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Aliases for RPL7L1 Gene

Aliases for RPL7L1 Gene

  • Ribosomal Protein L7 Like 1 2 3 5
  • 60S Ribosomal Protein L7-Like 1 3
  • Ribosomal Protein L7-Like 1 2
  • DJ475N16.4 3

External Ids for RPL7L1 Gene

Previous GeneCards Identifiers for RPL7L1 Gene

  • GC06P042894
  • GC06P042956
  • GC06P042565

Summaries for RPL7L1 Gene

GeneCards Summary for RPL7L1 Gene

RPL7L1 (Ribosomal Protein L7 Like 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RPL7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7L1 Gene

Genomics for RPL7L1 Gene

Regulatory Elements for RPL7L1 Gene

Enhancers for RPL7L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F042901 1.2 Ensembl ENCODE 33.1 +23.4 23433 3.3 ZFP64 SIN3A ARID4B DMAP1 ZNF48 ZNF2 SLC30A9 ZNF143 ZNF207 SP5 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D KLC4 RN7SL403P CUL7 KLHDC3 MEA1
GH06F042910 1.4 Ensembl ENCODE 26.5 +32.0 31970 1.8 HDGF ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 PEX6 RPL7L1 RPL24P4 UBR2 ENSG00000271970 CUL7 ENSG00000231113 POLH RRP36 PPP2R5D
GH06F042923 1.3 Ensembl ENCODE 25.5 +44.4 44384 1.6 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ELK1 ZNF143 ZNF207 RPL7L1 ENSG00000271970 RPS2P28 ENSG00000223469 RPL24P4 PEX6 PPP2R5D KLHDC3 MEA1 KLC4
GH06F042893 1.2 Ensembl ENCODE 24.6 +14.3 14283 1.8 ELF3 HDAC1 ARID4B PTRF CHAMP1 ZBTB2 ZEB2 HDAC8 KAT8 CREB3 RPL7L1 CNPY3 ENSG00000231113 RNU6-890P PPP2R5D KLHDC3 MEA1 PEX6 RN7SL403P KLC4
GH06F042889 1.1 ENCODE 23.3 +11.0 11032 2.2 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RPL7L1 RPS2P29 ENSG00000271970 RPS2P28 ENSG00000223469 POLH PRPH2 ENSG00000271754 C6orf226 PIR42130
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL7L1 on UCSC Golden Path with GeneCards custom track

Promoters for RPL7L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216919 482 2201 HDGF ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for RPL7L1 Gene

Chromosome:
6
Start:
42,879,618 bp from pter
End:
42,889,925 bp from pter
Size:
10,308 bases
Orientation:
Plus strand

Genomic View for RPL7L1 Gene

Genes around RPL7L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7L1 Gene

Proteins for RPL7L1 Gene

  • Protein details for RPL7L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DKI1-RL7L_HUMAN
    Recommended name:
    60S ribosomal protein L7-like 1
    Protein Accession:
    Q6DKI1
    Secondary Accessions:
    • A8K7D4
    • B7Z652
    • Q5TFZ5
    • Q6PEK3

    Protein attributes for RPL7L1 Gene

    Size:
    246 amino acids
    Molecular mass:
    28661 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RPL7L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL7L1 Gene

Post-translational modifications for RPL7L1 Gene

  • Ubiquitination at Lys 122 and Lys 129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7L1 Gene

No data available for DME Specific Peptides for RPL7L1 Gene

Domains & Families for RPL7L1 Gene

Gene Families for RPL7L1 Gene

Suggested Antigen Peptide Sequences for RPL7L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6DKI1

UniProtKB/Swiss-Prot:

RL7L_HUMAN :
  • Belongs to the ribosomal protein L30P family.
Family:
  • Belongs to the ribosomal protein L30P family.
genes like me logo Genes that share domains with RPL7L1: view

Function for RPL7L1 Gene

Gene Ontology (GO) - Molecular Function for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL7L1: view
genes like me logo Genes that share phenotypes with RPL7L1: view

Animal Models for RPL7L1 Gene

MGI Knock Outs for RPL7L1:

Animal Model Products

miRNA for RPL7L1 Gene

miRTarBase miRNAs that target RPL7L1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPL7L1 Gene

Localization for RPL7L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7L1 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL7L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7L1 Gene

Pathways & Interactions for RPL7L1 Gene

SuperPathways for RPL7L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPL7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0001825 blastocyst formation IEA --
GO:0002181 cytoplasmic translation IBA --
genes like me logo Genes that share ontologies with RPL7L1: view

No data available for Pathways by source and SIGNOR curated interactions for RPL7L1 Gene

Transcripts for RPL7L1 Gene

mRNA/cDNA for RPL7L1 Gene

Unigene Clusters for RPL7L1 Gene

Ribosomal protein L7-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7L1 Gene

No ASD Table

Relevant External Links for RPL7L1 Gene

GeneLoc Exon Structure for
RPL7L1
ECgene alternative splicing isoforms for
RPL7L1

Expression for RPL7L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL7L1 Gene

Protein differential expression in normal tissues from HIPED for RPL7L1 Gene

This gene is overexpressed in Lung (47.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL7L1 Gene



Protein tissue co-expression partners for RPL7L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPL7L1 Gene:

RPL7L1

SOURCE GeneReport for Unigene cluster for RPL7L1 Gene:

Hs.520133
genes like me logo Genes that share expression patterns with RPL7L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL7L1 Gene

Orthologs for RPL7L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL7L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL7L1 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 89 (a)
OneToMany
RPL7L1 34
  • 88.62 (n)
-- 35
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL7L1 34 35
  • 87.53 (n)
rat
(Rattus norvegicus)
Mammalia Rpl7l1 34
  • 86.39 (n)
mouse
(Mus musculus)
Mammalia Rpl7l1 34 16 35
  • 84.63 (n)
1700084J12Rik 35
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL7L1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL7L1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL7L1 34 35
  • 68.29 (n)
lizard
(Anolis carolinensis)
Reptilia RPL7L1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76334 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25248 34
zebrafish
(Danio rerio)
Actinopterygii rpl7l1 34 35
  • 59.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL7 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-7 35
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL7A 35
  • 33 (a)
ManyToMany
RPL7B 35
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2360 35
  • 45 (a)
OneToMany
Species where no ortholog for RPL7L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL7L1 Gene

ENSEMBL:
Gene Tree for RPL7L1 (if available)
TreeFam:
Gene Tree for RPL7L1 (if available)

Paralogs for RPL7L1 Gene

Variants for RPL7L1 Gene

Sequence variations from dbSNP and Humsavar for RPL7L1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456520 -- 42,882,848(+) ttgca(A/G)tgagc intron-variant
rs1055969 -- 42,888,592(+) CAGAT(A/G)GTGTT nc-transcript-variant, utr-variant-3-prime
rs1055972 -- 42,889,179(+) CTCAC(A/G)CCTGT nc-transcript-variant, utr-variant-3-prime
rs1056055 -- 42,889,781(+) GAGCA(A/C)ACTGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1062253 -- 42,887,138(+) TTTTT(A/G)TTGCT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL7L1 Gene

Variant ID Type Subtype PubMed ID
esv3576145 CNV gain 25503493
nsv1017398 CNV gain 25217958
nsv830651 CNV loss 17160897
nsv969394 CNV duplication 23825009

Variation tolerance for RPL7L1 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL7L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL7L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7L1 Gene

Disorders for RPL7L1 Gene

Relevant External Links for RPL7L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL7L1

No disorders were found for RPL7L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL7L1 Gene

Publications for RPL7L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RPL7L1 Gene

Sources for RPL7L1 Gene

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