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Aliases for RPL9 Gene

Aliases for RPL9 Gene

  • Ribosomal Protein L9 2 3 5
  • Large Ribosomal Subunit Protein UL6 3 4
  • RPL9 RPL9P7 RPL9P8 RPL9P9 4
  • 60S Ribosomal Protein L9 3
  • NPC-A-16 3
  • L9 3

External Ids for RPL9 Gene

Previous GeneCards Identifiers for RPL9 Gene

  • GC04M039630
  • GC04M039290
  • GC04M039352
  • GC04M039278
  • GC04M039131
  • GC04M038780

Summaries for RPL9 Gene

Entrez Gene Summary for RPL9 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RPL9 Gene

RPL9 (Ribosomal Protein L9) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include RNA binding and rRNA binding.

Gene Wiki entry for RPL9 Gene

Additional gene information for RPL9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL9 Gene

Genomics for RPL9 Gene

Regulatory Elements for RPL9 Gene

Enhancers for RPL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H039456 1.4 ENCODE dbSUPER 151 +0.4 419 3.7 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302 ZNF207 RPL9 PDS5A WDR19 ENSG00000250568 RFC1 KLF3-AS1 FAM114A1 UGDH-AS1 KLF3 LOC401127
GH04H039450 0.6 dbSUPER 144.7 +8.1 8106 1.2 PAF1 SSRP1 POLR2A SCRT2 HNF4A ZNF384 KDM1A SUPT5H RPL9 ENSG00000238797 LIAS
GH04H039446 1.1 Ensembl ENCODE 63.8 +11.8 11781 1.7 PKNOX1 NFIB SIN3A RAD21 ELK1 ZNF143 RUNX3 CREM ZNF202 HCFC1 RPL9 PDS5A N4BP2 KLB RNU6-887P RFC1 WDR19 ENSG00000238797 LIAS
GH04H039484 0.9 Ensembl ENCODE 55.1 -25.9 -25908 0.7 SMARCE1 MTA2 SOX6 TAL1 DPF2 TCF12 SMARCA4 NCOR1 IKZF1 ADNP RPL9 KLB RNU6-887P LOC401127 GC04M039495
GH04H039466 0.8 ENCODE dbSUPER 54.6 -7.8 -7762 0.6 JUND ATF3 CEBPA HNF4A MAFK NFE2L2 RPL9 LOC401127
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL9 on UCSC Golden Path with GeneCards custom track

Promoters for RPL9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167617 -52 2801 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302 ZNF207

Genomic Locations for RPL9 Gene

Genomic Locations for RPL9 Gene
4,825 bases
Minus strand

Genomic View for RPL9 Gene

Genes around RPL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL9 Gene

Proteins for RPL9 Gene

  • Protein details for RPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L9
    Protein Accession:

    Protein attributes for RPL9 Gene

    192 amino acids
    Molecular mass:
    21863 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL9 Gene

neXtProt entry for RPL9 Gene

Post-translational modifications for RPL9 Gene

  • Ubiquitination at isoforms=2, Lys21, Lys174, and isoforms=184
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL9 Gene

No data available for DME Specific Peptides for RPL9 Gene

Domains & Families for RPL9 Gene

Gene Families for RPL9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL6 family.
  • Belongs to the universal ribosomal protein uL6 family.
genes like me logo Genes that share domains with RPL9: view

Function for RPL9 Gene

Molecular function for RPL9 Gene

GENATLAS Biochemistry:
ribosomal protein L9

Phenotypes From GWAS Catalog for RPL9 Gene

Gene Ontology (GO) - Molecular Function for RPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8597601
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 16189514
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL9: view
genes like me logo Genes that share phenotypes with RPL9: view

Clone Products

  • Addgene plasmids for RPL9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL9 Gene

Localization for RPL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL9 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS,IEA 8597601
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL9 Gene

Pathways & Interactions for RPL9 Gene

genes like me logo Genes that share pathways with RPL9: view

Pathways by source for RPL9 Gene

1 KEGG pathway for RPL9 Gene
1 GeneGo (Thomson Reuters) pathway for RPL9 Gene

Gene Ontology (GO) - Biological Process for RPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL9: view

No data available for SIGNOR curated interactions for RPL9 Gene

Drugs & Compounds for RPL9 Gene

(1) Drugs for RPL9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RPL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL9: view

Transcripts for RPL9 Gene

Unigene Clusters for RPL9 Gene

Ribosomal protein L9:
Representative Sequences:

Clone Products

  • Addgene plasmids for RPL9

Alternative Splicing Database (ASD) splice patterns (SP) for RPL9 Gene

No ASD Table

Relevant External Links for RPL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL9 Gene

This gene is overexpressed in Tlymphocyte (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL9 Gene

Protein tissue co-expression partners for RPL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL9 Gene:


SOURCE GeneReport for Unigene cluster for RPL9 Gene:


Evidence on tissue expression from TISSUES for RPL9 Gene

  • Eye(5)
  • Liver(5)
  • Nervous system(5)
  • Lung(4.9)
  • Muscle(4.9)
  • Pancreas(4.9)
  • Intestine(4.6)
  • Skin(4.6)
  • Heart(4.4)
  • Kidney(4.4)
  • Blood(4.3)
  • Bone(4.2)
  • Stomach(4)
  • Spleen(3.2)
  • Lymph node(2.5)
  • Thyroid gland(2.5)
  • Adrenal gland(2.3)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with RPL9: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL9 Gene

Orthologs for RPL9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL9 34 33
  • 99.65 (n)
(Bos Taurus)
Mammalia RPL9 34
  • 99 (a)
-- 34
  • 98 (a)
-- 34
  • 97 (a)
-- 34
  • 97 (a)
-- 34
  • 97 (a)
-- 34
  • 96 (a)
-- 34
  • 74 (a)
(Monodelphis domestica)
Mammalia RPL9 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL9 34
  • 96 (a)
(Canis familiaris)
Mammalia RPL9 34 33
  • 92.71 (n)
(Rattus norvegicus)
Mammalia LOC100360449 33
  • 91.49 (n)
(Mus musculus)
Mammalia Rpl9 16 34 33
  • 89.93 (n)
(Gallus gallus)
Aves RPL9 33 34
  • 81.6 (n)
(Anolis carolinensis)
Reptilia RPL9 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl9 33
  • 83.51 (n)
Str.2012 33
African clawed frog
(Xenopus laevis)
Amphibia rpl9-prov 33
(Danio rerio)
Actinopterygii rpl9 34 33
  • 75.04 (n)
Dr.24810 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10591 33
fruit fly
(Drosophila melanogaster)
Insecta RpL9 35 33 34
  • 61.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009508 33
  • 59.82 (n)
(Caenorhabditis elegans)
Secernentea rpl-9 35 33 34
  • 58.38 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04499g 33
  • 58.55 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL290W 33
  • 57.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL9B 34 36 33
  • 57.12 (n)
RPL9A 34
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10450 33
  • 58.82 (n)
(Glycine max)
eudicotyledons Gma.4113 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7563 33
(Oryza sativa)
Liliopsida Os09g0485900 33
  • 55.32 (n)
Os.4982 33
(Hordeum vulgare)
Liliopsida Hv.590 33
(Zea mays)
Liliopsida Zm.5244 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11337 34
  • 64 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02744 33
  • 57.12 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl902 33
  • 55.44 (n)
Species where no ortholog for RPL9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL9 Gene

Gene Tree for RPL9 (if available)
Gene Tree for RPL9 (if available)

Paralogs for RPL9 Gene

(3) SIMAP similar genes for RPL9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL9: view

No data available for Paralogs for RPL9 Gene

Variants for RPL9 Gene

Sequence variations from dbSNP and Humsavar for RPL9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs761295906 Uncertain significance 39,460,866(+) ACAGA(A/G)TGGAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs796052701 Uncertain significance 39,460,833(+) AAGCT(C/T)CTTGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs370817832 Benign 39,459,083(+) GATCC(C/G/T)TCAAC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs78325971 Benign 39,459,086(+) CCCTC(A/G/T)ACCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000123042 -- 39,460,427(+) TACTC(A/G)GGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL9 Gene

Variant ID Type Subtype PubMed ID
nsv980196 CNV duplication 23825009
nsv966263 CNV duplication 23825009
nsv1010784 CNV gain 25217958
nsv1010189 CNV gain 25217958

Variation tolerance for RPL9 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL9 Gene

Disorders for RPL9 Gene

Relevant External Links for RPL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL9 Gene

Publications for RPL9 Gene

  1. Structural organization and chromosomal localization of the human ribosomal protein L9 gene. (PMID: 8597601) Mazuruk K … Rodriguez IR (Biochimica et biophysica acta 1996) 2 3 4 22 60
  2. A new human ribosomal protein sequence, homologue of rat L9. (PMID: 8415001) Hori N … Matsubara K (Nucleic acids research 1993) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RPL9 Gene

Sources for RPL9 Gene

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