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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPL8 Gene

protein-coding GIFtS: 61
GCID: GC08M145985

ribosomal protein L8

Explore 8 diseases affiliated with
RPL8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein L8¹ ²
L8¹ ²
60S Ribosomal Protein L8²

External Ids:	HGNC: 10368¹	Entrez Gene: 6132²	Ensembl: ENSG00000161016⁷	OMIM: 604177⁵	UniProtKB: P62917³

Export aliases for RPL8 gene to outside databases

Previous GC identifers: GC08M143622 GC08M146052 GC08M145619 GC08M146019 GC08M141130

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL8:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal

proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates

in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal

subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes

encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

(provided by RefSeq, Jul 2008)

Gene Wiki entry for RPL8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_037704.5

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPL8 gene promoter:
TBP Pax-3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL8 promoter sequence

Search SABiosciences Chromatin IP Primers for RPL8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

RPL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL8 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M145985: view genomic region (about GC identifiers)

Start:	146,015,150 bp from pter	End:	146,017,972 bp from pter
Size:	2,823 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL8_HUMAN, P62917 (See protein sequence)

Recommended Name: 60S ribosomal protein L8

Size: 257 amino acids; 28025 Da

Subcellular location: Cytoplasm

Miscellaneous: This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the

endogenous protein

Secondary accessions: A8K094 D3DWN2 P25120 Q567Q7 Q969V7 Q9BWQ9

Explore the universe of human proteins at neXtProt for RPL8: NX_P62917

Post-translational modifications:

Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62917

RPL8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000964.1 NP_150644.1

ENSEMBL proteins:

ENSP00000437062 ENSP00000378378 ENSP00000436460 ENSP00000262584 ENSP00000433464

ENSP00000431931 ENSP00000433703 ENSP00000435313 ENSP00000434535

Reactome Protein details: P62917
Human Recombinant Protein Products for RPL8:

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	Uscn Proteins for RPL8

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0022625	cytosolic large ribosomal subunit	IDA	12962325

RPL8 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPL8 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR012340 NA-bd_OB-fold

IPR014722 Rib_L2_dom2

IPR002171 Ribosomal_L2

IPR023672 Ribosomal_L2_arc

IPR008991 Translation_prot_SH3-like

Graphical View of Domain Structure for InterPro Entry P62917

ProtoNet protein and cluster: P62917

1 Blocks protein family: IPB002171 Ribosomal protein L2

UniProtKB/Swiss-Prot: RL8_HUMAN, P62917

Similarity: Belongs to the ribosomal protein L2P family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for RPL8:

60S ribosomal protein L8

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	7506540
GO:0003735	structural constituent of ribosome	NAS	12962325
GO:0019843	rRNA binding	IEA	--

RPL8 for ontologies About GeneDecksing

Phenotypes:
7 GenomeRNAi human phenotypes for RPL8:

Decreased homologous recombina	Decreased number of cells in m	Decreased viability of wild-ty	Increased S DNA content
Nuclear 60S biogenesis defects	Nucleolar pre-40S maturation d	S arrest

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPL8

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPL8

CFTR translational fidelity (class I mutations)

2 BioSystems Pathways for RPL8

	Cytoplasmic Ribosomal Proteins
	TNF-alpha/NF-kB Signaling Pathway

5/28 Reactome Pathways for RPL8 (see all 28)

	Nonsense Mediated Decay Independent of the Exon Junction Complex
	Nonsense-Mediated Decay
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Eukaryotic Translation Initiation

1 Kegg Pathway (Kegg details for RPL8):

Ribosome

RPL8 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPL8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1026 Interacting proteins for RPL8 (P62917^{2, 3} ENSP00000262584⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1026)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS3	P23396²^,³, ENSP00000278572⁴	MINT-6542674 MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000278572
RPL4	P36578²^,³, ENSP00000311430⁴	MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=8 STRING: ENSP00000311430
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6542674 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=6 STRING: ENSP00000363676
RPL12	P30050²^,³, ENSP00000354739⁴	MINT-6542674 MINT-7945693 MINT-6489539 MINT-6488791 I2D: score=6 STRING: ENSP00000354739
RPL26	P61254²^,³, ENSP00000293842⁴	MINT-6542674 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=5 STRING: ENSP00000293842

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPL8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPL8

3 DrugBank Compounds for RPL8 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
ANISOMYCIN	--	--	target	--	10592235
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid	--	--	target	--	10592235
PUROMYCIN	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about RPL8 / RL8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPL8 gene (2 alternative transcripts):

NM_000973.3 NM_033301.1

Unigene Cluster for RPL8:

Ribosomal protein L8

Hs.178551 [show with all ESTs]

Unigene Representative Sequence: BF205975

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534781 ENST00000531975 ENST00000529163 ENST00000526668 ENST00000528296

ENST00000394920(uc003zeb.3) ENST00000527914 ENST00000262584(uc003zec.3)

ENST00000528957 ENST00000534813 ENST00000529920 ENST00000533397 ENST00000532702

ENST00000525232(uc010mgc.3) ENST00000531767

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPL8 Browse OriGene MicroRNA Expression Plasmids
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Additional cDNA sequence:

AK289459.1 AK301073.1 AK309619.1 BC000047.2 BC000077.2 BC012197.1 BC013104.1 BC030151.2

BC093064.1 BT007379.1 CR457046.1 Z28407.1

24/90 DOTS entries (see all 90):

DT.100772277 DT.75198014 DT.100855756 DT.91855316 DT.100060265 DT.98083411 DT.100699419 DT.100637334

DT.95365905 DT.100699413 DT.100699463 DT.121465589 DT.121465584 DT.97853480 DT.121465483 DT.121465436

DT.100699455 DT.121465399 DT.95366063 DT.100699433 DT.100808373 DT.121465545 DT.100699428 DT.121465501

24/3389 AceView cDNA sequences (see all 3389):

BU631470 CD242733 BM550486 BE799869 BQ882502 BM458616 CD515528 BM744077

BG820178 CA424398 BQ073493 BQ953003 CR592009 BQ424492 CA411672 BM824890

BM971775 CA443007 BU170283 BU500391 BM915755 BI518528 BU859094 CB151219

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	·	4e	·	4f	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:					-		-								-										-								-		-
SP2:															-										-								-		-
SP3:							-								-										-								-		-
SP4:															-										-								-
SP5:					-		-								-		-		-		-		-		-		-		-				-		-

ECgene alternative splicing isoforms for RPL8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPL8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCCTGTGG

About this image

RPL8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Endoderm-like cells (Generation of hepato...)

See RPL8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL8

SOURCE GeneReport for Unigene cluster: Hs.178551

SABiosciences Custom PCR Arrays for RPL8

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL8

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for RPL8 gene from 11/46 species (see all 46) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rpl8^{1 , 5}	ribosomal protein L8^{1, 5}	87.68(n)¹ 100(a)¹		15 (36.28 cM)⁵ 26961¹ NM_012053.2¹ NP_036183.1¹ 76904071⁵
chicken (Gallus gallus)	Aves	RPL8¹	ribosomal protein L8	81.97(n) 98.05(a)		418568 XM_416772.3 XP_416772.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	99(a) 97(a)	many → 1 many → 1	3(134050846-134054911) GL343424.1(642518-643291)
African clawed frog (Xenopus laevis)	Amphibia	rpl8-prov²	ribosomal protein L8	79.97(n)		BC043823.1
zebrafish (Danio rerio)	Actinopterygii	zgc73105²	hypothetical protein MGC73105	79.01(n)		393686 BC059473.1
fruit fly (Drosophila melanogaster)	Insecta	RpL8^{1 , 3}	protein biosynthesis structural constituent of more³ Ribosomal protein L8¹	80(a)³ 74.13(n)¹ 80.8(a)¹		62E7³ 44251¹ NM_079987.2¹ NP_524726.1¹
worm (Caenorhabditis elegans)	Secernentea	rpl-2^{1 , 3}	Ribosomal Proteins L2³ Protein RPL-2¹	73(a)³ 67.06(n)¹ 73.91(a)¹		V(20471411-20473015)³ 180343¹ NM_075539.4¹ NP_507940.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPL2B(YIL018W)⁴ RPL2A¹	Protein component of the large (60S) ribosomal subunit, more⁴ Rpl2ap¹	63.52(n)¹ 71.65(a)¹		9(316768-317932)⁴ 850590¹ NP_116688.3¹ 854794⁴ NP_012246.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	EMB2296¹	60S ribosomal protein L8-1	66.67(n) 71.37(a)		816314 NM_127358.5 NP_179393.1
rice (Oryza sativa)	Liliopsida	Os.11297²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	78.64(n)		AK070647.1

ENSEMBL Gene Tree for RPL8 (if available)
TreeFam Gene Tree for RPL8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPL8 gene

RPL8 for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for RPL8 (see all 6)
PGOHUM00000239062 PGOHUM00000258127 PGOHUM00000237800 PGOHUM00000238273 PGOHUM00000258204

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2953886^1,2	C,F,A,H	--	146014740(+)	`GGTGTC/TGCTAA`	2	--	ds500¹		16		NA NS EA WA	1070
rs186628018^1,2		--	146014744(+)	`TCGCTA/GAAAGA`	2	--	ds500¹		0	--	--	--	--
rs139517030^1,2		--	146014763(+)	`AAAGGA/GCTGCC`	2	--	ds500¹		0	--	--	--	--
rs117641665^1,2	C,F	--	146014787(+)	`AAGTTA/GGCAGG`	2	--	ds500¹		1		NS	142
rs113525260^1,2	C	--	146014789(+)	`GTTAG-/CAGG GAGCTGACAGAG`	2	--	ds500¹		1		CSA	2
rs2979088^1,2	C	--	146014797(-)	`CTGTCA/CGCTCC`	2	--	ds500¹		2		CSA NS	140
rs186485688^1,2		--	146014859(+)	`TTCCTA/GATACG`	2	--	ds500¹		0	--	--	--	--
rs149814075^1,2		--	146014864(+)	`GATACA/GTGAAA`	2	--	ds500¹		0	--	--	--	--
rs2280933^1,2	C,F,H	--	146014918(+)	`CCCACA/CTAAGT`	2	--	ds500¹		24		EA NA NS WA CSA	3002
rs113314702^1,2	C	--	146014998(+)	`ACCCCG/ATTTCT`	2	--	ds500¹		3		CSA WA NS	257

HapMap Linkage Disequilibrium report for RPL8 (146015150 - 146017972 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPL8: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RPL8 for disorders           About GeneDecksing

OMIM gene information: 604177    OMIM disorders: --

8 diseases for RPL8:    About MalaCards

diamond-blackfan anemia treacher collins syndrome ovarian carcinoma osteosarcoma

anemia melanoma carcinoma malaria

Export disorders for RPL8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPL8 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with RPL8)

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Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PubMed id 7506540)^{1, 2, 3, 9} Hanes J.... Scheit K.H. (1993)
A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 2, 3} Kenmochi N.... Page D.C. (1998)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)^{1, 2} Odintsova T.I....Karpova G.G. (2003)
The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)^{1, 2} Yoshihama M.... Kenmochi N. (2002)
Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies. (PubMed id 9531480)^{1, 2} Uehlein M.... Wittmann-Liebold B. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6132	HGNC: 10368	AceView: RPL8	Ensembl:ENSG00000161016	euGenes: HUgn6132
ECgene: RPL8	Kegg: 6132	H-InvDB: RPL8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RPL8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPL8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPL8 gene:
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GeneCards and IP:
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ribosomal protein L8

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ribosomal protein L8

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