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Aliases for RPRD1A Gene

Aliases for RPRD1A Gene

  • Regulation Of Nuclear Pre-MRNA Domain Containing 1A 2 3
  • P15RS 3 4 6
  • Cyclin-Dependent Kinase Inhibitor 2B-Related Protein (P15INK4B-Related Protein) 2 3
  • Cyclin-Dependent Kinase 2B-Inhibitor-Related Protein 2 3
  • P15INK4B-Related Protein 3 4
  • Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 1A 3
  • Cyclin-Dependent Kinase Inhibitor 2B-Related Protein 4
  • CDKN2B-Related Protein 3
  • FLJ10656 6
  • HsT3101 3

External Ids for RPRD1A Gene

Summaries for RPRD1A Gene

Entrez Gene Summary for RPRD1A Gene

  • This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]

GeneCards Summary for RPRD1A Gene

RPRD1A (Regulation Of Nuclear Pre-MRNA Domain Containing 1A) is a Protein Coding gene. An important paralog of this gene is RPRD1B.

UniProtKB/Swiss-Prot for RPRD1A Gene

  • Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPRD1A Gene

Genomics for RPRD1A Gene

Genomic Location for RPRD1A Gene

Start:
35,984,387 bp from pter
End:
36,067,576 bp from pter
Size:
83,190 bases
Orientation:
Minus strand

Genomic View for RPRD1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPRD1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPRD1A Gene

Regulatory Elements for RPRD1A Gene

Proteins for RPRD1A Gene

  • Protein details for RPRD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P16-RPR1A_HUMAN
    Recommended name:
    Regulation of nuclear pre-mRNA domain-containing protein 1A
    Protein Accession:
    Q96P16
    Secondary Accessions:
    • A8KA42
    • B2RBA3
    • Q7Z5G8
    • Q96FY9
    • Q9NVL4

    Protein attributes for RPRD1A Gene

    Size:
    312 amino acids
    Molecular mass:
    35720 Da
    Quaternary structure:
    • Associates with the RNA polymerase II complex.
    SequenceCaution:
    • Sequence=AAH10136.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPRD1A Gene

    Alternative splice isoforms for RPRD1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPRD1A Gene

Proteomics data for RPRD1A Gene at MOPED

Post-translational modifications for RPRD1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPRD1A Gene

Domains for RPRD1A Gene

Protein Domains for RPRD1A Gene

UniProtKB/Swiss-Prot:

RPR1A_HUMAN
Domain:
  • Contains 1 CID domain.:
    • Q96P16
Family:
  • Belongs to the UPF0400 (RTT103) family.:
    • Q96P16
genes like me logo Genes that share domains with RPRD1A: view

No data available for Gene Families for RPRD1A Gene

Function for RPRD1A Gene

Molecular function for RPRD1A Gene

UniProtKB/Swiss-Prot Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
UniProtKB/Swiss-Prot Induction: Up-regulated in cells overexpressing CDKN2B.

Gene Ontology (GO) - Molecular Function for RPRD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPRD1A: view

Phenotypes for RPRD1A Gene

genes like me logo Genes that share phenotypes with RPRD1A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPRD1A Gene

Localization for RPRD1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPRD1A Gene COMPARTMENTS Subcellular localization image for RPRD1A gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RPRD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016591 DNA-directed RNA polymerase II, holoenzyme IDA 22231121
genes like me logo Genes that share ontologies with RPRD1A: view

Pathways for RPRD1A Gene

SuperPathways for RPRD1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPRD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain IMP 22231121
genes like me logo Genes that share ontologies with RPRD1A: view

No data available for Pathways by source for RPRD1A Gene

Transcripts for RPRD1A Gene

Unigene Clusters for RPRD1A Gene

Regulation of nuclear pre-mRNA domain containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPRD1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - -
SP8:

Relevant External Links for RPRD1A Gene

GeneLoc Exon Structure for
RPRD1A
ECgene alternative splicing isoforms for
RPRD1A

Expression for RPRD1A Gene

mRNA expression in normal human tissues for RPRD1A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPRD1A Gene

SOURCE GeneReport for Unigene cluster for RPRD1A Gene Hs.464912

genes like me logo Genes that share expressions with RPRD1A: view

Orthologs for RPRD1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPRD1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPRD1A 36
  • 99.68 (n)
  • 100 (a)
RPRD1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPRD1A 36
  • 94.93 (n)
  • 100 (a)
RPRD1A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPRD1A 36
  • 95.62 (n)
  • 100 (a)
RPRD1A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rprd1a 36
  • 91.24 (n)
  • 98.72 (a)
Rprd1a 16
Rprd1a 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPRD1A 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rprd1a 36
  • 90.92 (n)
  • 98.72 (a)
chicken
(Gallus gallus)
Aves RPRD1A 36
  • 84.86 (n)
  • 90.84 (a)
RPRD1A 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPRD1A 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rprd1b 36
  • 75.53 (n)
  • 86.54 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560565 36
  • 68.18 (n)
  • 74.68 (a)
RPRD1A 37
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9018 37
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cids-1 36
  • 41.7 (n)
  • 26.5 (a)
cids-1 37
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT103 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4640 37
  • 48 (a)
OneToMany
Species with no ortholog for RPRD1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPRD1A Gene

ENSEMBL:
Gene Tree for RPRD1A (if available)
TreeFam:
Gene Tree for RPRD1A (if available)

Paralogs for RPRD1A Gene

Paralogs for RPRD1A Gene

Selected SIMAP similar genes for RPRD1A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RPRD1A Gene

genes like me logo Genes that share paralogs with RPRD1A: view

Variants for RPRD1A Gene

Sequence variations from dbSNP and Humsavar for RPRD1A Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1102 -- 36,027,067(-) AAGAA(C/T)CTGGA missense, reference
rs1103 -- 36,027,187(-) AAATA(A/G)CAGAT reference, missense
rs1047866 -- 36,025,790(-) TAAAC(A/C)TAGTG intron-variant
rs1060324 -- 35,990,394(-) CTATA(A/G)GAAAT utr-variant-3-prime
rs1540045 -- 36,031,199(-) CAGGG(A/G)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPRD1A Gene

Variant ID Type Subtype PubMed ID
esv1506593 CNV Insertion 17803354
esv25678 CNV Loss 19812545
nsv7303 OTHER Inversion 18451855
nsv522157 CNV Loss 19592680
esv275291 CNV Loss 21479260

Relevant External Links for RPRD1A Gene

HapMap Linkage Disequilibrium report
RPRD1A

Disorders for RPRD1A Gene

(1) Novoseek inferred disease relationships for RPRD1A Gene

Disease -log(P) Hits PubMed IDs
tumors 5.79 1
genes like me logo Genes that share disorders with RPRD1A: view

No data available for UniProtKB/Swiss-Prot for RPRD1A Gene

Publications for RPRD1A Gene

  1. Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression. (PMID: 12470661) Liu J. … Hu Z. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23
  2. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. (PMID: 22231121) Ni Z. … Greenblatt J.F. (Transcription 2011) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for RPRD1A Gene

Sources for RPRD1A Gene

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