RPP30 Gene
protein-coding GIFtS : 53
GCID: GC10 P092621
ribonuclease P/MRP 30kDa subunit
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Aliasesfor RPP30 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribonuclease P/MRP 30kDa Subunit 1 2 Ribonuclease P Protein Subunit P302 TSG151 2 EC 3.1.26.53 RNase P Subunit 22 3 RNASEP23 RNaseP Protein P302 3
Export aliases for RPP30 gene to outside databases Previous GC identifers: GC10P091512 GC10P091852 GC10P092762 GC10P092295 GC10P086260
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Summariesfor RPP30 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RPP30_HUMAN, P78346 Function : Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-endsGene Wiki entry for RPP30
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Genomic Viewsfor RPP30 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPP30 gene promoter: CREB deltaCREB Other transcription factors Search SABiosciences Chromatin IP Primers for RPP30 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPP30
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q23.31 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23.32-q23.33 RPP30 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P092621: view genomic region
(about GC identifiers )
Start:
92,631,473 bp from pter
End:
92,668,312 bp from pter
Size:
36,840 bases
Orientation:
plus strand
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Proteinsfor RPP30 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RPP30_HUMAN, P78346 (See
protein sequence )Recommended Name: Ribonuclease P protein subunit p30 Size : 268 amino acids; 29321 Da
Subunit : RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4,RPP30, RPP38 and RPP40
Subcellular location : Nucleus, nucleolus (Potential)
Miscellaneous : Autoantibodies against RPP30 are found in sera from scleroderma patients
Secondary accessions : B2R799 E9PB02Alternative splicing : 2 isoforms : P78346-1 P78346-2 (No experimental confirmation available. Ref.3 (AK225532) sequence is in conflict in position: 291:K->R)Explore the universe of human proteins at neXtProt for RPP30: NX_P78346 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P78346 RPP30 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001098016.1 NP_006404.1 ENSEMBL proteins: ENSP00000360768 ENSP00000277882 ENSP00000407972 ENSP00000389182 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
RPP30 for ontologies About GeneDecksing RPP30 Antibody Products: Assay Products for RPP30:
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Protein
Domains / Familiesfor RPP30 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPP30 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P78346 ProtoNet protein and cluster: P78346
1 Blocks protein family : IPB002738 RNase P subunit p30 UniProtKB/Swiss-Prot: RPP30_HUMAN, P78346 Similarity : Belongs to the eukaryotic/archaeal RNase P protein component 3 family
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Functionfor RPP30 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RPP30_HUMAN, P78346 Function : Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-endsCatalytic activity : Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursorEnzyme Number (IUBMB): EC 3.1.26.5 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPP30 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPP30 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): RPP30 (NM_006413 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP30 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPP30
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP30
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004526 ribonuclease P activity
IEA -- GO:0004540 ribonuclease activity
-- --
RPP30 for ontologies About GeneDecksing 4 GenomeRNAi human phenotypes for RPP30 :
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Pathways & Interactionsfor RPP30 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ribosome biogenesis in eukaryotes 2 RNA transport
Pathway sources See GeneCards unified pathways Show all pathways 2
Kegg Pathways (Kegg details for RPP30) :
RPP30 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPP30 STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)5/21 Interacting proteins for RPP30 (P78346 3 ENSP00000389182 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 21 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008033 tRNA processing
IEA --
RPP30 for ontologies About GeneDecksing
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Drugs & Compoundsfor RPP30 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPP30 Search CenterWatch for drugs/clinical trials and news about RPP30
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Transcriptsfor RPP30 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPP30 gene (2 alternative transcripts): NM_001104546.1 NM_006413.4 Unigene Cluster for RPP30:
Ribonuclease P/MRP 30kDa subunit Hs.139120 [show with all ESTs ] Unigene Representative Sequence: NM_001104546 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000371703 (uc009xtx.3 ) ENST00000487998 (uc010qnj.2 ) ENST00000277882 ENST00000414836 ENST00000466462 ENST00000480635 ENST00000489806 ENST00000480406 ENST00000479678 ENST00000470933 ENST00000413330 (uc001khd.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPP30 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPP30 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): RPP30 (NM_006413 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP30 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPP30
Additional cDNA sequence: AK095810.1 AK225532.1 AK296196.1 AK312900.1 AL833628.1 BC006991.1 BC044601.1 U77665.1
13 DOTS entries : DT.445622 DT.97792649
DT.40132060 DT.95090988 DT.75156434 DT.97832982 DT.121258062 DT.75107717 DT.95090967 DT.97858674 DT.100792003 DT.121258059 DT.91643347 24/239 AceView cDNA sequences (see all 239 ):
BU737046 BU726114 BE018525 BM854042 BG566583 AI123222 AA651912 BM979524 AA291373 BM978236 AL042024 AA179321 CR610035 AI215446 BM793265 CR591791 BM836995 CR618623 BI770215 BM544589 CF995207 CA866348 BM706276 CD107673 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RPP30 (see all 8 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 SP1 :             -                 -       -             -     SP2 :             -                 -       -                 SP3 :                             -       -   -               SP4 :     -   -   -   -   -                                       SP5 :             -                                      
ECgene alternative splicing isoforms for RPP30
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Expression for RPP30 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPP30 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image See RPP30 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPP30 SOURCE GeneReport for Unigene cluster: Hs.139120 SABiosciences Custom PCR Arrays for RPP30 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPP30Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RPP30 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPP30 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPP30 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP30
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Orthologsfor RPP30 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPP30 gene from 10/31 species (see all 31 ) About this table
ENSEMBL Gene Tree for RPP30 (if available)TreeFam Gene Tree for RPP30 (if available)
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Paralogsfor RPP30 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor RPP30 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPP30 (92631473 - 92668312 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPP30: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPP30
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Disorders
/ Diseasesfor RPP30 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RPP30 for disorders About GeneDecksing
OMIM gene information: 606115
OMIM disorders : --5 diseases for RPP30 : About MalaCards microphthalmia with linear skin defects microphthalmia systemic scleroderma scleroderma alzheimer's disease Human Genome Epidemiology (HuGE) Navigator: RPP30 (1 document)Export disorders for RPP30 gene to outside databases
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Publicationsfor RPP30 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPP30 gene, integrated from 9 sources (see all 35 ): (articles sorted by number of sources associating them with RPP30) Utopia : connect your pdf to the dynamic world of online information
Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PubMed id 9037013) 1 , 2 , 3, 9 Eder P.S.... Altman S. (1997) Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. (PubMed id 9308968) 1 , 3, 9 Stolc V. and Altman S. (1997) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 1 , 2 Deloukas P.... Rogers J. (2004) Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. (PubMed id 9630247) 1 , 9 Jarrous N.... Altman S. (1998) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118) 1 Woods N.T....Monteiro A.N. (2012) The genetic architecture of economic and political pre ferences. (PubMed id 22566634) 1 Benjamin D.J....Visscher P.M. (2012)
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External Searches for RPP30 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPP30 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPP30 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RPP30 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RPP30 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RPP30 gene: Search GeneIP for patents involving RPP30 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPP30 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RPP30 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RPP30 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPP30 OriGene Protein Over-expression Lysate for RPP30 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPP30 OriGene 3'-UTR Clone for RPP30 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPP30 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPP30 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RPP30 OriGene Custom Protein Services for RPP30 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPP30 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPP30 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPP30 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPP30 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPP30 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPP30
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RPP30 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP30
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPP30
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Aliases for RPP30
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Disorders / Diseases for RPP30
Domains / Families for RPP30
Drugs / Compounds for RPP30
Expression for RPP30
Function for RPP30
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Pathways / Interactions for RPP30
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Transcripts for RPP30
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