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Aliases for RPLP1 Gene

Aliases for RPLP1 Gene

  • Ribosomal Protein Lateral Stalk Subunit P1 2 3
  • Ribosomal Protein, Large, P1 2 3 5
  • Acidic Ribosomal Phosphoprotein P1 3
  • RPP1 3
  • RRP1 4
  • LP1 3
  • P1 3

External Ids for RPLP1 Gene

Previous GeneCards Identifiers for RPLP1 Gene

  • GC15P065586
  • GC15P062843
  • GC15P067324
  • GC15P067460
  • GC15P067532
  • GC15P069745
  • GC15P046578

Summaries for RPLP1 Gene

Entrez Gene Summary for RPLP1 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP1 Gene

RPLP1 (Ribosomal Protein Lateral Stalk Subunit P1) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP1 Gene

  • Plays an important role in the elongation step of protein synthesis.

Gene Wiki entry for RPLP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP1 Gene

Genomics for RPLP1 Gene

Regulatory Elements for RPLP1 Gene

Promoters for RPLP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPLP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPLP1 Gene

Chromosome:
15
Start:
69,452,784 bp from pter
End:
69,456,194 bp from pter
Size:
3,411 bases
Orientation:
Plus strand

Genomic View for RPLP1 Gene

Genes around RPLP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP1 Gene

Proteins for RPLP1 Gene

  • Protein details for RPLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05386-RLA1_HUMAN
    Recommended name:
    60S acidic ribosomal protein P1
    Protein Accession:
    P05386
    Secondary Accessions:
    • A6NIB2

    Protein attributes for RPLP1 Gene

    Size:
    114 amino acids
    Molecular mass:
    11514 Da
    Quaternary structure:
    • Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPLP1 Gene

    Alternative splice isoforms for RPLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPLP1 Gene

Proteomics data for RPLP1 Gene at MOPED

Post-translational modifications for RPLP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPLP1 Gene

No data available for DME Specific Peptides for RPLP1 Gene

Domains & Families for RPLP1 Gene

Gene Families for RPLP1 Gene

Protein Domains for RPLP1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPLP1 Gene

Graphical View of Domain Structure for InterPro Entry

P05386

UniProtKB/Swiss-Prot:

RLA1_HUMAN :
  • Belongs to the ribosomal protein L12P family.
Family:
  • Belongs to the ribosomal protein L12P family.
genes like me logo Genes that share domains with RPLP1: view

Function for RPLP1 Gene

Molecular function for RPLP1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the elongation step of protein synthesis.

Gene Ontology (GO) - Molecular Function for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS --
GO:0005515 protein binding IPI 12054647
GO:0070180 large ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with RPLP1: view
genes like me logo Genes that share phenotypes with RPLP1: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP1 Gene

Localization for RPLP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPLP1 Gene COMPARTMENTS Subcellular localization image for RPLP1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RPLP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPLP1 Gene

Pathways & Interactions for RPLP1 Gene

genes like me logo Genes that share pathways with RPLP1: view

Pathways by source for RPLP1 Gene

1 BioSystems pathway for RPLP1 Gene
1 KEGG pathway for RPLP1 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP1 Gene

Gene Ontology (GO) - Biological Process for RPLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPLP1: view

No data available for SIGNOR curated interactions for RPLP1 Gene

Drugs & Compounds for RPLP1 Gene

No Compound Related Data Available

Transcripts for RPLP1 Gene

Unigene Clusters for RPLP1 Gene

Ribosomal protein, large, P1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: -

Relevant External Links for RPLP1 Gene

GeneLoc Exon Structure for
RPLP1
ECgene alternative splicing isoforms for
RPLP1

Expression for RPLP1 Gene

mRNA expression in normal human tissues for RPLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPLP1 Gene



SOURCE GeneReport for Unigene cluster for RPLP1 Gene Hs.356502

genes like me logo Genes that share expression patterns with RPLP1: view

Protein tissue co-expression partners for RPLP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPLP1 Gene

Orthologs for RPLP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPLP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPLP1 35
  • 99.71 (n)
  • 100 (a)
RPLP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPLP1 36
  • 98 (a)
OneToOne
RPLP1 35
  • 93.27 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RPLP1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10073 36
  • 96 (a)
OneToMany
Gm17511 36
  • 95 (a)
OneToMany
Rplp1 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rplp1 35
  • 88.89 (n)
  • 98.25 (a)
chicken
(Gallus gallus)
Aves RPLP1 36
  • 90 (a)
OneToOne
RPLP1 35
  • 80.41 (n)
  • 85.96 (a)
lizard
(Anolis carolinensis)
Reptilia RPLP1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20833 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp1 35
  • 73.16 (n)
  • 74.34 (a)
zebrafish
(Danio rerio)
Actinopterygii rplp1 36
  • 81 (a)
OneToOne
rplp1 35
  • 70.5 (n)
  • 75.22 (a)
wufa93f02 35
fruit fly
(Drosophila melanogaster)
Insecta RpLP1 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rla-1 36
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP1A 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for RPLP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP1 Gene

ENSEMBL:
Gene Tree for RPLP1 (if available)
TreeFam:
Gene Tree for RPLP1 (if available)

Paralogs for RPLP1 Gene

genes like me logo Genes that share paralogs with RPLP1: view

No data available for Paralogs for RPLP1 Gene

Variants for RPLP1 Gene

Sequence variations from dbSNP and Humsavar for RPLP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11119 -- 69,452,974(+) CGCCT(G/T)CATCT reference, missense
rs1463911 -- 69,455,336(+) TTTTT(A/T)AAAAA intron-variant
rs1463912 -- 69,455,996(+) TTATG(A/G)TAACA downstream-variant-500B
rs2102265 -- 69,452,925(+) GCAGC(G/T)CCAGC utr-variant-5-prime
rs3809504 -- 69,451,791(-) AATAA(C/T)CATCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPLP1 Gene

Variant ID Type Subtype PubMed ID
dgv753e1 CNV Complex 17122850
nsv520964 CNV Gain 19592680
nsv1585 CNV Insertion 18451855

Variation tolerance for RPLP1 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPLP1 Gene

HapMap Linkage Disequilibrium report
RPLP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP1 Gene

Disorders for RPLP1 Gene

Relevant External Links for RPLP1

Genetic Association Database (GAD)
RPLP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPLP1

No disorders were found for RPLP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPLP1 Gene

Publications for RPLP1 Gene

  1. Identification and characterization of phosphorylated proteins in the human pituitary. (PMID: 14997482) Giorgianni F. … Desiderio D.M. (Proteomics 2004) 3 4 23 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3

Products for RPLP1 Gene

Sources for RPLP1 Gene

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