RPP25 Gene

Aliases
for RPP25 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC15M072964 GC15M073034 GC15M052044

Summaries
for RPP25 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for RPP25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000015.9  NC_018926.2  NT_010194.18  

SwitchGear Promoter luciferase reporter plasmid: RPP25 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPP25

RPP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075247:  view genomic region     (about GC identifiers)

Proteins
for RPP25 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for RPP25: NX_Q9BUL9

Explore proteomics data for RPP25 at MOPED

Post-translational modifications: 

RPP25 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for RPP25 Browse OriGene Protein Over-expression Lysates OriGene MassSpec for RPP25 OriGene Custom Protein Services for RPP25
	GenScript Custom Purified and Recombinant Proteins Services for RPP25
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RPP25
	Search eBioscience for Proteins for RPP25
	Search GeneTex for Proteins for RPP25
	antibodies-online proteins for RPP25 (2 products)
	antibodies-online peptides for RPP25

RPP25 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RPP25
	Novus Biologicals RPP25 Antibody
	Abcam antibodies for RPP25
	Cloud-Clone Corp. Antibodies for RPP25
	Search ThermoFisher Antibodies for RPP25
	antibodies-online antibodies for RPP25 (7 products)

RPP25 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RPP25
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPP25
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RPP25 Cloud-Clone Corp. CLIAs for RPP25
	Search eBioscience for ELISAs for RPP25
	antibodies-online kits for RPP25 (6 products)

Domains /
Families
for RPP25 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9BUL9

Find genes that share domains with RPP25           About GenesLikeMe

Function
for RPP25 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Enzyme Number (IUBMB): EC 3.1.26.5¹

     Gene Ontology (GO): 5 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for RPP25

miRNA Products:		Block miRNA regulation of human, mouse, rat RPP25 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate RPP25:
		hsa-miR-550a hsa-miR-1266 hsa-miR-24 hsa-miR-488 hsa-miR-766
		SwitchGear 3'UTR luciferase reporter plasmid: RPP25 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RPP25
		Predesigned siRNA for gene silencing in human, mouse, rat RPP25

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RPP25

Clone Products:		OriGene clones in human, mouse for RPP25 (see all 6) OriGene ORF clones in mouse, rat for RPP25 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RPP25 (NM_017793)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPP25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP25

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPP25
		Browse ESI BIO Cell Lines and PureStem Progenitors for RPP25

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP25

Localization
for RPP25 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytoskeleton	4
mitochondrion	4
cytosol	2

About this image

Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for RPP25 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for RPP25 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	RNA transport	RNA transport
2	Ribosome biogenesis in eukaryotes	Ribosome biogenesis in eukaryotes

2 Kegg Pathways  (Kegg details for RPP25)

	Ribosome biogenesis in eukaryotes
	RNA transport

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for RPP25 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for RPP25 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for RPP25 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPP25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACCTTAAGG

About this image

Brain (Nervous System)    fully expand to see all 5 entries
Cerebral Cortex
Neural Tube (Nervous System)    fully expand to see all 4 entries
Metencephalon
Neurons
GABAergic Amacrine Cells Inner Nuclear Layer
Eye (Sensory Organs)    fully expand to see all 2 entries
GABAergic Amacrine Cells Inner Nuclear Layer
Gut Tube (Gastrointestinal Tract)
Foregut

Primer Products:		OriGene qPCR primer pairs and template standards for RPP25 OriGene qSTAR qPCR primer pairs in human, mouse for RPP25
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RPP25
		QuantiTect SYBR Green Assays in human, mouse, rat RPP25
		QuantiFast Probe-based Assays in human, mouse, rat RPP25

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPP25

Orthologs
for RPP25 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for RPP25 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for RPP25 gene

RPP25L²  

1 SIMAP similar gene for RPP25 using alignment to 1 protein entry:     RPP25_HUMAN:

RPP25L

Find genes that share paralogs with RPP25           About GenesLikeMe

Genomic Variants
for RPP25 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for RPP25 (see all 71)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs124407071,2	C,H	--	75246945(+)	CCCCAC/ACCCCC	1	--	ds5001		5		NS EA NA	420
rs1493390401,2	C	--	75247037(+)	TATCAA/GGAGGC	1	--	ds5001		0	--	--	--	--
rs1446921811,2		--	75247128(+)	CTCCCA/CCTTTC	1	--	ds5001		0	--	--	--	--
rs1889021391,2		--	75247129(+)	TCCCCC/TTTTCC	1	--	ds5001		0	--	--	--	--
rs340636701,2	C,F	--	75247156(+)	TTTCTC/GAGAGA	1	--	ds5001		11		NA EA CSA WA	728
rs1485160211,2		--	75247183(+)	AGATCC/TTACCC	1	--	ds5001		0	--	--	--	--
rs1811847921,2	C	--	75247592(+)	CAGGCA/GAGAGC	1	--	ut31		0	--	--	--	--
rs1428640441,2	C	--	75247706(+)	AGGAGA/GCCTGG	1	--	ut31		0	--	--	--	--
rs115402661,2	C	--	75247755(-)	CACCCC/ATTTTC	1	--	ut31		1		NA	2
rs1401288981,2	C	--	75247857(+)	GGCCCC/GCACAT	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for RPP25 (75246757 - 75249805 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RPP25:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv1612	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RPP25

DNA2.0 Custom Variant and Variant Library Synthesis for RPP25

Disorders / Diseases
for RPP25 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for RPP25 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. (PubMed id 12003489)^{1, 2, 3, 9} Guerrier-Takada C.... Altman S. (RNA 2002)
2. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)^{1, 2} Welting T.J.... Pruijn G.J. (Nucleic Acids Res. 2004)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
6. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
7. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)¹ Lee O.H....Songyang Z. (amp 2011)
8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (Sci. Signal. 2010)
9. RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder. (PubMed id 20632321)¹ Huang H.S....Akbarian S. (Autism Res 2010)
10. Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA. (PubMed id 20215441)¹ Hands-Taylor K.L....Conte M.R. (Nucleic Acids Res. 2010)

External Searches for RPP25 gene

Genome Databases showing RPP25 gene

Other Databases showing RPP25 gene

Specialized Databases showing RPP25 gene

Products
for RPP25 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section