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Aliases for RPLP2 Gene

Aliases for RPLP2 Gene

  • Ribosomal Protein Lateral Stalk Subunit P2 2 3 5
  • Acidic Ribosomal Phosphoprotein P2 2 3
  • Large Ribosomal Subunit Protein P2 3 4
  • Renal Carcinoma Antigen NY-REN-44 3 4
  • 60S Acidic Ribosomal Protein P2 2 3
  • Ribosomal Protein, Large, P2 2 3
  • D11S2243E 3 4
  • RPP2 3 4
  • LP2 3
  • P2 3

External Ids for RPLP2 Gene

Previous HGNC Symbols for RPLP2 Gene

  • D11S2243E

Previous GeneCards Identifiers for RPLP2 Gene

  • GC11U990117
  • GC11M000732
  • GC11M000385
  • GC11P000801
  • GC11P000799
  • GC11P000625

Summaries for RPLP2 Gene

Entrez Gene Summary for RPLP2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP2 Gene

RPLP2 (Ribosomal Protein Lateral Stalk Subunit P2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP2 Gene

  • Plays an important role in the elongation step of protein synthesis.

Gene Wiki entry for RPLP2 Gene

Additional gene information for RPLP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP2 Gene

Genomics for RPLP2 Gene

Regulatory Elements for RPLP2 Gene

Enhancers for RPLP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H000807 1.4 ENCODE dbSUPER 49.1 +1.3 1341 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RPLP2 ENSG00000255108 TMEM80 PIDD1 ENSG00000255158 PHRF1 ENSG00000255142 MOB2 RIC8A BET1L
GH11H000818 1.3 ENCODE dbSUPER 30.3 +10.9 10916 4 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF207 RPLP2 ENSG00000255108 LOC171391 TMEM80 RIC8A PIDD1 BET1L SNORA52 ENSG00000255158 PHRF1
GH11H000745 1.6 FANTOM5 ENCODE dbSUPER 22.1 -61.6 -61638 5 HDGF ATF1 FOXA2 ARID4B SIN3A GLIS2 ELK1 ZNF143 ATF7 RUNX3 ENSG00000255108 RPLP2 TALDO1 MOB2 IRF7 LOC171391 CD151 DEAF1 TMEM80 IFITM2
GH11H000839 1.3 ENCODE dbSUPER 26.6 +34.1 34134 7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 CD151 TMEM80 PIDD1 SNORA52 RPLP2 TSPAN4 RIC8A ENSG00000255158 BET1L ENSG00000255237
GH11H000725 1.6 Ensembl ENCODE dbSUPER 20.5 -82.0 -82038 5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF143 FOS PAF1 SP3 SP5 ENSG00000255108 RPLP2 LOC171391 TMEM80 CD151 EPS8L2 ENSG00000269915 LOC105376509
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPLP2 on UCSC Golden Path with GeneCards custom track

Promoters for RPLP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035694 253 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for RPLP2 Gene

Chromosome:
11
Start:
809,647 bp from pter
End:
812,880 bp from pter
Size:
3,234 bases
Orientation:
Plus strand

Genomic View for RPLP2 Gene

Genes around RPLP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP2 Gene

Proteins for RPLP2 Gene

  • Protein details for RPLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05387-RLA2_HUMAN
    Recommended name:
    60S acidic ribosomal protein P2
    Protein Accession:
    P05387
    Secondary Accessions:
    • Q6FG96

    Protein attributes for RPLP2 Gene

    Size:
    115 amino acids
    Molecular mass:
    11665 Da
    Quaternary structure:
    • Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPLP2 Gene

neXtProt entry for RPLP2 Gene

Post-translational modifications for RPLP2 Gene

  • Ubiquitination at Lys21, isoforms=25, Lys41, and Lys61
  • Modification sites at PhosphoSitePlus

Other Protein References for RPLP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPLP2 Gene

Domains & Families for RPLP2 Gene

Gene Families for RPLP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Ribosomal proteins

Protein Domains for RPLP2 Gene

Suggested Antigen Peptide Sequences for RPLP2 Gene

Graphical View of Domain Structure for InterPro Entry

P05387

UniProtKB/Swiss-Prot:

RLA2_HUMAN :
  • Belongs to the eukaryotic ribosomal protein P1/P2 family.
Family:
  • Belongs to the eukaryotic ribosomal protein P1/P2 family.
genes like me logo Genes that share domains with RPLP2: view

Function for RPLP2 Gene

Molecular function for RPLP2 Gene

GENATLAS Biochemistry:
60S acidic ribosomal protein P2
UniProtKB/Swiss-Prot Function:
Plays an important role in the elongation step of protein synthesis.

Phenotypes From GWAS Catalog for RPLP2 Gene

Gene Ontology (GO) - Molecular Function for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 22135285
genes like me logo Genes that share ontologies with RPLP2: view
genes like me logo Genes that share phenotypes with RPLP2: view

Animal Model Products

CRISPR Products

miRNA for RPLP2 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPLP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP2 Gene

Localization for RPLP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPLP2 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
nucleus 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPLP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPLP2 Gene

Pathways & Interactions for RPLP2 Gene

genes like me logo Genes that share pathways with RPLP2: view

Pathways by source for RPLP2 Gene

1 KEGG pathway for RPLP2 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP2 Gene

SIGNOR curated interactions for RPLP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPLP2: view

Drugs & Compounds for RPLP2 Gene

(1) Additional Compounds for RPLP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPLP2: view

Transcripts for RPLP2 Gene

Unigene Clusters for RPLP2 Gene

Ribosomal protein, large, P2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPLP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP2 Gene

No ASD Table

Relevant External Links for RPLP2 Gene

GeneLoc Exon Structure for
RPLP2
ECgene alternative splicing isoforms for
RPLP2

Expression for RPLP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPLP2 Gene

This gene is overexpressed in Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPLP2 Gene



Protein tissue co-expression partners for RPLP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPLP2 Gene:

RPLP2

SOURCE GeneReport for Unigene cluster for RPLP2 Gene:

Hs.437594

Evidence on tissue expression from TISSUES for RPLP2 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Skin(4.8)
  • Kidney(4.6)
  • Lung(4.4)
  • Muscle(4.2)
  • Pancreas(4.2)
  • Heart(3.9)
  • Intestine(3.9)
  • Eye(3.8)
  • Spleen(3.3)
  • Stomach(2.9)
  • Blood(2.8)
  • Lymph node(2.8)
  • Bone marrow(2.4)
  • Adrenal gland(2.3)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with RPLP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPLP2 Gene

Orthologs for RPLP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPLP2 34 33
  • 98.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rplp2 16 34 33
  • 89.86 (n)
cow
(Bos Taurus)
Mammalia RPLP2 34 33
  • 87.54 (n)
OneToMany
-- 34
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPLP2 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPLP2 34 33
  • 81.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPLP2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp2 33
  • 67.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24718 33
zebrafish
(Danio rerio)
Actinopterygii rplp2l 34 33
  • 73.74 (n)
OneToOne
Dr.26791 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003025 33
  • 62.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpLP2 34
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C37A2.7 34
  • 58 (a)
OneToMany
rla-2 34
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP2B 36 34
  • 55 (a)
RPP2A 34
  • 55 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.5710 33
wheat
(Triticum aestivum)
Liliopsida Ta.2539 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11199 34
  • 65 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4372 33
Species where no ortholog for RPLP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPLP2 Gene

ENSEMBL:
Gene Tree for RPLP2 (if available)
TreeFam:
Gene Tree for RPLP2 (if available)

Paralogs for RPLP2 Gene

Pseudogenes.org Pseudogenes for RPLP2 Gene

genes like me logo Genes that share paralogs with RPLP2: view

No data available for Paralogs for RPLP2 Gene

Variants for RPLP2 Gene

Sequence variations from dbSNP and Humsavar for RPLP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000118985 -- 811,147(+) AGTCT(A/G)ACAGA intron-variant, upstream-variant-2KB
rs1000267176 -- 809,693(+) CTTTG(A/G)ACTCG upstream-variant-2KB
rs1000272107 -- 811,007(+) CTCCA(A/C)AAAAA intron-variant, upstream-variant-2KB
rs1000340319 -- 809,521(+) GCCGT(G/T)CCGGG upstream-variant-2KB
rs1001051325 -- 810,435(+) CGGCC(A/C)CATGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPLP2 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv1526n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
nsv1040044 CNV gain+loss 25217958
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552870 CNV loss 21841781
nsv552871 CNV loss 21841781
nsv832044 CNV loss 17160897
nsv8759 CNV gain 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for RPLP2 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPLP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPLP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP2 Gene

Disorders for RPLP2 Gene

Relevant External Links for RPLP2

Genetic Association Database (GAD)
RPLP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPLP2

No disorders were found for RPLP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPLP2 Gene

Publications for RPLP2 Gene

  1. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PMID: 3323886) Rich BE … Steitz JA (Molecular and cellular biology 1987) 2 3 4 60
  2. Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk. (PMID: 20385603) Lee KM … Wong KB (Nucleic acids research 2010) 3 4 60
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RPLP2 Gene

Sources for RPLP2 Gene

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