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Aliases for RPP25 Gene

Aliases for RPP25 Gene

  • Ribonuclease P And MRP Subunit P25 2 3 5
  • RNase P Protein Subunit P25 2 4
  • Ribonuclease P/MRP 25kDa Subunit 2
  • Ribonuclease P/MRP Subunit P25 2
  • Ribonuclease P 25kDa Subunit 2
  • EC 3.1.26.5 4

External Ids for RPP25 Gene

Previous GeneCards Identifiers for RPP25 Gene

  • GC15M072964
  • GC15M073034
  • GC15M075247
  • GC15M052044

Summaries for RPP25 Gene

GeneCards Summary for RPP25 Gene

RPP25 (Ribonuclease P And MRP Subunit P25) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include nucleic acid binding and ribonuclease P activity. An important paralog of this gene is RPP25L.

UniProtKB/Swiss-Prot for RPP25 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

Additional gene information for RPP25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25 Gene

Genomics for RPP25 Gene

Regulatory Elements for RPP25 Gene

Enhancers for RPP25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H074953 1.5 FANTOM5 ENCODE 52.3 +0.8 808 5 PKNOX1 ARNT SIN3A DMAP1 YY1 ZNF766 ZNF207 FOS SP3 SP5 RPP25 MAN2C1 SIN3A DNM1P35 EDC3 ENSG00000260274 FBXO22 GOLGA6D LOC105370902 DNM1P49
GH15H075041 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -88.4 -88423 8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SCAMP5 C15orf39 RPP25 LOC441728 PPCDC SIN3A DNM1P35 EDC3 ENSG00000203392 ULK3
GH15H074865 1.8 FANTOM5 ENCODE dbSUPER 37.9 +87.6 87647 8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF207 RPP25 EDC3 SIN3A ENSG00000260274 SNUPN SCAMP2 UBL7-AS1 DNM1P34 MPI SCAMP5
GH15H075034 1.7 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -79.0 -78974 4 HDGF PKNOX1 INSM2 SIN3A GLIS2 EGR1 ZSCAN5C FOS KLF7 ZNF548 SCAMP5 RPP25 MAN2C1 SIN3A GOLGA6D LOC105370902 DNM1P49 LOC732265 ENSG00000260274 GOLGA6A
GH15H074888 1.4 ENCODE dbSUPER 38.1 +66.8 66835 3 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF416 RPP25 SIN3A ENSG00000203392 SNX33 ISLR PTPN9 MPI GOLGA6D LOC105370902 LOC732265
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPP25 on UCSC Golden Path with GeneCards custom track

Promoters for RPP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000278351 -636 201 POLR2A EZH2
ENSR00000278352 664 1201 ATF1 SIN3A GLIS2 ZNF207 KLF7 ATF7 RUNX3 SP3 REST SMARCB1
ENSR00000079322 -1036 201 ELF3 CTCF KLF1 ZNF792 SAP130 DMAP1 ZIC2 KMT2B POLR2A NR2F6

Genomic Location for RPP25 Gene

Chromosome:
15
Start:
74,954,416 bp from pter
End:
74,957,464 bp from pter
Size:
3,049 bases
Orientation:
Minus strand

Genomic View for RPP25 Gene

Genes around RPP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25 Gene

Proteins for RPP25 Gene

  • Protein details for RPP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUL9-RPP25_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p25
    Protein Accession:
    Q9BUL9
    Secondary Accessions:
    • D3DW70
    • Q9NX88

    Protein attributes for RPP25 Gene

    Size:
    199 amino acids
    Molecular mass:
    20632 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.

neXtProt entry for RPP25 Gene

Post-translational modifications for RPP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25 Gene

Domains & Families for RPP25 Gene

Gene Families for RPP25 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RPP25 Gene

Suggested Antigen Peptide Sequences for RPP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUL9

UniProtKB/Swiss-Prot:

RPP25_HUMAN :
  • Belongs to the histone-like Alba family.
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25: view

Function for RPP25 Gene

Molecular function for RPP25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA.

Enzyme Numbers (IUBMB) for RPP25 Gene

Phenotypes From GWAS Catalog for RPP25 Gene

Gene Ontology (GO) - Molecular Function for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0004526 contributes_to ribonuclease P activity IEA,IDA 16723659
GO:0005515 protein binding IPI 15096576
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPP25: view
genes like me logo Genes that share phenotypes with RPP25: view

Animal Model Products

CRISPR Products

miRNA for RPP25 Gene

miRTarBase miRNAs that target RPP25

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPP25
  • Applied Biological Materials Clones for RPP25
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP25 Gene

Localization for RPP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP25 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000172 ribonuclease MRP complex IDA 16723659
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005815 microtubule organizing center IDA --
GO:0030681 multimeric ribonuclease P complex IDA 16723659
genes like me logo Genes that share ontologies with RPP25: view

Pathways & Interactions for RPP25 Gene

genes like me logo Genes that share pathways with RPP25: view

Gene Ontology (GO) - Biological Process for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP25: view

No data available for SIGNOR curated interactions for RPP25 Gene

Drugs & Compounds for RPP25 Gene

No Compound Related Data Available

Transcripts for RPP25 Gene

mRNA/cDNA for RPP25 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(232) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25 Gene

Ribonuclease P/MRP 25kDa subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPP25
  • Applied Biological Materials Clones for RPP25
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25 Gene

No ASD Table

Relevant External Links for RPP25 Gene

GeneLoc Exon Structure for
RPP25
ECgene alternative splicing isoforms for
RPP25

Expression for RPP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP25 Gene

This gene is overexpressed in Breast (28.7), Lung (20.3), and Pancreas (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP25 Gene



Protein tissue co-expression partners for RPP25 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPP25 Gene:

RPP25

SOURCE GeneReport for Unigene cluster for RPP25 Gene:

Hs.8562

Evidence on tissue expression from TISSUES for RPP25 Gene

  • Skin(4.6)
  • Nervous system(4.6)
  • Lung(2.6)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with RPP25: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPP25 Gene

Orthologs for RPP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP25 33 34
  • 98.66 (n)
cow
(Bos Taurus)
Mammalia RPP25 34 33
  • 89.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPP25 33
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Rpp25 33
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Rpp25 16 34 33
  • 86.26 (n)
chicken
(Gallus gallus)
Aves RPP25 34 33
  • 65.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP25 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp25 33
  • 55.71 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885168 33
  • 63.1 (n)
rpp25l 34
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9422 34
  • 31 (a)
OneToMany
Species where no ortholog for RPP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25 Gene

ENSEMBL:
Gene Tree for RPP25 (if available)
TreeFam:
Gene Tree for RPP25 (if available)

Paralogs for RPP25 Gene

Paralogs for RPP25 Gene

(1) SIMAP similar genes for RPP25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25: view

Variants for RPP25 Gene

Sequence variations from dbSNP and Humsavar for RPP25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000079190 -- 74,958,314(+) GGGGT(C/T)TGAGA upstream-variant-2KB
rs1000193348 -- 74,958,036(+) ATGCA(C/T)TGCAT upstream-variant-2KB
rs1001254326 -- 74,957,886(+) GCTGA(A/G)GGCTG upstream-variant-2KB
rs1001362948 -- 74,955,224(+) CTGGA(A/G)GGGAG utr-variant-3-prime
rs1001769015 -- 74,957,608(+) GAGAT(A/C)CAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPP25 Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv1612 CNV deletion 18451855
nsv569993 CNV gain 21841781

Variation tolerance for RPP25 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP25 Gene

Disorders for RPP25 Gene

Relevant External Links for RPP25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP25

No disorders were found for RPP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP25 Gene

Publications for RPP25 Gene

  1. Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. (PMID: 12003489) Guerrier-Takada C … Altman S (RNA (New York, N.Y.) 2002) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting TJ … Pruijn GJ (Nucleic acids research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RPP25 Gene

  • Addgene plasmids for RPP25

Sources for RPP25 Gene

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