Aliases for RPL9 Gene
Aliases for RPL9 Gene
External Ids for RPL9 Gene
- HGNC: 10369
- Entrez Gene: 6133
- Ensembl: ENSG00000163682
- OMIM: 603686
- UniProtKB: P32969
Previous GeneCards Identifiers for RPL9 Gene
- GC04M039630
- GC04M039290
- GC04M039352
- GC04M039278
- GC04M039131
- GC04M038780
Summaries for RPL9 Gene
-
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for RPL9 Gene
RPL9 (Ribosomal Protein L9) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. Gene Ontology (GO) annotations related to this gene include RNA binding and rRNA binding.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL9 Gene
Genomics for RPL9 Gene
GeneHancer (GH) Regulatory Elements for RPL9 Gene
- Top Transcription factor binding sites by QIAGEN in the RPL9 gene promoter:
Regulatory Element Products
Genomic Locations for RPL9 Gene
- chr4:39,454,124-39,458,948
- (GRCh38/hg38)
- Size:
- 4,825 bases
- Orientation:
- Minus strand
- chr4:39,455,744-39,460,568
- (GRCh37/hg19)
Genomic View for RPL9 Gene
- Cytogenetic band:
-
- 4p14 by Ensembl
- 4p14 by Entrez Gene
- 4p14 by HGNC


RefSeq DNA sequence for RPL9 Gene
Proteins for RPL9 Gene
-
Protein details for RPL9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32969-RL9_HUMAN
- Recommended name:
- 60S ribosomal protein L9
- Protein Accession:
- P32969
Protein attributes for RPL9 Gene
- Size:
- 192 amino acids
- Molecular mass:
- 21863 Da
- Quaternary structure:
- No Data Available
Protein Expression for RPL9 Gene
Post-translational modifications for RPL9 Gene
- Ubiquitination at Lys2, Lys21, isoforms=174, and isoforms=184
Other Protein References for RPL9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Assay Products
- antibodies-online: Search results for available RPL9 related products ranked by validation data
No data available for DME Specific Peptides for RPL9 Gene
Domains & Families for RPL9 Gene
Gene Families for RPL9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for RPL9 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RPL9 Gene
Graphical View of Domain Structure for InterPro Entry
P32969- Family:
-
- Belongs to the universal ribosomal protein uL6 family.
Function for RPL9 Gene
Molecular function for RPL9 Gene
- GENATLAS Biochemistry:
- ribosomal protein L9
Phenotypes From GWAS Catalog for RPL9 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | TAS | 8597601 |
GO:0003735 | structural constituent of ribosome | IEA,NAS | 12962325 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0019843 | rRNA binding | IEA | -- |
Phenotypes for RPL9 Gene
- GenomeRNAi human phenotypes for RPL9:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Nucleoplasmic pre-40S maturation defects
- Nuclear 60S biogenesis defects
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
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miRNA for RPL9 Gene
- miRTarBase miRNAs that target RPL9
-
- hsa-mir-16-5p (MIRT031465)
- hsa-mir-615-3p (MIRT039617)
- hsa-mir-505-3p (MIRT041007)
- hsa-mir-193b-3p (MIRT041211)
- hsa-mir-320a (MIRT044491)
- hsa-mir-186-5p (MIRT045207)
- hsa-mir-125a-5p (MIRT045745)
- hsa-mir-93-5p (MIRT048764)
- hsa-mir-18a-5p (MIRT050666)
- hsa-let-7a-5p (MIRT052396)
- hsa-mir-5696 (MIRT504644)
- hsa-mir-513b-5p (MIRT504646)
- hsa-mir-137 (MIRT504647)
- hsa-mir-4711-5p (MIRT504648)
- hsa-mir-4729 (MIRT504649)
- hsa-mir-7112-3p (MIRT504650)
- hsa-mir-4457 (MIRT504651)
- hsa-mir-125b-2-3p (MIRT504652)
- hsa-mir-92b-3p (MIRT504653)
- hsa-mir-92a-3p (MIRT504654)
- hsa-mir-367-3p (MIRT504655)
- hsa-mir-363-3p (MIRT504656)
- hsa-mir-32-5p (MIRT504657)
- hsa-mir-25-3p (MIRT504658)
- hsa-mir-5697 (MIRT551671)
miRNA Products
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-
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL9 Gene
Localization for RPL9 Gene
- Cytosol (3)
- Endoplasmic reticulum (3)
- Nucleoli (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005634 | nucleus | IDA,HDA | 21630459 |
GO:0005829 | cytosol | TAS | -- |
GO:0005840 | ribosome | IEA,TAS | 8597601 |
GO:0005925 | focal adhesion | IDA,HDA | 21423176 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL9 Gene
Pathways & Interactions for RPL9 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
.55
|
|
2 | Influenza Viral RNA Transcription and Replication | ||
3 | rRNA processing in the nucleus and cytosol |
.89
|
|
4 | HIV Life Cycle |
.45
|
|
5 | Gene Expression |
.48
|
Pathways by source for RPL9 Gene
1 BioSystems pathway for RPL9 Gene
28 Reactome pathways for RPL9 Gene
1 KEGG pathway for RPL9 Gene
1 GeneGo (Thomson Reuters) pathway for RPL9 Gene
Interacting Proteins for RPL9 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0002181 | cytoplasmic translation | IBA | -- |
GO:0006364 | rRNA processing | TAS | -- |
GO:0006412 | translation | IEA,NAS | 12962325 |
GO:0006413 | translational initiation | TAS | -- |
No data available for SIGNOR curated interactions for RPL9 Gene
Transcripts for RPL9 Gene
mRNA/cDNA for RPL9 Gene
- (2) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (2298) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RPL9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RPL9
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-
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Inhibitory RNA Products
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for RPL9
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RPL9
- Applied Biological Materials Clones for RPL9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RPL9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Umbilical Cord (Extraembryonic Tissues)
-
Tonsil (Hematopoietic System)
-
Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL9 Gene
NURSA nuclear receptor signaling pathways regulating expression of RPL9 Gene:
RPL9SOURCE GeneReport for Unigene cluster for RPL9 Gene:
Hs.412370Evidence on tissue expression from TISSUES for RPL9 Gene
- Eye(5)
- Liver(5)
- Nervous system(5)
- Lung(4.9)
- Muscle(4.9)
- Pancreas(4.9)
- Intestine(4.6)
- Skin(4.6)
- Heart(4.4)
- Kidney(4.4)
- Blood(4.3)
- Bone(4.2)
- Stomach(4)
- Spleen(3.2)
- Lymph node(2.5)
- Thyroid gland(2.5)
- Adrenal gland(2.3)
- Bone marrow(2.1)
Primer Products
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OriGene qPCR primer pairs and template standards for RPL9
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL9 Gene
Orthologs for RPL9 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RPL9 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | RPL9 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | RPL9 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | RPL9 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | RPL9 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | LOC100364457 33 |
|
||
mouse (Mus musculus) |
Mammalia | Rpl9 33 16 34 |
|
||
chicken (Gallus gallus) |
Aves | RPL9 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | RPL9 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rpl9 33 |
|
||
Str.2012 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | rpl9-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rpl9 33 34 |
|
||
Dr.24810 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10591 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | RpL9 35 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009508 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | rpl-9 35 33 34 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F04499g 33 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL290W 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL9B 34 36 33 |
|
OneToMany | |
RPL9A 34 |
|
OneToMany | |||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G10450 33 |
|
||
soybean (Glycine max) |
eudicotyledons | Gma.4113 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7563 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os09g0485900 33 |
|
||
Os.4982 33 |
|
||||
barley (Hordeum vulgare) |
Liliopsida | Hv.590 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.5244 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11337 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU02744 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpl902 33 |
|
- Species where no ortholog for RPL9 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RPL9 Gene
(3) SIMAP similar genes for RPL9 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for RPL9 Gene
- PGOHUM00000290879
- PGOHUM00000291062
- PGOHUM00000291784
- PGOHUM00000292312
- PGOHUM00000292427
- PGOHUM00000292624
- PGOHUM00000292683
- PGOHUM00000292855
- PGOHUM00000292918
- PGOHUM00000292991
- PGOHUM00000294145
- PGOHUM00000294146
- PGOHUM00000294227
- PGOHUM00000294273
- PGOHUM00000294374
- PGOHUM00000294796
- PGOHUM00000294973
- PGOHUM00000295418
- PGOHUM00000295681
- PGOHUM00000296205
- PGOHUM00000296815
- PGOHUM00000298166
- PGOHUM00000298302
- PGOHUM00000299234
- PGOHUM00000300438
- PGOHUM00000300544
- PGOHUM00000301151
- PGOHUM00000301413
- PGOHUM00000302524
- PGOHUM00000302963
- PGOHUM00000303119
- PGOHUM00000289826
No data available for Paralogs for RPL9 Gene
Variants for RPL9 Gene
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1041843537 | uncertain-significance, Pyruvate dehydrogenase lipoic acid synthetase deficiency | 39,460,864(-) | G/T | upstream_transcript_variant | |
rs140921822 | likely-benign, benign, not specified, Pyruvate dehydrogenase lipoic acid synthetase deficiency | 39,460,801(-) | A/C | upstream_transcript_variant | |
rs201996792 | likely-benign, Pyruvate dehydrogenase lipoic acid synthetase deficiency | 39,460,804(-) | T/C | upstream_transcript_variant | |
rs750439302 | likely-benign, Pyruvate dehydrogenase lipoic acid synthetase deficiency | 39,460,858(-) | C/A/G | upstream_transcript_variant | |
rs761295906 | uncertain-significance, not specified, Pyruvate dehydrogenase lipoic acid synthetase deficiency | 39,460,866(-) | A/G | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1010189 | CNV | gain | 25217958 |
nsv1010784 | CNV | gain | 25217958 |
nsv966263 | CNV | duplication | 23825009 |
nsv980196 | CNV | duplication | 23825009 |
Additional Variant Information for RPL9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPL9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL9 Gene
Disorders for RPL9 Gene
Additional Disease Information for RPL9
No disorders were found for RPL9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL9 Gene
Publications for RPL9 Gene
- Structural organization and chromosomal localization of the human ribosomal protein L9 gene. (PMID: 8597601) Mazuruk K … Rodriguez IR (Biochimica et biophysica acta 1996) 2 3 4 22 58
- A new human ribosomal protein sequence, homologue of rat L9. (PMID: 8415001) Hori N … Matsubara K (Nucleic acids research 1993) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RPL9
- antibodies-online: Search results for 76 available RPL9 Antibodies ranked by validation data
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- genomics-online: gRNA clones - Search results for 194 available RPL9 gene related products
- Overview of 194 available RPL9 gene related products
- genomics-online: primer clones - Search results for 194 available RPL9 gene related products
- Overview of 194 available RPL9 gene related products
- genomics-online: shRNA clones - Search results for 194 available RPL9 gene related products
- Overview of 194 available RPL9 gene related products
Sources for RPL9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew