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Aliases for RPP30 Gene

Aliases for RPP30 Gene

  • Ribonuclease P/MRP Subunit P30 2 3 5
  • Ribonuclease P Protein Subunit P30 2 3
  • Ribonuclease P/MRP 30kDa Subunit 2 3
  • RNaseP Protein P30 3 4
  • RNase P Subunit 2 3 4
  • EC 4
  • RNASEP2 4
  • TSG15 3

External Ids for RPP30 Gene

Previous GeneCards Identifiers for RPP30 Gene

  • GC10P091512
  • GC10P091852
  • GC10P092762
  • GC10P092295
  • GC10P092621
  • GC10P086260
  • GC10P092631

Summaries for RPP30 Gene

GeneCards Summary for RPP30 Gene

RPP30 (Ribonuclease P/MRP Subunit P30) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP30 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Gene Wiki entry for RPP30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP30 Gene

Genomics for RPP30 Gene

Regulatory Elements for RPP30 Gene

Enhancers for RPP30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G091607 1.9 FANTOM5 Ensembl ENCODE dbSUPER 40.9 +737.1 737053 2.6 PKNOX1 CREB3L1 ARNT DMAP1 YY1 ZNF766 ZNF416 DEK MCM3 REST RPP30 PPP1R3C FGFBP3 BTAF1 TNKS2-AS1 HECTD2 TNKS2 HECTD2-AS1 LOC105378433
GH10G090813 1.1 ENCODE 29.5 -57.9 -57895 1.4 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS ZNF548 ZNF263 RPP30 HTR7 TNKS2 NUDT9P1 PIR38191 PIR51660
GH10G091103 1.2 Ensembl ENCODE 14.4 +232.2 232194 1.7 HDAC1 ATF1 CBX3 TBL1XR1 CHAMP1 TCF12 ZNF766 GATA2 EGR1 ZNF416 RPP30 LOC105378429 NUDT9P1
GH10G090136 0.7 ENCODE 23.8 -734.8 -734828 0.1 FOXA2 CBX3 KLF17 ZNF324 RBAK CBX5 ZNF547 ZNF416 ZNF143 ZNF391 RPP30 GC10M090120 GC10M090146 PIR49337
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPP30 on UCSC Golden Path with GeneCards custom track

Promoters for RPP30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000031493 284 1601 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF48 YY1 ETS1 ZNF143 SP3

Transcription factor binding sites by QIAGEN in the RPP30 gene promoter:

Genomic Location for RPP30 Gene

90,871,716 bp from pter
90,908,558 bp from pter
36,843 bases
Plus strand

Genomic View for RPP30 Gene

Genes around RPP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP30 Gene

Proteins for RPP30 Gene

  • Protein details for RPP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease P protein subunit p30
    Protein Accession:
    Secondary Accessions:
    • B2R799
    • E9PB02

    Protein attributes for RPP30 Gene

    268 amino acids
    Molecular mass:
    29321 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
    • Autoantibodies against RPP30 are found in sera from scleroderma patients.

    Alternative splice isoforms for RPP30 Gene


neXtProt entry for RPP30 Gene

Post-translational modifications for RPP30 Gene

  • Ubiquitination at Lys138
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPP30 Gene

Domains & Families for RPP30 Gene

Protein Domains for RPP30 Gene

Suggested Antigen Peptide Sequences for RPP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
  • Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
genes like me logo Genes that share domains with RPP30: view

No data available for Gene Families for RPP30 Gene

Function for RPP30 Gene

Molecular function for RPP30 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Enzyme Numbers (IUBMB) for RPP30 Gene

Gene Ontology (GO) - Molecular Function for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003824 catalytic activity IEA --
GO:0004526 contributes_to ribonuclease P activity TAS,IBA --
GO:0004540 ribonuclease activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPP30: view
genes like me logo Genes that share phenotypes with RPP30: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP30 Gene

Localization for RPP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP30 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP30 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9630247
GO:0005654 nucleoplasm TAS --
GO:0005655 nucleolar ribonuclease P complex TAS 9630247
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with RPP30: view

Pathways & Interactions for RPP30 Gene

genes like me logo Genes that share pathways with RPP30: view

Gene Ontology (GO) - Biological Process for RPP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IBA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IBA --
genes like me logo Genes that share ontologies with RPP30: view

No data available for SIGNOR curated interactions for RPP30 Gene

Drugs & Compounds for RPP30 Gene

No Compound Related Data Available

Transcripts for RPP30 Gene

Unigene Clusters for RPP30 Gene

Ribonuclease P/MRP 30kDa subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP30 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: -
SP8: - - -

Relevant External Links for RPP30 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPP30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3) and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP30 Gene

Protein tissue co-expression partners for RPP30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPP30 Gene:


SOURCE GeneReport for Unigene cluster for RPP30 Gene:


Evidence on tissue expression from TISSUES for RPP30 Gene

  • Nervous system(4.3)
  • Kidney(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RPP30: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPP30 Gene

Orthologs for RPP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPP30 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPP30 34 35
  • 99.69 (n)
(Canis familiaris)
Mammalia RPP30 34 35
  • 91.23 (n)
(Bos Taurus)
Mammalia RPP30 34 35
  • 91.07 (n)
(Mus musculus)
Mammalia Rpp30 34 16 35
  • 88.68 (n)
(Rattus norvegicus)
Mammalia Rpp30 34
  • 88.3 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 82 (a)
-- 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RPP30 35
  • 81 (a)
(Gallus gallus)
Aves RPP30 34 35
  • 72.98 (n)
(Anolis carolinensis)
Reptilia RPP30 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp30 34
  • 69.81 (n)
Str.6755 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24769 34
(Danio rerio)
Actinopterygii rpp30 34 35
  • 63.6 (n)
Dr.28586 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5477 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008481 34
  • 43.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rpp30 34 35
  • 42.39 (n)
(Caenorhabditis elegans)
Secernentea H35B03.2 35
  • 16 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14718g 34
  • 44.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP1 34 35 37
  • 41.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL046C 34
  • 34.32 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3A12.04c 34
  • 46.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for RPP30 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPP30 Gene

Gene Tree for RPP30 (if available)
Gene Tree for RPP30 (if available)

Paralogs for RPP30 Gene

No data available for Paralogs for RPP30 Gene

Variants for RPP30 Gene

Sequence variations from dbSNP and Humsavar for RPP30 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000004952 -- 90,861,207(+) ATAGC(A/G)TCAAG intron-variant
rs1000009013 -- 90,906,572(+) GCATT(G/T)TAGAA intron-variant, utr-variant-3-prime
rs1000079898 -- 90,904,952(+) CAGGT(A/C/G)GATTA intron-variant
rs1000080805 -- 90,883,096(+) ATGGG(C/T)ATCTC intron-variant
rs1000200213 -- 90,886,788(+) GATTA(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPP30 Gene

Variant ID Type Subtype PubMed ID
nsv473583 CNV novel sequence insertion 20440878
nsv831945 CNV gain 17160897

Variation tolerance for RPP30 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP30 Gene

Disorders for RPP30 Gene

Relevant External Links for RPP30

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP30 Gene

Publications for RPP30 Gene

  1. Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (PMID: 9037013) Eder P.S. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. (PMID: 9308968) Stolc V. … Altman S. (Genes Dev. 1997) 2 3 22 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for RPP30 Gene

Sources for RPP30 Gene

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