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RPL8 Gene

protein-coding   GIFtS: 66
GCID: GC08M146015

Ribosomal Protein L8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribosomal Protein L81 2
60S Ribosomal Protein L82
L82

External Ids:    HGNC: 103681   Entrez Gene: 61322   Ensembl: ENSG000001610167   OMIM: 6041775   UniProtKB: P629173   
ORGUL members:         

Export aliases for RPL8 gene to outside databases

Previous GC identifers: GC08M143622 GC08M146052 GC08M145619 GC08M146019 GC08M145985 GC08M141130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL8 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of
ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very
likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding
site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein
exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene
dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL8 Gene:
RPL8 (ribosomal protein L8) is a protein-coding gene. GO annotations related to this gene include RNA binding and rRNA binding.

Gene Wiki entry for RPL8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL8 gene promoter:
         TBP   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL8 promoter sequence
   Search Chromatin IP Primers for RPL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

RPL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL8 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M146015:  view genomic region     (about GC identifiers)

Start:
146,015,150 bp from pter      End:
146,017,972 bp from pter
Size:
2,823 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RL8_HUMAN, P62917 (See protein sequence)
Recommended Name: 60S ribosomal protein L8  
Size: 257 amino acids; 28025 Da
Miscellaneous: This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace
the endogenous protein
1 PDB 3D structure from and Proteopedia for RPL8:
3J3B (3D)    
Secondary accessions: A8K094 D3DWN2 P25120 Q567Q7 Q969V7 Q9BWQ9

Explore the universe of human proteins at neXtProt for RPL8: NX_P62917

Explore proteomics data for RPL8 at MOPED

Post-translational modifications: 

  • Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia1
  • Ubiquitination2 at Lys10, Lys46, Lys60, Lys181
  • Modification sites at PhosphoSitePlus

  • See RPL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000964.1  NP_150644.1  

    ENSEMBL proteins: 
     ENSP00000437062   ENSP00000378378   ENSP00000436460   ENSP00000262584   ENSP00000433464  
     ENSP00000433703   ENSP00000435313   ENSP00000434535  
    Reactome Protein details: P62917

    RPL8 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    Selected InterPro protein domains (see all 9):
     IPR012340 NA-bd_OB-fold
     IPR014722 Rib_L2_dom2
     IPR002171 Ribosomal_L2
     IPR023672 Ribosomal_L2_arc
     IPR008991 Translation_prot_SH3-like

    Graphical View of Domain Structure for InterPro Entry P62917

    ProtoNet protein and cluster: P62917

    1 Blocks protein domain: IPB002171 Ribosomal protein L2

    UniProtKB/Swiss-Prot: RL8_HUMAN, P62917
    Similarity: Belongs to the ribosomal protein L2P family


    Find genes that share domains with RPL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL8:
    60S ribosomal protein L8

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7506540
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0019843rRNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPL8           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for RPL8:
     Decreased homologous recombina  Decreased number of cells in m  Decreased viability of wild-ty  Increased S DNA content 
     Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPL8

    miRNA
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    hsa-mir-92a-3p (MIRT049424), hsa-mir-296-3p (MIRT038359), hsa-mir-130b-5p (MIRT038297), hsa-mir-455-3p (MIRT037866), hsa-mir-92b-3p (MIRT040617), hsa-mir-320a (MIRT044588), hsa-mir-222-3p (MIRT046643), hsa-mir-193b-3p (MIRT041298)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RL8_HUMAN, P62917: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus3
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    Find genes that share ontologies with RPL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL8 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with RPL8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL8
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL8
        TNF-alpha/NF-kB Signaling Pathway
    Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL8 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL8):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL8
    Interactions:

        Search GeneGlobe Interaction Network for RPL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL8 (P629172, 3 ENSP000002625844) via UniProtKB, MINT, STRING, and/or I2D (see all 1124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000278572
    ENSG00000096150P622692, 3, ENSP000002113724MINT-7945693 I2D: score=3 STRING: ENSP00000211372
    ENSG00000223367P622692, 3, ENSP000004125834MINT-7945693 I2D: score=3 STRING: ENSP00000412583
    ENSG00000235650P622692, 3, ENSP000004161104MINT-7945693 I2D: score=3 STRING: ENSP00000416110
    RPL4P365782, 3, ENSP000003114304MINT-7945693 MINT-6489539 MINT-6489355 MINT-6488791 I2D: score=8 STRING: ENSP00000311430
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL8 (RL8)

    3 DrugBank Compounds for RPL8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPL8 gene (2 alternative transcripts): 
    NM_000973.3  NM_033301.1  

    Unigene Cluster for RPL8:

    Ribosomal protein L8
    Hs.178551  [show with all ESTs]
    Unigene Representative Sequence: BF205975
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534781 ENST00000531975 ENST00000529163 ENST00000526668 ENST00000528296
    ENST00000394920(uc003zeb.3) ENST00000527914 ENST00000262584(uc003zec.3)
    ENST00000528957 ENST00000529920 ENST00000533397 ENST00000532702 ENST00000525232(uc010mgc.3)
    ENST00000531767
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    Additional mRNA sequence: 

    AK289459.1 AK301073.1 AK309619.1 BC000047.2 BC000077.2 BC012197.1 BC013104.1 BC030151.2 
    BC093064.1 BT007379.1 CR457046.1 Z28407.1 

    Selected DOTS entries (see all 90):

    DT.100772277  DT.75198014  DT.100855756  DT.91855316  DT.100060265  DT.98083411  DT.100699419  DT.100637334 
    DT.95365905  DT.100699413  DT.100699463  DT.121465589  DT.121465584  DT.97853480  DT.121465483  DT.121465436 
    DT.100699455  DT.121465399  DT.95366063  DT.100699433  DT.100808373  DT.121465545  DT.100699428  DT.121465501 

    Selected AceView cDNA sequences (see all 3389):

    CR625112 BM850941 CD108999 BQ919555 CR590460 BU628603 BE790514 F20617 
    BG675382 BM542914 AW161465 BQ049126 BU727006 BQ957763 CR626383 BM853567 
    BU857226 BM927728 BG249969 H38985 BG387915 BM841680 BQ071479 BU163518 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:              -     -                       -                             -                       -     -                                 
    SP2:                                            -                             -                       -     -                                 
    SP3:                    -                       -                             -                       -     -                                 
    SP4:                                            -                             -                       -                                       
    SP5:              -     -                       -     -     -     -     -     -     -     -           -     -                                 


    ECgene alternative splicing isoforms for RPL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCTGTGG
    RPL8 Expression
    About this image


    RPL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Tonsil (Hematopoietic System)
    RPL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.178551
        Custom PCR Arrays for RPL8
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL8 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl81 , 5 ribosomal protein L81, 5 87.68(n)1
    100(a)1
      15 (36.28 cM)5
    269611  NM_012053.21  NP_036183.11 
     769040715 
    chicken
    (Gallus gallus)
    Aves RPL81 ribosomal protein L8 81.97(n)
    98.05(a)
      418568  NM_001277728.1  NP_001264657.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    97(a)
    many → 1
    many → 1
    3(134050846-134057531)
    GL343424.1(642518-643291)
    African clawed frog
    (Xenopus laevis)
    Amphibia rpl8-prov2 ribosomal protein L8 79.97(n)    BC043823.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731052 hypothetical protein MGC73105 79.01(n)   393686  BC059473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL81 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein L81
    80(a)3
    74.13(n)1
    80.8(a)1
      62E73
    442511  NM_167955.21  NP_728756.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-21 , 3 Ribosomal Proteins L23
    rpl-21
    73(a)3
    67.19(n)1
    73.54(a)1
      V(20471411-20473015)3
    1803431  NM_075539.51  NP_507940.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL2B(YIL018W)4
    RPL2A1
    Protein component of the large (60S) ribosomal subunit, more4
    RPL2A1
    63.52(n)1
    71.65(a)1
      9(316768-317932)4
    8505901  NP_116688.31  8547944 
     NP_012246.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G511901 AT3G51190 64.52(n)
    70.68(a)
      824282  NM_114978.2  NP_190687.2 
    rice
    (Oryza sativa)
    Liliopsida Os.112972 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.64(n)    AK070647.1 


    ENSEMBL Gene Tree for RPL8 (if available)
    TreeFam Gene Tree for RPL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL8 gene

    Find genes that share paralogs with RPL8           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL8 (see all 6)
    PGOHUM00000239062 PGOHUM00000258127 PGOHUM00000237800 PGOHUM00000238273 PGOHUM00000258204


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL8 (see all 220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29538861,2
    C,F,A,H--146014740(+) GGTGTC/TGCTAA 2 -- ds500116Minor allele frequency- T:0.43NA NS EA WA 1070
    rs1866280181,2
    C--146014744(+) TCGCTA/GAAAGA 2 -- ds50010--------
    rs1395170301,2
    --146014763(+) AAAGGA/GCTGCC 2 -- ds50010--------
    rs1176416651,2
    C,F--146014787(+) AAGTTA/GGCAGG 2 -- ds50011Minor allele frequency- G:0.01NS 142
    rs1135252601,2
    C--146014789(+) GTTAG-/CAGG  
     GAGCTGA
    CAGAG
    2 -- ds50011Minor allele frequency- CAGGGAGCTGA:0.00CSA 2
    rs29790881,2
    C--146014797(-) CTGTCA/CGCTCC 2 -- ds50012Minor allele frequency- C:0.06CSA NS 140
    rs1864856881,2
    --146014859(+) TTCCTA/GATACG 2 -- ds50010--------
    rs1498140751,2
    --146014864(+) GATACA/GTGAAA 2 -- ds50010--------
    rs22809331,2
    C,F,H--146014918(+) CCCACA/CTAAGT 2 -- ds500124Minor allele frequency- N:0.00EA NA NS WA CSA 3002
    rs1133147021,2
    C,F--146014998(+) ACCCCG/ATTTCT 2 -- ds50013Minor allele frequency- A:0.17CSA WA NS 257

    HapMap Linkage Disequilibrium report for RPL8 (146015150 - 146017972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RPL8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891929CNV Loss21882294
    nsv522459CNV Loss19592680
    nsv891897CNV Loss21882294
    dgv7985n71CNV Loss21882294
    nsv891925CNV Loss21882294
    nsv891807CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL8
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604177    OMIM disorders: --


    Find genes that share disorders with RPL8           About GenesLikeMe


    Export disorders for RPL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL8 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with RPL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PubMed id 7506540)1, 2, 3, 9 Hanes J.... Scheit K.H. (Biochem. Biophys. Res. Commun. 1993)
    2. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    6. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    7. Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies. (PubMed id 9531480)1, 2 Uehlein M.... Wittmann-Liebold B. (Biochem. J. 1998)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6132 HGNC: 10368 AceView: RPL8 Ensembl:ENSG00000161016 euGenes: HUgn6132
    ECgene: RPL8 Kegg: 6132 H-InvDB: RPL8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPL8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL8 gene:
    Search GeneIP for patents involving RPL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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