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Aliases for RPP25 Gene

Aliases for RPP25 Gene

  • Ribonuclease P And MRP Subunit P25 2 3 5
  • RNase P Protein Subunit P25 2 4
  • Ribonuclease P/MRP 25kDa Subunit 2
  • Ribonuclease P/MRP Subunit P25 2
  • Ribonuclease P 25kDa Subunit 2
  • EC 3.1.26.5 4

External Ids for RPP25 Gene

Previous GeneCards Identifiers for RPP25 Gene

  • GC15M072964
  • GC15M073034
  • GC15M075247
  • GC15M052044

Summaries for RPP25 Gene

GeneCards Summary for RPP25 Gene

RPP25 (Ribonuclease P And MRP Subunit P25) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease P activity. An important paralog of this gene is RPP25L.

UniProtKB/Swiss-Prot for RPP25 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

Additional gene information for RPP25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25 Gene

Genomics for RPP25 Gene

GeneHancer (GH) Regulatory Elements for RPP25 Gene

Promoters and enhancers for RPP25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074953 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 602.4 +0.8 808 5.4 PKNOX1 CLOCK SMAD1 ARNT SIN3A DMAP1 YY1 ZNF766 E2F8 ZNF207 RPP25 SCAMP5 MAN2C1 ENSG00000260274 FBXO22 ENSG00000203392 SIN3A FAM219B MPI ULK3
GH15I074865 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.9 +87.6 87646 8.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 SCAMP2 RPP25 EDC3 SIN3A ENSG00000260274 SNUPN UBL7-AS1 DNM1P34 MPI SCAMP5
GH15I074888 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.1 +66.8 66835 4 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 MPI RPP25 SIN3A ENSG00000203392 SNX33 ISLR PTPN9 MAN2C1 PML SCAMP5
GH15I075041 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.9 -88.4 -88422 8.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 PPCDC SCAMP5 C15orf39 RPP25 LOC441728 SIN3A DNM1P35 EDC3 ENSG00000203392 ULK3
GH15I074904 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 38.1 +51.1 51073 2.9 HDGF PKNOX1 SMAD1 SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 FAM219B RPP25 DNM1P35 ULK3 ODF3L1 GC15P074895
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPP25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPP25 gene promoter:

Genomic Locations for RPP25 Gene

Genomic Locations for RPP25 Gene
chr15:74,954,416-74,957,464
(GRCh38/hg38)
Size:
3,049 bases
Orientation:
Minus strand
chr15:75,246,757-75,249,805
(GRCh37/hg19)

Genomic View for RPP25 Gene

Genes around RPP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25 Gene

Proteins for RPP25 Gene

  • Protein details for RPP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUL9-RPP25_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p25
    Protein Accession:
    Q9BUL9
    Secondary Accessions:
    • D3DW70
    • Q9NX88

    Protein attributes for RPP25 Gene

    Size:
    199 amino acids
    Molecular mass:
    20632 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.

neXtProt entry for RPP25 Gene

Post-translational modifications for RPP25 Gene

No Post-translational modifications

Other Protein References for RPP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25 Gene

Domains & Families for RPP25 Gene

Gene Families for RPP25 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RPP25 Gene

Suggested Antigen Peptide Sequences for RPP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUL9

UniProtKB/Swiss-Prot:

RPP25_HUMAN :
  • Belongs to the histone-like Alba family.
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25: view

Function for RPP25 Gene

Molecular function for RPP25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

Enzyme Numbers (IUBMB) for RPP25 Gene

Phenotypes From GWAS Catalog for RPP25 Gene

Gene Ontology (GO) - Molecular Function for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0004526 contributes_to ribonuclease P activity IEA,IDA 16723659
GO:0005515 protein binding IPI 15096576
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPP25: view
genes like me logo Genes that share phenotypes with RPP25: view

miRNA for RPP25 Gene

miRTarBase miRNAs that target RPP25

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP25 Gene

Localization for RPP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP25 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000172 ribonuclease MRP complex IDA 16723659
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005815 microtubule organizing center IDA --
GO:0030681 multimeric ribonuclease P complex IDA 16723659
genes like me logo Genes that share ontologies with RPP25: view

Pathways & Interactions for RPP25 Gene

genes like me logo Genes that share pathways with RPP25: view

Gene Ontology (GO) - Biological Process for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP25: view

No data available for SIGNOR curated interactions for RPP25 Gene

Drugs & Compounds for RPP25 Gene

No Compound Related Data Available

Transcripts for RPP25 Gene

mRNA/cDNA for RPP25 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(232) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25 Gene

Ribonuclease P/MRP 25kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25 Gene

No ASD Table

Relevant External Links for RPP25 Gene

GeneLoc Exon Structure for
RPP25
ECgene alternative splicing isoforms for
RPP25

Expression for RPP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP25 Gene

This gene is overexpressed in Breast (28.7), Lung (20.3), and Pancreas (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP25 Gene



Protein tissue co-expression partners for RPP25 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPP25 Gene:

RPP25

SOURCE GeneReport for Unigene cluster for RPP25 Gene:

Hs.8562

Evidence on tissue expression from TISSUES for RPP25 Gene

  • Skin(4.6)
  • Nervous system(4.6)
  • Lung(2.6)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with RPP25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPP25 Gene

Orthologs for RPP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP25 33 34
  • 98.66 (n)
cow
(Bos Taurus)
Mammalia RPP25 33 34
  • 89.61 (n)
dog
(Canis familiaris)
Mammalia RPP25 33
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Rpp25 33
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Rpp25 33 16 34
  • 86.26 (n)
chicken
(Gallus gallus)
Aves RPP25 33 34
  • 65.95 (n)
lizard
(Anolis carolinensis)
Reptilia RPP25 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp25 33
  • 55.71 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885168 33
  • 63.1 (n)
rpp25l 34
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9422 34
  • 31 (a)
OneToMany
Species where no ortholog for RPP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25 Gene

ENSEMBL:
Gene Tree for RPP25 (if available)
TreeFam:
Gene Tree for RPP25 (if available)

Paralogs for RPP25 Gene

Paralogs for RPP25 Gene

(1) SIMAP similar genes for RPP25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25: view

Variants for RPP25 Gene

Sequence variations from dbSNP and Humsavar for RPP25 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000079190 -- 74,958,314(-) C/T upstream_transcript_variant
rs1000193348 -- 74,958,036(-) T/C upstream_transcript_variant
rs1001254326 -- 74,957,886(-) A/G upstream_transcript_variant
rs1001362948 -- 74,955,224(-) G/A 3_prime_UTR_variant
rs1001769015 -- 74,957,608(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPP25 Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv1612 CNV deletion 18451855
nsv569993 CNV gain 21841781

Variation tolerance for RPP25 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP25 Gene

Disorders for RPP25 Gene

Additional Disease Information for RPP25

No disorders were found for RPP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP25 Gene

Publications for RPP25 Gene

  1. Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. (PMID: 12003489) Guerrier-Takada C … Altman S (RNA (New York, N.Y.) 2002) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting TJ … Pruijn GJ (Nucleic acids research 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RPP25 Gene

  • Addgene plasmids for RPP25

Sources for RPP25 Gene

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