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Aliases for RPP30 Gene

Aliases for RPP30 Gene

  • Ribonuclease P/MRP Subunit P30 2 3
  • Ribonuclease P/MRP 30kDa Subunit 2 3 5
  • RNaseP Protein P30 3 4
  • RNase P Subunit 2 3 4
  • Ribonuclease P Protein Subunit P30 2
  • EC 3.1.26.5 4
  • RNASEP2 4
  • TSG15 3

External Ids for RPP30 Gene

Previous GeneCards Identifiers for RPP30 Gene

  • GC10P091512
  • GC10P091852
  • GC10P092762
  • GC10P092295
  • GC10P092621
  • GC10P086260
  • GC10P092631

Summaries for RPP30 Gene

GeneCards Summary for RPP30 Gene

RPP30 (Ribonuclease P/MRP Subunit P30) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding and ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP30 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Gene Wiki entry for RPP30 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP30 Gene

Genomics for RPP30 Gene

Regulatory Elements for RPP30 Gene

Promoters for RPP30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPP30 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPP30 gene promoter:

Genomic Location for RPP30 Gene

Chromosome:
10
Start:
90,871,716 bp from pter
End:
90,908,558 bp from pter
Size:
36,843 bases
Orientation:
Plus strand

Genomic View for RPP30 Gene

Genes around RPP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP30 Gene

Proteins for RPP30 Gene

  • Protein details for RPP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78346-RPP30_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p30
    Protein Accession:
    P78346
    Secondary Accessions:
    • B2R799
    • E9PB02

    Protein attributes for RPP30 Gene

    Size:
    268 amino acids
    Molecular mass:
    29321 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
    Miscellaneous:
    • Autoantibodies against RPP30 are found in sera from scleroderma patients.

    Alternative splice isoforms for RPP30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPP30 Gene

Proteomics data for RPP30 Gene at MOPED

Post-translational modifications for RPP30 Gene

  • Ubiquitination at Lys 138
  • Modification sites at PhosphoSitePlus

Other Protein References for RPP30 Gene

Antibody Products

No data available for DME Specific Peptides for RPP30 Gene

Domains & Families for RPP30 Gene

Protein Domains for RPP30 Gene

Suggested Antigen Peptide Sequences for RPP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78346

UniProtKB/Swiss-Prot:

RPP30_HUMAN :
  • Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
Family:
  • Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
genes like me logo Genes that share domains with RPP30: view

No data available for Gene Families for RPP30 Gene

Function for RPP30 Gene

Molecular function for RPP30 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Enzyme Numbers (IUBMB) for RPP30 Gene

Gene Ontology (GO) - Molecular Function for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004540 ribonuclease activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPP30: view
genes like me logo Genes that share phenotypes with RPP30: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP30 Gene

Localization for RPP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP30 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP30 Gene COMPARTMENTS Subcellular localization image for RPP30 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for RPP30 Gene

Pathways & Interactions for RPP30 Gene

genes like me logo Genes that share pathways with RPP30: view

Gene Ontology (GO) - Biological Process for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0008033 tRNA processing IEA,IBA --
GO:0010467 gene expression TAS --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
genes like me logo Genes that share ontologies with RPP30: view

No data available for SIGNOR curated interactions for RPP30 Gene

Drugs & Compounds for RPP30 Gene

No Compound Related Data Available

Transcripts for RPP30 Gene

Unigene Clusters for RPP30 Gene

Ribonuclease P/MRP 30kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP30 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: -
SP8: - - -

Relevant External Links for RPP30 Gene

GeneLoc Exon Structure for
RPP30
ECgene alternative splicing isoforms for
RPP30

Expression for RPP30 Gene

mRNA expression in normal human tissues for RPP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3) and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP30 Gene



SOURCE GeneReport for Unigene cluster for RPP30 Gene Hs.139120

genes like me logo Genes that share expression patterns with RPP30: view

Protein tissue co-expression partners for RPP30 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP30 Gene

Orthologs for RPP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPP30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPP30 35
  • 91.07 (n)
  • 93.21 (a)
RPP30 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP30 35
  • 91.23 (n)
  • 93.61 (a)
RPP30 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpp30 35
  • 88.68 (n)
  • 90.19 (a)
Rpp30 16
Rpp30 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPP30 35
  • 99.69 (n)
  • 99.38 (a)
RPP30 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp30 35
  • 88.3 (n)
  • 90.94 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPP30 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPP30 35
  • 72.98 (n)
  • 74.62 (a)
RPP30 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP30 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp30 35
  • 69.81 (n)
  • 71.32 (a)
Str.6755 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24769 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28586 35
rpp30 35
  • 63.6 (n)
  • 62.07 (a)
rpp30 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5477 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008481 35
  • 43.84 (n)
  • 34.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpp30 35
  • 42.39 (n)
  • 32.76 (a)
Rpp30 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H35B03.2 36
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL046C 35
  • 34.32 (n)
  • 29.96 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14718g 35
  • 44.34 (n)
  • 30.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP1 35
  • 41.51 (n)
  • 30.56 (a)
RPP1 36
  • 25 (a)
OneToOne
RPP1 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3A12.04c 35
  • 46.99 (n)
  • 33.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for RPP30:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPP30 Gene

ENSEMBL:
Gene Tree for RPP30 (if available)
TreeFam:
Gene Tree for RPP30 (if available)

Paralogs for RPP30 Gene

No data available for Paralogs for RPP30 Gene

Variants for RPP30 Gene

Sequence variations from dbSNP and Humsavar for RPP30 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11544145 - 90,872,021(-) CAGAA(A/C/T)CCGCT reference, missense
rs1804767 -- 90,900,683(+) GAAAA(C/G)AATGC intron-variant, utr-variant-3-prime
rs4144422 -- 90,885,930(+) TTTGA(A/G)TCTTA intron-variant
rs4144423 -- 90,884,083(+) CATCA(G/T)ATAAA intron-variant
rs4522081 -- 90,906,926(+) AAAAA(A/T)TGACT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPP30 Gene

Variant ID Type Subtype PubMed ID
nsv831945 CNV Gain 17160897

Variation tolerance for RPP30 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP30 Gene

HapMap Linkage Disequilibrium report
RPP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP30 Gene

Disorders for RPP30 Gene

Relevant External Links for RPP30

Genetic Association Database (GAD)
RPP30
Human Genome Epidemiology (HuGE) Navigator
RPP30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP30

No disorders were found for RPP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP30 Gene

Publications for RPP30 Gene

  1. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder P.S. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. (PMID: 9308968) Stolc V. … Altman S. (Genes Dev. 1997) 2 3 23
  3. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RPP30 Gene

Sources for RPP30 Gene

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