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Aliases for RPP25L Gene

Aliases for RPP25L Gene

  • Ribonuclease P/MRP Subunit P25 Like 2 3
  • Ribonuclease P/MRP 25kDa Subunit-Like 2 3 5
  • RNase P Protein Subunit-Like P25 3 4
  • Rpp25-Like Protein 3 4
  • C9orf23 3 4
  • Chromosome 9 Open Reading Frame 23 2
  • Alba-Like Protein C9orf23 3
  • BA296L22.5 3

External Ids for RPP25L Gene

Previous HGNC Symbols for RPP25L Gene

  • C9orf23

Summaries for RPP25L Gene

Entrez Gene Summary for RPP25L Gene

  • This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPP25L Gene

RPP25L (Ribonuclease P/MRP Subunit P25 Like) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is RPP25.

UniProtKB/Swiss-Prot for RPP25L Gene

  • May be a component of ribonuclease P or MRP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25L Gene

Genomics for RPP25L Gene

Regulatory Elements for RPP25L Gene

Enhancers for RPP25L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPP25L on UCSC Golden Path with GeneCards custom track

Promoters for RPP25L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPP25L on UCSC Golden Path with GeneCards custom track

Genomic Location for RPP25L Gene

34,610,485 bp from pter
34,612,113 bp from pter
1,629 bases
Minus strand

Genomic View for RPP25L Gene

Genes around RPP25L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP25L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP25L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25L Gene

Proteins for RPP25L Gene

  • Protein details for RPP25L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease P protein subunit p25-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DRM5

    Protein attributes for RPP25L Gene

    163 amino acids
    Molecular mass:
    17631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPP25L Gene

Proteomics data for RPP25L Gene at MOPED

Post-translational modifications for RPP25L Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for RPP25L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25L Gene

Domains & Families for RPP25L Gene

Protein Domains for RPP25L Gene

Suggested Antigen Peptide Sequences for RPP25L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the histone-like Alba family.
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25L: view

No data available for Gene Families for RPP25L Gene

Function for RPP25L Gene

Molecular function for RPP25L Gene

UniProtKB/Swiss-Prot Function:
May be a component of ribonuclease P or MRP.

Gene Ontology (GO) - Molecular Function for RPP25L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPP25L: view
genes like me logo Genes that share phenotypes with RPP25L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP25L Gene

Localization for RPP25L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25L Gene

Subcellular locations from

Jensen Localization Image for RPP25L Gene COMPARTMENTS Subcellular localization image for RPP25L gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for RPP25L Gene

Pathways & Interactions for RPP25L Gene

genes like me logo Genes that share pathways with RPP25L: view

Pathways by source for RPP25L Gene

2 KEGG pathways for RPP25L Gene

Gene Ontology (GO) - Biological Process for RPP25L Gene


No data available for SIGNOR curated interactions for RPP25L Gene

Drugs & Compounds for RPP25L Gene

No Compound Related Data Available

Transcripts for RPP25L Gene

mRNA/cDNA for RPP25L Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(163) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25L Gene

Ribonuclease P/MRP 25kDa subunit-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -

Relevant External Links for RPP25L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPP25L Gene

mRNA expression in normal human tissues for RPP25L Gene

mRNA differential expression in normal tissues according to GTEx for RPP25L Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for RPP25L Gene

This gene is overexpressed in Monocytes (23.0), Lung (20.5), Breast (8.7), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP25L Gene

SOURCE GeneReport for Unigene cluster for RPP25L Gene Hs.15961

genes like me logo Genes that share expression patterns with RPP25L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RPP25L Gene

Orthologs for RPP25L Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPP25L 35
  • 84.77 (n)
  • 92.59 (a)
RPP25L 36
  • 92 (a)
(Mus musculus)
Mammalia Rpp25l 35
  • 84.87 (n)
  • 94.74 (a)
Rpp25l 16
Rpp25l 36
  • 94 (a)
(Pan troglodytes)
Mammalia RPP25L 35
  • 99.8 (n)
  • 100 (a)
RPP25L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpp25l 35
  • 85.09 (n)
  • 95.39 (a)
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
-- 36
  • 95 (a)
(Monodelphis domestica)
Mammalia RPP25L 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia RPP25L 36
  • 51 (a)
(Gallus gallus)
Aves C9ORF23 35
  • 59.66 (n)
  • 55.07 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
(Danio rerio)
Actinopterygii rpp25l 35
  • 59.42 (n)
  • 57.97 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007301 35
  • 46.76 (n)
  • 41.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9422 35
  • 49.38 (n)
  • 40.74 (a)
CG9422 36
  • 28 (a)
Species with no ortholog for RPP25L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25L Gene

Gene Tree for RPP25L (if available)
Gene Tree for RPP25L (if available)

Paralogs for RPP25L Gene

Paralogs for RPP25L Gene

(1) SIMAP similar genes for RPP25L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25L: view

Variants for RPP25L Gene

Sequence variations from dbSNP and Humsavar for RPP25L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113300465 -- 34,610,762(+) AGCAC(C/T)CCAGA utr-variant-3-prime
rs113382168 -- 34,612,892(+) CACGC(C/T)GAATT upstream-variant-2KB
rs114115547 -- 34,610,378(+) TCCCA(C/G)CACCG downstream-variant-500B
rs116406161 -- 34,611,629(+) CCAGG(A/C)CCCCT intron-variant
rs191847496 -- 34,610,278(+) CTGGC(A/C/T)GTGTT downstream-variant-500B

Variation tolerance for RPP25L Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RPP25L Gene

Disorders for RPP25L Gene

Relevant External Links for RPP25L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPP25L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP25L Gene

Publications for RPP25L Gene

  1. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. (PMID: 16998185) Rosenblad M.A. … Samuelsson T. (Nucleic Acids Res. 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for RPP25L Gene

Sources for RPP25L Gene