RPP25L Gene
protein-coding GIFtS: 45
GCID: GC09M034610
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|
ribonuclease P/MRP 25kDa subunit-like(Previous name: chromosome 9 open reading frame 23 )
(Previous symbol: C9orf23)
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Aliases
for RPP25L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease P/MRP 25kDa Subunit-Like1 2 | | MGC296351 | | C9orf231 2 3 | | Chromosome 9 Open Reading Frame 231 | | BA296L22.51 | | Alba-Like Protein C9orf232 | | Rpp25-Like Protein2 3 | | Ribonuclease P Protein Subunit P25-Like Protein2 | | RNase P Protein Subunit-Like P252 3 | | |
Export aliases for RPP25L gene to outside databases |
Summaries
for RPP25L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPP25L:
This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that mayshare one or more domains in common. Members of this family are small archaebacterial proteins with no known function.Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have beenidentified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RP25L_HUMAN, Q8N5L8Function: May be a component of ribonuclease P or MRP
|
Genomic Views
for RPP25L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RPP25L
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPP25L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPP25L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2RPP25L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M034610: view genomic region
(about GC identifiers)
Start:
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34,610,483 bp from pter |
End:
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34,612,101 bp from pter |
Size:
|
1,619 bases |
Orientation:
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minus strand |
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Proteins
for RPP25L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RP25L_HUMAN, Q8N5L8 (See
protein sequence)Recommended Name: Ribonuclease P protein subunit p25-like protein Size: 163 amino acids; 17631 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: D3DRM5Explore the universe of human proteins at neXtProt for RPP25L: NX_Q8N5L8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5L8
RPP25L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_680544.1 NP_680545.1
ENSEMBL proteins: ENSP00000368242 ENSP00000297613
Human Recombinant Protein Products for RPP25L:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
RPP25L for ontologies About GeneDecksing
RPP25L Antibody Products:
Assay Products for RPP25L: |
Protein
Domains /
Families
for RPP25L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPP25L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N5L8ProtoNet protein and cluster: Q8N5L8 1 Blocks protein family: IPB002775 Alba
UniProtKB/Swiss-Prot: RP25L_HUMAN, Q8N5L8Similarity: Belongs to the histone-like Alba family |
Function
for RPP25L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RP25L_HUMAN, Q8N5L8Function: May be a component of ribonuclease P or MRP Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
RPP25L for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for RPP25L:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP25L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP25L |
|
Pathways & Interactions
for RPP25L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | | | 2 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for RPP25L):
RPP25L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPP25L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RPP25L (ENSP000002976134) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RPP25L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPP25L
Search CenterWatch for drugs/clinical trials and news about RPP25L / RP25L
|
Transcripts
for RPP25L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPP25L gene (2 alternative transcripts): NM_148178.2 NM_148179.2 Unigene Cluster for RPP25L: Ribonuclease P/MRP 25kDa subunit-like Hs.15961 [show with all ESTs]Unigene Representative Sequence: BM4672002 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378959(uc003zuv.3) ENST00000297613(uc003zuu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPP25L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP25L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for RPP25L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP25L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP25L |
Additional cDNA sequence: BC032136.2 3 DOTS entries: DT.75169832 DT.95272960 DT.86842596 24/163 AceView cDNA sequences (see all 163): BU689983 BQ887804 NM_148179 BQ224958 CD672978 AW002064 BM806218 AI139667 BQ056288 AA581877 AI499259 BM664215 BM701721 AI183286 AA832171 AI419408 BQ063771 BU732092 F18139 BX280954 AA469996 BE742621 F20651 BC032136
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RPP25L About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b |
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| SP1: | | | | | - | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for RPP25L
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Expression
for RPP25L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPP25L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGAAGGGA
About this image
See RPP25L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPP25L
SOURCE GeneReport for Unigene cluster: Hs.15961
SABiosciences Custom PCR Arrays for RPP25L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPP25L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RPP25L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPP25L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPP25L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP25L |
Orthologs
for RPP25L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPP25L gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for RPP25L (if available)
TreeFam Gene Tree for RPP25L (if available) |
Paralogs
for RPP25L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPP25L gene
- RPP252
1 SIMAP similar gene for RPP25L using alignment to 1 protein entry: RP25L_HUMAN:RPP25
RPP25L for paralogs About GeneDecksing
|
Genomic Variants
for RPP25L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPP25L (34610483 - 34612101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPP25L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPP25L |
|
Disorders
/ Diseases
for RPP25L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPP25L for disorders About GeneDecksing
2  diseases for RPP25L: About MalaCardsparkinson's disease malaria
Export disorders for RPP25L gene to outside databases
|
Publications
for RPP25L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPP25L gene integrated from 9 sources:
(articles sorted by number of sources associating them with RPP25L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeas t and human enzymes. (PubMed id 16998185)1, 2, 3 Rosenblad M.A....Samuelsson T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M....Kim N.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RPP25L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPP25L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPP25L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPP25L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPP25L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPP25L gene:
Search GeneIP for patents involving RPP25L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPP25L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPP25L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPP25L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPP25L | | | OriGene Protein Over-expression Lysate for RPP25L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPP25L | | OriGene 3'-UTR Clone for RPP25L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP25L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPP25L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RPP25L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |  |  |  | | | | |
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 | | | RPP25L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP25L |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RPP25L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP25L |
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