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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPPH1 Gene

RNA gene   GIFtS: 22
GCID: GC14M020811

ribonuclease P RNA component H1
  Search for RPPH1
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Biological research products
for RPPH1    

Aliases
for RPPH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 5

Aliases
Ribonuclease P RNA Component H11 2
H1RNA1 2

External Ids:    HGNC: 192731   Entrez Gene: 854952   Ensembl: ENSG000002526787   OMIM: 6085135   
ORGUL members:    fRNAdb10:FR290828 FR186486 FR290828 FR185141 FR174566      
H-InvDB:HIT000321513    
NCBI:S68670 X15624 AL355075 X16612 X15624 see all 6    
NONCODE:u5339 n338205    
Rfam:RF00009    

Export aliases for RPPH1 gene to outside databases

Previous GC identifers: GC14U900464 GC14M019884 GC14M000933


Summaries
for RPPH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPPH1:
H1RNA is the RNA component of the RNase P ribonucleoprotein, an endoribonuclease that cleaves tRNA precursor molecules
to form the mature 5-prime termini of their tRNA sequences (Baer et al., 1989 (PubMed 2308839)).(supplied by OMIM, Mar
2008)



fRNAdb sequence ontology for RPPH1:
RNase_P_RNA - The RNA component of Ribonuclease P (RNase P), a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterised activity is the generation of mature 5 prime ends of tRNAs by cleaving the 5 prime leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e. it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown to retain its catalytic function, but is still essential for the catalytic activity of the holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the bacterial ones, the RNA cores from all the three lineages are homologous. Helices corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs.

View fRNAdb secondary structures for RPPH1

Genomic Views
for RPPH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPPH1 gene promoter:
         HOXA9   HOXA9B   GCNF   Nkx2-5   PPAR-gamma1   GCNF-1   Meis-1a   PPAR-gamma2   GCNF-2   Meis-1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

RPPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPPH1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020811:  view genomic region     (about GC identifiers)

Start:
 20,811,230 bp from pter      End:
 20,811,570 bp from pter
Size:
 341 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • FR0185141
  • n338205
  • FR0174566
  • FR0290828
  • FR0186486
20811229 20811398 20811567 chr14

Proteins
for RPPH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for RPPH1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for RPPH1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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In Situ Assay
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Pathways & Interactions
for RPPH1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPPH1

Drugs & Compounds
for RPPH1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPPH1
Search CenterWatch for drugs/clinical trials and news about RPPH1 

Transcripts
for RPPH1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 4 fRNAdb Secondary structures:


Unigene Cluster for RPPH1:

Ribonuclease P RNA component H1
Hs.613102  [show with all ESTs]
Unigene Representative Sequence: CA413366
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000516869(misc_RNA)

miRNA
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Inhib. RNA
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Additional cDNA sequence: X15624.1 

1 DOTS entry:

DT.95269349 

GeneLoc Exon Structure


Expression
for RPPH1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for RPPH1:H-invDB

RPPH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCTTGGGA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
Genevestigator expression for RPPH1

SOURCE GeneReport for Unigene cluster: Hs.613102
    SABiosciences Custom PCR Arrays for RPPH1
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In Situ
Assay Products: 
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Orthologs
for RPPH1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for RPPH1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Rpph15 ribonuclease P RNA component H1   --   14 (26.25 cM) 50807447 


ENSEMBL Gene Tree for RPPH1 (if available)
TreeFam Gene Tree for RPPH1 (if available) 

Paralogs
for RPPH1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RPPH1 gene
ENSG000002523502  ENSG000002524972  

RPPH1 for paralogs           About GeneDecksing



Genomic Variants
for RPPH1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPPH1
     1 CNV: 71865
SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for RPPH1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
RPPH1 for disorders           About MalaCards

RPPH1 for disorders           About GeneDecksing

OMIM gene information: 608513   

Export disorders for RPPH1 gene to outside databases

Publications
for RPPH1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RPPH1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RPPH1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Recent studies of ribonuclease P. (PubMed id 7916700)1, 3 Altman S....Talbot S. (1993)
  2. Identification and characterization of an RNA molecul e that copurifies with RNase P activity from HeLa cells. (PubMed id 2470644)1, 3 Bartkiewicz M....Altman S. (1989)
  3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)1 Welting T.J.... Pruijn G.J. (2004)
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
  5. Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P. (PubMed id 2308839)1 Baer M....Altman S. (1990)
  6. Developmental validation of the Quantifiler Duo DNA Quantification kit for simultaneous quantification of total human and human male DNA and detection of PCR inhibitors in biological samples. (PubMed id 19175708)9 Barbisin M....Shewale J.G. (2009)
  7. RNA polymerase II mediated transcription from the polymerase III promoters in short hairpin RNA expression vector. (PubMed id 16300730)9 Rumi M....Kinoshita Y. (2006)
  8. (PubMed id 9759486)10 
  9. (PubMed id 9847214)10 
  10. (PubMed id 11142387)10 

External Searches for RPPH1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing RPPH1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 85495 HGNC: 19273 Ensembl:ENSG00000252678 euGenes: HUgn85495 ECgene: RPPH1
H-InvDB: RPPH1

Other Databases showing RPPH1 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing RPPH1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RPPH1 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for RPPH1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RPPH1 gene:
Search GeneIP for patents involving RPPH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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