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Aliases for RPL7A Gene

Aliases for RPL7A Gene

  • Ribosomal Protein L7a 2 3 5
  • Surfeit Locus Protein 3 2 3 4
  • PLA-X Polypeptide 2 3 4
  • Thyroid Hormone Receptor Uncoupling Protein 2 3
  • Large Ribosomal Subunit Protein EL8 3 4
  • 60S Ribosomal Protein L7a 2 3
  • Surfeit 3 2 3
  • SURF3 3 4
  • SURF-3 4
  • TRUP 3
  • L7A 3
  • ; 2

External Ids for RPL7A Gene

Previous GeneCards Identifiers for RPL7A Gene

  • GC09P127304
  • GC09P127771
  • GC09P129568
  • GC09P131491
  • GC09P133231
  • GC09P135194
  • GC09P135217
  • GC09P135222
  • GC09P135228
  • GC09P135235
  • GC09P135240
  • GC09P136215

Summaries for RPL7A Gene

Entrez Gene Summary for RPL7A Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7A Gene

RPL7A (Ribosomal Protein L7a) is a Protein Coding gene. Diseases associated with RPL7A include Tuberous Sclerosis-1. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL7A Gene

Additional gene information for RPL7A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7A Gene

Genomics for RPL7A Gene

Regulatory Elements for RPL7A Gene

Enhancers for RPL7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H132977 1.6 Ensembl ENCODE dbSUPER 33 -370.1 -370139 2 HDGF ARNT ZFP64 ZNF133 ARID4B DMAP1 GLI4 TCF12 GLIS2 GATA2 SETX RPL7A MED22 GTF3C5 EEF1A1P5 GFI1B TSC1 SURF4 AK8 GC09P132965
GH09H133416 1.5 FANTOM5 ENCODE 23.3 +69.8 69764 3.5 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SURF1 MED22 SURF6 RPL7A ENSG00000273473 BRD3 BRD3OS ADAMTS13 CACFD1 SURF2
GH09H133112 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15 -219.2 -219242 33.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 RALGDS GTF3C5 SETX BRD3 DDX31 TTF1 GTF3C4 TSC1 RPL7A GBGT1
GH09H134162 1.2 ENCODE 21.2 +816.3 816272 3.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 WDR5 BRD3 LOC100130548 REXO4 RPL7A SURF6 ENSG00000273249 MED22 COL5A1-AS1 ENSG00000273473
GH09H133236 1.5 Ensembl ENCODE dbSUPER 11.7 -110.0 -109956 3.3 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 GLIS2 ZNF143 SP3 SP5 ABO SETX BRD3OS OBP2B MED22 RPL7A EEF1A1P5 LCN1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL7A on UCSC Golden Path with GeneCards custom track

Promoters for RPL7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242571 -114 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for RPL7A Gene

Genomic Locations for RPL7A Gene
3,213 bases
Plus strand

Genomic View for RPL7A Gene

Genes around RPL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7A Gene

Proteins for RPL7A Gene

  • Protein details for RPL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L7a
    Protein Accession:
    Secondary Accessions:
    • P11518
    • Q5T8U4

    Protein attributes for RPL7A Gene

    266 amino acids
    Molecular mass:
    29996 Da
    Quaternary structure:
    • Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).

    Three dimensional structures from OCA and Proteopedia for RPL7A Gene

neXtProt entry for RPL7A Gene

Post-translational modifications for RPL7A Gene

  • Ubiquitination at isoforms=26, Lys37, Lys48, Lys75, Lys97, Lys197, Lys217, isoforms=245, and isoforms=264
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL7A Gene

Domains & Families for RPL7A Gene

Gene Families for RPL7A Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPL7A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL8 family.
  • Belongs to the eukaryotic ribosomal protein eL8 family.
genes like me logo Genes that share domains with RPL7A: view

Function for RPL7A Gene

Molecular function for RPL7A Gene

GENATLAS Biochemistry:
ribosomal protein L7a (see SURF@)

Phenotypes From GWAS Catalog for RPL7A Gene

Gene Ontology (GO) - Molecular Function for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
GO:0005515 protein binding IPI 15303970
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL7A: view
genes like me logo Genes that share phenotypes with RPL7A: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL7A Gene

Localization for RPL7A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL7A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPL7A Gene

Pathways & Interactions for RPL7A Gene

genes like me logo Genes that share pathways with RPL7A: view

Pathways by source for RPL7A Gene

1 Cell Signaling Technology pathway for RPL7A Gene
1 BioSystems pathway for RPL7A Gene
1 KEGG pathway for RPL7A Gene
1 GeneGo (Thomson Reuters) pathway for RPL7A Gene

Gene Ontology (GO) - Biological Process for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IBA 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL7A: view

No data available for SIGNOR curated interactions for RPL7A Gene

Drugs & Compounds for RPL7A Gene

No Compound Related Data Available

Transcripts for RPL7A Gene

Unigene Clusters for RPL7A Gene

Ribosomal protein L7a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for RPL7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL7A Gene

Protein differential expression in normal tissues from HIPED for RPL7A Gene

This gene is overexpressed in Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL7A Gene

Protein tissue co-expression partners for RPL7A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL7A Gene:


SOURCE GeneReport for Unigene cluster for RPL7A Gene:


Evidence on tissue expression from TISSUES for RPL7A Gene

  • Eye(5)
  • Lung(5)
  • Skin(5)
  • Nervous system(5)
  • Liver(4.9)
  • Pancreas(4.9)
  • Intestine(4.7)
  • Muscle(4.7)
  • Kidney(4.4)
  • Stomach(4.3)
  • Blood(4.1)
  • Bone(3.8)
  • Heart(2.7)
  • Lymph node(2.3)
  • Bone marrow(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RPL7A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL7A Gene

Orthologs for RPL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7A Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gm8226 34
  • 100 (a)
Gm16477 34
  • 99 (a)
Gm5619 34
  • 99 (a)
Rpl7a-ps10 34
  • 98 (a)
Rpl7a-ps5 34
  • 97 (a)
Rpl7a-ps3 34
  • 96 (a)
Rpl7a-ps8 34
  • 95 (a)
Gm14214 34
  • 92 (a)
Rpl7a 33 16 34
  • 88.35 (n)
Gm4877 34
  • 87 (a)
(Pan troglodytes)
Mammalia RPL7A 33 34
  • 99.62 (n)
(Monodelphis domestica)
Mammalia RPL7A 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RPL7A 34
  • 90 (a)
(Canis familiaris)
Mammalia RPL7A 33 34
  • 89.72 (n)
(Rattus norvegicus)
Mammalia Rpl7a 33
  • 89.47 (n)
(Bos Taurus)
Mammalia RPL7A 33 34
  • 88.1 (n)
(Gallus gallus)
Aves RPL7A 33 34
  • 82.34 (n)
(Anolis carolinensis)
Reptilia RPL7A 34
  • 98 (a)
(Danio rerio)
Actinopterygii rpl7a 33 34
  • 81.81 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta RpL7A 35 34
  • 68 (a)
(Caenorhabditis elegans)
Secernentea Y24D9A.4a 35
  • 63 (a)
rpl-7A 34
  • 62 (a)
Y24D9A.4c 35
  • 58 (a)
Y73B3A.18 34
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL070C 33
  • 60.3 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL8B 33 34 36
  • 58.79 (n)
RPL8A 34
  • 57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00573g 33
  • 55.87 (n)
(Oryza sativa)
Liliopsida Os.37882 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04779 33
  • 62.26 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl8 33
  • 58.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5318 34
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14745 33
Species where no ortholog for RPL7A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL7A Gene

Gene Tree for RPL7A (if available)
Gene Tree for RPL7A (if available)

Paralogs for RPL7A Gene

(1) SIMAP similar genes for RPL7A Gene using alignment to 3 proteins: Pseudogenes for RPL7A Gene

genes like me logo Genes that share paralogs with RPL7A: view

No data available for Paralogs for RPL7A Gene

Variants for RPL7A Gene

Sequence variations from dbSNP and Humsavar for RPL7A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000171207 -- 133,346,889(+) CCTTT(G/T)CCAGA intron-variant, upstream-variant-2KB
rs1000288609 -- 133,350,957(+) AGGGA(A/G)ACTAA intron-variant, downstream-variant-500B
rs1000438055 -- 133,347,855(+) CACCC(A/C)CCCAC intron-variant, upstream-variant-2KB
rs1000861174 -- 133,347,994(+) CTCTG(C/T)GACCC upstream-variant-2KB, utr-variant-5-prime
rs1001079473 -- 133,347,738(+) TCTGG(A/C)GCACG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL7A Gene

Variant ID Type Subtype PubMed ID
nsv972461 CNV duplication 23825009
nsv1125319 OTHER inversion 24896259
esv2739138 CNV deletion 23290073

Variation tolerance for RPL7A Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7A Gene

Disorders for RPL7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL7A Gene - From: GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis-1
  • tuberous sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search RPL7A in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.

Relevant External Links for RPL7A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL7A: view

No data available for Genatlas for RPL7A Gene

Publications for RPL7A Gene

  1. Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene. (PMID: 8482538) De Falco S … Pietropaolo C (Gene 1993) 3 4 22 60
  2. The organization and expression of the human L7a ribosomal protein gene. (PMID: 1756182) Colombo P … Fried M (Biochimica et biophysica acta 1991) 3 4 22 60
  3. Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. (PMID: 2966065) Kozma SC … Hynes NE (The EMBO journal 1988) 2 3 4 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Down-regulation of ribosomal protein L7A in human osteosarcoma. (PMID: 19125294) Zheng SE … Tang LN (Journal of cancer research and clinical oncology 2009) 3 22 60

Products for RPL7A Gene

Sources for RPL7A Gene