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Aliases for RPP38 Gene

Aliases for RPP38 Gene

  • Ribonuclease P/MRP 38kDa Subunit 2 3
  • RNaseP Protein P38 4
  • EC 3.1.26.5 4

External Ids for RPP38 Gene

Previous GeneCards Identifiers for RPP38 Gene

  • GC10P015121
  • GC10P015289
  • GC10P015143
  • GC10P015179
  • GC10P015050
  • GC10P015140

Summaries for RPP38 Gene

GeneCards Summary for RPP38 Gene

RPP38 (Ribonuclease P/MRP 38kDa Subunit) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and RNA transport. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP38 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus

Gene Wiki entry for RPP38 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP38 Gene

Genomics for RPP38 Gene

Regulatory Elements for RPP38 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPP38 Gene

Start:
15,097,180 bp from pter
End:
15,139,818 bp from pter
Size:
42,639 bases
Orientation:
Plus strand

Genomic View for RPP38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP38 Gene

Proteins for RPP38 Gene

  • Protein details for RPP38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78345-RPP38_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p38
    Protein Accession:
    P78345
    Secondary Accessions:
    • B3KPY0
    • D3DRT8
    • Q53F71
    • Q8NHS8

    Protein attributes for RPP38 Gene

    Size:
    283 amino acids
    Molecular mass:
    31834 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RPP38 is probably a dimer
    Miscellaneous:
    • Autoantibodies against RPP38 are found in sera from scleroderma patients

neXtProt entry for RPP38 Gene

Proteomics data for RPP38 Gene at MOPED

Post-translational modifications for RPP38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPP38 Gene

Domains for RPP38 Gene

Protein Domains for RPP38 Gene

Suggested Antigen Peptide Sequences for RPP38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78345

UniProtKB/Swiss-Prot:

RPP38_HUMAN :
  • P78345
Family:
  • Belongs to the ribosomal protein L7Ae family.
genes like me logo Genes that share domains with RPP38: view

No data available for Gene Families for RPP38 Gene

Function for RPP38 Gene

Molecular function for RPP38 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus

Enzyme Numbers (IUBMB) for RPP38 Gene

Gene Ontology (GO) - Molecular Function for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 ribonuclease P activity IEA --
GO:0005515 protein binding IPI 15096576
genes like me logo Genes that share ontologies with RPP38: view

Phenotypes for RPP38 Gene

GenomeRNAi human phenotypes for RPP38:
genes like me logo Genes that share phenotypes with RPP38: view

Animal Model Products

CRISPR Products

miRNA for RPP38 Gene

miRTarBase miRNAs that target RPP38

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RPP38 Gene

Localization for RPP38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP38 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP38 Gene COMPARTMENTS Subcellular localization image for RPP38 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9630247
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
genes like me logo Genes that share ontologies with RPP38: view

Pathways for RPP38 Gene

genes like me logo Genes that share pathways with RPP38: view

Pathways by source for RPP38 Gene

1 BioSystems pathway for RPP38 Gene
2 KEGG pathways for RPP38 Gene

Gene Ontology (GO) - Biological Process for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic TAS 9630247
genes like me logo Genes that share ontologies with RPP38: view

Transcripts for RPP38 Gene

Unigene Clusters for RPP38 Gene

Ribonuclease P/MRP 38kDa subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP38

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RPP38

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for RPP38 Gene

GeneLoc Exon Structure for
RPP38
ECgene alternative splicing isoforms for
RPP38

Expression for RPP38 Gene

mRNA expression in normal human tissues for RPP38 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP38 Gene

SOURCE GeneReport for Unigene cluster for RPP38 Gene Hs.94986

genes like me logo Genes that share expressions with RPP38: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP38 Gene

Orthologs for RPP38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP38 35
  • 99.53 (n)
  • 98.59 (a)
RPP38 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPP38 35
  • 76.83 (n)
  • 73.4 (a)
RPP38 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP38 35
  • 80.55 (n)
  • 75.8 (a)
RPP38 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpp38 35
  • 79.62 (n)
  • 77.7 (a)
Rpp38 16
Rpp38 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPP38 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp38 35
  • 78.65 (n)
  • 76.03 (a)
chicken
(Gallus gallus)
Aves RPP38 35
  • 59.06 (n)
  • 54.37 (a)
RPP38 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp38 35
  • 55.6 (n)
  • 52.12 (a)
zebrafish
(Danio rerio)
Actinopterygii rpp38 35
  • 50.46 (n)
  • 49.4 (a)
rpp38 36
  • 47 (a)
OneToOne
Species with no ortholog for RPP38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP38 Gene

ENSEMBL:
Gene Tree for RPP38 (if available)
TreeFam:
Gene Tree for RPP38 (if available)

Paralogs for RPP38 Gene

No data available for Paralogs for RPP38 Gene

Variants for RPP38 Gene

Sequence variations from dbSNP and Humsavar for RPP38 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10242 - 15,103,949(+) CAGAA(C/T)TGAAG missense, reference
rs15772 - 15,103,856(+) CTTGG(C/G)GTTCA reference, missense
rs1052156 -- 15,103,503(+) GATAA(A/G)AAGAA synonymous-codon, reference
rs1052157 - 15,103,578(+) AGTGA(G/T)AATCT reference, missense
rs1132078 - 15,103,655(+) GCTTG(C/T)CATTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RPP38 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV Loss 17160897
dgv618n71 CNV Gain 21882294
nsv894899 CNV Gain 21882294

Relevant External Links for RPP38 Gene

HapMap Linkage Disequilibrium report
RPP38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP38 Gene

Disorders for RPP38 Gene

Relevant External Links for RPP38

Genetic Association Database (GAD)
RPP38
Human Genome Epidemiology (HuGE) Navigator
RPP38
genes like me logo Genes that share disorders with RPP38: view

No data available for UniProtKB/Swiss-Prot for RPP38 Gene

Publications for RPP38 Gene

  1. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder P.S. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. (PMID: 10444065) Jarrous N. … Altman S. (J. Cell Biol. 1999) 3 23

Products for RPP38 Gene

Sources for RPP38 Gene

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