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Aliases for RPP40 Gene

Aliases for RPP40 Gene

  • Ribonuclease P/MRP 40kDa Subunit 2 3
  • RNaseP Protein P40 3 4
  • RNase P Subunit 1 3 4
  • Ribonuclease P1 2 3
  • EC 3.1.26.5 4 63
  • RNASEP1 3 4
  • Ribonuclease P 40kDa Subunit 2
  • Ribonuclease P, 40kD Subunit 3
  • Ribonuclease P (40 KD) 3
  • BA428J1.3 3

External Ids for RPP40 Gene

Previous HGNC Symbols for RPP40 Gene

  • RNASEP1

Previous GeneCards Identifiers for RPP40 Gene

  • GC06M004980
  • GC06M004941
  • GC06M004942

Summaries for RPP40 Gene

GeneCards Summary for RPP40 Gene

RPP40 (Ribonuclease P/MRP 40kDa Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP40 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Gene Wiki entry for RPP40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP40 Gene

Genomics for RPP40 Gene

Regulatory Elements for RPP40 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPP40 Gene

Chromosome:
6
Start:
4,992,414 bp from pter
End:
5,004,063 bp from pter
Size:
11,650 bases
Orientation:
Minus strand

Genomic View for RPP40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP40 Gene

Proteins for RPP40 Gene

  • Protein details for RPP40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75818-RPP40_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p40
    Protein Accession:
    O75818
    Secondary Accessions:
    • Q5VX97
    • Q8WVK8

    Protein attributes for RPP40 Gene

    Size:
    363 amino acids
    Molecular mass:
    41834 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40
    SequenceCaution:
    • Sequence=AAC24114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17871.1; Type=Frameshift; Positions=327; Evidence={ECO:0000305}; Sequence=CAH73740.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RPP40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPP40 Gene

Proteomics data for RPP40 Gene at MOPED

Selected DME Specific Peptides for RPP40 Gene

Post-translational modifications for RPP40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP40 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for RPP40
  • Santa Cruz Biotechnology (SCBT) Antibodies for RPP40

Domains & Families for RPP40 Gene

Protein Domains for RPP40 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPP40 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPP40: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RPP40 Gene

Function for RPP40 Gene

Molecular function for RPP40 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Enzyme Numbers (IUBMB) for RPP40 Gene

Gene Ontology (GO) - Molecular Function for RPP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 ribonuclease P activity IEA --
genes like me logo Genes that share ontologies with RPP40: view

Phenotypes for RPP40 Gene

genes like me logo Genes that share phenotypes with RPP40: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP40

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RPP40 Gene

Localization for RPP40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP40 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP40 Gene COMPARTMENTS Subcellular localization image for RPP40 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for RPP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9630247
GO:0005654 nucleoplasm TAS --
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
genes like me logo Genes that share ontologies with RPP40: view

Pathways & Interactions for RPP40 Gene

genes like me logo Genes that share pathways with RPP40: view

Pathways by source for RPP40 Gene

2 KEGG pathways for RPP40 Gene

Gene Ontology (GO) - Biological Process for RPP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic TAS 9630247
genes like me logo Genes that share ontologies with RPP40: view

No data available for SIGNOR curated interactions for RPP40 Gene

Drugs & Compounds for RPP40 Gene

No Compound Related Data Available

Transcripts for RPP40 Gene

Unigene Clusters for RPP40 Gene

Ribonuclease P/MRP 40kDa subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP40

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP40 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for RPP40 Gene

GeneLoc Exon Structure for
RPP40
ECgene alternative splicing isoforms for
RPP40

Expression for RPP40 Gene

mRNA expression in normal human tissues for RPP40 Gene

Protein differential expression in normal tissues from HIPED for RPP40 Gene

This gene is overexpressed in Breast (47.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP40 Gene



SOURCE GeneReport for Unigene cluster for RPP40 Gene Hs.511756

genes like me logo Genes that share expression patterns with RPP40: view

Protein tissue co-expression partners for RPP40 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP40 Gene

Orthologs for RPP40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP40 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPP40 35
  • 83.29 (n)
  • 82.64 (a)
RPP40 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP40 35
  • 86.96 (n)
  • 86.5 (a)
RPP40 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpp40 35
  • 84.57 (n)
  • 84.3 (a)
Rpp40 16
Rpp40 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPP40 35
  • 99.17 (n)
  • 98.07 (a)
RPP40 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp40 35
  • 84.16 (n)
  • 84.16 (a)
oppossum
(Monodelphis domestica)
Mammalia RPP40 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPP40 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPP40 35
  • 69.54 (n)
  • 65.28 (a)
RPP40 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP40 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp40 35
  • 64.06 (n)
  • 60.06 (a)
Str.102 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7016 35
zebrafish
(Danio rerio)
Actinopterygii rpp40 35
  • 58.52 (n)
  • 50.28 (a)
rpp40 36
  • 50 (a)
OneToOne
Species with no ortholog for RPP40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP40 Gene

ENSEMBL:
Gene Tree for RPP40 (if available)
TreeFam:
Gene Tree for RPP40 (if available)

Paralogs for RPP40 Gene

genes like me logo Genes that share paralogs with RPP40: view

No data available for Paralogs for RPP40 Gene

Variants for RPP40 Gene

Sequence variations from dbSNP and Humsavar for RPP40 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs396839 -- 4,998,959(+) AAATT(A/G)TTTTA intron-variant
rs431282 -- 5,000,816(+) CAAGC(A/T)TGCAG intron-variant
rs439795 -- 4,999,793(+) TGGAA(C/T)ACACA intron-variant
rs443167 -- 4,997,873(+) TAAAA(C/T)AGTTA intron-variant
rs728151 -- 4,995,574(+) GGATC(C/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPP40 Gene

Variant ID Type Subtype PubMed ID
esv2422499 CNV Duplication 17116639
nsv830577 CNV Loss 17160897
nsv462622 CNV Gain 19166990
esv2668988 CNV Deletion 23128226

Variation tolerance for RPP40 Gene

Residual Variation Intolerance Score: 88.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 73.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP40 Gene

HapMap Linkage Disequilibrium report
RPP40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP40 Gene

Disorders for RPP40 Gene

Relevant External Links for RPP40

Genetic Association Database (GAD)
RPP40
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP40
genes like me logo Genes that share disorders with RPP40: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP40 Gene

Publications for RPP40 Gene

  1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 23 67
  2. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PMID: 10024167) Jarrous N. … Altman S. (RNA 1999) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 67

Products for RPP40 Gene

Sources for RPP40 Gene

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