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Aliases for RPP21 Gene

Aliases for RPP21 Gene

  • Ribonuclease P/MRP 21kDa Subunit 2 3
  • Ribonucleoprotein V 3 4
  • RNaseP Protein P21 3 4
  • C6orf135 3 4
  • CAT60 3 4
  • Chromosome 6 Open Reading Frame 135 2
  • Ribonuclease P Protein Subunit P21 3
  • Ribonuclease P/MRP 21 KDa Subunit 4
  • Ribonuclease P 21kDa Subunit 2
  • EC 4

External Ids for RPP21 Gene

Previous Symbols for RPP21 Gene

  • C6orf135

Summaries for RPP21 Gene

Entrez Gene Summary for RPP21 Gene

  • RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

GeneCards Summary for RPP21 Gene

RPP21 (Ribonuclease P/MRP 21kDa Subunit) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP21 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP21 Gene

Genomics for RPP21 Gene

Genomic Location for RPP21 Gene

30,345,129 bp from pter
30,346,884 bp from pter
1,756 bases
Plus strand

Genomic View for RPP21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for RPP21 Gene

Proteins for RPP21 Gene

  • Protein details for RPP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease P protein subunit p21
    Protein Accession:
    Secondary Accessions:
    • A2AAZ8
    • B0S834
    • B0S835
    • Q5JPL9
    • Q5JPM1
    • Q5STF8
    • Q5STF9
    • Q5STG2
    • Q5SU41
    • Q5SU42
    • Q86Y49
    • Q86Y50
    • Q86Y51
    • Q96F16

    Protein attributes for RPP21 Gene

    154 amino acids
    Molecular mass:
    17570 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40
    • Sequence=BI598757; Type=Erroneous termination; Positions=155; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPP21 Gene


neXtProt entry for RPP21 Gene

Proteomics data for RPP21 Gene at MOPED

Post-translational modifications for RPP21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP21 Gene

No data available for DME Specific Peptides for RPP21 Gene

Domains for RPP21 Gene

Protein Domains for RPP21 Gene


Suggested Antigen Peptide Sequences for RPP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic/archaeal RNase P protein component 4 family.:
    • Q9H633
genes like me logo Genes that share domains with RPP21: view

No data available for Gene Families for RPP21 Gene

Function for RPP21 Gene

Molecular function for RPP21 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Enzyme Numbers (IUBMB) for RPP21 Gene

Gene Ontology (GO) - Molecular Function for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004526 contributes_to ribonuclease P activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPP21: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPP21 Gene

Localization for RPP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP21 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RPP21 Gene COMPARTMENTS Subcellular localization image for RPP21 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005655 nucleolar ribonuclease P complex IBA --
genes like me logo Genes that share ontologies with RPP21: view

Pathways for RPP21 Gene

SuperPathways for RPP21 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RPP21: view

Pathways by source for RPP21 Gene

1 KEGG pathway for RPP21 Gene

Gene Ontology (GO) - Biological Process for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IBA --
GO:0042493 response to drug IEP 18291362
GO:0090501 RNA phosphodiester bond hydrolysis IBA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP21: view

Transcripts for RPP21 Gene

mRNA/cDNA for RPP21 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP21 Gene

Ribonuclease P/MRP 21kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP21 Gene

No ASD Table

Relevant External Links for RPP21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPP21 Gene

mRNA expression in normal human tissues for RPP21 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP21 Gene

SOURCE GeneReport for Unigene cluster for RPP21 Gene Hs.183232

genes like me logo Genes that share expressions with RPP21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP21 Gene

Orthologs for RPP21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPP21 35
  • 99.13 (n)
  • 98.7 (a)
RPP21 36
  • 86 (a)
(Canis familiaris)
Mammalia RPP21 35
  • 88.74 (n)
  • 87.66 (a)
RPP21 36
  • 56 (a)
(Mus musculus)
Mammalia Rpp21 35
  • 81.84 (n)
  • 84.14 (a)
Rpp21 16
Rpp21 36
  • 81 (a)
(Monodelphis domestica)
Mammalia RPP21 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Rpp21 35
  • 82.53 (n)
  • 84.14 (a)
(Anolis carolinensis)
Reptilia RPP21 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp21 35
  • 57.85 (n)
  • 66.12 (a)
Str.10978 35
(Danio rerio)
Actinopterygii rpp21 35
  • 58.4 (n)
  • 66.94 (a)
rpp21 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5673 36
  • 36 (a)
Species with no ortholog for RPP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP21 Gene

Gene Tree for RPP21 (if available)
Gene Tree for RPP21 (if available)

Paralogs for RPP21 Gene

Selected SIMAP similar genes for RPP21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP21: view

No data available for Paralogs for RPP21 Gene

Variants for RPP21 Gene

Sequence variations from dbSNP and Humsavar for RPP21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_019116 -
VAR_045986 -

Structural Variations from Database of Genomic Variants (DGV) for RPP21 Gene

Variant ID Type Subtype PubMed ID
nsv5241 CNV Insertion 18451855

Relevant External Links for RPP21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP21 Gene

Disorders for RPP21 Gene

(1) University of Copenhagen DISEASES for RPP21 Gene

Relevant External Links for RPP21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPP21: view

No data available for UniProtKB/Swiss-Prot for RPP21 Gene

Publications for RPP21 Gene

  1. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. (PMID: 11497433) Jarrous N. … Altman S. (RNA 2001) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PMID: 15096576) Welting T.J. … Pruijn G.J. (Nucleic Acids Res. 2004) 3

Products for RPP21 Gene

Sources for RPP21 Gene

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