Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPN2 Gene

Aliases for RPN2 Gene

  • Ribophorin II 2 3 4 5
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 63 KDa Subunit 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3
  • Ribophorin-2 3 4
  • RIBIIR 3 4
  • RPN-II 3 4
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 2 3
  • EC 2.4.1.119 61
  • EC 2.4.99.18 4
  • RPNII 3
  • SWP1 3

External Ids for RPN2 Gene

Previous GeneCards Identifiers for RPN2 Gene

  • GC20P035535
  • GC20P036445
  • GC20P036492
  • GC20P035240
  • GC20P035806
  • GC20P032542

Summaries for RPN2 Gene

Entrez Gene Summary for RPN2 Gene

  • This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for RPN2 Gene

RPN2 (Ribophorin II) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ribosome binding and dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

UniProtKB/Swiss-Prot for RPN2 Gene

  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Gene Wiki entry for RPN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPN2 Gene

Genomics for RPN2 Gene

Regulatory Elements for RPN2 Gene

Enhancers for RPN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPN2 on UCSC Golden Path with GeneCards custom track

Promoters for RPN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPN2 Gene

Chromosome:
20
Start:
37,178,410 bp from pter
End:
37,241,623 bp from pter
Size:
63,214 bases
Orientation:
Plus strand

Genomic View for RPN2 Gene

Genes around RPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPN2 Gene

Proteins for RPN2 Gene

  • Protein details for RPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04844-RPN2_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
    Protein Accession:
    P04844
    Secondary Accessions:
    • Q5JYR6
    • Q6IBA5
    • Q96E21
    • Q9BUQ3
    • Q9UBE1

    Protein attributes for RPN2 Gene

    Size:
    631 amino acids
    Molecular mass:
    69284 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains known members of the OST complex and may be a form of this complex.

    Alternative splice isoforms for RPN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPN2 Gene

Post-translational modifications for RPN2 Gene

  • Ubiquitination at Lys 154 and Lys 627
  • Glycosylation at Asn 106
  • Modification sites at PhosphoSitePlus

Domains & Families for RPN2 Gene

Gene Families for RPN2 Gene

Protein Domains for RPN2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P04844

UniProtKB/Swiss-Prot:

RPN2_HUMAN :
  • Belongs to the SWP1 family.
Family:
  • Belongs to the SWP1 family.
genes like me logo Genes that share domains with RPN2: view

Function for RPN2 Gene

Molecular function for RPN2 Gene

GENATLAS Biochemistry:
ribophorin II,69.5kDa,component with RPN1 and DDOST of N-oligosacccharyl transferase
UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
UniProtKB/Swiss-Prot Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Enzyme Numbers (IUBMB) for RPN2 Gene

Gene Ontology (GO) - Molecular Function for RPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity NAS 15835887
GO:0005515 protein binding IPI 24965446
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with RPN2: view
genes like me logo Genes that share phenotypes with RPN2: view

Animal Models for RPN2 Gene

MGI Knock Outs for RPN2:
  • Rpn2 tm1a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPN2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPN2 Gene

Localization for RPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPN2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPN2 Gene COMPARTMENTS Subcellular localization image for RPN2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
vacuole 3
extracellular 2
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005634 nucleus IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005791 rough endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RPN2: view

Pathways & Interactions for RPN2 Gene

genes like me logo Genes that share pathways with RPN2: view

UniProtKB/Swiss-Prot P04844-RPN2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for RPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10660554
GO:0006487 protein N-linked glycosylation IBA --
GO:0007568 aging IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with RPN2: view

No data available for SIGNOR curated interactions for RPN2 Gene

Drugs & Compounds for RPN2 Gene

(1) Drugs for RPN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra 0

(1) Additional Compounds for RPN2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
genes like me logo Genes that share compounds with RPN2: view

Transcripts for RPN2 Gene

Unigene Clusters for RPN2 Gene

Ribophorin II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - - -
SP8: - -
SP9:
SP10:
SP11:
SP12:

ExUns: 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RPN2 Gene

GeneLoc Exon Structure for
RPN2
ECgene alternative splicing isoforms for
RPN2

Expression for RPN2 Gene

mRNA expression in normal human tissues for RPN2 Gene

Protein differential expression in normal tissues from HIPED for RPN2 Gene

This gene is overexpressed in Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPN2 Gene



Protein tissue co-expression partners for RPN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPN2 Gene:

RPN2

SOURCE GeneReport for Unigene cluster for RPN2 Gene:

Hs.370895

mRNA Expression by UniProt/SwissProt for RPN2 Gene:

P04844-RPN2_HUMAN
Tissue specificity: Expressed in all tissues tested.
genes like me logo Genes that share expression patterns with RPN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RPN2 Gene

Orthologs for RPN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPN2 34
  • 91.34 (n)
  • 95.4 (a)
RPN2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPN2 34
  • 91.8 (n)
  • 95.71 (a)
RPN2 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpn2 34
  • 88.38 (n)
  • 92.39 (a)
Rpn2 16
Rpn2 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPN2 34
  • 99.26 (n)
  • 99.68 (a)
RPN2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpn2 34
  • 89.43 (n)
  • 93.03 (a)
oppossum
(Monodelphis domestica)
Mammalia RPN2 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPN2 34
  • 75.83 (n)
  • 78.22 (a)
RPN2 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPN2 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpn2 34
  • 69.27 (n)
  • 73.41 (a)
Str.9570 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53764 34
zebrafish
(Danio rerio)
Actinopterygii Dr.4217 34
rpn2 34
  • 66.83 (n)
  • 67.64 (a)
rpn2 35
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1730 34
fruit fly
(Drosophila melanogaster)
Insecta CG6370 36
  • 33 (a)
OstDelta 34
  • 45.96 (n)
  • 35.88 (a)
CG6370 35
  • 30 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007638 34
  • 44.55 (n)
  • 32.68 (a)
worm
(Caenorhabditis elegans)
Secernentea M01A10.3 36
  • 36 (a)
ostd-1 34
  • 48.85 (n)
  • 39.27 (a)
ostd-1 35
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons HAP6 34
  • 43.43 (n)
  • 29.17 (a)
rice
(Oryza sativa)
Liliopsida Os01g0911200 34
  • 43.51 (n)
  • 29.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10212 35
  • 33 (a)
OneToOne
Species where no ortholog for RPN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPN2 Gene

ENSEMBL:
Gene Tree for RPN2 (if available)
TreeFam:
Gene Tree for RPN2 (if available)

Paralogs for RPN2 Gene

No data available for Paralogs for RPN2 Gene

Variants for RPN2 Gene

Sequence variations from dbSNP and Humsavar for RPN2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs34951322 - 37,236,615(-) GTTGA(A/G)CTGAG reference, missense
rs4608 -- 37,236,651(+) CCATC(C/T)TGGGC reference, synonymous-codon
rs879818 -- 37,226,621(-) CCCAC(A/G)AATAC intron-variant
rs882562 -- 37,231,397(+) AAATA(C/T)CATCA intron-variant
rs909870 -- 37,232,027(-) CCATT(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPN2 Gene

Variant ID Type Subtype PubMed ID
dgv2248n106 CNV deletion 24896259
esv1174249 CNV deletion 17803354
esv2082246 CNV deletion 18987734
esv2516589 CNV deletion 19546169
esv2663037 CNV deletion 23128226
esv2722385 CNV deletion 23290073
esv3557043 CNV deletion 23714750
esv3567958 CNV loss 25503493
esv3645750 CNV gain 21293372
esv4013 CNV loss 18987735
esv8416 CNV loss 19470904
nsv1071694 CNV deletion 25765185
nsv1109378 CNV deletion 24896259
nsv1151621 CNV deletion 26484159
nsv519722 CNV loss 19592680
nsv956193 CNV deletion 24416366

Variation tolerance for RPN2 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPN2 Gene

Human Gene Mutation Database (HGMD)
RPN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPN2 Gene

Disorders for RPN2 Gene

Relevant External Links for RPN2

Genetic Association Database (GAD)
RPN2
Human Genome Epidemiology (HuGE) Navigator
RPN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPN2

No disorders were found for RPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPN2 Gene

Publications for RPN2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3 46 65
  3. RPN2 gene confers docetaxel resistance in breast cancer. (PMID: 18724378) Honma K. … Ochiya T. (Nat. Med. 2008) 3 22 65
  4. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PMID: 15835887) Shibatani T. … Skach W.R. (Biochemistry 2005) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for RPN2 Gene

Sources for RPN2 Gene

Content
Loading form....