Z5G8 Q96FY9 Q9NVL4Alternative splicing: 2 isoforms: Q96P16-1 Q96P16-3 Explore the universe of human proteins at neXtProt for RPRD1A: NX_Q96P16
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96P16
RPRD1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060640.2
ENSEMBL proteins: ENSP00000468108 ENSP00000468173 ENSP00000467991 ENSP00000381984 ENSP00000349955 ENSP00000465444 ENSP00000467268 ENSP00000468209 ENSP00000467949 ENSP00000337476 ENSP00000314602
Human Recombinant Protein Products for RPRD1A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016591 | DNA-directed RNA polymerase II, holoenzyme |
IDA | -- |
RPRD1A for ontologies About GeneDecksing
RPRD1A Antibody Products:
Assay Products for RPRD1A: |
Protein
Domains /
Families
for RPRD1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPRD1A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96P16ProtoNet protein and cluster: Q96P16 1 Blocks protein family: IPB006569 Regulation of nuclear pre-mRNA protein
UniProtKB/Swiss-Prot: RPR1A_HUMAN, Q96P16Similarity: Belongs to the UPF0400 (RTT103) familySimilarity: Contains 1 CID domain |
Function
for RPRD1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RPR1A_HUMAN, Q96P16Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase IIsubunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1)and cyclin-E (CCNE1) in the cell cycleInduction: Up-regulated in cells overexpressing CDKN2BPhenotypes:
3 GenomeRNAi human phenotypes for RPRD1A:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPRD1A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRD1A |
|
Pathways & Interactions
for RPRD1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPRD1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/8 Interacting proteins for RPRD1A (Q96P163 ENSP000003499554) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain |
IMP | -- |
RPRD1A for ontologies About GeneDecksing
|
Drugs & Compounds
for RPRD1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPRD1A
Search CenterWatch for drugs/clinical trials and news about RPRD1A / RPR1A
|
Transcripts
for RPRD1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPRD1A gene: NM_018170.3 Unigene Cluster for RPRD1A: Regulation of nuclear pre-mRNA domain containing 1A Hs.464912 [show with all ESTs]Unigene Representative Sequence: AF41984513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587563 ENST00000585879 ENST00000590898 ENST00000399022(uc002kze.1 uc002kzg.3 uc010dmw.3)
ENST00000357384 ENST00000588737 ENST00000585953 ENST00000591994 ENST00000589050
ENST00000592674 ENST00000588459 ENST00000337059 ENST00000319040(uc010dmx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPRD1A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPRD1A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPRD1A (NM_018170) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF419845.1 AK001518.1 AK056810.1 AK292907.1 AK314569.1 BC000225.1 BC010136.2 18 DOTS entries: DT.100798273 DT.95295061 DT.91756332 DT.408566 DT.121085367 DT.100798268 DT.121085379 DT.121085386 DT.121085404 DT.100798270 DT.121380832 DT.121085377 DT.92048565 DT.100831058 DT.121085360 DT.91803099 DT.100673604 DT.100798274 24/335 AceView cDNA sequences (see all 335): CB121734 BM013953 AA287861 AI859621 NM_018170 AA453209 AA886724 AW613180 BC010136 AI828693 AW001964 BX096043 CR617134 CK300464 AI200929 BF590199 N50338 BQ773437 CR612452 BQ021744 BU620285 BU633990 AA906717 AL709369
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RPRD1A (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | - | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RPRD1A
|
Expression
for RPRD1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPRD1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGATGAA
About this image
See RPRD1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPRD1A
SOURCE GeneReport for Unigene cluster: Hs.464912
SABiosciences Custom PCR Arrays for RPRD1A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPRD1A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRD1A |
Orthologs
for RPRD1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPRD1A gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for RPRD1A (if available)
TreeFam Gene Tree for RPRD1A (if available) |
Paralogs
for RPRD1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPRD1A gene
- RPRD1B2 RPRD22
1 SIMAP similar gene for RPRD1A using alignment to 4 protein entries: RPR1A_HUMAN (see all proteins):RPRD1B
RPRD1A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RPRD1A
PGOHUM00000249129
|
Genomic Variants
for RPRD1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPRD1A (33564350 - 33647539 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPRD1A
1 CNV: 67327 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPRD1A |
|
Disorders
/ Diseases
for RPRD1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPRD1A for disorders About GeneDecksing
OMIM gene information: 610347
OMIM disorders: --
3  diseases for RPRD1A: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia leukemia
1 Novoseek disease relationship for RPRD1A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
5.79 |
2 |
9892092 (1) |
Export disorders for RPRD1A gene to outside databases
|
Publications
for RPRD1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPRD1A gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with RPRD1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression. (PubMed id 12470661)1, 2, 3, 9 Liu J.... Hu Z. (2002)
- Control of the RNA polymerase II phosphorylation stat e in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. (PubMed id 22231121)1, 2, 3 Ni Z....Greenblatt J.F. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cellular and molecular evidence for malignancy-inhibit ory functions of p15RS. (PubMed id 22580456)1 Zhang X....Zhang W. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- p15RS attenuates Wnt/{beta}-catenin signaling by disr upting {beta}-cateninA^TCF4 Interaction. (PubMed id 20739273)1 Wu Y....Chang Z. (2010)
|
External Searches for RPRD1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPRD1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPRD1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPRD1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPRD1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPRD1A gene:
Search GeneIP for patents involving RPRD1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPRD1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | RPRD1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPRD1A |
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