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Aliases for RPLP0 Gene

Aliases for RPLP0 Gene

  • Ribosomal Protein Lateral Stalk Subunit P0 2 3 5
  • Neutral Ribosomal Phosphoprotein P0 2 3
  • Ribosomal Protein, Large, P0 2 3
  • 60S Ribosomal Protein L10E 3 4
  • Acidic Ribosomal Phosphoprotein P0 3
  • 60S Acidic Ribosomal Protein P0 3
  • PRLP0 3
  • L10E 3
  • RPP0 3
  • LP0 3
  • P0 3

External Ids for RPLP0 Gene

Previous GeneCards Identifiers for RPLP0 Gene

  • GC12M119507
  • GC12M120161
  • GC12M120417
  • GC12M119046
  • GC12M119097
  • GC12M120634
  • GC12M117643

Summaries for RPLP0 Gene

Entrez Gene Summary for RPLP0 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP0 Gene

RPLP0 (Ribosomal Protein Lateral Stalk Subunit P0) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP0 Gene

  • Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Gene Wiki entry for RPLP0 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP0 Gene

Genomics for RPLP0 Gene

Regulatory Elements for RPLP0 Gene

Enhancers for RPLP0 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F120223 1.2 FANTOM5 Ensembl ENCODE 13.2 -40.8 -40758 36.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 PXN SIRT4 RPLP0 RNU4-2 RNU4-1 PXN-AS1 RNU6-1088P NME2P1 PLA2G1B GCN1
GH12F120115 1.1 ENCODE 12 +82.2 82200 7.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 GCN1 PXN-AS1 RPLP0 PRKAB1 PXN RAB35 COQ5 MIR4498
GH12F120125 0.7 Ensembl ENCODE 11.6 +74.4 74406 2.3 PKNOX1 ESRRA RFX1 JUN MAX EBF1 POLR2A SCRT2 KDM1A MYC RPLP0 PXN-AS1 GCN1 PXN RAB35 MIR4498
GH12F120124 0.2 Ensembl 11.1 +76.9 76935 0.6 PAF1 ZNF362 MTA2 ATF2 RELA POLR2H ZNF316 IKZF1 MAFK EMSY PXN-AS1 RPLP0 RAB35 MIR4498
GH12F120602 0.7 Ensembl ENCODE 4.9 -401.3 -401267 1.0 ESRRA HLF MAFG CEBPB ZBTB7A JUND ZFHX2 NFE2 MAFK EGR2 COQ5 LOC101928300 CABP1 MLEC ACADS ENSG00000256569 MIR4700 UNC119B MSI1 RPS27P25
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPLP0 on UCSC Golden Path with GeneCards custom track

Promoters for RPLP0 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246688 235 2801 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for RPLP0 Gene

Chromosome:
12
Start:
120,196,686 bp from pter
End:
120,201,235 bp from pter
Size:
4,550 bases
Orientation:
Minus strand

Genomic View for RPLP0 Gene

Genes around RPLP0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP0 Gene

Proteins for RPLP0 Gene

  • Protein details for RPLP0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05388-RLA0_HUMAN
    Recommended name:
    60S acidic ribosomal protein P0
    Protein Accession:
    P05388
    Secondary Accessions:
    • Q3B7A4
    • Q9BVK4

    Protein attributes for RPLP0 Gene

    Size:
    317 amino acids
    Molecular mass:
    34274 Da
    Quaternary structure:
    • P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146). Interacts with Lassa virus Z protein.

    Three dimensional structures from OCA and Proteopedia for RPLP0 Gene

    Alternative splice isoforms for RPLP0 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPLP0 Gene

Post-translational modifications for RPLP0 Gene

  • Ubiquitination at Lys 50, Lys 57, Lys 77, Lys 246, and Lys 266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPLP0 Gene

Domains & Families for RPLP0 Gene

Gene Families for RPLP0 Gene

Protein Domains for RPLP0 Gene

Suggested Antigen Peptide Sequences for RPLP0 Gene

Graphical View of Domain Structure for InterPro Entry

P05388

UniProtKB/Swiss-Prot:

RLA0_HUMAN :
  • Belongs to the ribosomal protein L10P family.
Family:
  • Belongs to the ribosomal protein L10P family.
genes like me logo Genes that share domains with RPLP0: view

Function for RPLP0 Gene

Molecular function for RPLP0 Gene

GENATLAS Biochemistry:
60S acidic ribosomal protein P0,110p family,equivalent of E Coli protein L10
UniProtKB/Swiss-Prot Function:
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Gene Ontology (GO) - Molecular Function for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 15121898
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0070180 large ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with RPLP0: view
genes like me logo Genes that share phenotypes with RPLP0: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP0 Gene

Localization for RPLP0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPLP0 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661). {ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:19188445}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPLP0 Gene COMPARTMENTS Subcellular localization image for RPLP0 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 19188445
GO:0005737 cytoplasm IEA,IDA 19188445
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPLP0: view

Pathways & Interactions for RPLP0 Gene

genes like me logo Genes that share pathways with RPLP0: view

Pathways by source for RPLP0 Gene

1 KEGG pathway for RPLP0 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP0 Gene

Gene Ontology (GO) - Biological Process for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPLP0: view

No data available for SIGNOR curated interactions for RPLP0 Gene

Drugs & Compounds for RPLP0 Gene

(1) Drugs for RPLP0 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RPLP0 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPLP0: view

Transcripts for RPLP0 Gene

Unigene Clusters for RPLP0 Gene

Ribosomal protein, large, P0:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP0 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: -
SP10: - - -
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16: -

ExUns: 11b · 11c · 11d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RPLP0 Gene

GeneLoc Exon Structure for
RPLP0
ECgene alternative splicing isoforms for
RPLP0

Expression for RPLP0 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPLP0 Gene

Protein differential expression in normal tissues from HIPED for RPLP0 Gene

This gene is overexpressed in Tlymphocyte (9.4) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPLP0 Gene



Protein tissue co-expression partners for RPLP0 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPLP0 Gene:

RPLP0

SOURCE GeneReport for Unigene cluster for RPLP0 Gene:

Hs.546285
genes like me logo Genes that share expression patterns with RPLP0: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPLP0 Gene

Orthologs for RPLP0 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP0 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPLP0 34 35
  • 99.79 (n)
mouse
(Mus musculus)
Mammalia Gm8730 35
  • 97 (a)
OneToMany
Rplp0 34 16 35
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia RPLP0 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPLP0 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPLP0 35 34
  • 93.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPLP0 35 34
  • 92.01 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rplp0 34
  • 90.75 (n)
chicken
(Gallus gallus)
Aves RPLP0 34 35
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia RPLP0 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp0 34
  • 80.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia arbp-prov 34
zebrafish
(Danio rerio)
Actinopterygii rplp0 35 34
  • 79.58 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1089 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003592 34
  • 68.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpP0 36
  • 66 (a)
RpLP0 34 35
  • 64.56 (n)
worm
(Caenorhabditis elegans)
Secernentea rla-0 34 35
  • 65.28 (n)
rpa-0 36
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL178C 34
  • 59.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05918g 34
  • 59.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP0 34 35 37
  • 58.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09200 34
  • 58.12 (n)
rice
(Oryza sativa)
Liliopsida Os08g0130500 34
  • 59.95 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12996 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11194 35
  • 73 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07408 34
  • 62.66 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpp0 34
  • 59.89 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4852 34
Species where no ortholog for RPLP0 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP0 Gene

ENSEMBL:
Gene Tree for RPLP0 (if available)
TreeFam:
Gene Tree for RPLP0 (if available)

Paralogs for RPLP0 Gene

No data available for Paralogs for RPLP0 Gene

Variants for RPLP0 Gene

Sequence variations from dbSNP and Humsavar for RPLP0 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1045110 -- 120,199,396(-) CTTCG(C/T)GGGAA upstream-variant-2KB, reference, synonymous-codon
rs1051147 -- 120,196,770(-) TAATC(A/C)CCAAA utr-variant-3-prime
rs11065042 -- 120,201,850(+) ACCTG(G/T)CCGGG intron-variant, upstream-variant-2KB
rs11065043 -- 120,201,964(+) CGTCT(C/T)TACTA intron-variant, upstream-variant-2KB
rs11065044 -- 120,202,472(+) TTTGA(A/G)AAGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPLP0 Gene

Variant ID Type Subtype PubMed ID
nsv519657 CNV loss 19592680
nsv560433 CNV loss 21841781
nsv832530 CNV loss 17160897
nsv973128 CNV duplication 23825009
nsv976653 CNV duplication 23825009

Variation tolerance for RPLP0 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPLP0 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPLP0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP0 Gene

Disorders for RPLP0 Gene

Relevant External Links for RPLP0

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPLP0

No disorders were found for RPLP0 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPLP0 Gene

Publications for RPLP0 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. (PMID: 24658146) Taha M.S. … Ahmadian M.R. (PLoS ONE 2014) 3 4 64
  3. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C. … Tell G. (Mol. Cell. Biol. 2009) 3 4 64
  4. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PMID: 17621266) Chang T.-W. … Chang M.-C. (Oncogene 2008) 3 22 64
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64

Products for RPLP0 Gene

Sources for RPLP0 Gene

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