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Aliases for RPP25L Gene

Aliases for RPP25L Gene

  • Ribonuclease P/MRP 25kDa Subunit-Like 2 3
  • RNase P Protein Subunit-Like P25 3 4
  • Rpp25-Like Protein 3 4
  • C9orf23 3 4
  • Ribonuclease P Protein Subunit P25-Like Protein 3
  • Chromosome 9 Open Reading Frame 23 2
  • Alba-Like Protein C9orf23 3
  • BA296L22.5 3

External Ids for RPP25L Gene

Previous HGNC Symbols for RPP25L Gene

  • C9orf23

Summaries for RPP25L Gene

Entrez Gene Summary for RPP25L Gene

  • This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPP25L Gene

RPP25L (Ribonuclease P/MRP 25kDa Subunit-Like) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is RPP25.

UniProtKB/Swiss-Prot for RPP25L Gene

  • May be a component of ribonuclease P or MRP

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25L Gene

Genomics for RPP25L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPP25L Gene

Start:
34,610,485 bp from pter
End:
34,612,113 bp from pter
Size:
1,629 bases
Orientation:
Minus strand

Genomic View for RPP25L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP25L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25L Gene

No data available for Regulatory Elements for RPP25L Gene

Proteins for RPP25L Gene

  • Protein details for RPP25L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5L8-RP25L_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p25-like protein
    Protein Accession:
    Q8N5L8
    Secondary Accessions:
    • D3DRM5

    Protein attributes for RPP25L Gene

    Size:
    163 amino acids
    Molecular mass:
    17631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPP25L Gene

Proteomics data for RPP25L Gene at MOPED

Post-translational modifications for RPP25L Gene

  • Ubiquitination at Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for RPP25L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25L Gene

Domains for RPP25L Gene

Protein Domains for RPP25L Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5L8

UniProtKB/Swiss-Prot:

RP25L_HUMAN :
  • Q8N5L8
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25L: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RPP25L Gene

Function for RPP25L Gene

Molecular function for RPP25L Gene

UniProtKB/Swiss-Prot Function: May be a component of ribonuclease P or MRP

Gene Ontology (GO) - Molecular Function for RPP25L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPP25L: view

Phenotypes for RPP25L Gene

GenomeRNAi human phenotypes for RPP25L:
genes like me logo Genes that share phenotypes with RPP25L: view

Animal Model Products

CRISPR Products

miRNA for RPP25L Gene

miRTarBase miRNAs that target RPP25L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP25L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPP25L Gene

Localization for RPP25L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25L Gene

Gene Ontology (GO) - Cellular Components for RPP25L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RPP25L: view

No data available for Subcellular locations from COMPARTMENTS for RPP25L Gene

Pathways for RPP25L Gene

genes like me logo Genes that share pathways with RPP25L: view

Pathways by source for RPP25L Gene

2 KEGG pathways for RPP25L Gene

Gene Ontology (GO) - Biological Process for RPP25L Gene

None

Transcripts for RPP25L Gene

mRNA/cDNA for RPP25L Gene

(163) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25L Gene

Ribonuclease P/MRP 25kDa subunit-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP25L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for RPP25L Gene

GeneLoc Exon Structure for
RPP25L
ECgene alternative splicing isoforms for
RPP25L

Expression for RPP25L Gene

mRNA expression in normal human tissues for RPP25L Gene

mRNA differential expression in normal tissues according to GTEx for RPP25L Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP25L Gene

SOURCE GeneReport for Unigene cluster for RPP25L Gene Hs.15961

genes like me logo Genes that share expressions with RPP25L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RPP25L Gene

Orthologs for RPP25L Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP25L 35
  • 99.8 (n)
  • 100 (a)
RPP25L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPP25L 35
  • 84.77 (n)
  • 92.59 (a)
RPP25L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpp25l 35
  • 84.87 (n)
  • 94.74 (a)
Rpp25l 16
Rpp25l 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPP25L 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPP25L 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp25l 35
  • 85.09 (n)
  • 95.39 (a)
chicken
(Gallus gallus)
Aves C9ORF23 35
  • 59.66 (n)
  • 55.07 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rpp25l 35
  • 59.42 (n)
  • 57.97 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007301 35
  • 46.76 (n)
  • 41.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9422 35
  • 49.38 (n)
  • 40.74 (a)
CG9422 36
  • 28 (a)
OneToMany
Species with no ortholog for RPP25L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25L Gene

ENSEMBL:
Gene Tree for RPP25L (if available)
TreeFam:
Gene Tree for RPP25L (if available)

Paralogs for RPP25L Gene

Paralogs for RPP25L Gene

Selected SIMAP similar genes for RPP25L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25L: view

Variants for RPP25L Gene

Sequence variations from dbSNP and Humsavar for RPP25L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13339 -- 34,610,705(+) GGACT(C/T)AAACC utr-variant-3-prime
rs7032127 -- 34,610,333(+) AGATA(C/T)ATTCA downstream-variant-500B
rs10814126 -- 34,612,180(+) GAGGG(A/G)CGGGC upstream-variant-2KB
rs12003899 -- 34,610,646(+) GCAGT(C/T)CCTTC utr-variant-3-prime
rs13287296 -- 34,612,182(+) GGGAC(A/G)GGCCC upstream-variant-2KB

Relevant External Links for RPP25L Gene

HapMap Linkage Disequilibrium report
RPP25L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPP25L Gene

Disorders for RPP25L Gene

No disorders were found for RPP25L Gene.

No data available for UniProtKB/Swiss-Prot for RPP25L Gene

Publications for RPP25L Gene

  1. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. (PMID: 16998185) Rosenblad M.A. … Samuelsson T. (Nucleic Acids Res. 2006) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for RPP25L Gene

Sources for RPP25L Gene

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