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Aliases for RPP38 Gene

Aliases for RPP38 Gene

  • Ribonuclease P/MRP Subunit P38 2 3 5
  • Ribonuclease P/MRP 38kDa Subunit 2
  • RNaseP Protein P38 4
  • EC 3.1.26.5 4

External Ids for RPP38 Gene

Previous GeneCards Identifiers for RPP38 Gene

  • GC10P015121
  • GC10P015289
  • GC10P015143
  • GC10P015179
  • GC10P015050
  • GC10P015140

Summaries for RPP38 Gene

GeneCards Summary for RPP38 Gene

RPP38 (Ribonuclease P/MRP Subunit P38) is a Protein Coding gene. Among its related pathways are tRNA processing and Integrated Breast Cancer Pathway. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP38 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Gene Wiki entry for RPP38 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP38 Gene

Genomics for RPP38 Gene

Regulatory Elements for RPP38 Gene

Enhancers for RPP38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F015151 0.9 ENCODE 15.6 +55.3 55268 2.1 ELF3 ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 THAP11 SP5 RPP38 C10orf111 GAPDHP45 OLAH CDNF HSPA14 ACBD7 PPIAP30 GC10P015124
GH10F014507 1.4 FANTOM5 Ensembl ENCODE 9.7 -589.0 -589016 2.3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 RAD21 YY1 RARA SLC30A9 CREM C10orf111 GAPDHP45 RPP38 CDNF HSPA14 GC10M014524 FRMD4A
GH10F015140 1.2 Ensembl ENCODE 11.2 +44.5 44498 1.8 HDAC1 ATF1 PKNOX1 TBL1XR1 NFRKB WRNIP1 BMI1 ZNF335 ZNF766 GATA2 ACBD7 ENSG00000228181 NMT2 C10orf111 RPP38 GAPDHP45 DCLRE1CP1 PPIAP30 GC10P015124
GH10F015122 1.1 FANTOM5 ENCODE 11.7 +26.6 26608 1.7 HDGF TBP PKNOX1 MXI1 ZNF384 EBF1 RELA ZNF335 GATA3 POLR2A ACBD7 C10orf111 RPP38 GAPDHP45 DCLRE1CP1 OLAH GC10P015124 GC10P015108
GH10F015199 1.2 Ensembl ENCODE 10.1 +104.2 104239 4.3 HDAC1 PKNOX1 TBL1XR1 ZEB1 ZNF766 ZNF366 FOS CEBPB JUNB REST NMT2 C10orf111 RPP38 GAPDHP45 FAM171A1 LOC105376433 ENSG00000228181
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPP38 on UCSC Golden Path with GeneCards custom track

Promoters for RPP38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003180 521 2600 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for RPP38 Gene

Chromosome:
10
Start:
15,097,180 bp from pter
End:
15,139,818 bp from pter
Size:
42,639 bases
Orientation:
Plus strand

Genomic View for RPP38 Gene

Genes around RPP38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP38 Gene

Proteins for RPP38 Gene

  • Protein details for RPP38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78345-RPP38_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p38
    Protein Accession:
    P78345
    Secondary Accessions:
    • B3KPY0
    • D3DRT8
    • Q53F71
    • Q8NHS8

    Protein attributes for RPP38 Gene

    Size:
    283 amino acids
    Molecular mass:
    31834 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RPP38 is probably a dimer.
    Miscellaneous:
    • Autoantibodies against RPP38 are found in sera from scleroderma patients.

neXtProt entry for RPP38 Gene

Post-translational modifications for RPP38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPP38 Gene

Domains & Families for RPP38 Gene

Protein Domains for RPP38 Gene

Suggested Antigen Peptide Sequences for RPP38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78345

UniProtKB/Swiss-Prot:

RPP38_HUMAN :
  • Belongs to the ribosomal protein L7Ae family.
Family:
  • Belongs to the ribosomal protein L7Ae family.
genes like me logo Genes that share domains with RPP38: view

No data available for Gene Families for RPP38 Gene

Function for RPP38 Gene

Molecular function for RPP38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Enzyme Numbers (IUBMB) for RPP38 Gene

Gene Ontology (GO) - Molecular Function for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 ribonuclease P activity IEA,TAS --
GO:0005515 protein binding IPI 15096576
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPP38: view
genes like me logo Genes that share phenotypes with RPP38: view

Animal Model Products

miRNA for RPP38 Gene

miRTarBase miRNAs that target RPP38

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP38 Gene

Localization for RPP38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP38 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP38 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9630247
GO:0005654 nucleoplasm TAS --
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RPP38: view

Pathways & Interactions for RPP38 Gene

genes like me logo Genes that share pathways with RPP38: view

Gene Ontology (GO) - Biological Process for RPP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP38: view

No data available for SIGNOR curated interactions for RPP38 Gene

Transcripts for RPP38 Gene

Unigene Clusters for RPP38 Gene

Ribonuclease P/MRP 38kDa subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for RPP38 Gene

GeneLoc Exon Structure for
RPP38
ECgene alternative splicing isoforms for
RPP38

Expression for RPP38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPP38 Gene

Protein differential expression in normal tissues from HIPED for RPP38 Gene

This gene is overexpressed in Breast (21.4), Lung (16.9), Fetal gut (10.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP38 Gene



Protein tissue co-expression partners for RPP38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPP38 Gene:

RPP38

SOURCE GeneReport for Unigene cluster for RPP38 Gene:

Hs.94986
genes like me logo Genes that share expression patterns with RPP38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP38 Gene

Orthologs for RPP38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP38 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia RPP38 34 35
  • 80.55 (n)
mouse
(Mus musculus)
Mammalia Rpp38 34 16 35
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Rpp38 34
  • 78.65 (n)
cow
(Bos Taurus)
Mammalia RPP38 34 35
  • 76.83 (n)
oppossum
(Monodelphis domestica)
Mammalia RPP38 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPP38 34 35
  • 59.06 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp38 34
  • 55.6 (n)
zebrafish
(Danio rerio)
Actinopterygii rpp38 34 35
  • 50.46 (n)
Species where no ortholog for RPP38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP38 Gene

ENSEMBL:
Gene Tree for RPP38 (if available)
TreeFam:
Gene Tree for RPP38 (if available)

Paralogs for RPP38 Gene

No data available for Paralogs for RPP38 Gene

Variants for RPP38 Gene

Sequence variations from dbSNP and Humsavar for RPP38 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10242 -- 15,103,949(+) CAGAA(C/T)TGAAG upstream-variant-2KB, reference, missense
rs1052156 -- 15,103,503(+) GATAA(A/G)AAGAA upstream-variant-2KB, reference, synonymous-codon
rs1052157 -- 15,103,578(+) AGTGA(G/T)AATCT upstream-variant-2KB, reference, missense
rs10542485 -- 15,102,211(+) TTTTT(-/TTT)GCAGA intron-variant
rs10597505 -- 15,100,295(+) ACCCC(-/CT)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPP38 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV loss 17160897
nsv1113256 CNV deletion 24896259

Variation tolerance for RPP38 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPP38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP38 Gene

Disorders for RPP38 Gene

Relevant External Links for RPP38

Genetic Association Database (GAD)
RPP38
Human Genome Epidemiology (HuGE) Navigator
RPP38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP38

No disorders were found for RPP38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP38 Gene

Publications for RPP38 Gene

  1. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder P.S. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 2 3 22 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for RPP38 Gene

Sources for RPP38 Gene

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