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Aliases for RPP21 Gene

Aliases for RPP21 Gene

  • Ribonuclease P/MRP Subunit P21 2 3 5
  • Ribonuclease P/MRP 21kDa Subunit 2 3
  • Ribonucleoprotein V 3 4
  • RNaseP Protein P21 3 4
  • C6orf135 3 4
  • CAT60 3 4
  • Chromosome 6 Open Reading Frame 135 2
  • Ribonuclease P Protein Subunit P21 3
  • Ribonuclease P/MRP 21 KDa Subunit 4
  • Ribonuclease P 21kDa Subunit 2
  • EC 4

External Ids for RPP21 Gene

Previous HGNC Symbols for RPP21 Gene

  • C6orf135

Previous GeneCards Identifiers for RPP21 Gene

  • GC06P030420
  • GC06P030312
  • GC06P030111

Summaries for RPP21 Gene

Entrez Gene Summary for RPP21 Gene

  • RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

GeneCards Summary for RPP21 Gene

RPP21 (Ribonuclease P/MRP Subunit P21) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP21 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Additional gene information for RPP21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP21 Gene

Genomics for RPP21 Gene

Regulatory Elements for RPP21 Gene

Enhancers for RPP21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031137 1.3 Ensembl ENCODE 10.9 +792.6 792573 0.6 HDGF PKNOX1 ATF1 ARNT ARID4B DMAP1 ZNF2 GLIS2 ZNF143 ATF7 PSORS1C2 PSORS1C1 HCG18 HCG27 ZBTB12 RPP21 PRR3 GTF2H4 DXO HLA-C
GH06H030907 1.2 ENCODE 10.9 +563.3 563329 2.2 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A MEF2D MDC1 GTF2H4 TRIM39 LY6G5B LSM2 DDX39B HCG18 PPP1R10 ENSG00000233892 DHX16
GH06H030162 1.1 ENCODE 11 -181.4 -181364 2.8 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF302 SP3 SP5 ZC3H11A MXD4 MDC1 HCG18 GTF2H4 ZNRD1ASP TRIM39 PPP1R10 HLA-U ETF1P1 ERVK9-12 ENSG00000233892
GH06H030500 1 Ensembl ENCODE dbSUPER 4.9 +155.7 155672 0.8 ELF3 PRDM1 TEAD3 GNL1 PRR3 ABCF1 MIR877 RPP21 HLA-E LINC02569
GH06H030746 2 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +406.3 406299 9.5 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZNF766 FOS DEK PAF1 MDC1 IER3 GTF2H4 ENSG00000233892 LY6G5B DHX16 DDX39B TRIM39 PPP1R10 HLA-K
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPP21 on UCSC Golden Path with GeneCards custom track

Promoters for RPP21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195388 271 1201 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PAF1 SP3

Genomic Locations for RPP21 Gene

Genomic Locations for RPP21 Gene
1,756 bases
Plus strand

Genomic View for RPP21 Gene

Genes around RPP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RPP21 Gene

  • Protein details for RPP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease P protein subunit p21
    Protein Accession:
    Secondary Accessions:
    • A2AAZ8
    • B0S834
    • B0S835
    • Q5JPL9
    • Q5JPM1
    • Q5STF8
    • Q5STF9
    • Q5STG2
    • Q5SU41
    • Q5SU42
    • Q86Y49
    • Q86Y50
    • Q86Y51
    • Q96F16

    Protein attributes for RPP21 Gene

    154 amino acids
    Molecular mass:
    17570 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
    • Sequence=BI598757; Type=Erroneous termination; Positions=155; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPP21 Gene


neXtProt entry for RPP21 Gene

Post-translational modifications for RPP21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP21 Gene

No data available for DME Specific Peptides for RPP21 Gene

Domains & Families for RPP21 Gene

Gene Families for RPP21 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RPP21 Gene


Suggested Antigen Peptide Sequences for RPP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
  • Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
genes like me logo Genes that share domains with RPP21: view

Function for RPP21 Gene

Molecular function for RPP21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Enzyme Numbers (IUBMB) for RPP21 Gene

Phenotypes From GWAS Catalog for RPP21 Gene

Gene Ontology (GO) - Molecular Function for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 contributes_to ribonuclease P activity IDA,IEA 16723659
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPP21: view

Phenotypes for RPP21 Gene

genes like me logo Genes that share phenotypes with RPP21: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPP21 Gene

Localization for RPP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP21 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP21 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005655 nucleolar ribonuclease P complex IBA --
GO:0005730 nucleolus IEA --
GO:0030681 multimeric ribonuclease P complex IDA 16723659
genes like me logo Genes that share ontologies with RPP21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RPP21 Gene

Pathways & Interactions for RPP21 Gene

genes like me logo Genes that share pathways with RPP21: view

Gene Ontology (GO) - Biological Process for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IBA --
GO:0042493 response to drug IEP 18291362
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RPP21: view

No data available for SIGNOR curated interactions for RPP21 Gene

Drugs & Compounds for RPP21 Gene

No Compound Related Data Available

Transcripts for RPP21 Gene

mRNA/cDNA for RPP21 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP21 Gene

Ribonuclease P/MRP 21kDa subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP21 Gene

No ASD Table

Relevant External Links for RPP21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPP21 Gene

Protein differential expression in normal tissues from HIPED for RPP21 Gene

This gene is overexpressed in Lung (44.6), Testis (14.4), and Heart (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP21 Gene

Protein tissue co-expression partners for RPP21 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPP21 Gene:


SOURCE GeneReport for Unigene cluster for RPP21 Gene:


Evidence on tissue expression from TISSUES for RPP21 Gene

  • Intestine(4.4)
  • Skin(4.4)
  • Nervous system(4.3)
  • Spleen(4.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RPP21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPP21 Gene

Orthologs for RPP21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPP21 33 34
  • 99.13 (n)
(Canis familiaris)
Mammalia RPP21 34 33
  • 88.74 (n)
(Rattus norvegicus)
Mammalia Rpp21 33
  • 82.53 (n)
(Mus musculus)
Mammalia Rpp21 16 34 33
  • 81.84 (n)
(Monodelphis domestica)
Mammalia RPP21 34
  • 75 (a)
(Anolis carolinensis)
Reptilia RPP21 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp21 33
  • 57.85 (n)
Str.10978 33
(Danio rerio)
Actinopterygii rpp21 34 33
  • 58.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5673 34
  • 36 (a)
Species where no ortholog for RPP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP21 Gene

Gene Tree for RPP21 (if available)
Gene Tree for RPP21 (if available)

Paralogs for RPP21 Gene

(1) SIMAP similar genes for RPP21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP21: view

No data available for Paralogs for RPP21 Gene

Variants for RPP21 Gene

Sequence variations from dbSNP and Humsavar for RPP21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000849666 -- 30,343,376(+) TTGCT(G/T)GTTTG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001659756 -- 30,344,072(+) GTCTC(A/G)AACTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002989312 -- 30,346,033(+) TGCTC(A/G)CTTAC intron-variant
rs1003345190 -- 30,343,849(+) TGGGC(C/T)GGACA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003822 -- 30,345,104(-) CGCGA(A/G)GCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPP21 Gene

Variant ID Type Subtype PubMed ID
nsv601264 CNV loss 21841781
nsv5241 CNV insertion 18451855
nsv1144137 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3411275 CNV duplication 20981092

Variation tolerance for RPP21 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP21 Gene

Disorders for RPP21 Gene

Relevant External Links for RPP21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP21 Gene

Publications for RPP21 Gene

  1. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. (PMID: 11497433) Jarrous N … Altman S (RNA (New York, N.Y.) 2001) 3 4 22 60
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RPP21 Gene

Sources for RPP21 Gene

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