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Aliases for RPP21 Gene

Aliases for RPP21 Gene

  • Ribonuclease P/MRP Subunit P21 2 3
  • Ribonuclease P/MRP 21kDa Subunit 2 3 5
  • Ribonucleoprotein V 3 4
  • RNaseP Protein P21 3 4
  • C6orf135 3 4
  • CAT60 3 4
  • Chromosome 6 Open Reading Frame 135 2
  • Ribonuclease P/MRP 21 KDa Subunit 4
  • Ribonuclease P 21kDa Subunit 2
  • EC 3.1.26.5 4

External Ids for RPP21 Gene

Previous HGNC Symbols for RPP21 Gene

  • C6orf135

Previous GeneCards Identifiers for RPP21 Gene

  • GC06P030420
  • GC06P030312
  • GC06P030111

Summaries for RPP21 Gene

Entrez Gene Summary for RPP21 Gene

  • RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

GeneCards Summary for RPP21 Gene

RPP21 (Ribonuclease P/MRP Subunit P21) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP21 Gene

  • Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP21 Gene

Genomics for RPP21 Gene

Regulatory Elements for RPP21 Gene

Enhancers for RPP21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPP21 on UCSC Golden Path with GeneCards custom track

Promoters for RPP21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPP21 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPP21 Gene

Chromosome:
6
Start:
30,345,129 bp from pter
End:
30,346,884 bp from pter
Size:
1,756 bases
Orientation:
Plus strand

Genomic View for RPP21 Gene

Genes around RPP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RPP21 Gene

  • Protein details for RPP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H633-RPP21_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p21
    Protein Accession:
    Q9H633
    Secondary Accessions:
    • A2AAZ8
    • B0S834
    • B0S835
    • Q5JPL9
    • Q5JPM1
    • Q5STF8
    • Q5STF9
    • Q5STG2
    • Q5SU41
    • Q5SU42
    • Q86Y49
    • Q86Y50
    • Q86Y51
    • Q96F16

    Protein attributes for RPP21 Gene

    Size:
    154 amino acids
    Molecular mass:
    17570 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
    SequenceCaution:
    • Sequence=BI598757; Type=Erroneous termination; Positions=155; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPP21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPP21 Gene

Proteomics data for RPP21 Gene at MOPED

Post-translational modifications for RPP21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP21 Gene

No data available for DME Specific Peptides for RPP21 Gene

Domains & Families for RPP21 Gene

Protein Domains for RPP21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H633

UniProtKB/Swiss-Prot:

RPP21_HUMAN :
  • Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
Family:
  • Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
genes like me logo Genes that share domains with RPP21: view

No data available for Gene Families for RPP21 Gene

Function for RPP21 Gene

Molecular function for RPP21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Enzyme Numbers (IUBMB) for RPP21 Gene

Phenotypes for RPP21 Gene

genes like me logo Genes that share phenotypes with RPP21: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPP21 Gene

Localization for RPP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP21 Gene

Nucleus, nucleolus.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RPP21 Gene

Pathways & Interactions for RPP21 Gene

genes like me logo Genes that share pathways with RPP21: view

Pathways by source for RPP21 Gene

Gene Ontology (GO) - Biological Process for RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0010467 gene expression TAS --
GO:0090501 RNA phosphodiester bond hydrolysis IBA --
genes like me logo Genes that share ontologies with RPP21: view

No data available for SIGNOR curated interactions for RPP21 Gene

Drugs & Compounds for RPP21 Gene

No Compound Related Data Available

Transcripts for RPP21 Gene

mRNA/cDNA for RPP21 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPP21 Gene

Ribonuclease P/MRP 21kDa subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPP21 Gene

No ASD Table

Relevant External Links for RPP21 Gene

GeneLoc Exon Structure for
RPP21
ECgene alternative splicing isoforms for
RPP21

Expression for RPP21 Gene

mRNA expression in normal human tissues for RPP21 Gene

Protein differential expression in normal tissues from HIPED for RPP21 Gene

This gene is overexpressed in Lung (44.6), Testis (14.4), and Heart (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP21 Gene



SOURCE GeneReport for Unigene cluster for RPP21 Gene Hs.183232

genes like me logo Genes that share expression patterns with RPP21: view

Protein tissue co-expression partners for RPP21 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPP21 Gene

Orthologs for RPP21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RPP21 35
  • 88.74 (n)
  • 87.66 (a)
RPP21 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpp21 35
  • 81.84 (n)
  • 84.14 (a)
Rpp21 16
Rpp21 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPP21 35
  • 99.13 (n)
  • 98.7 (a)
RPP21 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp21 35
  • 82.53 (n)
  • 84.14 (a)
oppossum
(Monodelphis domestica)
Mammalia RPP21 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP21 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp21 35
  • 57.85 (n)
  • 66.12 (a)
Str.10978 35
zebrafish
(Danio rerio)
Actinopterygii rpp21 35
  • 58.4 (n)
  • 66.94 (a)
rpp21 36
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5673 36
  • 36 (a)
OneToOne
Species with no ortholog for RPP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP21 Gene

ENSEMBL:
Gene Tree for RPP21 (if available)
TreeFam:
Gene Tree for RPP21 (if available)

Paralogs for RPP21 Gene

(1) SIMAP similar genes for RPP21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPP21: view

No data available for Paralogs for RPP21 Gene

Variants for RPP21 Gene

Sequence variations from dbSNP and Humsavar for RPP21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_019116 -
VAR_045986 -

Structural Variations from Database of Genomic Variants (DGV) for RPP21 Gene

Variant ID Type Subtype PubMed ID
nsv5241 CNV Insertion 18451855

Variation tolerance for RPP21 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPP21 Gene

Disorders for RPP21 Gene

Relevant External Links for RPP21

Genetic Association Database (GAD)
RPP21
Human Genome Epidemiology (HuGE) Navigator
RPP21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP21

No disorders were found for RPP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP21 Gene

Publications for RPP21 Gene

  1. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. (PMID: 11497433) Jarrous N. … Altman S. (RNA 2001) 3 4 23 67
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3
  3. Sulindac suppresses beta-catenin expression in human cancer cells. (PMID: 18291362) Han A. … Yang W. (Eur. J. Pharmacol. 2008) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein. (PMID: 17601797) Roberts J.D.Jr. … Bloch K.D. (Am. J. Physiol. Lung Cell. Mol. Physiol. 2007) 3

Products for RPP21 Gene

Sources for RPP21 Gene

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