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Aliases for RPP25 Gene

Aliases for RPP25 Gene

  • Ribonuclease P/MRP 25kDa Subunit 2 3
  • RNase P Protein Subunit P25 2 4
  • Ribonuclease P 25kDa Subunit 2
  • EC 3.1.26.5 4

External Ids for RPP25 Gene

Previous GeneCards Identifiers for RPP25 Gene

  • GC15M072964
  • GC15M073034
  • GC15M075247
  • GC15M052044

Summaries for RPP25 Gene

GeneCards Summary for RPP25 Gene

RPP25 (Ribonuclease P/MRP 25kDa Subunit) is a Protein Coding gene. Diseases associated with RPP25 include cartilage-hair hypoplasia and autism spectrum disorder. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and ribonuclease P activity. An important paralog of this gene is RPP25L.

UniProtKB/Swiss-Prot for RPP25 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP25 Gene

Genomics for RPP25 Gene

Regulatory Elements for RPP25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPP25 Gene

Start:
74,954,416 bp from pter
End:
74,957,464 bp from pter
Size:
3,049 bases
Orientation:
Minus strand

Genomic View for RPP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP25 Gene

Proteins for RPP25 Gene

  • Protein details for RPP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUL9-RPP25_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p25
    Protein Accession:
    Q9BUL9
    Secondary Accessions:
    • D3DW70
    • Q9NX88

    Protein attributes for RPP25 Gene

    Size:
    199 amino acids
    Molecular mass:
    20632 Da
    Quaternary structure:
    • Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.

neXtProt entry for RPP25 Gene

Proteomics data for RPP25 Gene at MOPED

Post-translational modifications for RPP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPP25 Gene

Domains for RPP25 Gene

Protein Domains for RPP25 Gene

Suggested Antigen Peptide Sequences for RPP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUL9

UniProtKB/Swiss-Prot:

RPP25_HUMAN :
  • Q9BUL9
Family:
  • Belongs to the histone-like Alba family.
genes like me logo Genes that share domains with RPP25: view

No data available for Gene Families for RPP25 Gene

Function for RPP25 Gene

Molecular function for RPP25 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP. This subunit binds to RNA

Enzyme Numbers (IUBMB) for RPP25 Gene

Gene Ontology (GO) - Molecular Function for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004526 ribonuclease P activity IEA --
GO:0005515 protein binding IPI 15096576
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPP25: view

Phenotypes for RPP25 Gene

GenomeRNAi human phenotypes for RPP25:
genes like me logo Genes that share phenotypes with RPP25: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPP25 Gene

Localization for RPP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP25 Gene COMPARTMENTS Subcellular localization image for RPP25 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with RPP25: view

Pathways for RPP25 Gene

genes like me logo Genes that share pathways with RPP25: view

Pathways by source for RPP25 Gene

2 KEGG pathways for RPP25 Gene

Gene Ontology (GO) - Biological Process for RPP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP25: view

Transcripts for RPP25 Gene

mRNA/cDNA for RPP25 Gene

(232) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP25 Gene

Ribonuclease P/MRP 25kDa subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP25

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP25 Gene

No ASD Table

Relevant External Links for RPP25 Gene

GeneLoc Exon Structure for
RPP25
ECgene alternative splicing isoforms for
RPP25

Expression for RPP25 Gene

mRNA expression in normal human tissues for RPP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP25 Gene

SOURCE GeneReport for Unigene cluster for RPP25 Gene Hs.8562

genes like me logo Genes that share expressions with RPP25: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP25 Gene

Orthologs for RPP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP25 35
  • 98.66 (n)
  • 97.99 (a)
RPP25 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPP25 35
  • 89.61 (n)
  • 90.95 (a)
RPP25 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP25 35
  • 87.86 (n)
  • 88.72 (a)
mouse
(Mus musculus)
Mammalia Rpp25 35
  • 86.26 (n)
  • 87.94 (a)
Rpp25 16
Rpp25 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp25 35
  • 87.44 (n)
  • 88.44 (a)
chicken
(Gallus gallus)
Aves RPP25 35
  • 65.95 (n)
  • 62.14 (a)
RPP25 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP25 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp25 35
  • 55.71 (n)
  • 52.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885168 35
  • 63.1 (n)
  • 57.86 (a)
rpp25l 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9422 36
  • 31 (a)
OneToMany
Species with no ortholog for RPP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP25 Gene

ENSEMBL:
Gene Tree for RPP25 (if available)
TreeFam:
Gene Tree for RPP25 (if available)

Paralogs for RPP25 Gene

Paralogs for RPP25 Gene

Selected SIMAP similar genes for RPP25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP25: view

Variants for RPP25 Gene

Sequence variations from dbSNP and Humsavar for RPP25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs11540265 -- 74,956,674(-) CCCCT(C/G)CTGGC utr-variant-5-prime
rs11540266 -- 74,955,414(-) CACCC(A/C)TTTTC utr-variant-3-prime
rs12440707 -- 74,954,604(+) CCCCA(A/C)CCCCC downstream-variant-500B
rs12912343 -- 74,958,700(+) TCTTA(C/G)CACTT upstream-variant-2KB
rs12912688 -- 74,958,960(+) AGAAA(A/G)AGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPP25 Gene

Variant ID Type Subtype PubMed ID
nsv1612 CNV Loss 18451855

Relevant External Links for RPP25 Gene

HapMap Linkage Disequilibrium report
RPP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP25 Gene

Disorders for RPP25 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RPP25 Gene including...

Search for RPP25 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RPP25 Gene

genes like me logo Genes that share disorders with RPP25: view

No data available for UniProtKB/Swiss-Prot for RPP25 Gene

Publications for RPP25 Gene

  1. Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. (PMID: 12003489) Guerrier-Takada C. … Altman S. (RNA 2002) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RPP25 Gene

Sources for RPP25 Gene

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