Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL7A Gene

Aliases for RPL7A Gene

  • Ribosomal Protein L7a 2 3 5
  • Surfeit Locus Protein 3 2 3 4
  • PLA-X Polypeptide 2 3 4
  • Thyroid Hormone Receptor Uncoupling Protein 2 3
  • 60S Ribosomal Protein L7a 2 3
  • Surfeit 3 2 3
  • SURF3 3 4
  • SURF-3 4
  • TRUP 3
  • L7A 3
  • ; 2

External Ids for RPL7A Gene

Previous GeneCards Identifiers for RPL7A Gene

  • GC09P127304
  • GC09P127771
  • GC09P129568
  • GC09P131491
  • GC09P133231
  • GC09P135194
  • GC09P135217
  • GC09P135222
  • GC09P135228
  • GC09P135235
  • GC09P135240
  • GC09P136215

Summaries for RPL7A Gene

Entrez Gene Summary for RPL7A Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7A Gene

RPL7A (Ribosomal Protein L7a) is a Protein Coding gene. Diseases associated with RPL7A include Tuberous Sclerosis-1. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL7A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7A Gene

Genomics for RPL7A Gene

Regulatory Elements for RPL7A Gene

Enhancers for RPL7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPL7A on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL7A Gene

133,348,214 bp from pter
133,351,426 bp from pter
3,213 bases
Plus strand

Genomic View for RPL7A Gene

Genes around RPL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7A Gene

Proteins for RPL7A Gene

  • Protein details for RPL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L7a
    Protein Accession:
    Secondary Accessions:
    • P11518
    • Q5T8U4

    Protein attributes for RPL7A Gene

    266 amino acids
    Molecular mass:
    29996 Da
    Quaternary structure:
    • Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

    Three dimensional structures from OCA and Proteopedia for RPL7A Gene

neXtProt entry for RPL7A Gene

Post-translational modifications for RPL7A Gene

  • Ubiquitination at Lys 26, Lys 37, Lys 48, Lys 75, Lys 97, Lys 197, Lys 217, Lys 245, and Lys 264
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL7A Gene

Domains & Families for RPL7A Gene

Gene Families for RPL7A Gene

Suggested Antigen Peptide Sequences for RPL7A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L7Ae family.
  • Belongs to the ribosomal protein L7Ae family.
genes like me logo Genes that share domains with RPL7A: view

Function for RPL7A Gene

Molecular function for RPL7A Gene

GENATLAS Biochemistry:
ribosomal protein L7a (see SURF@)

Gene Ontology (GO) - Molecular Function for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8360149
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 15303970
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with RPL7A: view
genes like me logo Genes that share phenotypes with RPL7A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL7A Gene

Localization for RPL7A Gene

Subcellular locations from

Jensen Localization Image for RPL7A Gene COMPARTMENTS Subcellular localization image for RPL7A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with RPL7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7A Gene

Pathways & Interactions for RPL7A Gene

genes like me logo Genes that share pathways with RPL7A: view

Pathways by source for RPL7A Gene

1 Cell Signaling Technology pathway for RPL7A Gene
1 BioSystems pathway for RPL7A Gene
1 KEGG pathway for RPL7A Gene
1 GeneGo (Thomson Reuters) pathway for RPL7A Gene

Gene Ontology (GO) - Biological Process for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for SIGNOR curated interactions for RPL7A Gene

Drugs & Compounds for RPL7A Gene

No Compound Related Data Available

Transcripts for RPL7A Gene

Unigene Clusters for RPL7A Gene

Ribosomal protein L7a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for RPL7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL7A Gene

mRNA expression in normal human tissues for RPL7A Gene

Protein differential expression in normal tissues from HIPED for RPL7A Gene

This gene is overexpressed in Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL7A Gene

Protein tissue co-expression partners for RPL7A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL7A Gene:


SOURCE GeneReport for Unigene cluster for RPL7A Gene:

genes like me logo Genes that share expression patterns with RPL7A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL7A Gene

Orthologs for RPL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL7A 34
  • 88.1 (n)
  • 99.62 (a)
RPL7A 35
  • 100 (a)
(Canis familiaris)
Mammalia RPL7A 34
  • 89.72 (n)
  • 100 (a)
RPL7A 35
  • 72 (a)
(Mus musculus)
Mammalia Rpl7a 34
  • 88.35 (n)
  • 99.62 (a)
Rpl7a 16
Gm14214 35
  • 92 (a)
Gm16477 35
  • 99 (a)
Gm4877 35
  • 87 (a)
Gm5619 35
  • 99 (a)
Gm8226 35
  • 100 (a)
Rpl7a 35
  • 100 (a)
Rpl7a-ps10 35
  • 98 (a)
Rpl7a-ps3 35
  • 96 (a)
Rpl7a-ps5 35
  • 97 (a)
Rpl7a-ps8 35
  • 95 (a)
(Pan troglodytes)
Mammalia RPL7A 34
  • 99.62 (n)
  • 100 (a)
RPL7A 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl7a 34
  • 89.47 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPL7A 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RPL7A 35
  • 90 (a)
(Gallus gallus)
Aves RPL7A 34
  • 82.34 (n)
  • 96.41 (a)
RPL7A 35
  • 97 (a)
(Anolis carolinensis)
Reptilia RPL7A 35
  • 98 (a)
(Danio rerio)
Actinopterygii -- 34
rpl7a 34
  • 81.81 (n)
  • 92.43 (a)
rpl7a 35
  • 92 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL7A 36
  • 68 (a)
RpL7A 35
  • 67 (a)
(Caenorhabditis elegans)
Secernentea Y24D9A.4a 36
  • 63 (a)
Y24D9A.4c 36
  • 58 (a)
rpl-7A 35
  • 62 (a)
Y73B3A.18 35
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL070C 34
  • 60.3 (n)
  • 58.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00573g 34
  • 55.87 (n)
  • 56.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL8B 34
  • 58.79 (n)
  • 57.81 (a)
RPL8A 35
  • 57 (a)
RPL8B 35
  • 58 (a)
RPL8B 37
(Oryza sativa)
Liliopsida Os.37882 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14745 34
bread mold
(Neurospora crassa)
Ascomycetes NCU04779 34
  • 62.26 (n)
  • 63.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl8 34
  • 58.26 (n)
  • 62.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5318 35
  • 58 (a)
Species where no ortholog for RPL7A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL7A Gene

Gene Tree for RPL7A (if available)
Gene Tree for RPL7A (if available)

Paralogs for RPL7A Gene

(1) SIMAP similar genes for RPL7A Gene using alignment to 3 proteins: Pseudogenes for RPL7A Gene

genes like me logo Genes that share paralogs with RPL7A: view

No data available for Paralogs for RPL7A Gene

Variants for RPL7A Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL7A Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv972461 CNV duplication 23825009

Variation tolerance for RPL7A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPL7A Gene

Disorders for RPL7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL7A Gene - From: GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis-1
  • tuberous sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search RPL7A in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.

Relevant External Links for RPL7A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL7A: view

No data available for Genatlas for RPL7A Gene

Publications for RPL7A Gene

  1. Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene. (PMID: 8482538) De Falco S. … Pietropaolo C. (Gene 1993) 3 4 22 65
  2. The organization and expression of the human L7a ribosomal protein gene. (PMID: 1756182) Colombo P. … Fried M. (Biochim. Biophys. Acta 1991) 3 4 22 65
  3. Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. (PMID: 2966065) Kozma S.C. … Hynes N.E. (EMBO J. 1988) 2 3 4 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. Down-regulation of ribosomal protein L7A in human osteosarcoma. (PMID: 19125294) Zheng S.E. … Tang L.N. (J. Cancer Res. Clin. Oncol. 2009) 3 22 65

Products for RPL7A Gene

Sources for RPL7A Gene

Loading form....