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Aliases for RPP38 Gene

Aliases for RPP38 Gene

  • Ribonuclease P/MRP Subunit P38 2 3
  • Ribonuclease P/MRP 38kDa Subunit 2 5
  • RNaseP Protein P38 4
  • EC 3.1.26.5 4

External Ids for RPP38 Gene

Previous GeneCards Identifiers for RPP38 Gene

  • GC10P015121
  • GC10P015289
  • GC10P015143
  • GC10P015179
  • GC10P015050
  • GC10P015140

Summaries for RPP38 Gene

GeneCards Summary for RPP38 Gene

RPP38 (Ribonuclease P/MRP Subunit P38) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes and RNA transport. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP38 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Gene Wiki entry for RPP38 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP38 Gene

Genomics for RPP38 Gene

Regulatory Elements for RPP38 Gene

Enhancers for RPP38 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPP38 on UCSC Golden Path with GeneCards custom track

Promoters for RPP38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPP38 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPP38 Gene

Chromosome:
10
Start:
15,097,180 bp from pter
End:
15,139,818 bp from pter
Size:
42,639 bases
Orientation:
Plus strand

Genomic View for RPP38 Gene

Genes around RPP38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP38 Gene

Proteins for RPP38 Gene

  • Protein details for RPP38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78345-RPP38_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p38
    Protein Accession:
    P78345
    Secondary Accessions:
    • B3KPY0
    • D3DRT8
    • Q53F71
    • Q8NHS8

    Protein attributes for RPP38 Gene

    Size:
    283 amino acids
    Molecular mass:
    31834 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RPP38 is probably a dimer.
    Miscellaneous:
    • Autoantibodies against RPP38 are found in sera from scleroderma patients.

neXtProt entry for RPP38 Gene

Proteomics data for RPP38 Gene at MOPED

Post-translational modifications for RPP38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPP38 Gene

Domains & Families for RPP38 Gene

Protein Domains for RPP38 Gene

Suggested Antigen Peptide Sequences for RPP38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78345

UniProtKB/Swiss-Prot:

RPP38_HUMAN :
  • Belongs to the ribosomal protein L7Ae family.
Family:
  • Belongs to the ribosomal protein L7Ae family.
genes like me logo Genes that share domains with RPP38: view

No data available for Gene Families for RPP38 Gene

Function for RPP38 Gene

Molecular function for RPP38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Enzyme Numbers (IUBMB) for RPP38 Gene

genes like me logo Genes that share phenotypes with RPP38: view

Animal Model Products

miRNA for RPP38 Gene

miRTarBase miRNAs that target RPP38

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP38 Gene

Localization for RPP38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP38 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP38 Gene COMPARTMENTS Subcellular localization image for RPP38 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RPP38: view

Pathways & Interactions for RPP38 Gene

genes like me logo Genes that share pathways with RPP38: view

Pathways by source for RPP38 Gene

Gene Ontology (GO) - Biological Process for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
genes like me logo Genes that share ontologies with RPP38: view

No data available for SIGNOR curated interactions for RPP38 Gene

Drugs & Compounds for RPP38 Gene

No Compound Related Data Available

Transcripts for RPP38 Gene

Unigene Clusters for RPP38 Gene

Ribonuclease P/MRP 38kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for RPP38 Gene

GeneLoc Exon Structure for
RPP38
ECgene alternative splicing isoforms for
RPP38

Expression for RPP38 Gene

mRNA expression in normal human tissues for RPP38 Gene

Protein differential expression in normal tissues from HIPED for RPP38 Gene

This gene is overexpressed in Breast (21.4), Lung (16.9), Fetal gut (10.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP38 Gene



SOURCE GeneReport for Unigene cluster for RPP38 Gene Hs.94986

genes like me logo Genes that share expression patterns with RPP38: view

Protein tissue co-expression partners for RPP38 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP38 Gene

Orthologs for RPP38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP38 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPP38 35
  • 76.83 (n)
  • 73.4 (a)
RPP38 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP38 35
  • 80.55 (n)
  • 75.8 (a)
RPP38 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpp38 35
  • 79.62 (n)
  • 77.7 (a)
Rpp38 16
Rpp38 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPP38 35
  • 99.53 (n)
  • 98.59 (a)
RPP38 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp38 35
  • 78.65 (n)
  • 76.03 (a)
oppossum
(Monodelphis domestica)
Mammalia RPP38 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPP38 35
  • 59.06 (n)
  • 54.37 (a)
RPP38 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp38 35
  • 55.6 (n)
  • 52.12 (a)
zebrafish
(Danio rerio)
Actinopterygii rpp38 35
  • 50.46 (n)
  • 49.4 (a)
rpp38 36
  • 47 (a)
OneToOne
Species with no ortholog for RPP38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP38 Gene

ENSEMBL:
Gene Tree for RPP38 (if available)
TreeFam:
Gene Tree for RPP38 (if available)

Paralogs for RPP38 Gene

No data available for Paralogs for RPP38 Gene

Variants for RPP38 Gene

Sequence variations from dbSNP and Humsavar for RPP38 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_023960 -
VAR_023961 -
VAR_023962 -
VAR_029298 -
VAR_051811 -

Structural Variations from Database of Genomic Variants (DGV) for RPP38 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV Loss 17160897
dgv618n71 CNV Gain 21882294
nsv894899 CNV Gain 21882294

Variation tolerance for RPP38 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP38 Gene

HapMap Linkage Disequilibrium report
RPP38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP38 Gene

Disorders for RPP38 Gene

Relevant External Links for RPP38

Genetic Association Database (GAD)
RPP38
Human Genome Epidemiology (HuGE) Navigator
RPP38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP38

No disorders were found for RPP38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP38 Gene

Publications for RPP38 Gene

  1. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder P.S. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 3 23
  3. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. (PMID: 10444065) Jarrous N. … Altman S. (J. Cell Biol. 1999) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RPP38 Gene

Sources for RPP38 Gene

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