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Aliases for RPN1 Gene

Aliases for RPN1 Gene

  • Ribophorin I 2 3 4
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 KDa Subunit 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3
  • Ribophorin-1 3 4
  • RPN-I 3 4
  • Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase 67 KDa Subunit 3
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 1 3
  • Oligosaccharyltransferase 1 Homolog (S. Cerevisiae) 2
  • Oligosaccharyltransferase 1 Homolog 3
  • EC 2.4.1.119 63
  • EC 2.4.99.18 4
  • RBPH1 3
  • OST1 3

External Ids for RPN1 Gene

Previous GeneCards Identifiers for RPN1 Gene

  • GC03M125171
  • GC03M128535
  • GC03M129620
  • GC03M129659
  • GC03M129821
  • GC03M128338
  • GC03M125722

Summaries for RPN1 Gene

Entrez Gene Summary for RPN1 Gene

  • This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPN1 Gene

RPN1 (Ribophorin I) is a Protein Coding gene. Diseases associated with RPN1 include 'acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)'. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

UniProtKB/Swiss-Prot for RPN1 Gene

  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains

Gene Wiki entry for RPN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPN1 Gene

Genomics for RPN1 Gene

Regulatory Elements for RPN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPN1 Gene

Start:
128,619,970 bp from pter
End:
128,681,075 bp from pter
Size:
61,106 bases
Orientation:
Minus strand

Genomic View for RPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPN1 Gene

Proteins for RPN1 Gene

  • Protein details for RPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04843-RPN1_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
    Protein Accession:
    P04843
    Secondary Accessions:
    • B2R5Z0
    • D3DNB6
    • Q68DT1

    Protein attributes for RPN1 Gene

    Size:
    607 amino acids
    Molecular mass:
    68569 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains known members of the OST complex and may be a form of this complex.

neXtProt entry for RPN1 Gene

Proteomics data for RPN1 Gene at MOPED

Post-translational modifications for RPN1 Gene

  • Ubiquitination at Lys187, Lys281, Lys474, Lys488, Lys538, Lys553, and Lys559
  • Glycosylation at Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for RPN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RPN1 Gene

Protein Domains for RPN1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P04843

UniProtKB/Swiss-Prot:

RPN1_HUMAN :
  • P04843
Family:
  • Belongs to the OST1 family.
genes like me logo Genes that share domains with RPN1: view

No data available for Gene Families for RPN1 Gene

Function for RPN1 Gene

Molecular function for RPN1 Gene

GENATLAS Biochemistry: ribophorin I,68.6kDa,component with RPN2 and DDOST,of N-oligosaccharyl transferase
UniProtKB/Swiss-Prot CatalyticActivity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
UniProtKB/Swiss-Prot Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains

Enzyme Numbers (IUBMB) for RPN1 Gene

Gene Ontology (GO) - Molecular Function for RPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity TAS 15835887
GO:0005515 protein binding IPI 22988243
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPN1: view

Phenotypes for RPN1 Gene

genes like me logo Genes that share phenotypes with RPN1: view

miRNA for RPN1 Gene

miRTarBase miRNAs that target RPN1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RPN1 Gene

Localization for RPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPN1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPN1 Gene COMPARTMENTS Subcellular localization image for RPN1 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0008250 oligosaccharyltransferase complex TAS 15835887
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPN1: view

Pathways for RPN1 Gene

genes like me logo Genes that share pathways with RPN1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
    • Unfolded Protein Response in human,mouse,rat

UniProtKB/Swiss-Prot P04843-RPN1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for RPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006464 cellular protein modification process TAS 10660554
GO:0006486 protein glycosylation --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RPN1: view

Compounds for RPN1 Gene

(2) HMDB Compounds for RPN1 Gene

Compound Synonyms Cas Number PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
L-Asparagine
  • (-)-Asparagine
70-47-3

(2) Novoseek inferred chemical compound relationships for RPN1 Gene

Compound -log(P) Hits PubMed IDs
polysaccharide 23.7 1
sucrose 12.8 1
genes like me logo Genes that share compounds with RPN1: view

Transcripts for RPN1 Gene

Unigene Clusters for RPN1 Gene

Ribophorin I:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - - - - -
SP9: -
SP10: -
SP11:

Relevant External Links for RPN1 Gene

GeneLoc Exon Structure for
RPN1
ECgene alternative splicing isoforms for
RPN1

Expression for RPN1 Gene

mRNA expression in normal human tissues for RPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPN1 Gene

SOURCE GeneReport for Unigene cluster for RPN1 Gene Hs.518244

mRNA Expression by UniProt/SwissProt for RPN1 Gene

P04843-RPN1_HUMAN
Tissue specificity: Expressed in all tissues tested.
genes like me logo Genes that share expressions with RPN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RPN1 Gene

Orthologs for RPN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPN1 35
  • 99.73 (n)
  • 99.51 (a)
RPN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToMany
RPN1 35
  • 86.71 (n)
  • 94.55 (a)
RPN1 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPN1 35
  • 91.93 (n)
  • 96.21 (a)
RPN1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpn1 35
  • 87.86 (n)
  • 95.06 (a)
Rpn1 16
Rpn1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpn1 35
  • 88.76 (n)
  • 95.59 (a)
chicken
(Gallus gallus)
Aves RPN1 35
  • 78.96 (n)
  • 88.76 (a)
RPN1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPN1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52808 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76266 35
rpn1 35
  • 74.77 (n)
  • 81.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8469 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rpn1 35
  • 69.47 (n)
  • 73.15 (a)
rpn1 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010174 35
  • 56.53 (n)
  • 53.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33303 35
  • 55.22 (n)
  • 47.76 (a)
CG33303 36
  • 45 (a)
OneToOne
rho-5 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea ribo-1 35
  • 49.8 (n)
  • 44.14 (a)
ribo-1 36
  • 39 (a)
OneToOne
T22D1.4 37
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OST1 36
  • 25 (a)
OneToOne
OST1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G76400 35
  • 47.04 (n)
  • 36.2 (a)
rice
(Oryza sativa)
Liliopsida Os05g0301500 35
  • 47.45 (n)
  • 35.07 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4362 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2016 36
  • 51 (a)
OneToOne
Species with no ortholog for RPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPN1 Gene

ENSEMBL:
Gene Tree for RPN1 (if available)
TreeFam:
Gene Tree for RPN1 (if available)

Paralogs for RPN1 Gene

No data available for Paralogs for RPN1 Gene

Variants for RPN1 Gene

Sequence variations from dbSNP and Humsavar for RPN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1697 -- 128,638,009(-) CATCC(A/G)TATCC synonymous-codon, reference
rs14560 -- 128,620,384(-) GGGCC(C/T)AGGGT utr-variant-3-prime
rs1126828 -- 128,625,943(-) CTGGA(C/T)ACATT reference, synonymous-codon
rs1126829 -- 128,625,572(-) TCACC(A/G/T)TTATC missense, reference
rs1127020 -- 128,620,213(-) ttttt(A/T)aaaaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPN1 Gene

Variant ID Type Subtype PubMed ID
dgv1494e1 CNV Complex 17122850
essv17207 CNV CNV 17122850
nsv10319 CNV Gain 18304495
nsv508952 CNV Insertion 20534489
esv2725894 CNV Deletion 23290073
dgv36n50 OTHER Inversion 21212237
nsv3994 CNV Insertion 18451855
nsv511200 CNV Loss 21212237
nsv433360 CNV Gain 18776910

Relevant External Links for RPN1 Gene

HapMap Linkage Disequilibrium report
RPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPN1 Gene

Disorders for RPN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RPN1 Gene including...

Search for RPN1 Gene in MalaCards »

Relevant External Links for RPN1

Genetic Association Database (GAD)
RPN1
Human Genome Epidemiology (HuGE) Navigator
RPN1
genes like me logo Genes that share disorders with RPN1: view

No data available for UniProtKB/Swiss-Prot for RPN1 Gene

Publications for RPN1 Gene

  1. Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. (PMID: 10660554) Fu J. … Kreibich G. (J. Biol. Chem. 2000) 3 23
  2. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. (PMID: 9307271) Pekarsky Y. … Gardiner K. (Cancer Res. 1997) 3 23
  3. Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. (PMID: 3034581) Crimaudo C. … Meyer D.I. (EMBO J. 1987) 3 4
  4. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PMID: 12887896) Kelleher D.J. … Gilmore R. (Mol. Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPN1 Gene

Sources for RPN1 Gene

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