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Aliases for RPN1 Gene

Aliases for RPN1 Gene

  • Ribophorin I 2 3 4 5
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 KDa Subunit 3 4
  • Oligosaccharyltransferase Complex Subunit (Non-Catalytic) 2 3
  • Ribophorin-1 3 4
  • RPN-I 3 4
  • Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase 67 KDa Subunit 3
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 1 3
  • Oligosaccharyltransferase 1 Homolog (S. Cerevisiae) 2
  • Oligosaccharyltransferase 1 Homolog 3
  • EC 2.4.1.119 61
  • EC 2.4.99.18 4
  • RBPH1 3
  • OST1 3

External Ids for RPN1 Gene

Previous GeneCards Identifiers for RPN1 Gene

  • GC03M125171
  • GC03M128535
  • GC03M129620
  • GC03M129659
  • GC03M129821
  • GC03M128338
  • GC03M125722

Summaries for RPN1 Gene

Entrez Gene Summary for RPN1 Gene

  • This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPN1 Gene

RPN1 (Ribophorin I) is a Protein Coding gene. Diseases associated with RPN1 include Acute Myeloid Leukemia With Inv3(P21;Q26.2) Or T(3;3)(P21;Q26.2). Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

UniProtKB/Swiss-Prot for RPN1 Gene

  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Gene Wiki entry for RPN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPN1 Gene

Genomics for RPN1 Gene

Regulatory Elements for RPN1 Gene

Enhancers for RPN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPN1 on UCSC Golden Path with GeneCards custom track

Promoters for RPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPN1 Gene

Chromosome:
3
Start:
128,619,970 bp from pter
End:
128,681,075 bp from pter
Size:
61,106 bases
Orientation:
Minus strand

Genomic View for RPN1 Gene

Genes around RPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPN1 Gene

Proteins for RPN1 Gene

  • Protein details for RPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04843-RPN1_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
    Protein Accession:
    P04843
    Secondary Accessions:
    • B2R5Z0
    • D3DNB6
    • Q68DT1

    Protein attributes for RPN1 Gene

    Size:
    607 amino acids
    Molecular mass:
    68569 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains known members of the OST complex and may be a form of this complex.

neXtProt entry for RPN1 Gene

Post-translational modifications for RPN1 Gene

  • Ubiquitination at Lys 187, Lys 281, Lys 474, Lys 488, Lys 538, and Lys 559
  • Glycosylation at Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for RPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RPN1 Gene

Gene Families for RPN1 Gene

Protein Domains for RPN1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P04843

UniProtKB/Swiss-Prot:

RPN1_HUMAN :
  • Belongs to the OST1 family.
Family:
  • Belongs to the OST1 family.
genes like me logo Genes that share domains with RPN1: view

Function for RPN1 Gene

Molecular function for RPN1 Gene

GENATLAS Biochemistry:
ribophorin I,68.6kDa,component with RPN2 and DDOST,of N-oligosaccharyl transferase
UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
UniProtKB/Swiss-Prot Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Enzyme Numbers (IUBMB) for RPN1 Gene

Gene Ontology (GO) - Molecular Function for RPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity TAS 15835887
GO:0005515 protein binding IPI 22988243
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPN1: view
genes like me logo Genes that share phenotypes with RPN1: view

Animal Model Products

CRISPR Products

miRNA for RPN1 Gene

miRTarBase miRNAs that target RPN1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPN1 Gene

Localization for RPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPN1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPN1 Gene COMPARTMENTS Subcellular localization image for RPN1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0005791 rough endoplasmic reticulum IEA,ISS --
GO:0008250 oligosaccharyltransferase complex TAS 15835887
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RPN1: view

Pathways & Interactions for RPN1 Gene

genes like me logo Genes that share pathways with RPN1: view

UniProtKB/Swiss-Prot P04843-RPN1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

SIGNOR curated interactions for RPN1 Gene

Activates:

Gene Ontology (GO) - Biological Process for RPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10660554
GO:0018279 protein N-linked glycosylation via asparagine TAS 15835887
genes like me logo Genes that share ontologies with RPN1: view

Drugs & Compounds for RPN1 Gene

(2) Drugs for RPN1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra 0

(2) Additional Compounds for RPN1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
genes like me logo Genes that share compounds with RPN1: view

Transcripts for RPN1 Gene

Unigene Clusters for RPN1 Gene

Ribophorin I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - - - - -
SP9: -
SP10: -
SP11:

Relevant External Links for RPN1 Gene

GeneLoc Exon Structure for
RPN1
ECgene alternative splicing isoforms for
RPN1

Expression for RPN1 Gene

mRNA expression in normal human tissues for RPN1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPN1 Gene



Protein tissue co-expression partners for RPN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPN1 Gene:

RPN1

SOURCE GeneReport for Unigene cluster for RPN1 Gene:

Hs.518244

mRNA Expression by UniProt/SwissProt for RPN1 Gene:

P04843-RPN1_HUMAN
Tissue specificity: Expressed in all tissues tested.
genes like me logo Genes that share expression patterns with RPN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for RPN1 Gene

Orthologs for RPN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPN1 34
  • 86.71 (n)
  • 94.55 (a)
-- 35
  • 83 (a)
OneToMany
RPN1 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPN1 34
  • 91.93 (n)
  • 96.21 (a)
RPN1 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpn1 34
  • 87.86 (n)
  • 95.06 (a)
Rpn1 16
Rpn1 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpn1 34
  • 88.76 (n)
  • 95.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPN1 35
  • 100 (a)
OneToOne
RPN1 34
  • 99.73 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves RPN1 34
  • 78.96 (n)
  • 88.76 (a)
RPN1 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPN1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76266 34
rpn1 34
  • 74.77 (n)
  • 81.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52808 34
zebrafish
(Danio rerio)
Actinopterygii -- 34
rpn1 34
  • 69.47 (n)
  • 73.15 (a)
rpn1 35
  • 71 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8469 34
fruit fly
(Drosophila melanogaster)
Insecta rho-5 36
  • 45 (a)
CG33303 34
  • 55.22 (n)
  • 47.76 (a)
CG33303 35
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010174 34
  • 56.53 (n)
  • 53.44 (a)
worm
(Caenorhabditis elegans)
Secernentea T22D1.4 36
  • 41 (a)
ribo-1 34
  • 49.8 (n)
  • 44.14 (a)
ribo-1 35
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OST1 37
OST1 35
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G76400 34
  • 47.04 (n)
  • 36.2 (a)
rice
(Oryza sativa)
Liliopsida Os05g0301500 34
  • 47.45 (n)
  • 35.07 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4362 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2016 35
  • 51 (a)
OneToOne
Species where no ortholog for RPN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPN1 Gene

ENSEMBL:
Gene Tree for RPN1 (if available)
TreeFam:
Gene Tree for RPN1 (if available)

Paralogs for RPN1 Gene

No data available for Paralogs for RPN1 Gene

Variants for RPN1 Gene

Sequence variations from dbSNP and Humsavar for RPN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1697 -- 128,638,009(-) CATCC(A/G)TATCC reference, synonymous-codon
rs14560 -- 128,620,384(-) GGGCC(C/T)AGGGT utr-variant-3-prime
rs2335236 -- 128,622,875(-) ctgtc(A/G)cccag intron-variant
rs4557179 -- 128,647,883(+) GTAAA(A/C)AGAGA intron-variant
rs1126828 -- 128,625,943(-) CTGGA(C/T)ACATT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPN1 Gene

Variant ID Type Subtype PubMed ID
dgv36n50 OTHER inversion 21212237
dgv4855n100 CNV gain 25217958
dgv4856n100 CNV gain 25217958
esv2725894 CNV deletion 23290073
esv2759176 CNV loss 17122850
esv2763764 CNV gain+loss 21179565
esv32649 CNV gain 17666407
esv3365174 OTHER inversion 20981092
nsv10319 CNV gain 18304495
nsv3994 CNV insertion 18451855
nsv433360 CNV gain 18776910
nsv508952 CNV insertion 20534489
nsv511200 CNV loss 21212237

Variation tolerance for RPN1 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPN1 Gene

Disorders for RPN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPN1 Gene - From: Orphanet

Disorder Aliases PubMed IDs
acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)
  • aml with inv3(p21
- elite association - COSMIC cancer census association via MalaCards
Search RPN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPN1

Genetic Association Database (GAD)
RPN1
Human Genome Epidemiology (HuGE) Navigator
RPN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPN1
genes like me logo Genes that share disorders with RPN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPN1 Gene

Publications for RPN1 Gene

  1. Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core. (PMID: 18607003) Wilson C.M. … High S. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 65
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 65
  3. Ribophorin I acts as a substrate-specific facilitator of N-glycosylation. (PMID: 17264154) Wilson C.M. … High S. (J. Cell. Sci. 2007) 3 22 65
  4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4 65
  5. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PMID: 15835887) Shibatani T. … Skach W.R. (Biochemistry 2005) 3 4 65

Products for RPN1 Gene

Sources for RPN1 Gene

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