RPP38 Gene
protein-coding GIFtS: 54
GCID: GC10P015140
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ribonuclease P/MRP 38kDa subunit
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Aliases for RPP38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribonuclease P/MRP 38kDa Subunit1 2 | | RNaseP Protein P382 3 | | Ribonuclease P Protein Subunit P382 | | EC 3.1.26.53 |
Export aliases for RPP38 gene to outside databasesPrevious GC identifers: GC10P015121 GC10P015289 GC10P015143 GC10P015179 GC10P015050 |
Summaries for RPP38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RPP38_HUMAN, P78345Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to theputative site of its assembly in the cell, the nucleolus Gene Wiki entry for RPP38
|
Genomic Views for RPP38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPP38 gene promoter: p53 Pax-6 ATF-2 CUTL1 NF-kappaB Evi-1 CRE-BP1 Egr-2 NRF-2 LyF-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for RPP38
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPP38 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13RPP38 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P015140: view genomic region
(about GC identifiers)
Start:
|
15,139,179 bp from pter |
End:
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15,148,129 bp from pter |
Size:
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8,951 bases |
Orientation:
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plus strand |
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Proteins for RPP38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RPP38_HUMAN, P78345 (See
protein sequence)Recommended Name: Ribonuclease P protein subunit p38 Size: 283 amino acids; 31834 Da
Subunit: RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4,RPP30, RPP38 and RPP40. RPP38 is probably a dimer
Subcellular location: Nucleus, nucleolus (Potential)
Miscellaneous: Autoantibodies against RPP38 are found in sera from scleroderma patients
Secondary accessions: B3KPY0 D3DRT8 Q53F71 Q8NHS8Explore the universe of human proteins at neXtProt for RPP38: NX_P78345
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P78345 RPP38 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (4 alternative transcripts):
NP_001091059.1 NP_001252530.1 NP_006405.2 NP_892117.1 ENSEMBL proteins: ENSP00000367445 ENSP00000367443 ENSP00000367444 ENSP00000367439 ENSP00000402635 Human Recombinant Protein Products for RPP38:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RPP38 for ontologies About GeneDecksing
RPP38 Antibody Products: Assay Products for RPP38: |
Protein
Domains / Families for RPP38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPP38 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P78345ProtoNet protein and cluster: P78345 1 Blocks protein family: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
UniProtKB/Swiss-Prot: RPP38_HUMAN, P78345Similarity: Belongs to the ribosomal protein L7Ae family |
Function for RPP38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: RPP38_HUMAN, P78345Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to theputative site of its assembly in the cell, the nucleolusCatalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor Enzyme Number (IUBMB): EC 3.1.26.51
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RPP38 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for RPP38: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPP38 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP38 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RPP38 (NM_183005) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP38 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP38  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP38 |
|
Pathways & Interactions for RPP38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA transport | | | 2 | Ribosome biogenesis in eukaryotes | | | 3 | Integrated Breast Cancer Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for RPP38 
2
Kegg Pathways (Kegg details for RPP38):
RPP38 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPP38
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
 5/22 Interacting proteins for RPP38 (P783451, 3 ENSP000003674394) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008033 | tRNA processing |
IEA | -- |
RPP38 for ontologies About GeneDecksing
|
Drugs & Compounds for RPP38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPP38 Search CenterWatch for drugs/clinical trials and news about RPP38 
|
Transcripts for RPP38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPP38 gene (4 alternative transcripts): NM_001097590.2 NM_001265601.1 NM_006414.4 NM_183005.4 Unigene Cluster for RPP38: Ribonuclease P/MRP 38kDa subunit Hs.94986 [show with all ESTs]Unigene Representative Sequence: NM_1830055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378203(uc009xjm.3 uc001inx.4) ENST00000378201 ENST00000378202 ENST00000378197(uc001iny.4) ENST00000441850
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPP38 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP38 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RPP38 (NM_183005) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP38 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP38  |
Additional cDNA sequence: AF079567.1 AK057006.1 AK223418.1 BC029494.1 CR541816.1 U77664.1 6 DOTS entries: DT.100008423 DT.309451 DT.99943905 DT.100648588 DT.121229568 DT.121229585 24/80 AceView cDNA sequences (see all 80): BF222678 AW292674 BU616848 CA414693 AI638697 AI433471 CR600741 BE671046 AW611895 AI434778 BU180901 AI798684 AA480681 BE773996 AW405964 BU949052 BX112877 AI926198 BM680914 BQ181588 BI462117 AI566040 BM975685 CD050516 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RPP38 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for RPP38
|
Expression for RPP38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPP38 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCATACAGTT
 About this image See RPP38 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPP38
SOURCE GeneReport for Unigene cluster: Hs.94986 SABiosciences Custom PCR Arrays for RPP38
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPP38 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPP38 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPP38 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPP38 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP38 |
Orthologs for RPP38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RPP38 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for RPP38 (if available) TreeFam Gene Tree for RPP38 (if available)  |
Paralogs for RPP38 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for RPP38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPP38 (15139179 - 15148129 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPP38: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPP38 |
|
Disorders
/ Diseases for RPP38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPP38 for disorders About GeneDecksing
OMIM gene information: 606116
OMIM disorders: --
2 diseases for RPP38: About MalaCardsscleroderma alzheimer's disease Human Genome Epidemiology (HuGE) Navigator: RPP38 (1 document) Export disorders for RPP38 gene to outside databases
|
Publications for RPP38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPP38 gene, integrated from 9 sources (see all 29): (articles sorted by number of sources associating them with RPP38) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PubMed id 9037013)1, 2, 3, 9 Eder P.S.... Altman S. (1997)
- Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PubMed id 9630247)1, 3, 9 Jarrous N.... Altman S. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. (PubMed id 10444065)1, 9 Jarrous N....Altman S. (1999)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for RPP38 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPP38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPP38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPP38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPP38 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPP38 gene: Search GeneIP for patents involving RPP38
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPP38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | |
 |
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 | | RPP38 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP38 |
|  |  |  |  | | | Search ThermoFisher Antibodies for RPP38 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP38 |
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