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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL8 Gene

protein-coding   GIFtS: 64
GCID: GC08M145985

Ribosomal Protein L8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein L81 2
60S Ribosomal Protein L82
L82

External Ids:    HGNC: 103681   Entrez Gene: 61322   Ensembl: ENSG000001610167   OMIM: 6041775   UniProtKB: P629173   

Export aliases for RPL8 gene to outside databases

Previous GC identifers: GC08M143622 GC08M146052 GC08M145619 GC08M146019 GC08M141130


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL8 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of
ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very
likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding
site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein
exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene
dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL8 Gene: 
RPL8 (ribosomal protein L8) is a protein-coding gene. Diseases associated with RPL8 include diamond-blackfan anemia, and osteosarcoma, and among its related super-pathways are Eukaryotic Translation Initiation and Metabolism of RNA. GO annotations related to this gene include RNA binding and rRNA binding.

Gene Wiki entry for RPL8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_037704.5  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL8 gene promoter:
         TBP   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL8 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

RPL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL8 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145985:  view genomic region     (about GC identifiers)

Start:
146,015,150 bp from pter      End:
146,017,972 bp from pter
Size:
2,823 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL8_HUMAN, P62917 (See protein sequence)
Recommended Name: 60S ribosomal protein L8  
Size: 257 amino acids; 28025 Da
Subcellular location: Cytoplasm
Miscellaneous: This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace
the endogenous protein
1 PDB 3D structure from and Proteopedia for RPL8:
3J3B (3D)    
Secondary accessions: A8K094 D3DWN2 P25120 Q567Q7 Q969V7 Q9BWQ9

Explore the universe of human proteins at neXtProt for RPL8: NX_P62917

Explore proteomics data for RPL8 at MOPED 

Post-translational modifications:

  • UniProtKB: Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62917

  • RPL8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000964.1  NP_150644.1  

    ENSEMBL proteins: 
     ENSP00000437062   ENSP00000378378   ENSP00000436460   ENSP00000262584   ENSP00000433464  
     ENSP00000433703   ENSP00000435313   ENSP00000434535  
    Reactome Protein details: P62917
    Human Recombinant Protein Products for RPL8: 
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    Cloud-Clone Corp. Proteins for RPL8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    RPL8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPL: L ribosomal proteins

    5/9 InterPro protein domains (see all 9):
     IPR012340 NA-bd_OB-fold
     IPR014722 Rib_L2_dom2
     IPR002171 Ribosomal_L2
     IPR023672 Ribosomal_L2_arc
     IPR008991 Translation_prot_SH3-like

    Graphical View of Domain Structure for InterPro Entry P62917

    ProtoNet protein and cluster: P62917

    1 Blocks protein domain: IPB002171 Ribosomal protein L2

    UniProtKB/Swiss-Prot: RL8_HUMAN, P62917
    Similarity: Belongs to the ribosomal protein L2P family


    RPL8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPL8:
    60S ribosomal protein L8

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7506540
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0019843rRNA binding IEA--
         
    RPL8 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for RPL8:
     Decreased homologous recombina  Decreased number of cells in m  Decreased viability of wild-ty  Increased S DNA content 
     Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPL8 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL8
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL8
        Cytoplasmic Ribosomal Proteins
    TNF-alpha/NF-kB Signaling Pathway

    5/23        Reactome Pathways for RPL8 (see all 23)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL8):
        Ribosome


    RPL8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1059 Interacting proteins for RPL8 (P629172, 3 ENSP000002625844) via UniProtKB, MINT, STRING, and/or I2D (see all 1059)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000278572
    RPL4P365782, 3, ENSP000003114304MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=8 STRING: ENSP00000311430
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=6 STRING: ENSP00000363676
    RPL12P300502, 3, ENSP000003547394MINT-6542674 MINT-7945693 MINT-6489539 MINT-6488791 I2D: score=6 STRING: ENSP00000354739
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=5 STRING: ENSP00000293842
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL8 (RL8)

    3 DrugBank Compounds for RPL8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about RPL8 / RL8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL8 gene (2 alternative transcripts): 
    NM_000973.3  NM_033301.1  

    Unigene Cluster for RPL8:

    Ribosomal protein L8
    Hs.178551  [show with all ESTs]
    Unigene Representative Sequence: BF205975
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534781 ENST00000531975 ENST00000529163 ENST00000526668 ENST00000528296
    ENST00000394920(uc003zeb.3) ENST00000527914 ENST00000262584(uc003zec.3)
    ENST00000528957 ENST00000529920 ENST00000533397 ENST00000532702 ENST00000525232(uc010mgc.3)
    ENST00000531767
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK289459.1 AK301073.1 AK309619.1 BC000047.2 BC000077.2 BC012197.1 BC013104.1 BC030151.2 
    BC093064.1 BT007379.1 CR457046.1 Z28407.1 

    24/90 DOTS entries (see all 90):

    DT.100772277  DT.75198014  DT.100855756  DT.91855316  DT.100060265  DT.98083411  DT.100699419  DT.100637334 
    DT.95365905  DT.100699413  DT.100699463  DT.121465589  DT.121465584  DT.97853480  DT.121465483  DT.121465436 
    DT.100699455  DT.121465399  DT.95366063  DT.100699433  DT.100808373  DT.121465545  DT.100699428  DT.121465501 

    24/3389 AceView cDNA sequences (see all 3389):

    CB124694 CD370376 BU786186 CR603238 BE278294 BQ071261 BM842554 BP870617 
    BQ895966 BU166497 BM741703 AI128278 BG250081 AI638863 BQ668418 BE877517 
    BQ070788 BQ279212 BM555229 BU508962 CR590177 BQ065702 BQ061014 CR611740 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:              -     -                       -                             -                       -     -                                 
    SP2:                                            -                             -                       -     -                                 
    SP3:                    -                       -                             -                       -     -                                 
    SP4:                                            -                             -                       -                                       
    SP5:              -     -                       -     -     -     -     -     -     -     -           -     -                                 


    ECgene alternative splicing isoforms for RPL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL8 expression in normal human tissues (normalized intensities)      RPL8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCTGTGG
    RPL8 Expression
    About this image


    RPL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See RPL8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL8

    SOURCE GeneReport for Unigene cluster: Hs.178551
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL8 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl81 , 5 ribosomal protein L81, 5 87.68(n)1
    100(a)1
      15 (36.28 cM)5
    269611  NM_012053.21  NP_036183.11 
     769040715 
    chicken
    (Gallus gallus)
    Aves RPL81 ribosomal protein L8 81.97(n)
    98.05(a)
      418568  XM_416772.3  XP_416772.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    97(a)
    many → 1
    many → 1
    3(134050846-134057531)
    GL343424.1(642518-643291)
    African clawed frog
    (Xenopus laevis)
    Amphibia rpl8-prov2 ribosomal protein L8 79.97(n)    BC043823.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731052 hypothetical protein MGC73105 79.01(n)   393686  BC059473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL81 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein L81
    80(a)3
    74.13(n)1
    80.8(a)1
      62E73
    442511  NM_079987.21  NP_524726.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-21 , 3 Ribosomal Proteins L23
    Protein RPL-21
    73(a)3
    67.06(n)1
    73.91(a)1
      V(20471411-20473015)3
    1803431  NM_075539.41  NP_507940.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL2B(YIL018W)4
    RPL2A1
    Protein component of the large (60S) ribosomal subunit, more4
    Rpl2ap1
    63.52(n)1
    71.65(a)1
      9(316768-317932)4
    8505901  NP_116688.31  8547944 
     NP_012246.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB22961 60S ribosomal protein L8-1 66.67(n)
    71.37(a)
      816314  NM_127358.5  NP_179393.1 
    rice
    (Oryza sativa)
    Liliopsida Os.112972 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.64(n)    AK070647.1 


    ENSEMBL Gene Tree for RPL8 (if available)
    TreeFam Gene Tree for RPL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL8 gene

    RPL8 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for RPL8 (see all 6)
    PGOHUM00000239062 PGOHUM00000258127 PGOHUM00000237800 PGOHUM00000238273 PGOHUM00000258204


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/220 SNPs in RPL8 are shown (see all 220)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0196584
    ----see VAR_0196582 I V mis40--------
    rs29538861,2
    C,F,A,H--146014740(+) GGTGTC/TGCTAA 2 -- ds500116Minor allele frequency- T:0.43NA NS EA WA 1070
    rs1866280181,2
    C--146014744(+) TCGCTA/GAAAGA 2 -- ds50010--------
    rs1395170301,2
    --146014763(+) AAAGGA/GCTGCC 2 -- ds50010--------
    rs1176416651,2
    C,F--146014787(+) AAGTTA/GGCAGG 2 -- ds50011Minor allele frequency- G:0.01NS 142
    rs1135252601,2
    C--146014789(+) GTTAG-/CAGG  
     GAGCTGA
    CAGAG
    2 -- ds50011Minor allele frequency- CAGGGAGCTGA:0.00CSA 2
    rs29790881,2
    C--146014797(-) CTGTCA/CGCTCC 2 -- ds50012Minor allele frequency- C:0.06CSA NS 140
    rs1864856881,2
    --146014859(+) TTCCTA/GATACG 2 -- ds50010--------
    rs1498140751,2
    --146014864(+) GATACA/GTGAAA 2 -- ds50010--------
    rs22809331,2
    C,F,H--146014918(+) CCCACA/CTAAGT 2 -- ds500124Minor allele frequency- N:0.00EA NA NS WA CSA 3002

    HapMap Linkage Disequilibrium report for RPL8 (146015150 - 146017972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RPL8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv891929CNV Loss21882294
    nsv522459CNV Loss19592680
    nsv891897CNV Loss21882294
    dgv7985n71CNV Loss21882294
    nsv891925CNV Loss21882294
    nsv891807CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604177    OMIM disorders: --

    7 diseases for RPL8:    About MalaCards
    diamond-blackfan anemia    osteosarcoma    anemia    influenza
    pneumonia    melanoma    breast cancer


    RPL8 for disorders           About GeneDecksing


    Export disorders for RPL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL8 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with RPL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PubMed id 7506540)1, 2, 3, 9 Hanes J.... Scheit K.H. (1993)
    2. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
    6. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    7. Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies. (PubMed id 9531480)1, 2 Uehlein M.... Wittmann-Liebold B. (1998)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6132 HGNC: 10368 AceView: RPL8 Ensembl:ENSG00000161016 euGenes: HUgn6132
    ECgene: RPL8 Kegg: 6132 H-InvDB: RPL8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL8 gene:
    Search GeneIP for patents involving RPL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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