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Aliases for RPL9 Gene

Aliases for RPL9 Gene

  • Ribosomal Protein L9 2 3 5
  • RPL9 RPL9P7 RPL9P8 RPL9P9 4
  • 60S Ribosomal Protein L9 3
  • NPC-A-16 3
  • L9 3

External Ids for RPL9 Gene

Previous GeneCards Identifiers for RPL9 Gene

  • GC04M039630
  • GC04M039290
  • GC04M039352
  • GC04M039278
  • GC04M039131
  • GC04M038780

Summaries for RPL9 Gene

Entrez Gene Summary for RPL9 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RPL9 Gene

RPL9 (Ribosomal Protein L9) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and rRNA binding.

Gene Wiki entry for RPL9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL9 Gene

Genomics for RPL9 Gene

Regulatory Elements for RPL9 Gene

Enhancers for RPL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPL9 on UCSC Golden Path with GeneCards custom track

Promoters for RPL9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL9 Gene

Chromosome:
4
Start:
39,454,124 bp from pter
End:
39,458,948 bp from pter
Size:
4,825 bases
Orientation:
Minus strand

Genomic View for RPL9 Gene

Genes around RPL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL9 Gene

Proteins for RPL9 Gene

  • Protein details for RPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32969-RL9_HUMAN
    Recommended name:
    60S ribosomal protein L9
    Protein Accession:
    P32969

    Protein attributes for RPL9 Gene

    Size:
    192 amino acids
    Molecular mass:
    21863 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL9 Gene

neXtProt entry for RPL9 Gene

Post-translational modifications for RPL9 Gene

  • Ubiquitination at Lys 2, Lys 21, Lys 174, and Lys 184
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL9 Gene

No data available for DME Specific Peptides for RPL9 Gene

Domains & Families for RPL9 Gene

Gene Families for RPL9 Gene

Protein Domains for RPL9 Gene

Graphical View of Domain Structure for InterPro Entry

P32969

UniProtKB/Swiss-Prot:

RL9_HUMAN :
  • Belongs to the ribosomal protein L6P family.
Family:
  • Belongs to the ribosomal protein L6P family.
genes like me logo Genes that share domains with RPL9: view

Function for RPL9 Gene

Molecular function for RPL9 Gene

GENATLAS Biochemistry:
ribosomal protein L9

Gene Ontology (GO) - Molecular Function for RPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8597601
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 16189514
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL9: view
genes like me logo Genes that share phenotypes with RPL9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPL9

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL9 Gene

Localization for RPL9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL9 Gene COMPARTMENTS Subcellular localization image for RPL9 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 8597601
genes like me logo Genes that share ontologies with RPL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL9 Gene

Pathways & Interactions for RPL9 Gene

genes like me logo Genes that share pathways with RPL9: view

Pathways by source for RPL9 Gene

1 KEGG pathway for RPL9 Gene
1 GeneGo (Thomson Reuters) pathway for RPL9 Gene

Gene Ontology (GO) - Biological Process for RPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL9: view

No data available for SIGNOR curated interactions for RPL9 Gene

Drugs & Compounds for RPL9 Gene

(1) Drugs for RPL9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RPL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL9: view

Transcripts for RPL9 Gene

Unigene Clusters for RPL9 Gene

Ribosomal protein L9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPL9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL9 Gene

No ASD Table

Relevant External Links for RPL9 Gene

GeneLoc Exon Structure for
RPL9
ECgene alternative splicing isoforms for
RPL9

Expression for RPL9 Gene

mRNA expression in normal human tissues for RPL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL9 Gene

This gene is overexpressed in Tlymphocyte (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL9 Gene



Protein tissue co-expression partners for RPL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL9 Gene:

RPL9

SOURCE GeneReport for Unigene cluster for RPL9 Gene:

Hs.412370
genes like me logo Genes that share expression patterns with RPL9: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL9 Gene

Orthologs for RPL9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RPL9 34
  • 92.71 (n)
  • 100 (a)
RPL9 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl9 34
  • 89.93 (n)
  • 98.96 (a)
Rpl9 16
Rpl9 35
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL9 34
  • 99.65 (n)
  • 100 (a)
RPL9 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360449 34
  • 91.49 (n)
  • 98.96 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
RPL9 35
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL9 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL9 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL9 34
  • 81.6 (n)
  • 94.79 (a)
RPL9 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL9 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl9 34
  • 83.51 (n)
  • 92.71 (a)
Str.2012 34
African clawed frog
(Xenopus laevis)
Amphibia rpl9-prov 34
zebrafish
(Danio rerio)
Actinopterygii Dr.24810 34
rpl9 34
  • 75.04 (n)
  • 90.58 (a)
rpl9 35
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10591 34
fruit fly
(Drosophila melanogaster)
Insecta RpL9 36
  • 65 (a)
RpL9 34
  • 61.8 (n)
  • 65.95 (a)
RpL9 35
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009508 34
  • 59.82 (n)
  • 65.79 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-9 36
  • 62 (a)
rpl-9 34
  • 58.38 (n)
  • 63.49 (a)
rpl-9 35
  • 63 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL290W 34
  • 57.22 (n)
  • 51.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04499g 34
  • 58.55 (n)
  • 49.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL9B 34
  • 57.12 (n)
  • 51.35 (a)
RPL9A 35
  • 49 (a)
OneToMany
RPL9B 35
  • 49 (a)
OneToMany
RPL9B 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10450 34
  • 58.82 (n)
  • 58.29 (a)
soybean
(Glycine max)
eudicotyledons Gma.4113 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7563 34
barley
(Hordeum vulgare)
Liliopsida Hv.590 34
rice
(Oryza sativa)
Liliopsida Os.4982 34
Os09g0485900 34
  • 55.32 (n)
  • 57.98 (a)
corn
(Zea mays)
Liliopsida Zm.5244 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02744 34
  • 57.12 (n)
  • 56.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl902 34
  • 55.44 (n)
  • 52.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11337 35
  • 64 (a)
OneToOne
Species where no ortholog for RPL9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL9 Gene

ENSEMBL:
Gene Tree for RPL9 (if available)
TreeFam:
Gene Tree for RPL9 (if available)

Paralogs for RPL9 Gene

(3) SIMAP similar genes for RPL9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL9: view

No data available for Paralogs for RPL9 Gene

Variants for RPL9 Gene

Sequence variations from dbSNP and Humsavar for RPL9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1015450 -- 39,456,237(+) TTAAG(C/T)AGCAC intron-variant
rs1463478 -- 39,454,772(-) ATTAG(C/T)TTTTT intron-variant
rs1985998 -- 39,455,088(-) acagg(C/T)gtgag intron-variant
rs1802628 -- 39,454,158(-) ATGCA(A/G)TAAAA utr-variant-3-prime
rs2015627 -- 39,455,227(-) gggag(A/T)atagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL9 Gene

Variant ID Type Subtype PubMed ID
nsv1010189 CNV gain 25217958
nsv1010784 CNV gain 25217958
nsv966263 CNV duplication 23825009
nsv980196 CNV duplication 23825009

Variation tolerance for RPL9 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL9 Gene

Disorders for RPL9 Gene

Relevant External Links for RPL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL9

No disorders were found for RPL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL9 Gene

Publications for RPL9 Gene

  1. Structural organization and chromosomal localization of the human ribosomal protein L9 gene. (PMID: 8597601) Mazuruk K. … Rodriguez I.R. (Biochim. Biophys. Acta 1996) 2 3 4 22 65
  2. A new human ribosomal protein sequence, homologue of rat L9. (PMID: 8415001) Hori N. … Matsubara K. (Nucleic Acids Res. 1993) 2 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 3 4 65
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 65

Products for RPL9 Gene

Sources for RPL9 Gene

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