Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPLP0 Gene

Aliases for RPLP0 Gene

  • Ribosomal Protein Lateral Stalk Subunit P0 2 3 5
  • Large Ribosomal Subunit Protein UL10 3 4
  • Neutral Ribosomal Phosphoprotein P0 2 3
  • Ribosomal Protein, Large, P0 2 3
  • 60S Ribosomal Protein L10E 3 4
  • Acidic Ribosomal Phosphoprotein P0 3
  • 60S Acidic Ribosomal Protein P0 3
  • PRLP0 3
  • L10E 3
  • RPP0 3
  • LP0 3
  • P0 3

External Ids for RPLP0 Gene

Previous GeneCards Identifiers for RPLP0 Gene

  • GC12M119507
  • GC12M120161
  • GC12M120417
  • GC12M119046
  • GC12M119097
  • GC12M120634
  • GC12M117643

Summaries for RPLP0 Gene

Entrez Gene Summary for RPLP0 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP0 Gene

RPLP0 (Ribosomal Protein Lateral Stalk Subunit P0) is a Protein Coding gene. Diseases associated with RPLP0 include Charcot-Marie-Tooth Disease, Axonal, Type 2L. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP0 Gene

  • Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Gene Wiki entry for RPLP0 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP0 Gene

Genomics for RPLP0 Gene

Regulatory Elements for RPLP0 Gene

Enhancers for RPLP0 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120223 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -30.4 -30350 16.0 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12G120115 1.4 ENCODE dbSUPER 12 +82.2 82200 7.5 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 GCN1 PXN-AS1 RPLP0 PRKAB1 PXN RAB35 COQ5 MIR4498
GH12G120125 1.2 Ensembl ENCODE dbSUPER 11.6 +74.4 74380 2.2 PKNOX1 ESRRA RFX1 JUN MAX EBF1 BMI1 POLR2A SCRT2 KDM1A PXN-AS1 RPLP0 GCN1 PXN RAB35 MIR4498
GH12G120261 1.6 FANTOM5 ENCODE dbSUPER 4.3 -62.7 -62695 5.2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF766 ZNF143 FOS KLF13 GCN1 PRKAB1 RPL31P52 PXN SIRT4 RPLP0 MSI1 RAB35 RPS20P31
GH12G120198 1.7 FANTOM5 ENCODE dbSUPER 0.7 +0.8 784 4.2 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 RCOR2 GCN1 RAB35 SRSF9 PRKAB1 SPPL3 GC12M120197 RPLP0
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPLP0 on UCSC Golden Path with GeneCards custom track

Promoters for RPLP0 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058285 35 2401 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 RCOR2

Genomic Location for RPLP0 Gene

Chromosome:
12
Start:
120,196,686 bp from pter
End:
120,201,235 bp from pter
Size:
4,550 bases
Orientation:
Minus strand

Genomic View for RPLP0 Gene

Genes around RPLP0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP0 Gene

Proteins for RPLP0 Gene

  • Protein details for RPLP0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05388-RLA0_HUMAN
    Recommended name:
    60S acidic ribosomal protein P0
    Protein Accession:
    P05388
    Secondary Accessions:
    • Q3B7A4
    • Q9BVK4

    Protein attributes for RPLP0 Gene

    Size:
    317 amino acids
    Molecular mass:
    34274 Da
    Quaternary structure:
    • P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146). Interacts with Lassa virus Z protein.

    Three dimensional structures from OCA and Proteopedia for RPLP0 Gene

    Alternative splice isoforms for RPLP0 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPLP0 Gene

Post-translational modifications for RPLP0 Gene

  • Ubiquitination at isoforms=250, isoforms=257, isoforms=277, Lys246, and Lys266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPLP0 Gene

Domains & Families for RPLP0 Gene

Gene Families for RPLP0 Gene

Protein Domains for RPLP0 Gene

Suggested Antigen Peptide Sequences for RPLP0 Gene

Graphical View of Domain Structure for InterPro Entry

P05388

UniProtKB/Swiss-Prot:

RLA0_HUMAN :
  • Belongs to the universal ribosomal protein uL10 family.
Family:
  • Belongs to the universal ribosomal protein uL10 family.
genes like me logo Genes that share domains with RPLP0: view

Function for RPLP0 Gene

Molecular function for RPLP0 Gene

GENATLAS Biochemistry:
60S acidic ribosomal protein P0,110p family,equivalent of E Coli protein L10
UniProtKB/Swiss-Prot Function:
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Gene Ontology (GO) - Molecular Function for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IDA,NAS 12962325
GO:0005515 protein binding IPI 15121898
genes like me logo Genes that share ontologies with RPLP0: view
genes like me logo Genes that share phenotypes with RPLP0: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP0 Gene

Localization for RPLP0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPLP0 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661). {ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:19188445}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPLP0 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 4
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 19188445
GO:0005737 cytoplasm IDA,IEA 19188445
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPLP0: view

Pathways & Interactions for RPLP0 Gene

genes like me logo Genes that share pathways with RPLP0: view

Pathways by source for RPLP0 Gene

1 KEGG pathway for RPLP0 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP0 Gene

Gene Ontology (GO) - Biological Process for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPLP0: view

No data available for SIGNOR curated interactions for RPLP0 Gene

Drugs & Compounds for RPLP0 Gene

(1) Drugs for RPLP0 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RPLP0 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPLP0: view

Transcripts for RPLP0 Gene

Unigene Clusters for RPLP0 Gene

Ribosomal protein, large, P0:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP0 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: -
SP10: - - -
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16: -

ExUns: 11b · 11c · 11d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RPLP0 Gene

GeneLoc Exon Structure for
RPLP0
ECgene alternative splicing isoforms for
RPLP0

Expression for RPLP0 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPLP0 Gene

Protein differential expression in normal tissues from HIPED for RPLP0 Gene

This gene is overexpressed in Tlymphocyte (9.4) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPLP0 Gene



Protein tissue co-expression partners for RPLP0 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPLP0 Gene:

RPLP0

SOURCE GeneReport for Unigene cluster for RPLP0 Gene:

Hs.546285

Evidence on tissue expression from TISSUES for RPLP0 Gene

  • Intestine(5)
  • Lung(5)
  • Nervous system(5)
  • Pancreas(4.9)
  • Liver(4.8)
  • Muscle(4.7)
  • Kidney(4.6)
  • Skin(4.5)
  • Blood(4.4)
  • Eye(4.2)
  • Heart(4.1)
  • Stomach(3.7)
  • Bone(3.3)
  • Spleen(2.5)
  • Bone marrow(2.4)
  • Lymph node(2.4)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with RPLP0: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPLP0 Gene

Orthologs for RPLP0 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP0 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPLP0 34 35
  • 99.79 (n)
mouse
(Mus musculus)
Mammalia Gm8730 35
  • 97 (a)
OneToMany
Rplp0 34 16 35
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia RPLP0 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPLP0 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPLP0 34 35
  • 93.69 (n)
cow
(Bos Taurus)
Mammalia RPLP0 34 35
  • 92.01 (n)
rat
(Rattus norvegicus)
Mammalia Rplp0 34
  • 90.75 (n)
chicken
(Gallus gallus)
Aves RPLP0 34 35
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia RPLP0 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp0 34
  • 80.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia arbp-prov 34
zebrafish
(Danio rerio)
Actinopterygii rplp0 34 35
  • 79.58 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1089 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003592 34
  • 68.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpP0 36
  • 66 (a)
RpLP0 34 35
  • 64.56 (n)
worm
(Caenorhabditis elegans)
Secernentea rla-0 34 35
  • 65.28 (n)
rpa-0 36
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL178C 34
  • 59.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05918g 34
  • 59.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP0 34 35 37
  • 58.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09200 34
  • 58.12 (n)
rice
(Oryza sativa)
Liliopsida Os08g0130500 34
  • 59.95 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12996 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11194 35
  • 73 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07408 34
  • 62.66 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpp0 34
  • 59.89 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4852 34
Species where no ortholog for RPLP0 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP0 Gene

ENSEMBL:
Gene Tree for RPLP0 (if available)
TreeFam:
Gene Tree for RPLP0 (if available)

Paralogs for RPLP0 Gene

No data available for Paralogs for RPLP0 Gene

Variants for RPLP0 Gene

Sequence variations from dbSNP and Humsavar for RPLP0 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000661459 -- 120,199,074(+) TTAAG(A/G)AGCAA intron-variant
rs1000683619 -- 120,201,039(+) CATGC(G/T)TCCCG intron-variant, upstream-variant-2KB
rs1001291606 -- 120,201,891(+) TTCGG(A/G)AGGAC intron-variant, upstream-variant-2KB
rs1001389164 -- 120,202,087(+) AAGAT(C/T)ACACC intron-variant, upstream-variant-2KB
rs1001529744 -- 120,201,481(+) TTTCT(C/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPLP0 Gene

Variant ID Type Subtype PubMed ID
nsv519657 CNV loss 19592680
nsv560433 CNV loss 21841781
nsv832530 CNV loss 17160897
nsv973128 CNV duplication 23825009
nsv976653 CNV duplication 23825009

Variation tolerance for RPLP0 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPLP0 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPLP0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP0 Gene

Disorders for RPLP0 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPLP0 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease axonal type 2l
- elite association - COSMIC cancer census association via MalaCards
Search RPLP0 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPLP0

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPLP0
genes like me logo Genes that share disorders with RPLP0: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPLP0 Gene

Publications for RPLP0 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. (PMID: 24658146) Taha M.S. … Ahmadian M.R. (PLoS ONE 2014) 3 4 64
  3. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C. … Tell G. (Mol. Cell. Biol. 2009) 3 4 64
  4. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PMID: 17621266) Chang T.-W. … Chang M.-C. (Oncogene 2008) 3 22 64
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64

Products for RPLP0 Gene

Sources for RPLP0 Gene

Content
Loading form....