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Aliases for RPP25 Gene

Aliases for RPP25 Gene

  • Ribonuclease P/MRP Subunit P25 2 3 5
  • RNase P Protein Subunit P25 2 4
  • Ribonuclease P/MRP 25kDa Subunit 2
  • Ribonuclease P 25kDa Subunit 2
  • EC 3.1.26.5 4

External Ids for RPP25 Gene

Previous GeneCards Identifiers for RPP25 Gene

  • GC15M072964
  • GC15M073034
  • GC15M075247
  • GC15M052044

Summaries for RPP25 Gene

GeneCards Summary for RPP25 Gene

RPP25 (Ribonuclease P/MRP Subunit P25) is a Protein Coding gene. Among its related pathways are tRNA processing and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include nucleic acid binding and ribonuclease P activity. An important paralog of this gene is RPP25L.

UniProtKB/Swiss-Prot for RPP25 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25 Gene

Genomics for RPP25 Gene

Regulatory Elements for RPP25 Gene

Enhancers for RPP25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F074953 1.5 FANTOM5 ENCODE 52.4 +0.8 808 5.4 PKNOX1 ARNT CREB3L1 SIN3A DMAP1 YY1 ZNF207 FOS ZNF263 SP3 RPP25 LOC105370902 LOC732265 DNM1P49 LOC441728 GOLGA6A EDC3 FAM219B MPI ULK3
GH15F075041 1.9 FANTOM5 Ensembl ENCODE 33.9 -88.3 -88312 8.4 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SCAMP5 C15orf39 RPP25 PPCDC FBXO22 ISLR ENSG00000203392 SNX33 DNM1P35 PTPN9
GH15F074865 1.5 FANTOM5 ENCODE 37.9 +87.6 87647 8.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 RPP25 ISLR ENSG00000203392 SNX33 PTPN9 SCAMP2 MPI SCAMP5 C15orf39 MAN2C1
GH15F074950 1.2 Ensembl ENCODE 42.4 +6.9 6876 0.8 PKNOX1 KLF17 ARID4B ZNF2 RAD21 ZEB1 RFX5 ZNF366 ZNF143 ZNF391 RPP25 SCAMP5 COX5A
GH15F075033 1.5 FANTOM5 Ensembl ENCODE 33.9 -79.3 -79337 6.0 HDGF PKNOX1 INSM2 SIN3A RAD21 GLIS2 RCOR1 KLF7 ZNF548 FOS SCAMP5 RPP25 LOC105370902 DNM1P49 LOC441728 LOC732265 ENSG00000260274 GOLGA6A ENSG00000203392 MPI
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPP25 on UCSC Golden Path with GeneCards custom track

Promoters for RPP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001796877 164 2601 ATF1 CREB3L1 SIN3A DMAP1 YY1 GLIS2 KLF7 ZNF263 SP3 SP5

Genomic Location for RPP25 Gene

Chromosome:
15
Start:
74,954,416 bp from pter
End:
74,957,464 bp from pter
Size:
3,049 bases
Orientation:
Minus strand

Genomic View for RPP25 Gene

Genes around RPP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25 Gene

Proteins for RPP25 Gene

  • Protein details for RPP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUL9-RPP25_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p25
    Protein Accession:
    Q9BUL9
    Secondary Accessions:
    • D3DW70
    • Q9NX88

    Protein attributes for RPP25 Gene

    Size:
    199 amino acids
    Molecular mass:
    20632 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.

neXtProt entry for RPP25 Gene

Post-translational modifications for RPP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25 Gene

Domains & Families for RPP25 Gene

Protein Domains for RPP25 Gene

Suggested Antigen Peptide Sequences for RPP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUL9

UniProtKB/Swiss-Prot:

RPP25_HUMAN :
  • Belongs to the histone-like Alba family.
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25: view

No data available for Gene Families for RPP25 Gene

Function for RPP25 Gene

Molecular function for RPP25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

Enzyme Numbers (IUBMB) for RPP25 Gene

Gene Ontology (GO) - Molecular Function for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004526 ribonuclease P activity IEA --
GO:0005515 protein binding IPI 15096576
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPP25: view
genes like me logo Genes that share phenotypes with RPP25: view

Animal Model Products

miRNA for RPP25 Gene

miRTarBase miRNAs that target RPP25

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP25 Gene

Localization for RPP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP25 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with RPP25: view

Pathways & Interactions for RPP25 Gene

genes like me logo Genes that share pathways with RPP25: view

Gene Ontology (GO) - Biological Process for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP25: view

No data available for SIGNOR curated interactions for RPP25 Gene

Transcripts for RPP25 Gene

mRNA/cDNA for RPP25 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(232) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25 Gene

Ribonuclease P/MRP 25kDa subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25 Gene

No ASD Table

Relevant External Links for RPP25 Gene

GeneLoc Exon Structure for
RPP25
ECgene alternative splicing isoforms for
RPP25

Expression for RPP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP25 Gene

This gene is overexpressed in Breast (28.7), Lung (20.3), and Pancreas (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP25 Gene



Protein tissue co-expression partners for RPP25 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPP25 Gene:

RPP25

SOURCE GeneReport for Unigene cluster for RPP25 Gene:

Hs.8562
genes like me logo Genes that share expression patterns with RPP25: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP25 Gene

Orthologs for RPP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP25 34 35
  • 98.66 (n)
cow
(Bos Taurus)
Mammalia RPP25 34 35
  • 89.61 (n)
dog
(Canis familiaris)
Mammalia RPP25 34
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Rpp25 34
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Rpp25 34 16 35
  • 86.26 (n)
chicken
(Gallus gallus)
Aves RPP25 34 35
  • 65.95 (n)
lizard
(Anolis carolinensis)
Reptilia RPP25 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp25 34
  • 55.71 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885168 34
  • 63.1 (n)
rpp25l 35
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9422 35
  • 31 (a)
OneToMany
Species where no ortholog for RPP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25 Gene

ENSEMBL:
Gene Tree for RPP25 (if available)
TreeFam:
Gene Tree for RPP25 (if available)

Paralogs for RPP25 Gene

Paralogs for RPP25 Gene

(1) SIMAP similar genes for RPP25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25: view

Variants for RPP25 Gene

Sequence variations from dbSNP and Humsavar for RPP25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111238268 -- 74,959,332(+) AAATG(A/T)ACATC upstream-variant-2KB
rs11540265 -- 74,956,674(-) CCCCT(C/G)CTGGC utr-variant-5-prime
rs11540266 -- 74,955,414(-) CACCC(A/C)TTTTC utr-variant-3-prime
rs12440707 -- 74,954,604(+) CCCCA(A/C)CCCCC downstream-variant-500B
rs12912343 -- 74,958,700(+) TCTTA(C/G)CACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPP25 Gene

Variant ID Type Subtype PubMed ID
nsv569993 CNV gain 21841781
nsv1612 CNV deletion 18451855
nsv1121512 CNV deletion 24896259

Variation tolerance for RPP25 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP25 Gene

Disorders for RPP25 Gene

Relevant External Links for RPP25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP25

No disorders were found for RPP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP25 Gene

Publications for RPP25 Gene

  1. Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. (PMID: 12003489) Guerrier-Takada C. … Altman S. (RNA 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RPP25 Gene

Sources for RPP25 Gene

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