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RPLP2 Gene

protein-coding   GIFtS: 62
GCID: GC11P000799

Ribosomal Protein, Large, P2


(Previous symbol: D11S2243E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribosomal Protein, Large, P21 2     Renal Carcinoma Antigen NY-REN-442 3
D11S2243E1 2 3     RPP22 3
60S Acidic Ribosomal Protein P21 2     LP22
Acidic Ribosomal Phosphoprotein P21 2     P22

External Ids:    HGNC: 103771   Entrez Gene: 61812   Ensembl: ENSG000001776007   OMIM: 1805305   UniProtKB: P053873   
ORGUL members:         

Export aliases for RPLP2 gene to outside databases

Previous GC identifers: GC11U990117 GC11M000732 GC11M000385 GC11P000801 GC11P000625


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPLP2 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a
functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins.
It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are
basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the
ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex
consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for
genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the
genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPLP2 Gene:
RPLP2 (ribosomal protein, large, P2) is a protein-coding gene. Diseases associated with RPLP2 include immune-complex glomerulonephritis, and babesiosis. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

UniProtKB/Swiss-Prot: RLA2_HUMAN, P05387
Function: Plays an important role in the elongation step of protein synthesis

Gene Wiki entry for RPLP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPLP2 gene promoter:
         Max1   Pax-5   p53   p300   RelA   NF-kappaB1   NF-kappaB   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPLP2 promoter sequence
   Search Chromatin IP Primers for RPLP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPLP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RPLP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPLP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000799:  view genomic region     (about GC identifiers)

Start:
809,647 bp from pter      End:
812,880 bp from pter
Size:
3,234 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RLA2_HUMAN, P05387 (See protein sequence)
Recommended Name: 60S acidic ribosomal protein P2  
Size: 115 amino acids; 11665 Da
Subunit: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit
6 PDB 3D structures from and Proteopedia for RPLP2:
1S4J (3D)        2JDL (3D)        2LBF (3D)        2W1O (3D)        3J3B (3D)        4BEH (3D)    
Secondary accessions: Q6FG96

Explore the universe of human proteins at neXtProt for RPLP2: NX_P05387

Explore proteomics data for RPLP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys25, Lys41, Lys49, Lys61
  • Modification sites at PhosphoSitePlus

  • See RPLP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000995.1  
    ENSEMBL proteins: 
     ENSP00000322419   ENSP00000431240   ENSP00000433443  
    Reactome Protein details: P05387

    RPLP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    2 InterPro protein domains:
     IPR001813 Ribosomal_L10/L12
     IPR027534 Ribosomal_L12

    Graphical View of Domain Structure for InterPro Entry P05387

    ProtoNet protein and cluster: P05387

    1 Blocks protein domain: IPB001813 60S Acidic ribosomal protein

    UniProtKB/Swiss-Prot: RLA2_HUMAN, P05387
    Similarity: Belongs to the ribosomal protein L12P family


    RPLP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RLA2_HUMAN, P05387
    Function: Plays an important role in the elongation step of protein synthesis

         Genatlas biochemistry entry for RPLP2:
    60S acidic ribosomal protein P2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS3323886
    GO:0003735structural constituent of ribosome NAS12962325
         
    RPLP2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPLP2:
     Increased S DNA content, incre  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPLP2
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    miRNA
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    miRTarBase miRNAs that target RPLP2:
    hsa-let-7e-5p (MIRT051678), hsa-mir-484 (MIRT041698), hsa-mir-766-3p (MIRT039035), hsa-mir-505-5p (MIRT037947)

    Block miRNA regulation of human, mouse, rat RPLP2 using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector: RPLP2 (NM_001004)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325
    GO:0070062extracellular vesicular exosome IDA--

    RPLP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPLP2 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPLP2
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPLP2
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPLP2 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPLP2):
        Ribosome


    RPLP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPLP2
    Interactions:

        GeneGlobe Interaction Network for RPLP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPLP2 (P053872, 3 ENSP000003224194) via UniProtKB, MINT, STRING, and/or I2D (see all 356)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3, ENSP000001894444MINT-48706 I2D: score=2 STRING: ENSP00000189444
    YWHAZP631042, 3, ENSP000003095034MINT-3297185 I2D: score=1 STRING: ENSP00000309503
    IKBKGQ9Y6K92, 3MINT-48147 I2D: score=2 
    MAP3K1Q132332, 3MINT-48285 I2D: score=2 
    MAP3K14Q995582, 3MINT-48796 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPLP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPLP2 (RLA2)

    1 Novoseek inferred chemical compound relationship for RPLP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 24.1 1 10224375 (1)



    RPLP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPLP2 gene: 
    NM_001004.3  

    Unigene Cluster for RPLP2:

    Ribosomal protein, large, P2
    Hs.437594  [show with all ESTs]
    Unigene Representative Sequence: BM912995
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321153(uc001lrq.1) ENST00000532004 ENST00000530797 ENST00000524867
    ENST00000530398 ENST00000526222 ENST00000525722 ENST00000527517
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RPLP2
      QuantiFast Probe-based Assays in human, mouse, rat RPLP2

    Additional mRNA sequence: 

    AK130959.1 AK311954.1 BC005354.1 BC005920.1 BC007573.1 BC062314.1 CR542212.1 CR542248.1 
    M17887.1 

    Selected DOTS entries (see all 47):

    DT.85102943  DT.100868243  DT.100871031  DT.100708269  DT.100043128  DT.95200484  DT.120711448  DT.100708290 
    DT.87005958  DT.91973249  DT.95215346  DT.100708261  DT.95101595  DT.120711552  DT.100856378  DT.87007877 
    DT.70104753  DT.100761040  DT.120910227  DT.87077768  DT.91708148  DT.97766178  DT.100708258  DT.100708285 

    Selected AceView cDNA sequences (see all 1400):

    BG818438 AA432172 AJ710740 BC005354 BE313108 BM852583 F19014 BG575592 
    AW515440 AW162561 AI360606 BP428485 AI306406 AA635537 BM767009 BX352674 
    BM352276 AW963026 BG574753 BM687400 BE793520 BE218161 BF057910 AW160390 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPLP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTTGGCC
    RPLP2 Expression
    About this image


    RPLP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    RPLP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPLP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437594
        Custom PCR Arrays for RPLP2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPLP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPLP2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rplp21 , 5 ribosomal protein, large P21, 5 89.86(n)1
    99.13(a)1
      7 (86.80 cM)5
    671861  NM_026020.61  NP_080296.31 
     1414473705 
    chicken
    (Gallus gallus)
    Aves RPLP21 ribosomal protein, large, P2 81.16(n)
    86.09(a)
      426492  XM_424134.4  XP_424134.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPLP26
    ribosomal protein, large, P2
    86(a)
    1 ↔ 1
    1(73742143-73755473)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247182 Xenopus laevis transcribed sequence with weak similarity more 78.27(n)    BJ074671.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.267912 Danio rerio cDNA clone MGC73372 IMAGE4199035, complete more 75.09(n)    BC059681.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpLP26
    Ribosomal protein LP2
    58(a)
    1 ↔ 1
    2R(12473599-12474237)
    worm
    (Caenorhabditis elegans)
    Secernentea C37A2.76
    rla-26
    Protein RLA-2 (rla-2) mRNA, complete cds
    58(a)
    55(a)
    many → 1
    many → 1
    I(6789060-6789738) WBGene00016493
    IV(13369424-13370285) WBGene00004410
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPP2B(YDR382W)4 Ribosomal protein P2 beta, a component of the ribosomal more   --   4(1239492-1239824) 851990  NP_010670.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.57102 Transcribed sequence with weak similarity to protein more 71.7(n)    AJ460081.1 


    ENSEMBL Gene Tree for RPLP2 (if available)
    TreeFam Gene Tree for RPLP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPLP2 gene

    RPLP2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for RPLP2
    PGOHUM00000239727 PGOHUM00000237467 PGOHUM00000235438 PGOHUM00000243534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPLP2 (see all 73)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884738231,2
    --808246(+) ACATGA/GTGAAA 1 -- us2k10--------
    rs749942111,2
    C--808257(+) CCCCGC/TCTGTA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs793267171,2
    C--808416(+) TGGGAC/GTCCTC 1 -- us2k13Minor allele frequency- G:0.23CSA WA EA 240
    rs286946341,2
    C,F--808423(+) CCTCAA/GAAAAA 1 -- us2k1 trp310Minor allele frequency- G:0.31NA WA CSA EA 371
    rs1812748381,2
    --808480(+) TCCCAA/GCACTT 1 -- us2k10--------
    rs578942861,2
    C--808549(+) AATTT-/TAGCCG 1 -- us2k10--------
    rs615397931,2
    --808554(+) TTTTAG/TCCGGG 1 -- us2k10--------
    rs65979801,2
    C,H--808556(-) cacccC/Ggctaa 1 -- us2k10--------
    rs1887905341,2
    --808579(+) CCTGTA/GGTCTC 1 -- us2k10--------
    rs575958621,2
    C--808620(+) GAGCCC/TAGGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPLP2 (809647 - 812880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPLP2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    nsv832044CNV Loss17160897
    nsv469923CNV Loss18288195
    dgv946n71CNV Loss21882294
    dgv944n71CNV Loss21882294
    dgv921n71CNV Loss21882294
    dgv936n71CNV Loss21882294
    dgv945n71CNV Loss21882294
    nsv896587CNV Loss21882294
    dgv948n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPLP2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 180530    OMIM disorders: --

    15 diseases for RPLP2:    
    About MalaCards
    immune-complex glomerulonephritis    babesiosis    cysticercosis    mouth disease
    diamond-blackfan anemia    lupus erythematosus    glomerulonephritis    influenza
    osteosarcoma    systemic lupus erythematosus    renal cell carcinoma    pancreatitis
    hepatocellular carcinoma    colorectal cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for RPLP2:
    Diamond-Blackfan anemia

    RPLP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPLP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 17.1 1 7913711 (1)
    tumors 0 1 20385220 (1)

    Genetic Association Database (GAD): RPLP2

    Export disorders for RPLP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RPLP2 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with RPLP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PubMed id 3323886)1, 2, 3 Rich B.E. and Steitz J.A. (Mol. Cell. Biol. 1987)
    2. Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk. (PubMed id 20385603)1, 2 Lee K.M....Wong K.B. (Nucleic Acids Res. 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Identification and characterization of phosphorylated proteins in the human pituitary. (PubMed id 14997482)1, 2 Giorgianni F.... Desiderio D.M. (Proteomics 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    8. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    9. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (Electrophoresis 1992)
    10. A sequence previously identified as metastasis-related encodes an acidic ribosomal phosphoprotein, P2. (PubMed id 2153399)1, 2 Sharp M.G.F....Varley J.M. (Br. J. Cancer 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6181 HGNC: 10377 AceView: RPLP2 Ensembl:ENSG00000177600 euGenes: HUgn6181
    ECgene: RPLP2 Kegg: 6181 H-InvDB: RPLP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPLP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RPLP2 gene:
    Search GeneIP for patents involving RPLP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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