RPP21 Gene
protein-coding GIFtS: 47
GCID: GC06P030312
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|
ribonuclease P/MRP 21kDa subunit(Previous names: chromosome 6 open reading frame 135, ribonuclease P 21kDa...)
(Previous symbol: C6orf135)
| |
Aliases
for RPP21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease P/MRP 21kDa Subunit1 2 | | FLJ226381 | | C6orf1351 2 3 | | Chromosome 6 Open Reading Frame 1351 | | Ribonucleoprotein V2 3 | | Ribonuclease P 21kDa Subunit1 | | CAT602 3 | | Ribonuclease P Protein Subunit P212 | | RNaseP Protein P212 3 | | EC 3.1.26.53 | | Em:AB014085.31 | | Ribonuclease P/MRP 21 KDa Subunit3 |
Export aliases for RPP21 gene to outside databasesPrevious GC identifers: GC06P030420 GC06P030111 |
Summaries
for RPP21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPP21:
RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs(Jarrous et al., 2001 (PubMed 11497433)).(supplied by OMIM, Jan 2009)
UniProtKB/Swiss-Prot: RPP21_HUMAN, Q9H633Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends
|
Genomic Views
for RPP21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167248.1
- NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPP21 gene promoter:
E2F-4 E2F-3a E2F-5 p53 Nkx2-5 E2F-2 PPAR-gamma1 E2F E2F-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPP21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPP21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.32RPP21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P030312: view genomic region
(about GC identifiers)
Start:
|
30,312,908 bp from pter |
End:
|
30,314,661 bp from pter |
Size:
|
1,754 bases |
Orientation:
|
plus strand |
6 alternative locations:
| Chr6+,ALT_REF_LOCI_6 30,302,412-30,339,717 | Chr6+,ALT_REF_LOCI_3 30,303,165-30,315,927 | Chr6+,ALT_REF_LOCI_2 30,302,714-30,343,626 | | Chr6+,ALT_REF_LOCI_4 30,280,673-30,282,368 | Chr6+,ALT_REF_LOCI_1 30,321,146-30,331,170 | Chr6+,ALT_REF_LOCI_7 30,232,380-30,234,075 | |
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Proteins
for RPP21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RPP21_HUMAN, Q9H633 (See
protein sequence)Recommended Name: Ribonuclease P protein subunit p21 Size: 154 amino acids; 17570 Da
Subunit: RNase P consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25,RPP29/POP4, RPP30, RPP38 and RPP40
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BI598757; Type=Erroneous termination; Positions=155; Note=Translated as stop;
Secondary accessions: A2AAZ8 B0S834 B0S835 Q5JPL9 Q5JPM1 Q5STF8 Q5STF9 Q5STG2 Q5SU41 Q5SU42 Q86Y49Q86Y50 Q86Y51 Q96F16Alternative splicing: 4 isoforms: Q9H633-1 Q9H633-2 Q9H633-3 Q9H633-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RPP21: NX_Q9H633
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H633
RPP21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186049.1 NP_001186050.1 NP_079115.1
ENSEMBL proteins: ENSP00000409799 ENSP00000403833 ENSP00000394320 ENSP00000397778
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
RPP21 for ontologies About GeneDecksing
RPP21 Antibody Products:
Assay Products for RPP21: |
Protein
Domains /
Families
for RPP21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPP21 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H633ProtoNet protein and cluster: Q9H633 UniProtKB/Swiss-Prot: RPP21_HUMAN, Q9H633Similarity: Belongs to the eukaryotic/archaeal RNase P protein component 4 family |
Function
for RPP21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RPP21_HUMAN, Q9H633Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-endsCatalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursorEnzyme Number (IUBMB): EC 3.1.26.51
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPP21 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): RPP21 (NM_198399) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004526 | ribonuclease P activity |
IEA | -- |
RPP21 for ontologies About GeneDecksing
|
Pathways & Interactions
for RPP21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for RPP21):
RPP21 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPP21
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for RPP21 (Q9H6333 ENSP000004038334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RPP21 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPP21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPP21
Search CenterWatch for drugs/clinical trials and news about RPP21
|
Transcripts
for RPP21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPP21 gene (3 alternative transcripts): NM_001199120.1 NM_001199121.1 NM_024839.2 Unigene Cluster for RPP21: Ribonuclease P/MRP 21kDa subunit Hs.183232 [show with all ESTs]Unigene Representative Sequence: BG4712989 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433076(uc003nqf.2 uc021yuc.1 uc003nqe.2) ENST00000466327
ENST00000498414 ENST00000489124 ENST00000491477 ENST00000473266 ENST00000442966
ENST00000428040(uc003nqd.2) ENST00000436442
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPP21 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPP21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): RPP21 (NM_198399) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPP21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP21 |
Additional cDNA sequence: AF212152.2 AJ504713.1 AJ504716.1 AK026291.1 BC011730.2 9 DOTS entries: DT.451748 DT.91698120 DT.100790826 DT.102843763 DT.121346198 DT.100790827 DT.121346194 DT.95068940 DT.95159558 9 AceView cDNA sequences: CR594375 AK026291 NM_024839 AF212152 AJ504715 BC011730 AJ504714 AJ504713 AJ504716
GeneLoc Exon Structure
|
Expression
for RPP21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPP21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGCGCAGC
About this image
See RPP21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPP21
SOURCE GeneReport for Unigene cluster: Hs.183232
SABiosciences Custom PCR Arrays for RPP21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPP21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPP21 |
Orthologs
for RPP21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RPP21 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rpp211 , 5 |
ribonuclease P 21 subunit (human)5
ribonuclease P 21 subunit1 |
81.94(n)1
84.72(a)1 |
|
17 (19.01 cM)5
676761 NM_026308.21 NP_080584.11
362556455 |
lizard
(Anolis carolinensis) |
Reptilia |
RPP216 |
-- |
62(a) |
1 ↔ 1 |
2(192236605-192243837) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.109782 |
Transcribed sequence with weak similarity to protein more |
71.29(n) |
|
137727054 |
zebrafish
(Danio rerio) |
Actinopterygii |
rpp211 |
ribonuclease P 21 subunit |
58.68(n)
67.77(a) |
|
445136 NM_001003530.1 NP_001003530.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG330826 |
-- |
17(a) |
1 ↔ 1 |
X(924791-925645) |
ENSEMBL Gene Tree for RPP21 (if available)
TreeFam Gene Tree for RPP21 (if available) |
Paralogs
for RPP21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RPP21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPP21 (30312908 - 30314661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPP21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPP21 |
|
Disorders
/ Diseases
for RPP21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPP21 for disorders About GeneDecksing
OMIM gene information: 612524
OMIM disorders: --
5  diseases for RPP21: About MalaCardsacute monocytic leukemia systemic lupus erythematosus lupus erythematosus monocytic leukemia
leukemia
1 disease from the University of Copenhagen DISEASES database for RPP21:Eating disorder Human Genome Epidemiology (HuGE) Navigator: RPP21 (2 documents)
Export disorders for RPP21 gene to outside databases
|
Publications
for RPP21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPP21 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RPP21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. (PubMed id 11497433)1, 2, 9 Jarrous N....Altman S. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Sulindac suppresses beta-catenin expression in human cancer cells. (PubMed id 18291362)1 Han A....Yang W. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein. (PubMed id 17601797)1 Roberts J.D.Jr.... Bloch K.D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex. (PubMed id 15096576)1 Welting T.J.... Pruijn G.J. (2004)
|
External Searches for RPP21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPP21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPP21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPP21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPP21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPP21 gene:
Search GeneIP for patents involving RPP21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPP21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPP21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPP21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPP21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPP21 |
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| |  |  |  |  | | | | |
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 | | | RPP21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RPP21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPP21 |
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