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Aliases for RPLP2 Gene

Aliases for RPLP2 Gene

  • Ribosomal Protein Lateral Stalk Subunit P2 2 3
  • Ribosomal Protein, Large, P2 2 3 5
  • Acidic Ribosomal Phosphoprotein P2 2 3
  • Renal Carcinoma Antigen NY-REN-44 3 4
  • D11S2243E 3 4
  • RPP2 3 4
  • 60S Acidic Ribosomal Protein P2 2
  • LP2 3
  • P2 3

External Ids for RPLP2 Gene

Previous HGNC Symbols for RPLP2 Gene

  • D11S2243E

Previous GeneCards Identifiers for RPLP2 Gene

  • GC11U990117
  • GC11M000732
  • GC11M000385
  • GC11P000801
  • GC11P000625

Summaries for RPLP2 Gene

Entrez Gene Summary for RPLP2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP2 Gene

RPLP2 (Ribosomal Protein Lateral Stalk Subunit P2) is a Protein Coding gene. Diseases associated with RPLP2 include Cysticercosis. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP2 Gene

  • Plays an important role in the elongation step of protein synthesis.

Gene Wiki entry for RPLP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP2 Gene

Genomics for RPLP2 Gene

Regulatory Elements for RPLP2 Gene

Enhancers for RPLP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPLP2 on UCSC Golden Path with GeneCards custom track

Promoters for RPLP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPLP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPLP2 Gene

Chromosome:
11
Start:
809,647 bp from pter
End:
812,880 bp from pter
Size:
3,234 bases
Orientation:
Plus strand

Genomic View for RPLP2 Gene

Genes around RPLP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP2 Gene

Proteins for RPLP2 Gene

  • Protein details for RPLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05387-RLA2_HUMAN
    Recommended name:
    60S acidic ribosomal protein P2
    Protein Accession:
    P05387
    Secondary Accessions:
    • Q6FG96

    Protein attributes for RPLP2 Gene

    Size:
    115 amino acids
    Molecular mass:
    11665 Da
    Quaternary structure:
    • Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPLP2 Gene

neXtProt entry for RPLP2 Gene

Proteomics data for RPLP2 Gene at MOPED

Post-translational modifications for RPLP2 Gene

  • Ubiquitination at Lys 21, Lys 25, Lys 41, and Lys 61
  • Modification sites at PhosphoSitePlus

Other Protein References for RPLP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPLP2 Gene

Domains & Families for RPLP2 Gene

Gene Families for RPLP2 Gene

Protein Domains for RPLP2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPLP2 Gene

Graphical View of Domain Structure for InterPro Entry

P05387

UniProtKB/Swiss-Prot:

RLA2_HUMAN :
  • Belongs to the ribosomal protein L12P family.
Family:
  • Belongs to the ribosomal protein L12P family.
genes like me logo Genes that share domains with RPLP2: view

Function for RPLP2 Gene

Molecular function for RPLP2 Gene

GENATLAS Biochemistry:
60S acidic ribosomal protein P2
UniProtKB/Swiss-Prot Function:
Plays an important role in the elongation step of protein synthesis.

Gene Ontology (GO) - Molecular Function for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22135285
genes like me logo Genes that share ontologies with RPLP2: view
genes like me logo Genes that share phenotypes with RPLP2: view

Animal Model Products

miRNA for RPLP2 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP2 Gene

Localization for RPLP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPLP2 Gene COMPARTMENTS Subcellular localization image for RPLP2 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPLP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPLP2 Gene

Pathways & Interactions for RPLP2 Gene

genes like me logo Genes that share pathways with RPLP2: view

Pathways by source for RPLP2 Gene

1 KEGG pathway for RPLP2 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP2 Gene

SIGNOR curated interactions for RPLP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPLP2: view

Drugs & Compounds for RPLP2 Gene

(1) Additional Compounds for RPLP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPLP2: view

Transcripts for RPLP2 Gene

Unigene Clusters for RPLP2 Gene

Ribosomal protein, large, P2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP2 Gene

No ASD Table

Relevant External Links for RPLP2 Gene

GeneLoc Exon Structure for
RPLP2
ECgene alternative splicing isoforms for
RPLP2

Expression for RPLP2 Gene

mRNA expression in normal human tissues for RPLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPLP2 Gene

This gene is overexpressed in Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPLP2 Gene



SOURCE GeneReport for Unigene cluster for RPLP2 Gene Hs.437594

genes like me logo Genes that share expression patterns with RPLP2: view

Protein tissue co-expression partners for RPLP2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPLP2 Gene

Orthologs for RPLP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPLP2 35
  • 87.54 (n)
  • 98.26 (a)
-- 36
  • 80 (a)
OneToMany
RPLP2 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rplp2 35
  • 89.86 (n)
  • 99.13 (a)
Rplp2 16
Rplp2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPLP2 35
  • 98.84 (n)
  • 100 (a)
RPLP2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPLP2 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPLP2 35
  • 81.16 (n)
  • 86.09 (a)
RPLP2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPLP2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp2 35
  • 67.83 (n)
  • 71.3 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24718 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26791 35
rplp2l 35
  • 73.74 (n)
  • 77.27 (a)
rplp2l 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003025 35
  • 62.63 (n)
  • 63.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpLP2 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C37A2.7 36
  • 58 (a)
OneToMany
rla-2 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP2A 36
  • 55 (a)
OneToMany
RPP2B 36
  • 55 (a)
OneToMany
RPP2B 38
barley
(Hordeum vulgare)
Liliopsida Hv.5710 35
wheat
(Triticum aestivum)
Liliopsida Ta.2539 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4372 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11199 36
  • 65 (a)
OneToOne
Species with no ortholog for RPLP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPLP2 Gene

ENSEMBL:
Gene Tree for RPLP2 (if available)
TreeFam:
Gene Tree for RPLP2 (if available)

Paralogs for RPLP2 Gene

Pseudogenes.org Pseudogenes for RPLP2 Gene

genes like me logo Genes that share paralogs with RPLP2: view

No data available for Paralogs for RPLP2 Gene

Variants for RPLP2 Gene

Sequence variations from dbSNP and Humsavar for RPLP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11828118 -- 813,185(+) gagac(A/C)agcct downstream-variant-500B
rs113191575 -- 812,874(+) CACAT(A/C/G)TCTCA utr-variant-3-prime
rs113243086 -- 812,533(+) TCTGT(A/G)GGTAT splice-acceptor-variant
rs113604888 -- 812,634(+) TGCAG(C/G)TAAGT splice-donor-variant
rs144524219 -- 813,009(+) AGGAG(G/T)GGAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPLP2 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
nsv896583 CNV Gain 21882294
dgv946n71 CNV Loss 21882294
nsv896587 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv8759 CNV Gain 18304495
dgv947n71 CNV Loss 21882294
dgv948n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294
nsv896600 CNV Gain 21882294
nsv832044 CNV Loss 17160897

Variation tolerance for RPLP2 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPLP2 Gene

Disorders for RPLP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPLP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cysticercosis
  • taeniasis
- elite association - COSMIC cancer census association via MalaCards
Search RPLP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPLP2

Genetic Association Database (GAD)
RPLP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPLP2
genes like me logo Genes that share disorders with RPLP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPLP2 Gene

Publications for RPLP2 Gene

  1. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PMID: 3323886) Rich B.E. … Steitz J.A. (Mol. Cell. Biol. 1987) 2 3 4 67
  2. Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies. (PMID: 14981896) Gardner-Thorpe J. … Whang E.E. (Anticancer Res. 2003) 3 23
  3. Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. (PMID: 12379128) Freeman J.L. … Lefkowitz R.J. (Biochemistry 2002) 3 23
  4. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for RPLP2 Gene

Sources for RPLP2 Gene

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