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Aliases for RPLP0 Gene

Aliases for RPLP0 Gene

  • Ribosomal Protein, Large, P0 2 3
  • Acidic Ribosomal Phosphoprotein P0 2 3
  • 60S Ribosomal Protein L10E 3 4
  • PRLP0 3
  • L10E 3
  • RPP0 3
  • LP0 3
  • P0 3

External Ids for RPLP0 Gene

Previous GeneCards Identifiers for RPLP0 Gene

  • GC12M119507
  • GC12M120161
  • GC12M120417
  • GC12M119046
  • GC12M119097
  • GC12M120634
  • GC12M117643

Summaries for RPLP0 Gene

Entrez Gene Summary for RPLP0 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP0 Gene

RPLP0 (Ribosomal Protein, Large, P0) is a Protein Coding gene. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP0 Gene

  • Ribosomal protein P0 is the functional equivalent of E.coli protein L10

Gene Wiki entry for RPLP0 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP0 Gene

Genomics for RPLP0 Gene

Regulatory Elements for RPLP0 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPLP0 Gene

Chromosome:
12
Start:
120,196,686 bp from pter
End:
120,201,235 bp from pter
Size:
4,550 bases
Orientation:
Minus strand

Genomic View for RPLP0 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPLP0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP0 Gene

Proteins for RPLP0 Gene

  • Protein details for RPLP0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05388-RLA0_HUMAN
    Recommended name:
    60S acidic ribosomal protein P0
    Protein Accession:
    P05388
    Secondary Accessions:
    • Q3B7A4
    • Q9BVK4

    Protein attributes for RPLP0 Gene

    Size:
    317 amino acids
    Molecular mass:
    34274 Da
    Quaternary structure:
    • P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with Lassa virus Z protein. Interacts with APEX1.

    Three dimensional structures from OCA and Proteopedia for RPLP0 Gene

    Alternative splice isoforms for RPLP0 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPLP0 Gene

Proteomics data for RPLP0 Gene at MOPED

Post-translational modifications for RPLP0 Gene

  • Ubiquitination at Lys 50, Lys 57, Lys 77, Lys 246, and Lys 266
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPLP0 Gene

Domains & Families for RPLP0 Gene

Gene Families for RPLP0 Gene

Protein Domains for RPLP0 Gene

Suggested Antigen Peptide Sequences for RPLP0 Gene

Graphical View of Domain Structure for InterPro Entry

P05388

UniProtKB/Swiss-Prot:

RLA0_HUMAN :
  • Belongs to the ribosomal protein L10P family.
Family:
  • Belongs to the ribosomal protein L10P family.
genes like me logo Genes that share domains with RPLP0: view

Function for RPLP0 Gene

Molecular function for RPLP0 Gene

GENATLAS Biochemistry:
60S acidic ribosomal protein P0,110p family,equivalent of E Coli protein L10
UniProtKB/Swiss-Prot Function:
Ribosomal protein P0 is the functional equivalent of E.coli protein L10

Gene Ontology (GO) - Molecular Function for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 3323886
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 15121898
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPLP0: view
genes like me logo Genes that share phenotypes with RPLP0: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPLP0

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP0 Gene

Localization for RPLP0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPLP0 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPLP0 Gene COMPARTMENTS Subcellular localization image for RPLP0 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 19188445
GO:0005737 cytoplasm IDA 19188445
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPLP0: view

Pathways & Interactions for RPLP0 Gene

genes like me logo Genes that share pathways with RPLP0: view

Pathways by source for RPLP0 Gene

1 BioSystems pathway for RPLP0 Gene
1 KEGG pathway for RPLP0 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP0 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Adipogenesis in human,mouse,rat

Gene Ontology (GO) - Biological Process for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPLP0: view

No data available for SIGNOR curated interactions for RPLP0 Gene

Drugs & Compounds for RPLP0 Gene

(1) Drugs for RPLP0 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Pharma Activator 0

(1) Additional Compounds for RPLP0 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glyceraldehyde 3-phosphate
genes like me logo Genes that share compounds with RPLP0: view

Transcripts for RPLP0 Gene

Unigene Clusters for RPLP0 Gene

Ribosomal protein, large, P0:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPLP0

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP0 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: -
SP10: - - -
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16: -

ExUns: 11b · 11c · 11d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RPLP0 Gene

GeneLoc Exon Structure for
RPLP0
ECgene alternative splicing isoforms for
RPLP0

Expression for RPLP0 Gene

mRNA expression in normal human tissues for RPLP0 Gene

Protein differential expression in normal tissues from HIPED for RPLP0 Gene

This gene is overexpressed in Tlymphocyte (9.4) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPLP0 Gene



SOURCE GeneReport for Unigene cluster for RPLP0 Gene Hs.546285

genes like me logo Genes that share expression patterns with RPLP0: view

Protein tissue co-expression partners for RPLP0 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPLP0 Gene

Orthologs for RPLP0 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP0 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPLP0 35
  • 92.01 (n)
  • 96.53 (a)
RPLP0 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPLP0 35
  • 93.69 (n)
  • 99.68 (a)
RPLP0 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rplp0 35
  • 90.43 (n)
  • 97.48 (a)
Rplp0 16
Gm8730 36
  • 97 (a)
OneToMany
Rplp0 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPLP0 35
  • 99.79 (n)
  • 100 (a)
RPLP0 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rplp0 35
  • 90.75 (n)
  • 98.11 (a)
oppossum
(Monodelphis domestica)
Mammalia RPLP0 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPLP0 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPLP0 35
  • 84.6 (n)
  • 94.3 (a)
RPLP0 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPLP0 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp0 35
  • 80.36 (n)
  • 90.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia arbp-prov 35
zebrafish
(Danio rerio)
Actinopterygii rplp0 35
  • 79.58 (n)
  • 88.25 (a)
rplp0 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1089 35
fruit fly
(Drosophila melanogaster)
Insecta RpP0 37
  • 66 (a)
RpLP0 35
  • 64.56 (n)
  • 66.25 (a)
RpLP0 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003592 35
  • 68.05 (n)
  • 72.29 (a)
worm
(Caenorhabditis elegans)
Secernentea rpa-0 37
  • 65 (a)
rla-0 35
  • 65.28 (n)
  • 66.67 (a)
rla-0 36
  • 67 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL178C 35
  • 59.93 (n)
  • 54.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05918g 35
  • 59.43 (n)
  • 53.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP0 35
  • 58.14 (n)
  • 54.75 (a)
RPP0 36
  • 54 (a)
OneToOne
RPP0 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09200 35
  • 58.12 (n)
  • 54.75 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12996 35
rice
(Oryza sativa)
Liliopsida Os08g0130500 35
  • 59.95 (n)
  • 54.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4852 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07408 35
  • 62.66 (n)
  • 56.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpp0 35
  • 59.89 (n)
  • 55.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11194 36
  • 73 (a)
OneToOne
Species with no ortholog for RPLP0:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP0 Gene

ENSEMBL:
Gene Tree for RPLP0 (if available)
TreeFam:
Gene Tree for RPLP0 (if available)

Paralogs for RPLP0 Gene

genes like me logo Genes that share paralogs with RPLP0: view

No data available for Paralogs for RPLP0 Gene

Variants for RPLP0 Gene

Sequence variations from dbSNP and Humsavar for RPLP0 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1051147 -- 120,196,770(-) TAATC(A/C)CCAAA utr-variant-3-prime
rs2074540 -- 120,198,746(+) TGAAC(A/C)AGATA intron-variant
rs3180961 -- 120,198,650(-) TCCTT(G/T)GGGCT missense, reference
rs3742040 -- 120,198,245(-) ACTAC(A/G)CCCGG intron-variant
rs3832873 -- 120,198,402(-) GGAtt(-/G)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPLP0 Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv519657 CNV Loss 19592680
nsv832530 CNV Loss 17160897

Variation tolerance for RPLP0 Gene

Residual Variation Intolerance Score: 24.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPLP0 Gene

HapMap Linkage Disequilibrium report
RPLP0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP0 Gene

Disorders for RPLP0 Gene

Relevant External Links for RPLP0

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPLP0
genes like me logo Genes that share disorders with RPLP0: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPLP0 Gene

Publications for RPLP0 Gene

  1. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PMID: 20083226) Michalec B. … TchA^rzewski M. (Int. J. Biochem. Cell Biol. 2010) 23 67
  2. Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome. (PMID: 19015737) Sorensen B. … Rajeevan M.S. (Mol. Med. 2009) 23 67
  3. Identification of antigenic proteins associated with trichloroethylene-induced autoimmune disease by serological proteome analysis. (PMID: 19647757) Liu J. … Zhuang Z. (Toxicol. Appl. Pharmacol. 2009) 23 67
  4. Three-dimensional studies of pathogenic peptides from the c-terminal of Trypanosoma cruzi ribosomal P proteins and their interaction with a monoclonal antibody structural model. (PMID: 19473527) MartA-n O.A. … Aguilar C.F. (PMC Biophys 2009) 23 67
  5. Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation. (PMID: 19003158) Saheki T. … Kojima I. (Cytotechnology 2008) 23 67

Products for RPLP0 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Adipogenesis in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPLP0
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPLP0
    • Block miRNA regulation of RPLP0 using miScript Target Protectors

    Sources for RPLP0 Gene

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