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Aliases for RPLP0 Gene

Aliases for RPLP0 Gene

  • Ribosomal Protein Lateral Stalk Subunit P0 2 3 5
  • Large Ribosomal Subunit Protein UL10 3 4
  • Neutral Ribosomal Phosphoprotein P0 2 3
  • Ribosomal Protein, Large, P0 2 3
  • 60S Ribosomal Protein L10E 3 4
  • Acidic Ribosomal Phosphoprotein P0 3
  • 60S Acidic Ribosomal Protein P0 3
  • PRLP0 3
  • L10E 3
  • RPP0 3
  • LP0 3
  • P0 3

External Ids for RPLP0 Gene

Previous GeneCards Identifiers for RPLP0 Gene

  • GC12M119507
  • GC12M120161
  • GC12M120417
  • GC12M119046
  • GC12M119097
  • GC12M120634
  • GC12M117643

Summaries for RPLP0 Gene

Entrez Gene Summary for RPLP0 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPLP0 Gene

RPLP0 (Ribosomal Protein Lateral Stalk Subunit P0) is a Protein Coding gene. Diseases associated with RPLP0 include Charcot-Marie-Tooth Disease, Axonal, Type 2L. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPLP0 Gene

  • Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Gene Wiki entry for RPLP0 Gene

Additional gene information for RPLP0 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPLP0 Gene

Genomics for RPLP0 Gene

GeneHancer (GH) Regulatory Elements for RPLP0 Gene

Promoters and enhancers for RPLP0 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I120198 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.8 784 4.2 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 PXN-AS1 RPLP0 GCN1 RAB35 RPL31P52 SRSF9 PXN RPL29P24 PRKAB1 SPPL3
GH12I120290 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.2 -91.0 -90995 3.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SIRT4 GC12M120292 GC12M120294 RNU4-1 RNU4-2 GCN1 RAB35 PXN SRSF9 RPLP0
GH12I120223 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 -30.4 -30350 16 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12I120115 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 +82.2 82200 7.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 RAB35 GCN1 RPLP0 PXN-AS1 PXN COQ5 ENSG00000277283 MIR4498
GH12I119666 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +530.1 530083 8.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PRKAB1 RPLP0 TMEM233 LOC105370027 ENSG00000255692
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPLP0 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPLP0 gene promoter:

Genomic Locations for RPLP0 Gene

Genomic Locations for RPLP0 Gene
chr12:120,196,686-120,201,235
(GRCh38/hg38)
Size:
4,550 bases
Orientation:
Minus strand
chr12:120,634,489-120,639,038
(GRCh37/hg19)

Genomic View for RPLP0 Gene

Genes around RPLP0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPLP0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPLP0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPLP0 Gene

Proteins for RPLP0 Gene

  • Protein details for RPLP0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05388-RLA0_HUMAN
    Recommended name:
    60S acidic ribosomal protein P0
    Protein Accession:
    P05388
    Secondary Accessions:
    • Q3B7A4
    • Q9BVK4

    Protein attributes for RPLP0 Gene

    Size:
    317 amino acids
    Molecular mass:
    34274 Da
    Quaternary structure:
    • P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146). Interacts with Lassa virus Z protein.

    Three dimensional structures from OCA and Proteopedia for RPLP0 Gene

    Alternative splice isoforms for RPLP0 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPLP0 Gene

Post-translational modifications for RPLP0 Gene

  • Ubiquitination at posLast=5050, isoforms=257, posLast=7777, isoforms=2246, and isoforms=2266

No data available for DME Specific Peptides for RPLP0 Gene

Domains & Families for RPLP0 Gene

Gene Families for RPLP0 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPLP0 Gene

Suggested Antigen Peptide Sequences for RPLP0 Gene

Graphical View of Domain Structure for InterPro Entry

P05388

UniProtKB/Swiss-Prot:

RLA0_HUMAN :
  • Belongs to the universal ribosomal protein uL10 family.
Family:
  • Belongs to the universal ribosomal protein uL10 family.
genes like me logo Genes that share domains with RPLP0: view

Function for RPLP0 Gene

Molecular function for RPLP0 Gene

GENATLAS Biochemistry:
60S acidic ribosomal protein P0,110p family,equivalent of E Coli protein L10
UniProtKB/Swiss-Prot Function:
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Phenotypes From GWAS Catalog for RPLP0 Gene

Gene Ontology (GO) - Molecular Function for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0003735 structural constituent of ribosome NAS,IDA 12962325
GO:0005515 protein binding IPI 15121898
genes like me logo Genes that share ontologies with RPLP0: view
genes like me logo Genes that share phenotypes with RPLP0: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPLP0 Gene

Localization for RPLP0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPLP0 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661). {ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:19188445}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPLP0 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 4
cytoskeleton 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 19188445
GO:0005737 cytoplasm IEA,IDA 19188445
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPLP0: view

Pathways & Interactions for RPLP0 Gene

genes like me logo Genes that share pathways with RPLP0: view

Pathways by source for RPLP0 Gene

1 KEGG pathway for RPLP0 Gene
1 GeneGo (Thomson Reuters) pathway for RPLP0 Gene

Gene Ontology (GO) - Biological Process for RPLP0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPLP0: view

No data available for SIGNOR curated interactions for RPLP0 Gene

Drugs & Compounds for RPLP0 Gene

(1) Drugs for RPLP0 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RPLP0 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPLP0: view

Transcripts for RPLP0 Gene

Unigene Clusters for RPLP0 Gene

Ribosomal protein, large, P0:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPLP0 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9: -
SP10: - - -
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16: -

ExUns: 11b · 11c · 11d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RPLP0 Gene

GeneLoc Exon Structure for
RPLP0
ECgene alternative splicing isoforms for
RPLP0

Expression for RPLP0 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPLP0 Gene

Protein differential expression in normal tissues from HIPED for RPLP0 Gene

This gene is overexpressed in Tlymphocyte (9.4) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPLP0 Gene



Protein tissue co-expression partners for RPLP0 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPLP0 Gene:

RPLP0

SOURCE GeneReport for Unigene cluster for RPLP0 Gene:

Hs.546285

Evidence on tissue expression from TISSUES for RPLP0 Gene

  • Intestine(5)
  • Lung(5)
  • Nervous system(5)
  • Pancreas(4.9)
  • Liver(4.8)
  • Muscle(4.7)
  • Kidney(4.6)
  • Skin(4.5)
  • Blood(4.4)
  • Eye(4.2)
  • Heart(4.1)
  • Stomach(3.7)
  • Bone(3.3)
  • Spleen(2.5)
  • Bone marrow(2.4)
  • Lymph node(2.4)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with RPLP0: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPLP0 Gene

Orthologs for RPLP0 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPLP0 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPLP0 33 34
  • 99.79 (n)
mouse
(Mus musculus)
Mammalia Gm8730 34
  • 97 (a)
OneToMany
Rplp0 33 16 34
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia RPLP0 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPLP0 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPLP0 33 34
  • 93.69 (n)
cow
(Bos Taurus)
Mammalia RPLP0 33 34
  • 92.01 (n)
rat
(Rattus norvegicus)
Mammalia Rplp0 33
  • 90.75 (n)
chicken
(Gallus gallus)
Aves RPLP0 33 34
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia RPLP0 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rplp0 33
  • 80.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia arbp-prov 33
zebrafish
(Danio rerio)
Actinopterygii rplp0 33 34
  • 79.58 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1089 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003592 33
  • 68.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpP0 35
  • 66 (a)
RpLP0 33 34
  • 64.56 (n)
worm
(Caenorhabditis elegans)
Secernentea rla-0 33 34
  • 65.28 (n)
rpa-0 35
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL178C 33
  • 59.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05918g 33
  • 59.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPP0 33 34 36
  • 58.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09200 33
  • 58.12 (n)
rice
(Oryza sativa)
Liliopsida Os08g0130500 33
  • 59.95 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12996 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11194 34
  • 73 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07408 33
  • 62.66 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpp0 33
  • 59.89 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4852 33
Species where no ortholog for RPLP0 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPLP0 Gene

ENSEMBL:
Gene Tree for RPLP0 (if available)
TreeFam:
Gene Tree for RPLP0 (if available)

Paralogs for RPLP0 Gene

No data available for Paralogs for RPLP0 Gene

Variants for RPLP0 Gene

Sequence variations from dbSNP and Humsavar for RPLP0 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000661459 -- 120,199,074(-) G/A intron_variant
rs1000683619 -- 120,201,039(-) T/G intron_variant
rs1001291606 -- 120,201,891(-) G/A upstream_transcript_variant
rs1001389164 -- 120,202,087(-) C/T upstream_transcript_variant
rs1001529744 -- 120,201,481(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RPLP0 Gene

Variant ID Type Subtype PubMed ID
nsv519657 CNV loss 19592680
nsv560433 CNV loss 21841781
nsv832530 CNV loss 17160897
nsv973128 CNV duplication 23825009
nsv976653 CNV duplication 23825009

Variation tolerance for RPLP0 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPLP0 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPLP0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPLP0 Gene

Disorders for RPLP0 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPLP0 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • cmt2l
- elite association - COSMIC cancer census association via MalaCards
Search RPLP0 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RPLP0

genes like me logo Genes that share disorders with RPLP0: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPLP0 Gene

Publications for RPLP0 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 58
  2. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. (PMID: 24658146) Taha MS … Ahmadian MR (PloS one 2014) 3 4 58
  3. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C … Tell G (Molecular and cellular biology 2009) 3 4 58
  4. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PMID: 17621266) Chang TW … Chang MC (Oncogene 2008) 3 22 58
  5. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 58

Products for RPLP0 Gene

Sources for RPLP0 Gene