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Aliases for RPP30 Gene

Aliases for RPP30 Gene

  • Ribonuclease P/MRP 30kDa Subunit 2 3
  • RNaseP Protein P30 3 4
  • RNase P Subunit 2 3 4
  • Ribonuclease P Protein Subunit P30 3
  • EC 4
  • RNASEP2 4
  • TSG15 3

External Ids for RPP30 Gene

Previous GeneCards Identifiers for RPP30 Gene

  • GC10P091512
  • GC10P091852
  • GC10P092762
  • GC10P092295
  • GC10P092621
  • GC10P086260
  • GC10P092631

Summaries for RPP30 Gene

GeneCards Summary for RPP30 Gene

RPP30 (Ribonuclease P/MRP 30kDa Subunit) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP30 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Gene Wiki entry for RPP30 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP30 Gene

Genomics for RPP30 Gene

Regulatory Elements for RPP30 Gene

Transcription factor binding sites by QIAGEN in the RPP30 gene promoter:

Genomic Location for RPP30 Gene

90,871,716 bp from pter
90,908,555 bp from pter
36,840 bases
Plus strand

Genomic View for RPP30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP30 Gene

Proteins for RPP30 Gene

  • Protein details for RPP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease P protein subunit p30
    Protein Accession:
    Secondary Accessions:
    • B2R799
    • E9PB02

    Protein attributes for RPP30 Gene

    268 amino acids
    Molecular mass:
    29321 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40
    • Autoantibodies against RPP30 are found in sera from scleroderma patients

    Alternative splice isoforms for RPP30 Gene


neXtProt entry for RPP30 Gene

Proteomics data for RPP30 Gene at MOPED

Post-translational modifications for RPP30 Gene

  • Ubiquitination at Lys138
  • Modification sites at PhosphoSitePlus

Other Protein References for RPP30 Gene

Antibody Products

No data available for DME Specific Peptides for RPP30 Gene

Domains for RPP30 Gene

Protein Domains for RPP30 Gene

Suggested Antigen Peptide Sequences for RPP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P78346
  • Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
genes like me logo Genes that share domains with RPP30: view

No data available for Gene Families for RPP30 Gene

Function for RPP30 Gene

Molecular function for RPP30 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Enzyme Numbers (IUBMB) for RPP30 Gene

Gene Ontology (GO) - Molecular Function for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004526 ribonuclease P activity IEA --
GO:0004540 ribonuclease activity --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPP30: view
genes like me logo Genes that share phenotypes with RPP30: view

Animal Model Products

miRNA for RPP30 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RPP30 Gene

Localization for RPP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP30 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RPP30 Gene COMPARTMENTS Subcellular localization image for RPP30 gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9630247
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
genes like me logo Genes that share ontologies with RPP30: view

Pathways for RPP30 Gene

genes like me logo Genes that share pathways with RPP30: view

Pathways by source for RPP30 Gene

2 KEGG pathways for RPP30 Gene

Gene Ontology (GO) - Biological Process for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IBA --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9630247
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic TAS 9630247
genes like me logo Genes that share ontologies with RPP30: view

Transcripts for RPP30 Gene

Unigene Clusters for RPP30 Gene

Ribonuclease P/MRP 30kDa subunit:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP30

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP30 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: -
SP8: - - -

Relevant External Links for RPP30 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPP30 Gene

mRNA expression in normal human tissues for RPP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPP30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3) and Fetal testis (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP30 Gene

SOURCE GeneReport for Unigene cluster for RPP30 Gene Hs.139120

genes like me logo Genes that share expressions with RPP30: view

Expression partners for RPP30 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP30 Gene

Orthologs for RPP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPP30 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPP30 35
  • 91.07 (n)
  • 93.21 (a)
RPP30 36
  • 92 (a)
(Canis familiaris)
Mammalia RPP30 35
  • 91.23 (n)
  • 93.61 (a)
RPP30 36
  • 93 (a)
(Mus musculus)
Mammalia Rpp30 35
  • 88.68 (n)
  • 90.19 (a)
Rpp30 16
Rpp30 36
  • 89 (a)
(Pan troglodytes)
Mammalia RPP30 35
  • 99.69 (n)
  • 99.38 (a)
RPP30 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Rpp30 35
  • 88.3 (n)
  • 90.94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
-- 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RPP30 36
  • 81 (a)
(Gallus gallus)
Aves RPP30 35
  • 72.98 (n)
  • 74.62 (a)
RPP30 36
  • 73 (a)
(Anolis carolinensis)
Reptilia RPP30 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp30 35
  • 69.81 (n)
  • 71.32 (a)
Str.6755 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24769 35
(Danio rerio)
Actinopterygii Dr.28586 35
rpp30 35
  • 63.6 (n)
  • 62.07 (a)
rpp30 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5477 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008481 35
  • 43.84 (n)
  • 34.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpp30 35
  • 42.39 (n)
  • 32.76 (a)
Rpp30 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea H35B03.2 36
  • 16 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL046C 35
  • 34.32 (n)
  • 29.96 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14718g 35
  • 44.34 (n)
  • 30.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP1 35
  • 41.51 (n)
  • 30.56 (a)
RPP1 36
  • 25 (a)
RPP1 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3A12.04c 35
  • 46.99 (n)
  • 33.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for RPP30:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPP30 Gene

Gene Tree for RPP30 (if available)
Gene Tree for RPP30 (if available)

Paralogs for RPP30 Gene

No data available for Paralogs for RPP30 Gene

Variants for RPP30 Gene

Sequence variations from dbSNP and Humsavar for RPP30 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1804767 -- 90,900,683(+) GAAAA(C/G)AATGC intron-variant, utr-variant-3-prime
rs4144422 -- 90,885,930(+) TTTGA(A/G)TCTTA intron-variant
rs4144423 -- 90,884,083(+) CATCA(G/T)ATAAA intron-variant
rs4282910 -- 90,871,487(+) CTTGG(A/G)GTAGT upstream-variant-2KB
rs4522081 -- 90,906,926(+) AAAAA(A/T)TGACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPP30 Gene

Variant ID Type Subtype PubMed ID
nsv831945 CNV Gain 17160897

Relevant External Links for RPP30 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP30 Gene

Disorders for RPP30 Gene

Relevant External Links for RPP30

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RPP30 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RPP30 Gene

Publications for RPP30 Gene

  1. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder P.S. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. (PMID: 9308968) Stolc V. … Altman S. (Genes Dev. 1997) 2 3 23
  3. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PMID: 9630247) Jarrous N. … Altman S. (RNA 1998) 3 23
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPP30 Gene

Sources for RPP30 Gene

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