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Aliases for RPP40 Gene

Aliases for RPP40 Gene

  • Ribonuclease P/MRP 40kDa Subunit 2 3
  • RNaseP Protein P40 3 4
  • RNase P Subunit 1 3 4
  • Ribonuclease P1 2 3
  • EC 4 64
  • RNASEP1 3 4
  • Ribonuclease P Protein Subunit P40 3
  • Ribonuclease P 40kDa Subunit 2
  • Ribonuclease P, 40kD Subunit 3
  • Ribonuclease P (40 KD) 3
  • BA428J1.3 3

External Ids for RPP40 Gene

Previous Symbols for RPP40 Gene


Summaries for RPP40 Gene

GeneCards Summary for RPP40 Gene

RPP40 (Ribonuclease P/MRP 40kDa Subunit) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP40 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Gene Wiki entry for RPP40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP40 Gene

Genomics for RPP40 Gene

Genomic Location for RPP40 Gene

4,994,732 bp from pter
5,004,063 bp from pter
9,332 bases
Minus strand

Genomic View for RPP40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP40 Gene

Regulatory Elements for RPP40 Gene

Proteins for RPP40 Gene

  • Protein details for RPP40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease P protein subunit p40
    Protein Accession:
    Secondary Accessions:
    • Q5VX97
    • Q8WVK8

    Protein attributes for RPP40 Gene

    363 amino acids
    Molecular mass:
    41834 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40
    • Sequence=AAC24114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17871.1; Type=Frameshift; Positions=327; Evidence={ECO:0000305}; Sequence=CAH73740.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RPP40 Gene


neXtProt entry for RPP40 Gene

Proteomics data for RPP40 Gene at MOPED

Selected DME Specific Peptides for RPP40 Gene

Post-translational modifications for RPP40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP40 Gene

Domains for RPP40 Gene

Protein Domains for RPP40 Gene

genes like me logo Genes that share domains with RPP40: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RPP40 Gene

Function for RPP40 Gene

Molecular function for RPP40 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Enzyme Numbers (IUBMB) for RPP40 Gene

Gene Ontology (GO) - Molecular Function for RPP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 ribonuclease P activity IEA --
genes like me logo Genes that share ontologies with RPP40: view

miRNA for RPP40 Gene

miRTarBase miRNAs that target RPP40

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPP40 Gene

Localization for RPP40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP40 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RPP40 Gene COMPARTMENTS Subcellular localization image for RPP40 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9630247
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
genes like me logo Genes that share ontologies with RPP40: view

Pathways for RPP40 Gene

genes like me logo Genes that share pathways with RPP40: view

Pathways by source for RPP40 Gene

2 KEGG pathways for RPP40 Gene

Gene Ontology (GO) - Biological Process for RPP40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic TAS 9630247
genes like me logo Genes that share ontologies with RPP40: view

Transcripts for RPP40 Gene

Unigene Clusters for RPP40 Gene

Ribonuclease P/MRP 40kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP40 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -

Relevant External Links for RPP40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPP40 Gene

mRNA expression in normal human tissues for RPP40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP40 Gene

SOURCE GeneReport for Unigene cluster for RPP40 Gene Hs.511756

genes like me logo Genes that share expressions with RPP40: view

Orthologs for RPP40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP40 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPP40 36
  • 99.17 (n)
  • 98.07 (a)
RPP40 37
  • 98 (a)
(Bos Taurus)
Mammalia RPP40 36
  • 83.29 (n)
  • 82.64 (a)
RPP40 37
  • 83 (a)
(Canis familiaris)
Mammalia RPP40 36
  • 86.96 (n)
  • 86.5 (a)
RPP40 37
  • 87 (a)
(Mus musculus)
Mammalia Rpp40 36
  • 84.57 (n)
  • 84.3 (a)
Rpp40 16
Rpp40 37
  • 84 (a)
(Monodelphis domestica)
Mammalia RPP40 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia RPP40 37
  • 73 (a)
(Rattus norvegicus)
Mammalia Rpp40 36
  • 84.16 (n)
  • 84.16 (a)
(Gallus gallus)
Aves RPP40 36
  • 69.54 (n)
  • 65.28 (a)
RPP40 37
  • 65 (a)
(Anolis carolinensis)
Reptilia RPP40 37
  • 55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7016 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp40 36
  • 64.06 (n)
  • 60.06 (a)
Str.102 36
(Danio rerio)
Actinopterygii rpp40 36
  • 58.52 (n)
  • 50.28 (a)
rpp40 37
  • 50 (a)
Species with no ortholog for RPP40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP40 Gene

Gene Tree for RPP40 (if available)
Gene Tree for RPP40 (if available)

Paralogs for RPP40 Gene

genes like me logo Genes that share paralogs with RPP40: view

No data available for Paralogs for RPP40 Gene

Variants for RPP40 Gene

Sequence variations from dbSNP and Humsavar for RPP40 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs396839 -- 4,998,959(+) AAATT(A/G)TTTTA intron-variant
rs412444 -- 5,004,653(+) GGGAA(A/G)GTAAA upstream-variant-2KB
rs431060 -- 5,004,362(+) GCATA(A/C)CTCGG upstream-variant-2KB
rs431282 -- 5,000,816(+) CAAGC(A/T)TGCAG intron-variant
rs439795 -- 4,999,793(+) TGGAA(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPP40 Gene

Variant ID Type Subtype PubMed ID
esv2422499 CNV Duplication 17116639
nsv830577 CNV Loss 17160897
nsv462622 CNV Gain 19166990
esv2668988 CNV Deletion 23128226

Relevant External Links for RPP40 Gene

HapMap Linkage Disequilibrium report

Disorders for RPP40 Gene

Relevant External Links for RPP40

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RPP40: view

No data available for UniProtKB/Swiss-Prot for RPP40 Gene

Publications for RPP40 Gene

  1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 3 4 23
  2. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PMID: 10024167) Jarrous N. … Altman S. (RNA 1999) 23
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3

Products for RPP40 Gene

Sources for RPP40 Gene

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