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Aliases for RPLP1 Gene

Aliases for RPLP1 Gene

  • Ribosomal Protein, Large, P1 2 3
  • Acidic Ribosomal Phosphoprotein P1 3
  • 60S Acidic Ribosomal Protein P1 3
  • RPP1 3
  • RRP1 4
  • LP1 3
  • P1 3

External Ids for RPLP1 Gene

Previous GeneCards Identifiers for RPLP1 Gene

  • GC15P065586
  • GC15P062843
  • GC15P067324
  • GC15P067460
  • GC15P067532
  • GC15P069745
  • GC15P046578

Summaries for RPLP1 Gene

Entrez Gene Summary for RPLP1 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP1 Gene

RPLP1 (Ribosomal Protein, Large, P1) is a Protein Coding gene. Diseases associated with RPLP1 include pandas. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP1 Gene

  • Plays an important role in the elongation step of protein synthesis

Gene Wiki entry for RPLP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP1 Gene

Genomics for RPLP1 Gene

Regulatory Elements for RPLP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPLP1 Gene

69,452,784 bp from pter
69,456,194 bp from pter
3,411 bases
Plus strand

Genomic View for RPLP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP1 Gene

Proteins for RPLP1 Gene

  • Protein details for RPLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S acidic ribosomal protein P1
    Protein Accession:
    Secondary Accessions:
    • A6NIB2

    Protein attributes for RPLP1 Gene

    114 amino acids
    Molecular mass:
    11514 Da
    Quaternary structure:
    • Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPLP1 Gene

    Alternative splice isoforms for RPLP1 Gene


neXtProt entry for RPLP1 Gene

Proteomics data for RPLP1 Gene at MOPED

Post-translational modifications for RPLP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPLP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPLP1 Gene

Domains for RPLP1 Gene

Gene Families for RPLP1 Gene

Protein Domains for RPLP1 Gene


Suggested Antigen Peptide Sequences for RPLP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L12P family.
  • Belongs to the ribosomal protein L12P family.
genes like me logo Genes that share domains with RPLP1: view

Function for RPLP1 Gene

Molecular function for RPLP1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the elongation step of protein synthesis

Gene Ontology (GO) - Molecular Function for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 3323886
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 12054647
genes like me logo Genes that share ontologies with RPLP1: view
genes like me logo Genes that share phenotypes with RPLP1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPLP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP1 Gene

Localization for RPLP1 Gene

Subcellular locations from

Jensen Localization Image for RPLP1 Gene COMPARTMENTS Subcellular localization image for RPLP1 gene
Compartment Confidence
cytosol 5
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPLP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPLP1 Gene

Pathways for RPLP1 Gene

genes like me logo Genes that share pathways with RPLP1: view

Pathways by source for RPLP1 Gene

1 KEGG pathway for RPLP1 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP1 Gene

Gene Ontology (GO) - Biological Process for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPLP1: view

Transcripts for RPLP1 Gene

Unigene Clusters for RPLP1 Gene

Ribosomal protein, large, P1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPLP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP2: -

Relevant External Links for RPLP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPLP1 Gene

mRNA expression in normal human tissues for RPLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPLP1 Gene

SOURCE GeneReport for Unigene cluster for RPLP1 Gene Hs.356502

genes like me logo Genes that share expressions with RPLP1: view

Expression partners for RPLP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPLP1 Gene

Orthologs for RPLP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPLP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPLP1 35
  • 93.27 (n)
  • 100 (a)
RPLP1 36
  • 98 (a)
(Pan troglodytes)
Mammalia RPLP1 35
  • 99.71 (n)
  • 100 (a)
RPLP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rplp1 35
  • 88.89 (n)
  • 98.25 (a)
(Mus musculus)
Mammalia Rplp1 16
Gm10073 36
  • 96 (a)
Gm17511 36
  • 95 (a)
Rplp1 36
  • 97 (a)
(Canis familiaris)
Mammalia RPLP1 36
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
-- 36
  • 86 (a)
(Gallus gallus)
Aves RPLP1 35
  • 80.41 (n)
  • 85.96 (a)
RPLP1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia RPLP1 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp1 35
  • 73.16 (n)
  • 74.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20833 35
(Danio rerio)
Actinopterygii rplp1 35
  • 70.5 (n)
  • 75.22 (a)
wufa93f02 35
rplp1 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpLP1 36
  • 63 (a)
(Caenorhabditis elegans)
Secernentea rla-1 36
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP1A 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for RPLP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP1 Gene

Gene Tree for RPLP1 (if available)
Gene Tree for RPLP1 (if available)

Paralogs for RPLP1 Gene

genes like me logo Genes that share paralogs with RPLP1: view

No data available for Paralogs for RPLP1 Gene

Variants for RPLP1 Gene

Sequence variations from dbSNP and Humsavar for RPLP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs577649307 -- 69,455,241(+) GCTGG(A/T)GCTGC synonymous-codon, reference
rs577135106 -- 69,454,214(+) GTTTA(A/G)TAGTG intron-variant
rs576544725 -- 69,455,414(+) TTGAC(-/T)TTTTT intron-variant
rs575401440 -- 69,452,972(+) CTCGC(C/T)TGCAT reference, synonymous-codon
rs575191075 -- 69,452,813(+) GGCGC(A/G)AGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPLP1 Gene

Variant ID Type Subtype PubMed ID
dgv753e1 CNV Complex 17122850
nsv520964 CNV Gain 19592680
nsv1585 CNV Insertion 18451855

Relevant External Links for RPLP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP1 Gene

Disorders for RPLP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPLP1 Gene in MalaCards »

(1) Disease for RPLP1 Gene

Relevant External Links for RPLP1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RPLP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RPLP1 Gene

Publications for RPLP1 Gene

  1. Identification and characterization of phosphorylated proteins in the human pituitary. (PMID: 14997482) Giorgianni F. … Desiderio D.M. (Proteomics 2004) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PMID: 3323886) Rich B.E. … Steitz J.A. (Mol. Cell. Biol. 1987) 3 4
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  5. Phosphoproteomic analysis of the human pituitary. (PMID: 16807684) Beranova-Giorgianni S. … Giorgianni F. (Pituitary 2006) 3 4

Products for RPLP1 Gene

Sources for RPLP1 Gene

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