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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPLP0 Gene

protein-coding GIFtS: 61
GCID: GC12M120634

ribosomal protein, large, P0

Explore 25 diseases affiliated with
RPLP0 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein, Large, P0¹ ²		RPP0¹ ²
L10E¹ ²		60S Ribosomal Protein L10E² ³
LP0¹ ²		60S Acidic Ribosomal Protein P0²
P0¹ ²		Acidic Ribosomal Phosphoprotein P0²
PRLP0¹ ²

External Ids:	HGNC: 10371¹	Entrez Gene: 6175²	Ensembl: ENSG00000089157⁷	OMIM: 180510⁵	UniProtKB: P05388³

Export aliases for RPLP0 gene to outside databases

Previous GC identifers: GC12M119507 GC12M120161 GC12M120417 GC12M119046 GC12M119097 GC12M117643

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPLP0:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of

the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein

with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and

P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0

monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they

encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes

of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RLA0_HUMAN, P05388

Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10

Gene Wiki entry for RPLP0

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPLP0 gene promoter:
GR GR-beta NRSF form 1 ATF-2 NRSF form 2 E47 COMP1 c-Jun GR-alpha Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPLP0 promoter sequence

Search SABiosciences Chromatin IP Primers for RPLP0

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPLP0

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.23 HGNC cytogenetic band: 12q24.2

RPLP0 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPLP0 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M120634: view genomic region (about GC identifiers)

Start:	120,634,489 bp from pter	End:	120,639,038 bp from pter
Size:	4,550 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RLA0_HUMAN, P05388 (See protein sequence)

Recommended Name: 60S acidic ribosomal protein P0

Size: 317 amino acids; 34274 Da

Subunit: P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a mRNP granule complex,

at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1,

HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP,

TROVE2, YBX1 and untranslated mRNAs. Interacts with Lassa virus Z protein. Interacts with APEX1

Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs

Secondary accessions: Q9BVK4

Explore the universe of human proteins at neXtProt for RPLP0: NX_P05388

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05388

RPLP0 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000993.1 NP_444505.1

ENSEMBL proteins:

ENSP00000376299 ENSP00000449328 ENSP00000446777 ENSP00000366471 ENSP00000449205

ENSP00000448919 ENSP00000448639 ENSP00000447311 ENSP00000450222 ENSP00000449854

ENSP00000450019 ENSP00000448046 ENSP00000450121 ENSP00000449765 ENSP00000448223

ENSP00000339027

Reactome Protein details: P05388
Human Recombinant Protein Products for RPLP0:

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	Uscn Proteins for RPLP0

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	19188445
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0022625	cytosolic large ribosomal subunit	IDA	12962325

RPLP0 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPLP0 for domains About GeneDecksing

2 InterPro domains/families:

IPR001813 Ribosomal_60S

IPR001790 Ribosomal_L10/acidic_P0

Graphical View of Domain Structure for InterPro Entry P05388

ProtoNet protein and cluster: P05388

1 Blocks protein family: IPB001813 60S Acidic ribosomal protein

UniProtKB/Swiss-Prot: RLA0_HUMAN, P05388

Similarity: Belongs to the ribosomal protein L10P family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RLA0_HUMAN, P05388

Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10

Genatlas biochemistry entry for RPLP0:

60S acidic ribosomal protein P0,110p family,equivalent of E Coli protein L10

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	3323886
GO:0003735	structural constituent of ribosome	NAS	12962325
GO:0005515	protein binding	IPI	15303970

RPLP0 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for RPLP0:

Decreased cell number, increas

Nuclear 60S biogenesis defects

Nucleolar pre-40S maturation d

S arrest

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPLP0

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPLP0

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPLP0

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPLP0

Cytoplasmic Ribosomal Proteins

5/28 Reactome Pathways for RPLP0 (see all 28)

	Nonsense Mediated Decay Independent of the Exon Junction Complex
	Nonsense-Mediated Decay
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Eukaryotic Translation Initiation

1 Kegg Pathway (Kegg details for RPLP0):

Ribosome

RPLP0 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RPLP0

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1230 Interacting proteins for RPLP0 (P05388^{1, 2, 3} ENSP00000339027⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1230)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=4
HIST1H4B	P62805³	I2D: score=4
HIST1H4C	P62805³	I2D: score=4
HIST1H4D	P62805³	I2D: score=4
HIST1H4E	P62805³	I2D: score=4

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPLP0 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RPLP0 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPLP0
2 Novoseek chemical compound relationships for RPLP0 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glyceraldehyde 3-phosphate	29.8	2	16220529 (1), 17196660 (1)
atp	0	1	16220529 (1)

Search CenterWatch for drugs/clinical trials and news about RPLP0 / RLA0

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPLP0 gene (2 alternative transcripts):

NM_001002.3 NM_053275.3

Unigene Cluster for RPLP0:

Ribosomal protein, large, P0

Hs.546285 [show with all ESTs]

Unigene Representative Sequence: BQ051850

18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000392514(uc001txq.3 uc001txr.3) ENST00000551217 ENST00000551150

ENST00000552292 ENST00000313104 ENST00000546989 ENST00000552461 ENST00000549098

ENST00000551258 ENST00000546990 ENST00000547475 ENST00000547211 ENST00000547173

ENST00000550856 ENST00000548568 ENST00000546564 ENST00000547191 ENST00000550296

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Additional cDNA sequence:

AF274958.1 AK129754.1 AK129823.1 AK222468.1 AK222571.1 AK291109.1 AK304674.1 BC000087.2

BC000345.2 BC000752.2 BC001127.2 BC001834.2 BC003655.2 BC005863.2 BC008092.1 BC008594.1

BC009867.2 BC015173.1 BC015690.1 BC019014.2 BC070194.1 BC104645.1 BC107717.1 M17885.1

Z36785.1

24/188 DOTS entries (see all 188):

DT.95271968 DT.91662095 DT.100749119 DT.100749070 DT.121112660 DT.100749104 DT.100749359 DT.121112710

DT.121000 DT.100749303 DT.100749211 DT.99953823 DT.98083336 DT.100749135 DT.95271857 DT.101957822

DT.95146787 DT.100749247 DT.91903137 DT.100749102 DT.100749056 DT.95272037 DT.95272013 DT.95272022

24/34 AceView cDNA sequences (see all 34):

CR597824 BC015173 BC008092 CR613873 AK129823 BC000752 D28418 AK129754

BC003655 BC000087 BC001834 BC005863 BC015690 NM_001002 BC019014 BC009867

CR602521 BC008594 CR625189 NM_053275 BC001127 CR625036 CR600402 CR599043

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for RPLP0 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11a	·
SP1:											-						-		-																-						-
SP2:											-																								-		-		-		-
SP3:											-																						-								-
SP4:																																			-						-
SP5:											-												-		-		-		-		-		-		-						-

ExUns:	11b	·	11c	·	11d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RPLP0

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPLP0 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAACATCT

About this image

RPLP0 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Heart

Outflow Tract

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPLP0 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPLP0

SOURCE GeneReport for Unigene cluster: Hs.546285

SABiosciences Expression via Pathway-Focused PCR Arrays including RPLP0 (see all 148):

Antiviral Response in human mouse rat

Multiple Sclerosis in human mouse rat

Wound Healing in human mouse rat

Prostate Cancer in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPLP0

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP0 gene from 10/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rplp0^{1 , 5}	ribosomal protein, large, P0^{1, 5}	90.43(n)¹ 97.48(a)¹		5 (56.10 cM)⁵ 11837¹ NM_007475.5¹ NP_031501.1¹ 115559467⁵
chicken (Gallus gallus)	Aves	RPLP0¹	ribosomal protein, large, P0	85.02(n) 95.57(a)		395835 NM_204987.1 NP_990318.1
lizard (Anolis carolinensis)	Reptilia	RPLP0⁶	--	96(a)	1 ↔ 1	GL343338.1(452041-455773)
African clawed frog (Xenopus laevis)	Amphibia	arbp-prov²	acidic ribosomal protein P0	81.56(n)		BC042268.1
zebrafish (Danio rerio)	Actinopterygii	rplp0²	ribosomal protein, large, P0	79.48(n)		58101 BC062854.1
fruit fly (Drosophila melanogaster)	Insecta	RpP0³ RpLP0¹	protein biosynthesis DNA-(apurinic or apyrimidinic more³ Ribosomal protein LP0¹	66(a)³ 64.56(n)¹ 66.25(a)¹		79B2³ 40451¹ NM_079487.3¹ NP_524211.1¹
worm (Caenorhabditis elegans)	Secernentea	rpa-0³ rla-0¹	deoxyribonuclease³ Protein RLA-0¹	65(a)³ 65.17(n)¹ 68.27(a)¹		I(10575873-10576820)³ 172943¹ NM_060365.6¹ NP_492766.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPP0(YLR340W)⁴ RPP0¹	Conserved ribosomal protein P0 of the ribosomal stalk, more⁴ Rpp0p¹	58.36(n)¹ 56.07(a)¹		12(805887-806825)⁴ 851052^{1, 4} NP_013444.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G11250¹	60S acidic ribosomal protein P0-3	56.89(n) 55.84(a)		820296 NM_111960.3 NP_187734.1
rice (Oryza sativa)	Liliopsida	Os08g0130500¹	hypothetical protein	59.66(n) 53.82(a)		4344590 NM_001067458.1 NP_001060923.1

ENSEMBL Gene Tree for RPLP0 (if available)
TreeFam Gene Tree for RPLP0 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RPLP0 gene

1 SIMAP similar gene for RPLP0 using alignment to 16 protein entries: RLA0_HUMAN (see all proteins):

RPLP0P6

RPLP0 for paralogs About GeneDecksing

5/13 Pseudogenes.org Pseudogenes for RPLP0 (see all 13)
PGOHUM00000242755 PGOHUM00000261140 PGOHUM00000247769 PGOHUM00000261169 PGOHUM00000235059

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141652582^1,2		--	120634038(+)	`TAATTA/CTAGTG`	3	--	us2k¹ ds500¹		0	--	--	--	--
rs185680757^1,2		--	120634168(+)	`GCATAC/TGGCAC`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs7978656^1,2	C,F,H	--	120634289(+)	`TGCAAC/TATCTC`	3	--	us2k¹ ds500¹		31		NS EA NA WA CSA	2779
rs147072200^1,2		--	120634304(+)	`AAAAAA/GAAATT`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs138389714^1,2	C	--	120634527(+)	`CTTTAC/TTTCCT`	2	--	ut3¹		0	--	--	--	--
rs202019208^1,2		--	120634569(+)	`GCTTTC/TTGGTG`	2	--	ut3¹		0	--	--	--	--
rs1051147^1,2	C	--	120634573(-)	`TAATCA/CCCAAA`	2	--	ut3¹		2		NA	4
rs60656828^1,2	C,F	--	120634612(+)	`TCCGAC/GTCCTC`	4	D E	mis¹		2		WA NA	4088
rs138059335^1,2	C	--	120634637(+)	`CTTCAA/GCCTTA`	4	A V	mis¹		1		NA	3484
rs190001053^1,2	C	--	120634795(+)	`CACCAC/G/TCCTCC`	2	--	int¹		1		EU	1011

HapMap Linkage Disequilibrium report for RPLP0 (120634489 - 120639038 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPLP0: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPLP0

DNA2.0 Custom Variant and Variant Library Synthesis for RPLP0

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPLP0 for disorders           About GeneDecksing

OMIM gene information: 180510    OMIM disorders: --

20/25 diseases for RPLP0 (see all 25):    About MalaCards

distal hereditary motor neuropathy mixed connective tissue disease connective tissue disease lupus erythematosus

metastasis efficiency chronic fatigue syndrome systemic lupus erythematosus chagas disease

sjogren's syndrome hepatocellular carcinoma endocarditis colon carcinoma

neuropathy pancreatic cancer cholangiocarcinoma carcinoma

breast cancer pancreatitis myeloma obesity

5 Novoseek disease relationships for RPLP0 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lupus erythematosus systemic	56.5	1	7876567 (1)
mimicry	54.5	1	7790824 (1)
chagas disease	42.9	1	1377223 (1)
hepatocellular carcinoma	21.9	3	17621266 (2), 1350508 (1)
tumors	0	1	17621266 (1)

Export disorders for RPLP0 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPLP0 gene, integrated from 9 sources (see all 118):
(articles sorted by number of sources associating them with RPLP0)

Utopia: connect your pdf to the dynamic
world of online information

A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 2, 3} Kenmochi N.... Page D.C. (1998)
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)^{1, 2} Vascotto C....Tell G. (2009)
Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PubMed id 3323886)^{1, 2} Rich B.E. and Steitz J.A. (1987)
Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PubMed id 17621266)^{1, 9} Chang T.-W....Chang M.-C. (2008)
The subcellular distribution of the human ribosomal 'stalk' components: P1, P2 and P0 proteins. (PubMed id 12479870)^{1, 9} Tchorzewski M....Grankowski N. (2003)
Characterization of Staufen 1 ribonucleoprotein complexes. (PubMed id 15303970)^{1, 9} Brendel C....Kindler S. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6175	HGNC: 10371	AceView: RPLP0	Ensembl:ENSG00000089157	euGenes: HUgn6175
ECgene: RPLP0	Kegg: 6175	H-InvDB: RPLP0

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RPLP0	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPLP0 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPLP0 gene:
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GeneCards and IP:
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ribosomal protein, large, P0

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ribosomal protein, large, P0

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