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Aliases for RPL7L1 Gene

Aliases for RPL7L1 Gene

  • Ribosomal Protein L7 Like 1 2 3 5
  • Large Ribosomal Subunit Protein UL30-Like 1 3 4
  • 60S Ribosomal Protein L7-Like 1 3
  • Ribosomal Protein L7-Like 1 2
  • DJ475N16.4 3

External Ids for RPL7L1 Gene

Previous GeneCards Identifiers for RPL7L1 Gene

  • GC06P042894
  • GC06P042956
  • GC06P042565

Summaries for RPL7L1 Gene

GeneCards Summary for RPL7L1 Gene

RPL7L1 (Ribosomal Protein L7 Like 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RPL7.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7L1 Gene

Genomics for RPL7L1 Gene

Regulatory Elements for RPL7L1 Gene

Enhancers for RPL7L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G042901 1.5 Ensembl ENCODE dbSUPER 33.1 +23.4 23433 3.3 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 TCF12 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D RN7SL403P KLC4 CUL7 KLHDC3 MEA1
GH06G042910 1.7 Ensembl ENCODE dbSUPER 26.6 +32.0 31970 1.8 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 PEX6 RPL7L1 ENSG00000231113 PPP2R5D KLHDC3 MEA1 RNU6-890P PTCRA LOC105375063
GH06G042893 1.2 Ensembl ENCODE 24.5 +14.3 14284 1.0 HDAC1 ELF3 ATF1 RB1 ARNT ARID4B CHAMP1 TCF12 RELB IKZF2 RPL7L1 CNPY3 ENSG00000231113 RNU6-890P PPP2R5D MEA1 KLHDC3 PEX6 RN7SL403P KLC4
GH06G042923 1.1 Ensembl ENCODE 25.4 +44.4 44383 1.2 AGO1 ZFP64 SIN3A ZNF335 CBFB CEBPB MEF2D SREBF1 ZNF579 SMARCA4 RPL7L1 RPL24P4 PEX6 PPP2R5D KLHDC3 MEA1 KLC4 CUL7 RN7SL403P DNPH1
GH06G042889 1.1 ENCODE 23.3 +11.0 11032 2.2 HDGF HNRNPUL1 PKNOX1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 RPL7L1 RPS2P29 ENSG00000271970 POLH ENSG00000271754 C6orf226 PIR42130
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL7L1 on UCSC Golden Path with GeneCards custom track

Promoters for RPL7L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197058 482 1801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for RPL7L1 Gene

42,879,618 bp from pter
42,889,925 bp from pter
10,308 bases
Plus strand

Genomic View for RPL7L1 Gene

Genes around RPL7L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7L1 Gene

Proteins for RPL7L1 Gene

  • Protein details for RPL7L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L7-like 1
    Protein Accession:
    Secondary Accessions:
    • A8K7D4
    • B7Z652
    • Q5TFZ5
    • Q6PEK3

    Protein attributes for RPL7L1 Gene

    246 amino acids
    Molecular mass:
    28661 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RPL7L1 Gene


neXtProt entry for RPL7L1 Gene

Post-translational modifications for RPL7L1 Gene

  • Ubiquitination at isoforms=2122 and Lys129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7L1 Gene

No data available for DME Specific Peptides for RPL7L1 Gene

Domains & Families for RPL7L1 Gene

Gene Families for RPL7L1 Gene

Suggested Antigen Peptide Sequences for RPL7L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL30 family.
  • Belongs to the universal ribosomal protein uL30 family.
genes like me logo Genes that share domains with RPL7L1: view

Function for RPL7L1 Gene

Gene Ontology (GO) - Molecular Function for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with RPL7L1: view
genes like me logo Genes that share phenotypes with RPL7L1: view

Animal Models for RPL7L1 Gene

MGI Knock Outs for RPL7L1:

Animal Model Products

miRNA for RPL7L1 Gene

miRTarBase miRNAs that target RPL7L1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPL7L1 Gene

Localization for RPL7L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7L1 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL7L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7L1 Gene

Pathways & Interactions for RPL7L1 Gene

SuperPathways for RPL7L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0001825 blastocyst formation IEA --
GO:0002181 cytoplasmic translation IBA --
genes like me logo Genes that share ontologies with RPL7L1: view

No data available for Pathways by source and SIGNOR curated interactions for RPL7L1 Gene

Drugs & Compounds for RPL7L1 Gene

No Compound Related Data Available

Transcripts for RPL7L1 Gene

mRNA/cDNA for RPL7L1 Gene

Unigene Clusters for RPL7L1 Gene

Ribosomal protein L7-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7L1 Gene

No ASD Table

Relevant External Links for RPL7L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL7L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL7L1 Gene

Protein differential expression in normal tissues from HIPED for RPL7L1 Gene

This gene is overexpressed in Lung (47.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL7L1 Gene

Protein tissue co-expression partners for RPL7L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL7L1 Gene:


SOURCE GeneReport for Unigene cluster for RPL7L1 Gene:


Evidence on tissue expression from TISSUES for RPL7L1 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Liver(3)
genes like me logo Genes that share expression patterns with RPL7L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL7L1 Gene

Orthologs for RPL7L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL7L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL7L1 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia -- 35
  • 89 (a)
RPL7L1 34
  • 88.62 (n)
-- 35
  • 80 (a)
(Bos Taurus)
Mammalia RPL7L1 34 35
  • 87.53 (n)
(Rattus norvegicus)
Mammalia Rpl7l1 34
  • 86.39 (n)
(Mus musculus)
Mammalia Rpl7l1 34 16 35
  • 84.63 (n)
1700084J12Rik 35
  • 76 (a)
(Monodelphis domestica)
Mammalia RPL7L1 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RPL7L1 35
  • 69 (a)
(Gallus gallus)
Aves RPL7L1 34 35
  • 68.29 (n)
(Anolis carolinensis)
Reptilia RPL7L1 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76334 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25248 34
(Danio rerio)
Actinopterygii rpl7l1 34 35
  • 59.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL7 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea rpl-7 35
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL7A 35
  • 33 (a)
RPL7B 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2360 35
  • 45 (a)
Species where no ortholog for RPL7L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL7L1 Gene

Gene Tree for RPL7L1 (if available)
Gene Tree for RPL7L1 (if available)

Paralogs for RPL7L1 Gene

Variants for RPL7L1 Gene

Sequence variations from dbSNP and Humsavar for RPL7L1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000375280 -- 42,886,954(+) GCACC(A/G)GTGCA intron-variant, utr-variant-3-prime
rs1000572564 -- 42,882,413(+) ATGGT(A/G)AAACC intron-variant
rs1000639245 -- 42,881,319(+) AATTA(C/G)CCGGG intron-variant
rs1000677699 -- 42,888,457(+) CCAGC(A/T)CTTGT nc-transcript-variant, utr-variant-3-prime
rs1001010086 -- 42,879,502(+) CTACA(C/T)GTGAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL7L1 Gene

Variant ID Type Subtype PubMed ID
esv3576145 CNV gain 25503493
nsv1017398 CNV gain 25217958
nsv830651 CNV loss 17160897
nsv969394 CNV duplication 23825009

Variation tolerance for RPL7L1 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL7L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7L1 Gene

Disorders for RPL7L1 Gene

Relevant External Links for RPL7L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL7L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL7L1 Gene

Publications for RPL7L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for RPL7L1 Gene

Sources for RPL7L1 Gene

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