Aliases for RPN1 Gene
- Ribophorin I 2 3 4 5
- Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 KDa Subunit 3 4
- Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3
- Ribophorin-1 3 4
- RPN-I 3 4
- Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase 67 KDa Subunit 3
- Oligosaccharyltransferase 1 Homolog (S. Cerevisiae) 2
External Ids for RPN1 Gene
Previous GeneCards Identifiers for RPN1 Gene
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPN1 Gene
RPN1 (Ribophorin I) is a Protein Coding gene. Diseases associated with RPN1 include Acute Myeloid Leukemia With Inv3(P21;Q26.2) Or T(3;3)(P21;Q26.2). Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and dolichyl-diphosphooligosaccharide-protein glycotransferase activity.
UniProtKB/Swiss-Prot for RPN1 Gene
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.