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Aliases for RPP14 Gene

Aliases for RPP14 Gene

  • Ribonuclease P/MRP 14kDa Subunit 2 3
  • EC 4.2.1.- 4 4
  • 3-Hydroxyacyl-[Acyl-Carrier-Protein] Dehydratase 4
  • Ribonuclease P Protein Subunit P14 3
  • Ribonuclease P 14kDa Subunit 2
  • EC 3.1.26.5 4
  • HsHTD2 4
  • P14 3

External Ids for RPP14 Gene

Previous GeneCards Identifiers for RPP14 Gene

  • GC03M057092
  • GC03P057660
  • GC03P058146
  • GC03P058249
  • GC03P058224
  • GC03P058267

Summaries for RPP14 Gene

GeneCards Summary for RPP14 Gene

RPP14 (Ribonuclease P/MRP 14kDa Subunit) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include RNA binding and ribonuclease P activity.

UniProtKB/Swiss-Prot for RPP14 Gene

  • Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.

  • Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Gene Wiki entry for RPP14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPP14 Gene

Genomics for RPP14 Gene

Regulatory Elements for RPP14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPP14 Gene

Start:
58,306,245 bp from pter
End:
58,324,695 bp from pter
Size:
18,451 bases
Orientation:
Plus strand

Genomic View for RPP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPP14 Gene

Proteins for RPP14 Gene

  • Protein details for RPP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95059-RPP14_HUMAN
    Recommended name:
    Ribonuclease P protein subunit p14
    Protein Accession:
    O95059
    Secondary Accessions:
    • Q53X97

    Protein attributes for RPP14 Gene

    Size:
    124 amino acids
    Molecular mass:
    13693 Da
    Quaternary structure:
    • RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40
    Miscellaneous:
    • This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame
  • Protein details for RPP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86397-HTD2_HUMAN
    Recommended name:
    Hydroxyacyl-thioester dehydratase type 2, mitochondrial
    Protein Accession:
    P86397
    Secondary Accessions:

    Protein attributes for RPP14 Gene

    Size:
    168 amino acids
    Molecular mass:
    18559 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein is produced by a bicistronic gene which also produces the RPP14 protein from an overlapping reading frame.

    Three dimensional structures from OCA and Proteopedia for RPP14 Gene

neXtProt entry for RPP14 Gene

Proteomics data for RPP14 Gene at MOPED

Post-translational modifications for RPP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPP14 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RPP14

No data available for DME Specific Peptides for RPP14 Gene

Domains for RPP14 Gene

Protein Domains for RPP14 Gene

Suggested Antigen Peptide Sequences for RPP14 Gene

Graphical View of Domain Structure for InterPro Entry

P86397

UniProtKB/Swiss-Prot:

HTD2_HUMAN :
  • P86397
Domain:
  • Contains 1 MaoC-like domain.
Family:
  • Belongs to the HTD2 family.
  • Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
genes like me logo Genes that share domains with RPP14: view

No data available for Gene Families for RPP14 Gene

Function for RPP14 Gene

Molecular function for RPP14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(3R)-hydroxyacyl-CoA = trans-2-enoyl-CoA + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(3R)-hydroxyacyl-[acyl-carrier-protein] = trans-2-enoyl-[acyl-carrier-protein] + H(2)O.
UniProtKB/Swiss-Prot Function:
Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage of RNA, removing 5-extranucleotides from tRNA precursor
UniProtKB/Swiss-Prot Function:
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends

Enzyme Numbers (IUBMB) for RPP14 Gene

Gene Ontology (GO) - Molecular Function for RPP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 10024167
GO:0004526 ribonuclease P activity IEA --
GO:0004540 ribonuclease activity --
genes like me logo Genes that share ontologies with RPP14: view

Animal Model Products

miRNA for RPP14 Gene

miRTarBase miRNAs that target RPP14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP14

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPP14 Gene

Localization for RPP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPP14 Gene

Nucleus.
Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPP14 Gene COMPARTMENTS Subcellular localization image for RPP14 gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RPP14: view

Pathways for RPP14 Gene

SuperPathways for RPP14 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RPP14: view

Pathways by source for RPP14 Gene

1 KEGG pathway for RPP14 Gene

Gene Ontology (GO) - Biological Process for RPP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RPP14: view

Transcripts for RPP14 Gene

Unigene Clusters for RPP14 Gene

Ribonuclease P/MRP 14kDa subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPP14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPP14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - - - - - - - -

Relevant External Links for RPP14 Gene

GeneLoc Exon Structure for
RPP14
ECgene alternative splicing isoforms for
RPP14

Expression for RPP14 Gene

mRNA expression in normal human tissues for RPP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPP14 Gene

This gene is overexpressed in Urine (39.0) and Breast (20.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPP14 Gene

SOURCE GeneReport for Unigene cluster for RPP14 Gene Hs.446320

mRNA Expression by UniProt/SwissProt for RPP14 Gene

O95059-RPP14_HUMAN
Tissue specificity: Highly expressed in heart and liver. Expressed at lower levels in skeletal muscle, spleen, kidney and placenta.
genes like me logo Genes that share expressions with RPP14: view

Expression partners for RPP14 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RPP14 Gene

Orthologs for RPP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPP14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPP14 35
  • 90.32 (n)
  • 92.74 (a)
RPP14 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPP14 35
  • 90.86 (n)
  • 92.74 (a)
RPP14 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpp14 35
  • 82.92 (n)
  • 85.95 (a)
Rpp14 16
Rpp14 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPP14 35
  • 99.19 (n)
  • 100 (a)
RPP14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpp14 35
  • 83.2 (n)
  • 84.3 (a)
oppossum
(Monodelphis domestica)
Mammalia RPP14 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPP14 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPP14 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPP14 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpp14 35
  • 63.66 (n)
  • 65.57 (a)
Str.2080 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8204 35
zebrafish
(Danio rerio)
Actinopterygii rpp14 35
  • 60.68 (n)
  • 61.54 (a)
rpp14 36
  • 58 (a)
OneToOne
Species with no ortholog for RPP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPP14 Gene

ENSEMBL:
Gene Tree for RPP14 (if available)
TreeFam:
Gene Tree for RPP14 (if available)

Paralogs for RPP14 Gene

No data available for Paralogs for RPP14 Gene

Variants for RPP14 Gene

Sequence variations from dbSNP and Humsavar for RPP14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1427 -- 58,312,228(-) CCTCA(A/C)ACACT intron-variant
rs10687 -- 58,319,508(+) GACCA(G/T)TTTTT utr-variant-3-prime, nc-transcript-variant
rs10940 -- 58,319,414(-) AGTAG(C/T)TACTG utr-variant-3-prime, nc-transcript-variant
rs12688 -- 58,319,352(+) TGCCA(C/T)GTGGG utr-variant-3-prime, nc-transcript-variant
rs14927 -- 58,319,306(+) GTCTC(A/C)GTTAT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RPP14 Gene

Variant ID Type Subtype PubMed ID
nsv528147 CNV Gain 19592680

Relevant External Links for RPP14 Gene

HapMap Linkage Disequilibrium report
RPP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPP14 Gene

Disorders for RPP14 Gene

No disorders were found for RPP14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPP14 Gene

Publications for RPP14 Gene

  1. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (PMID: 10024167) Jarrous N. … Altman S. (RNA 1999) 2 3 4 23
  2. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. (PMID: 11929972) Jiang T. … Altman S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for RPP14 Gene

Sources for RPP14 Gene

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