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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL7L1 Gene

protein-coding   GIFtS: 43
GCID: GC06P042847

Ribosomal Protein L7-Like 1

  Search for RPL7L1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein L7-Like 11 2
60S Ribosomal Protein L7-Like 12
dJ475N16.42

External Ids:    HGNC: 213701   Entrez Gene: 2858552   Ensembl: ENSG000001462237   UniProtKB: Q6DKI13   

Export aliases for RPL7L1 gene to outside databases

Previous GC identifers: GC06P042894 GC06P042956 GC06P042565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RPL7L1 Gene: 
RPL7L1 (ribosomal protein L7-like 1) is a protein-coding gene. An important paralog of this gene is RPL7.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL7L1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   GATA-1   C/EBPalpha   CHOP-10   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL7L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL7L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL7L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

RPL7L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL7L1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042847:  view genomic region     (about GC identifiers)

Start:
42,847,356 bp from pter      End:
42,857,663 bp from pter
Size:
10,308 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL7L_HUMAN, Q6DKI1 (See protein sequence)
Recommended Name: 60S ribosomal protein L7-like 1  
Size: 246 amino acids; 28661 Da
Secondary accessions: A8K7D4 Q5TFZ5 Q6PEK3

Explore the universe of human proteins at neXtProt for RPL7L1: NX_Q6DKI1

Explore proteomics data for RPL7L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6DKI1

  • RPL7L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL7L1 Protein Expression
    REFSEQ proteins: NP_940888.2  
    ENSEMBL proteins: 
     ENSP00000418221   ENSP00000346063   ENSP00000473356   ENSP00000445293  

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    Novus Biologicals RPL7L1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL7L1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005840ribosome IEA--

    RPL7L1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPL: L ribosomal proteins

    4 InterPro protein domains:
     IPR016082 Ribosomal_L30_ferredoxin-like
     IPR012988 Ribosomal_L30_N
     IPR005998 Ribosomal_L7_euk
     IPR018038 Ribosomal_L30_CS

    Graphical View of Domain Structure for InterPro Entry Q6DKI1

    ProtoNet protein and cluster: Q6DKI1

    1 Blocks protein domain: IPB000517 Ribosomal protein L30

    UniProtKB/Swiss-Prot: RL7L_HUMAN, Q6DKI1
    Similarity: Belongs to the ribosomal protein L30P family


    RPL7L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for RPL7L1:
     Decreased TP53 protein express  Decreased cell number, increas 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPL7L1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPL7L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL7L1 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RPL7L1:
    hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidRPL7L1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL7L1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL7L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for RPL7L1 (Q6DKI11, 3 ENSP000003460634) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494071, 3, ENSP000003771414EBI-1052408,EBI-743313 I2D: score=2 STRING: ENSP00000377141
    ARRB2P321211, 3, ENSP000002692604EBI-1052408,EBI-714559 I2D: score=2 STRING: ENSP00000269260
    GABARAPO951663I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL7L1 (RL7L)

    Search CenterWatch for drugs/clinical trials and news about RPL7L1 / RL7L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL7L1 gene: 
    NM_198486.2  

    Unigene Cluster for RPL7L1:

    Ribosomal protein L7-like 1
    Hs.520133  [show with all ESTs]
    Unigene Representative Sequence: AK074339
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483998 ENST00000493763(uc003osq.1) ENST00000397415(uc010jxw.1 uc003osr.1)
    ENST00000304734(uc003ost.3 uc003oss.2) ENST00000487619 ENST00000492836
    ENST00000497417 ENST00000602561 ENST00000462348 ENST00000459829 ENST00000424341(uc011dux.1 uc011duy.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL7L1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RPL7L1:
    hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidRPL7L1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of RPL7L1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL7L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL7L1

    Additional mRNA sequence: 

    AK021904.1 AK074339.1 AK091341.1 AK098059.1 AK291310.1 AK291949.1 AK297324.1 AK299816.1 
    BC036861.1 BC058020.1 BC064519.1 BC073890.1 

    24/38 DOTS entries (see all 38):

    DT.100769559  DT.446102  DT.100031514  DT.100883309  DT.101973747  DT.100760895  DT.100643471  DT.100883312 
    DT.101985327  DT.99965693  DT.100883311  DT.92450826  DT.97855350  DT.120680834  DT.92450838  DT.121373890 
    DT.95265993  DT.121315958  DT.121373856  DT.121373768  DT.120796549  DT.120866526  DT.121270621  DT.121373876 

    13 AceView cDNA sequences:

    CR595869 CR601324 BC058020 NM_198486 BC073890 CR626570 BI255539 AK021904 
    BC064519 BC036861 AK091341 BM480341 S81578 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL7L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTTAAAG
    RPL7L1 Expression
    About this image


    See RPL7L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL7L1

    SOURCE GeneReport for Unigene cluster: Hs.520133
        SABiosciences Custom PCR Arrays for RPL7L1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL7L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPL7L1 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl7l11 , 5 ribosomal protein L7-like 11, 5 84.63(n)1
    84.08(a)1
      17 (22.90 cM)5
    662291  NM_025433.31  NP_079709.21 
     467739075 
    chicken
    (Gallus gallus)
    Aves RPL7L11 ribosomal protein L7-like 1 68.29(n)
    69.11(a)
      422676  NM_001006452.1  NP_001006452.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL7L16
    ribosomal protein L7-like 1
    65(a)
    1 ↔ 1
    5(139795553-139807264)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252482 Xenopus laevis transcribed sequence with weak similarity more 74.37(n)    48062502 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl7l11 ribosomal protein L7-like 1 59.49(n)
    61.38(a)
      322251  NM_199590.1  NP_955884.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL76
    RpL7-like6
    Ribosomal protein L7-like
    35(a)
    27(a)
    many ↔ many
    many ↔ many
    2L(10201101-10202145)
    2L(12056324-12057416)
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-76
    60S ribosomal protein L7
    39(a)
    1 → many
    I(111036-112417)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL7A6
    RPL7B6
    Protein component of the large (60S) ribosomal sub...
    Protein component of the large (60S) ribosomal sub...
    33(a)
    33(a)
    many ↔ many
    many ↔ many
    VII(364335-365996)
    XVI(173152-174702)


    ENSEMBL Gene Tree for RPL7L1 (if available)
    TreeFam Gene Tree for RPL7L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL7L1 gene
    RPL72  
    2 SIMAP similar genes for RPL7L1 using alignment to 3 protein entries:     RL7L_HUMAN (see all proteins):
    RPL7    WUGSC

    RPL7L1 for paralogs           About GeneDecksing


    5/31 Pseudogenes.org Pseudogenes for RPL7L1 (see all 31)
    PGOHUM00000248460 PGOHUM00000248476 PGOHUM00000248675 PGOHUM00000246874 PGOHUM00000248702


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/254 SNPs in RPL7L1 are shown (see all 254)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94719381,2
    C,F,A,H--42756599(+) CACCAG/ATATCA 1 -- us2k120Minor allele frequency- A:0.18NS EA NA CSA WA 2183
    rs2012858061,2
    --42756680(+) TCCTG-/CCCCCC 1 -- us2k10--------
    rs1145530561,2
    F--42756685(+) GCCCCC/GCCTAG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs6850961,2
    C,F,H--42756686(-) ACTAGG/CGGGGG 1 -- us2k16Minor allele frequency- C:0.36NS EA NA 632
    rs1897479381,2
    --42756689(+) CCCCTA/CGTATC 1 -- us2k10--------
    rs132023071,2
    C,F,H--42756703(+) TGGaaG/Aaaata 1 -- us2k1 tfbs312Minor allele frequency- A:0.03NS EA NA 1458
    rs3769421,2
    C--42757050(+) gagccG/Aagatc 1 -- us2k15Minor allele frequency- A:0.00NA WA 10
    rs1856036001,2
    C--42757251(+) AGACTG/TGTGTT 1 -- us2k10--------
    rs1912069441,2
    --42757349(+) TGGCAC/TAAACT 1 -- us2k10--------
    rs1444724611,2
    --42757384(+) GGGACA/TTCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPL7L1 (42847356 - 42857663 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPL7L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830651CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL7L1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RPL7L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285855 HGNC: 21370 AceView: RPL7L1 Ensembl:ENSG00000146223 euGenes: HUgn285855
    ECgene: RPL7L1 H-InvDB: RPL7L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL7L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL7L1 gene:
    Search GeneIP for patents involving RPL7L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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