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Aliases for RPP25 Gene

Aliases for RPP25 Gene

  • Ribonuclease P/MRP Subunit P25 2 3
  • Ribonuclease P/MRP 25kDa Subunit 2 5
  • RNase P Protein Subunit P25 2 4
  • Ribonuclease P 25kDa Subunit 2
  • EC 3.1.26.5 4

External Ids for RPP25 Gene

Previous GeneCards Identifiers for RPP25 Gene

  • GC15M072964
  • GC15M073034
  • GC15M075247
  • GC15M052044

Summaries for RPP25 Gene

GeneCards Summary for RPP25 Gene

RPP25 (Ribonuclease P/MRP Subunit P25) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include nucleic acid binding and ribonuclease P activity. An important paralog of this gene is RPP25L.

UniProtKB/Swiss-Prot for RPP25 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25 Gene

Genomics for RPP25 Gene

Regulatory Elements for RPP25 Gene

Promoters for RPP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPP25 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPP25 Gene

Chromosome:
15
Start:
74,954,416 bp from pter
End:
74,957,464 bp from pter
Size:
3,049 bases
Orientation:
Minus strand

Genomic View for RPP25 Gene

Genes around RPP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25 Gene

Proteins for RPP25 Gene

  • Protein details for RPP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUL9-RPP25_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p25
    Protein Accession:
    Q9BUL9
    Secondary Accessions:
    • D3DW70
    • Q9NX88

    Protein attributes for RPP25 Gene

    Size:
    199 amino acids
    Molecular mass:
    20632 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.

neXtProt entry for RPP25 Gene

Proteomics data for RPP25 Gene at MOPED

Post-translational modifications for RPP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25 Gene

Domains & Families for RPP25 Gene

Protein Domains for RPP25 Gene

Suggested Antigen Peptide Sequences for RPP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUL9

UniProtKB/Swiss-Prot:

RPP25_HUMAN :
  • Belongs to the histone-like Alba family.
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25: view

No data available for Gene Families for RPP25 Gene

Function for RPP25 Gene

Molecular function for RPP25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

Enzyme Numbers (IUBMB) for RPP25 Gene

genes like me logo Genes that share phenotypes with RPP25: view

Animal Model Products

miRNA for RPP25 Gene

miRTarBase miRNAs that target RPP25

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP25 Gene

Localization for RPP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP25 Gene COMPARTMENTS Subcellular localization image for RPP25 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with RPP25: view

Pathways & Interactions for RPP25 Gene

genes like me logo Genes that share pathways with RPP25: view

Gene Ontology (GO) - Biological Process for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RPP25: view

No data available for SIGNOR curated interactions for RPP25 Gene

Drugs & Compounds for RPP25 Gene

No Compound Related Data Available

Transcripts for RPP25 Gene

mRNA/cDNA for RPP25 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(232) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25 Gene

Ribonuclease P/MRP 25kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25 Gene

No ASD Table

Relevant External Links for RPP25 Gene

GeneLoc Exon Structure for
RPP25
ECgene alternative splicing isoforms for
RPP25

Expression for RPP25 Gene

mRNA expression in normal human tissues for RPP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP25 Gene

This gene is overexpressed in Breast (28.7), Lung (20.3), and Pancreas (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP25 Gene



SOURCE GeneReport for Unigene cluster for RPP25 Gene Hs.8562

genes like me logo Genes that share expression patterns with RPP25: view

Protein tissue co-expression partners for RPP25 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP25 Gene

Orthologs for RPP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPP25 35
  • 89.61 (n)
  • 90.95 (a)
RPP25 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP25 35
  • 87.86 (n)
  • 88.72 (a)
mouse
(Mus musculus)
Mammalia Rpp25 35
  • 86.26 (n)
  • 87.94 (a)
Rpp25 16
Rpp25 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPP25 35
  • 98.66 (n)
  • 97.99 (a)
RPP25 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp25 35
  • 87.44 (n)
  • 88.44 (a)
chicken
(Gallus gallus)
Aves RPP25 35
  • 65.95 (n)
  • 62.14 (a)
RPP25 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP25 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp25 35
  • 55.71 (n)
  • 52.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885168 35
  • 63.1 (n)
  • 57.86 (a)
rpp25l 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9422 36
  • 31 (a)
OneToMany
Species with no ortholog for RPP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25 Gene

ENSEMBL:
Gene Tree for RPP25 (if available)
TreeFam:
Gene Tree for RPP25 (if available)

Paralogs for RPP25 Gene

Paralogs for RPP25 Gene

(1) SIMAP similar genes for RPP25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25: view

Variants for RPP25 Gene

Sequence variations from dbSNP and Humsavar for RPP25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11540265 -- 74,956,674(-) CCCCT(C/G)CTGGC utr-variant-5-prime
rs11540266 -- 74,955,414(+) CACCC(A/C/G/T)TTTTC utr-variant-3-prime
rs12440707 -- 74,954,604(+) CCCCA(A/C)CCCCC downstream-variant-500B
rs12914012 -- 74,958,997(+) CGGGC(C/T)GGTTG upstream-variant-2KB
rs12912343 -- 74,958,700(+) TCTTA(C/G)CACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPP25 Gene

Variant ID Type Subtype PubMed ID
nsv1612 CNV Loss 18451855

Variation tolerance for RPP25 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP25 Gene

HapMap Linkage Disequilibrium report
RPP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP25 Gene

Disorders for RPP25 Gene

Relevant External Links for RPP25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP25

No disorders were found for RPP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP25 Gene

Publications for RPP25 Gene

  1. Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. (PMID: 12003489) Guerrier-Takada C. … Altman S. (RNA 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay. (PMID: 23587095) Mahler M. … Satoh M. (Arthritis Res. Ther. 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for RPP25 Gene

Sources for RPP25 Gene

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