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Aliases for RPPH1 Gene

Subcategory (RNA class) for RPPH1 Gene

lncRNA

Quality Score for this RNA gene is

5

Aliases for RPPH1 Gene

  • Ribonuclease P RNA Component H1 2 3
  • H1RNA 3 6
  • RPPH1-1 3
  • H1 RNA 3

External Ids for RPPH1 Gene

Previous GeneCards Identifiers for RPPH1 Gene

  • GC14U900464
  • GC14M019884
  • GC14M020811
  • GC14M000933

Summaries for RPPH1 Gene

Entrez Gene Summary for RPPH1 Gene

  • H1RNA is the RNA component of the RNase P ribonucleoprotein, an endoribonuclease that cleaves tRNA precursor molecules to form the mature 5-prime termini of their tRNA sequences (Baer et al., 1989 [PubMed 2308839]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RPPH1 Gene

RPPH1 (Ribonuclease P RNA Component H1) is an RNA Gene, and is affiliated with the lncRNA class.

fRNAdb sequence ontologies for RPPH1 Gene

  • RNase_P_RNA: The RNA component of Ribonuclease P (RNase P), a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterised activity is the generation of mature 5 prime ends of tRNAs by cleaving the 5 prime leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e. it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown to retain its catalytic function, but is still essential for the catalytic activity of the holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the bacterial ones, the RNA cores from all the three lineages are homologous. Helices corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs.

View fRNAdb secondary structures for RPPH1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RPPH1 Gene

Genomics for RPPH1 Gene

Regulatory Elements for RPPH1 Gene

Genomic Location for RPPH1 Gene

Start:
20,343,048 bp from pter
End:
20,343,685 bp from pter
Size:
638 bases
Orientation:
Minus strand

Genomic View for RPPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPPH1 Gene

ORGUL Member Location for RPPH1 Gene

ORGUL Member Location for RPPH1 gene

Proteins for RPPH1 Gene

Post-translational modifications for RPPH1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RPPH1 Gene

Domains for RPPH1 Gene

Gene Families for RPPH1 Gene

HGNC:
  • MISCRNA :ncRNAs / Small misc ncRNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPPH1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RPPH1 Gene

Function for RPPH1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPPH1 Gene

Localization for RPPH1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RPPH1 Gene

Pathways for RPPH1 Gene

SuperPathways for RPPH1 Gene

No Data Available

Interacting Proteins for RPPH1 Gene

Gene Ontology (GO) - Biological Process for RPPH1 Gene

None

No data available for Pathways by source for RPPH1 Gene

Transcripts for RPPH1 Gene

fRNAdb Secondary structures for RPPH1 Gene

  • FR290828

mRNA/cDNA for RPPH1 Gene

(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPPH1 Gene

Ribonuclease P RNA component H1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPPH1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPPH1 Gene

No ASD Table

Relevant External Links for RPPH1 Gene

GeneLoc Exon Structure for
RPPH1
ECgene alternative splicing isoforms for
RPPH1

Expression for RPPH1 Gene

mRNA expression in normal human tissues for RPPH1 Gene

mRNA differential expression in normal tissues according to GTEx for RPPH1 Gene

This gene is overexpressed in Whole Blood (5.1).

SOURCE GeneReport for Unigene cluster for RPPH1 Gene Hs.613102

genes like me logo Genes that share expressions with RPPH1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for RPPH1 Gene

Orthologs for RPPH1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for RPPH1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rpph1 16
Species with no ortholog for RPPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPPH1 Gene

ENSEMBL:
Gene Tree for RPPH1 (if available)
TreeFam:
Gene Tree for RPPH1 (if available)

Paralogs for RPPH1 Gene

No data available for Paralogs for RPPH1 Gene

Variants for RPPH1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPPH1 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Relevant External Links for RPPH1 Gene

HapMap Linkage Disequilibrium report
RPPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPPH1 Gene

Disorders for RPPH1 Gene

No disorders were found for RPPH1 Gene.

No data available for UniProtKB/Swiss-Prot for RPPH1 Gene

Publications for RPPH1 Gene

  1. Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells. (PMID: 2470644) Bartkiewicz M. … Altman S. (Genes Dev. 1989) 2 3
  2. Recent studies of ribonuclease P. (PMID: 7916700) Altman S. … Talbot S. (FASEB J. 1993) 2 3
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3
  5. RNA polymerase II mediated transcription from the polymerase III promoters in short hairpin RNA expression vector. (PMID: 16300730) Rumi M. … Kinoshita Y. (Biochem. Biophys. Res. Commun. 2006) 23

Products for RPPH1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPPH1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPPH1
    • Block miRNA regulation of RPPH1 using miScript Target Protectors

    Sources for RPPH1 Gene

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