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RPLP0 Gene

protein-coding   GIFtS: 64
GCID: GC12M120634

Ribosomal Protein, Large, P0

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein, Large, P01 2     LP02
Acidic Ribosomal Phosphoprotein P01 2     P02
60S Ribosomal Protein L10E2 3     PRLP02
60S Acidic Ribosomal Protein P02     RPP02
L10E2     

External Ids:    HGNC: 103711   Entrez Gene: 61752   Ensembl: ENSG000000891577   OMIM: 1805105   UniProtKB: P053883   

Export aliases for RPLP0 gene to outside databases

Previous GC identifers: GC12M119507 GC12M120161 GC12M120417 GC12M119046 GC12M119097 GC12M117643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPLP0 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional
equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a
neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic
ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex
consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants
derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RPLP0 Gene:
RPLP0 (ribosomal protein, large, P0) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

UniProtKB/Swiss-Prot: RLA0_HUMAN, P05388
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10

Gene Wiki entry for RPLP0 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPLP0 gene promoter:
         GR   GR-beta   NRSF form 1   ATF-2   NRSF form 2   E47   COMP1   c-Jun   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPLP0 promoter sequence
   Search Chromatin IP Primers for RPLP0

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPLP0


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.2

RPLP0 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPLP0 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120634:  view genomic region     (about GC identifiers)

Start:
120,634,489 bp from pter      End:
120,639,038 bp from pter
Size:
4,550 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RLA0_HUMAN, P05388 (See protein sequence)
Recommended Name: 60S acidic ribosomal protein P0  
Size: 317 amino acids; 34274 Da
Subunit: P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a IGF2BP1-dependent
mRNP granule complex containing untranslated mRNAs. Interacts with Lassa virus Z protein. Interacts with APEX1
2 PDB 3D structures from and Proteopedia for RPLP0:
3J39 (3D)        3J3B (3D)    
Secondary accessions: Q9BVK4

Explore the universe of human proteins at neXtProt for RPLP0: NX_P05388

Explore proteomics data for RPLP0 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys26, Lys38, Lys50, Lys57, Lys77, Lys92, Lys106, Lys134, Lys146,
                                 Lys246, Lys266
  • Modification sites at PhosphoSitePlus

  • See RPLP0 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000993.1  NP_444505.1  

    ENSEMBL proteins: 
     ENSP00000376299   ENSP00000449328   ENSP00000446777   ENSP00000366471   ENSP00000449205  
     ENSP00000448919   ENSP00000448639   ENSP00000447311   ENSP00000450222   ENSP00000449854  
     ENSP00000450019   ENSP00000448046   ENSP00000450121   ENSP00000449765   ENSP00000448223  
     ENSP00000339027  
    Reactome Protein details: P05388

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    2 InterPro protein domains:
     IPR001813 Ribosomal_L10/L12
     IPR001790 Ribosomal_L10/acidic_P0

    Graphical View of Domain Structure for InterPro Entry P05388

    ProtoNet protein and cluster: P05388

    1 Blocks protein domain: IPB001813 60S Acidic ribosomal protein

    UniProtKB/Swiss-Prot: RLA0_HUMAN, P05388
    Similarity: Belongs to the ribosomal protein L10P family


    Find genes that share domains with RPLP0           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RLA0_HUMAN, P05388
    Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10

         Genatlas biochemistry entry for RPLP0:
    60S acidic ribosomal protein P0,110p family,equivalent of E Coli protein L10

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS3323886
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI15121898
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPLP0           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPLP0:
     Decreased cell number, increas  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target RPLP0:
    hsa-mir-505-3p (MIRT041065), hsa-mir-16-5p (MIRT031708), hsa-mir-30d-5p (MIRT047798), hsa-mir-30e-5p (MIRT044152), hsa-mir-324-3p (MIRT042891), hsa-mir-221-3p (MIRT046937), hsa-mir-484 (MIRT041756), hsa-mir-125b-5p (MIRT045966), hsa-mir-149-5p (MIRT045668), hsa-mir-92b-3p (MIRT040629), hsa-mir-331-3p (MIRT043394), hsa-mir-183-5p (MIRT047112), hsa-mir-15b-5p (MIRT046464)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RLA0_HUMAN, P05388: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA19188445
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----

    Find genes that share ontologies with RPLP0           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPLP0 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPLP0           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPLP0
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPLP0
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPLP0 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPLP0):
        Ribosome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPLP0 (see all 148): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPLP0

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPLP0 (P053881, 2, 3 ENSP000003390274) via UniProtKB, MINT, STRING, and/or I2D (see all 1411)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPLP0           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPLP0 (RLA0)

    2 Novoseek inferred chemical compound relationships for RPLP0 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 29.8 2 16220529 (1), 17196660 (1)
    atp 0 1 16220529 (1)



    Find genes that share compounds with RPLP0           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPLP0 gene (2 alternative transcripts): 
    NM_001002.3  NM_053275.3  

    Unigene Cluster for RPLP0:

    Ribosomal protein, large, P0
    Hs.546285  [show with all ESTs]
    Unigene Representative Sequence: BQ051850
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000392514(uc001txq.3 uc001txr.3) ENST00000551217 ENST00000551150
    ENST00000552292 ENST00000313104 ENST00000546989 ENST00000552461 ENST00000549098
    ENST00000551258 ENST00000546990 ENST00000547475 ENST00000547211 ENST00000547173
    ENST00000550856 ENST00000548568 ENST00000546564 ENST00000547191 ENST00000550296

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    Additional mRNA sequence: 

    AF274958.1 AK129754.1 AK129823.1 AK222468.1 AK222571.1 AK291109.1 AK304674.1 BC000087.2 
    BC000345.2 BC000752.2 BC001127.2 BC001834.2 BC003655.2 BC005863.2 BC008092.1 BC008594.1 
    BC009867.2 BC015173.1 BC015690.1 BC019014.2 BC070194.1 BC104645.1 BC107717.1 M17885.1 
    Z36785.1 

    Selected DOTS entries (see all 189):

    DT.95271968  DT.91662095  DT.100749119  DT.121112660  DT.100749070  DT.100749104  DT.100749359  DT.121112710 
    DT.100749303  DT.121000  DT.100749211  DT.98083336  DT.99953823  DT.100749135  DT.95271857  DT.101957822 
    DT.95146787  DT.100749247  DT.91903137  DT.100749102  DT.100749056  DT.95272013  DT.95272022  DT.95272037 

    Selected AceView cDNA sequences (see all 34):

    D28418 BC000752 BC001834 BC015173 BC000087 CR619416 BC015690 CR613873 
    CR625189 BC008092 BC000345 AK129823 CR600402 NM_053275 BC019014 AK129754 
    CR602521 BC005863 BC009867 CR599043 BC001127 BC008594 CR625036 BC003655 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPLP0 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a ·
    SP1:                                -                 -     -                                               -                 -                                 
    SP2:                                -                                                                       -     -     -     -                                 
    SP3:                                -                                                                 -                       -                                 
    SP4:                                                                                                        -                 -                                 
    SP5:                                -                                   -     -     -     -     -     -     -                 -                                 

    ExUns: 11b · 11c · 11d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RPLP0

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RPLP0 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAACATCT
    RPLP0 Expression
    About this image


    RPLP0 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    RPLP0 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPLP0 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546285
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPLP0 (see all 148): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPLP0 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rplp01 , 5 ribosomal protein, large, P01, 5 90.43(n)1
    97.48(a)1
      5 (56.10 cM)5
    118371  NM_007475.51  NP_031501.11 
     1155594675 
    chicken
    (Gallus gallus)
    Aves RPLP01 ribosomal protein, large, P0 84.6(n)
    94.3(a)
      395835  NM_204987.1  NP_990318.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPLP06
    ribosomal protein, large, P0
    96(a)
    1 ↔ 1
    GL343338.1(451988-456025)
    African clawed frog
    (Xenopus laevis)
    Amphibia arbp-prov2 acidic ribosomal protein P0 81.56(n)    BC042268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rplp02 ribosomal protein, large, P0 79.48(n)   58101  BC062854.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpP03
    RpLP01
    protein biosynthesis DNA-(apurinic or
    apyrimidinic more3
    Ribosomal protein LP01
    66(a)3
    64.56(n)1
    66.25(a)1
      79B23
    404511  NM_001275273.11  NP_001262202.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpa-03
    rla-01
    deoxyribonuclease3
    rla-01
    65(a)3
    65.28(n)1
    66.67(a)1
      I(10575873-10576820)3
    1729431  NM_060365.71  NP_492766.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPP0(YLR340W)4
    RPP01
    Conserved ribosomal protein P0 of the ribosomal stalk, more4
    RPP01
    58.14(n)1
    54.75(a)1
      12(805887-806825)4
    8510521, 4  NP_013444.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G092001 AT3G09200 58.12(n)
    54.75(a)
      820076  NM_111754.3  NP_187531.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01305001 Os08g0130500 59.95(n)
    54.21(a)
      4344590  NM_001067458.1  NP_001060923.1 


    ENSEMBL Gene Tree for RPLP0 (if available)
    TreeFam Gene Tree for RPLP0 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPLP0 gene
    1 SIMAP similar gene for RPLP0 using alignment to 16 protein entries:     RLA0_HUMAN (see all proteins):
    RPLP0P6

    Find genes that share paralogs with RPLP0           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPLP0 (see all 13)
    PGOHUM00000242755 PGOHUM00000261140 PGOHUM00000247769 PGOHUM00000261169 PGOHUM00000235059


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPLP0 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135033101,2
    C--120634519(+) AAGTAA/CGCCTT 2 -- ut310--------
    rs1383897141,2
    C--120634527(+) CTTTAC/TTTCCT 2 -- ut310--------
    rs2020192081,2
    --120634569(+) GCTTTC/TTGGTG 2 -- ut310--------
    rs1122562551,2
    C--120634571(+) TTTTTG/TGTGAT 2 -- ut310--------
    rs10511471,2
    C--120634573(-) TAATCA/CCCAAA 2 -- ut312Minor allele frequency- C:0.00NA 4
    rs606568281,2
    C,F--120634612(+) TCCGAC/GTCCTC 4 D E mis12Minor allele frequency- G:0.00WA NA 4088
    rs1380593351,2
    C--120634637(+) CTTCAA/GCCTTA 4 A V mis11Minor allele frequency- G:0.00NA 3484
    rs1900010531,2
    C--120634795(+) CACCAC/G/TCCTCC 2 -- int11EU 1011
    rs1440211681,2
    C--120634836(+) TCAAA-/GTCC  
            
    GTGTG
    2 -- int10--------
    rs1438605911,2
    --120634858(+) CCTGTA/CAGAAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for RPLP0 (120634489 - 120639038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RPLP0:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832530CNV Loss17160897
    nsv899555CNV Loss21882294
    nsv519657CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RPLP0
    DNA2.0 Custom Variant and Variant Library Synthesis for RPLP0

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180510    OMIM disorders: --


    Find genes that share disorders with RPLP0           About GenesLikeMe

    5 Novoseek inferred disease relationships for RPLP0 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 56.5 1 7876567 (1)
    mimicry 54.5 1 7790824 (1)
    chagas disease 42.9 1 1377223 (1)
    hepatocellular carcinoma 21.9 3 17621266 (2), 1350508 (1)
    tumors 0 1 17621266 (1)


    Export disorders for RPLP0 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPLP0 gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with RPLP0)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2 Vascotto C.... Tell G. (Mol. Cell. Biol. 2009)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    4. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. (PubMed id 3323886)1, 2 Rich B.E. and Steitz J.A. (Mol. Cell. Biol. 1987)
    7. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PubMed id 17621266)1, 9 Chang T.-W....Chang M.-C. (Oncogene 2008)
    8. The subcellular distribution of the human ribosomal &quot;stalk&quot; components: P1, P2 and P0 proteins. (PubMed id 12479870)1, 9 TchA^rzewski M....Grankowski N. (amp 2003)
    9. Characterization of Staufen 1 ribonucleoprotein complexes. (PubMed id 15303970)1, 9 Brendel C....Kindler S. (Biochem. J. 2004)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6175 HGNC: 10371 AceView: RPLP0 Ensembl:ENSG00000089157 euGenes: HUgn6175
    ECgene: RPLP0 Kegg: 6175 H-InvDB: RPLP0

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPLP0 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPLP0 gene:
    Search GeneIP for patents involving RPLP0

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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