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Aliases for RPP14 Gene

Aliases for RPP14 Gene

  • Ribonuclease P/MRP Subunit P14 2 3 5
  • Ribonuclease P/MRP 14kDa Subunit 2 3
  • Ribonuclease P Protein Subunit P14 3
  • Ribonuclease P 14kDa Subunit 2
  • EC 3.1.26.5 4
  • P14 3

External Ids for RPP14 Gene

Previous GeneCards Identifiers for RPP14 Gene

  • GC03M057092
  • GC03P057660
  • GC03P058146
  • GC03P058249
  • GC03P058224
  • GC03P058267

Summaries for RPP14 Gene

Entrez Gene Summary for RPP14 Gene

  • This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

GeneCards Summary for RPP14 Gene

RPP14 (Ribonuclease P/MRP Subunit P14) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include RNA binding and ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP14 Gene

  • Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Gene Wiki entry for RPP14 Gene

Additional gene information for RPP14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP14 Gene

Genomics for RPP14 Gene

Regulatory Elements for RPP14 Gene

Enhancers for RPP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H058469 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.6 +165.4 165380 3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 FOS SP3 RPP14 PXK PDHB LOC105377110 KCTD6 ACOX2 HTD2 FAM107A ENSG00000243384 ENSG00000272182
GH03H058305 1.4 ENCODE dbSUPER 41.4 +1.1 1064 3 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 RPP14 ABHD6 PDHB ENSG00000273493 PXK HTD2 PIR62243
GH03H058382 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.7 +80.2 80155 6 TAF1 JUN MAX RAD21 ZNF664 CTBP1 GATA3 ZNF316 POLR2A FOS PXK RPP14 FAM107A HTD2 ACOX2 ENSG00000243384 PDHB FLNB-AS1 ENSG00000275607 ENSG00000272182
GH03H058419 1.2 Ensembl ENCODE dbSUPER 33.5 +114.0 114000 1 PKNOX1 CBFB ZBED1 JUNB ELF1 EBF1 BATF ZNF217 BCL11A ATF7 RPP14 PXK HTD2 FLNB-AS1 FLNB ABHD6 ENSG00000272182 ENSG00000275607
GH03H058248 1.3 Ensembl ENCODE dbSUPER 30.5 -56.3 -56349 2 HDGF SOX13 CTCF TBP DRAP1 FOXA2 SAP130 ARID4B MAX CEBPG RPP14 PXK ABHD6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPP14 on UCSC Golden Path with GeneCards custom track

Promoters for RPP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000153207 456 1800 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for RPP14 Gene

Chromosome:
3
Start:
58,306,245 bp from pter
End:
58,324,695 bp from pter
Size:
18,451 bases
Orientation:
Plus strand

Genomic View for RPP14 Gene

Genes around RPP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP14 Gene

Proteins for RPP14 Gene

  • Protein details for RPP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95059-RPP14_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p14
    Protein Accession:
    O95059
    Secondary Accessions:
    • Q53X97

    Protein attributes for RPP14 Gene

    Size:
    124 amino acids
    Molecular mass:
    13693 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
    Miscellaneous:
    • This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.

neXtProt entry for RPP14 Gene

Post-translational modifications for RPP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP14 Gene

No data available for DME Specific Peptides for RPP14 Gene

Domains & Families for RPP14 Gene

Gene Families for RPP14 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RPP14 Gene

Suggested Antigen Peptide Sequences for RPP14 Gene

Graphical View of Domain Structure for InterPro Entry

O95059

UniProtKB/Swiss-Prot:

RPP14_HUMAN :
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Family:
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
genes like me logo Genes that share domains with RPP14: view

Function for RPP14 Gene

Molecular function for RPP14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor.
UniProtKB/Swiss-Prot Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends.

Enzyme Numbers (IUBMB) for RPP14 Gene

Phenotypes From GWAS Catalog for RPP14 Gene

Gene Ontology (GO) - Molecular Function for RPP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 10024167
GO:0004526 contributes_to ribonuclease P activity IEA,IDA 16723659
GO:0004540 ribonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RPP14: view

Phenotypes for RPP14 Gene

GenomeRNAi human phenotypes for RPP14:
genes like me logo Genes that share phenotypes with RPP14: view

Animal Model Products

CRISPR Products

miRNA for RPP14 Gene

miRTarBase miRNAs that target RPP14

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPP14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPP14 Gene

Localization for RPP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPP14 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10024167
GO:0005654 nucleoplasm TAS --
GO:0030681 multimeric ribonuclease P complex IDA 16723659
genes like me logo Genes that share ontologies with RPP14: view

Pathways & Interactions for RPP14 Gene

genes like me logo Genes that share pathways with RPP14: view

Interacting Proteins for RPP14 Gene

Gene Ontology (GO) - Biological Process for RPP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5-leader removal TAS --
GO:0006364 rRNA processing TAS --
GO:0008033 tRNA processing IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP14: view

No data available for SIGNOR curated interactions for RPP14 Gene

Drugs & Compounds for RPP14 Gene

(1) Drugs for RPP14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with RPP14: view

Transcripts for RPP14 Gene

Unigene Clusters for RPP14 Gene

Ribonuclease P/MRP 14kDa subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPP14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPP14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - - - - - - - -

Relevant External Links for RPP14 Gene

GeneLoc Exon Structure for
RPP14
ECgene alternative splicing isoforms for
RPP14

Expression for RPP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPP14 Gene

This gene is overexpressed in Urine (39.0) and Breast (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPP14 Gene



Protein tissue co-expression partners for RPP14 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPP14 Gene:

RPP14

SOURCE GeneReport for Unigene cluster for RPP14 Gene:

Hs.446320

Evidence on tissue expression from TISSUES for RPP14 Gene

  • Kidney(4.2)
  • Liver(4.2)
  • Spleen(4.2)
  • Skin(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with RPP14: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPP14 Gene

Orthologs for RPP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPP14 34 33
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPP14 34 33
  • 90.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPP14 34 33
  • 90.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp14 33
  • 83.2 (n)
mouse
(Mus musculus)
Mammalia Rpp14 16 34 33
  • 82.92 (n)
oppossum
(Monodelphis domestica)
Mammalia RPP14 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPP14 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPP14 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP14 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp14 33
  • 63.66 (n)
Str.2080 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8204 33
zebrafish
(Danio rerio)
Actinopterygii rpp14 33 34
  • 60.68 (n)
Species where no ortholog for RPP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP14 Gene

ENSEMBL:
Gene Tree for RPP14 (if available)
TreeFam:
Gene Tree for RPP14 (if available)

Paralogs for RPP14 Gene

No data available for Paralogs for RPP14 Gene

Variants for RPP14 Gene

Sequence variations from dbSNP and Humsavar for RPP14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000274592 -- 58,308,684(+) TGGTT(G/T)TGAAA intron-variant
rs1000635913 -- 58,312,825(+) GCATG(G/T)TGGCG intron-variant
rs1000643635 -- 58,316,767(+) GAGAG(C/G)GCAAA intron-variant
rs1000969611 -- 58,317,989(+) TTTTA(C/G)CTTCT nc-transcript-variant, utr-variant-3-prime
rs1000990659 -- 58,318,553(+) TGTAG(C/T)CCCAG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPP14 Gene

Variant ID Type Subtype PubMed ID
dgv4748n100 CNV gain 25217958
esv3568768 CNV loss 25503493
nsv1001814 CNV gain 25217958
nsv1127962 CNV deletion 24896259
nsv528147 CNV gain 19592680
nsv590369 CNV loss 21841781

Variation tolerance for RPP14 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP14 Gene

Disorders for RPP14 Gene

Relevant External Links for RPP14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPP14

No disorders were found for RPP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPP14 Gene

Publications for RPP14 Gene

  1. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PMID: 10024167) Jarrous N … Altman S (RNA (New York, N.Y.) 1999) 2 3 4 22 60
  2. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. (PMID: 11929972) Jiang T … Altman S (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 22 60
  3. An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing. (PMID: 17898086) Autio KJ … Hiltunen JK (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RPP14 Gene

Sources for RPP14 Gene

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