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Aliases for RPL7A Gene

Aliases for RPL7A Gene

  • Ribosomal Protein L7a 2 3
  • Surfeit Locus Protein 3 2 3 4
  • PLA-X Polypeptide 2 3 4
  • SURF3 3 4 6
  • Thyroid Hormone Receptor Uncoupling Protein 2 3
  • 60S Ribosomal Protein L7a 2 3
  • Surfeit 3 2 3
  • SURF-3 4
  • TRUP 3
  • L7A 3
  • ; 2

External Ids for RPL7A Gene

Summaries for RPL7A Gene

Entrez Gene Summary for RPL7A Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7A Gene

RPL7A (Ribosomal Protein L7a) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL7A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7A Gene

Genomics for RPL7A Gene

Genomic Location for RPL7A Gene

Start:
133,348,214 bp from pter
End:
133,351,426 bp from pter
Size:
3,213 bases
Orientation:
Plus strand

Genomic View for RPL7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7A Gene

Regulatory Elements for RPL7A Gene

Proteins for RPL7A Gene

  • Protein details for RPL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62424-RL7A_HUMAN
    Recommended name:
    60S ribosomal protein L7a
    Protein Accession:
    P62424
    Secondary Accessions:
    • P11518
    • Q5T8U4

    Protein attributes for RPL7A Gene

    Size:
    266 amino acids
    Molecular mass:
    29996 Da
    Quaternary structure:
    • Interacts with CRY1.

    Three dimensional structures from OCA and Proteopedia for RPL7A Gene

neXtProt entry for RPL7A Gene

Proteomics data for RPL7A Gene at MOPED

Post-translational modifications for RPL7A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys26, Lys34, Lys37, Lys48, Lys75, Lys97, Lys197, Lys212, Lys217, Lys245, and Lys264

Other Protein References for RPL7A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL7A Gene

Domains for RPL7A Gene

Gene Families for RPL7A Gene

HGNC:
  • RPL :L ribosomal proteins

UniProtKB/Swiss-Prot:

RL7A_HUMAN
Family:
  • Belongs to the ribosomal protein L7Ae family.:
    • P62424
genes like me logo Genes that share domains with RPL7A: view

Function for RPL7A Gene

Molecular function for RPL7A Gene

GENATLAS Biochemistry: ribosomal protein L7a (see SURF@)

Gene Ontology (GO) - Molecular Function for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8360149
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 15303970
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL7A: view
genes like me logo Genes that share phenotypes with RPL7A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL7A Gene

Localization for RPL7A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL7A Gene COMPARTMENTS Subcellular localization image for RPL7A gene
Compartment Confidence
cytosol 5
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL7A: view

Pathways for RPL7A Gene

genes like me logo Genes that share pathways with RPL7A: view

Pathways by source for RPL7A Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL7A Gene
1 Cell Signaling Technology pathway for RPL7A Gene
1 BioSystems pathway for RPL7A Gene

Gene Ontology (GO) - Biological Process for RPL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL7A: view

Transcripts for RPL7A Gene

Unigene Clusters for RPL7A Gene

Ribosomal protein L7a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -
SP9:
SP10:

Relevant External Links for RPL7A Gene

GeneLoc Exon Structure for
RPL7A
ECgene alternative splicing isoforms for
RPL7A

Expression for RPL7A Gene

mRNA expression in normal human tissues for RPL7A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL7A Gene

SOURCE GeneReport for Unigene cluster for RPL7A Gene Hs.499839

genes like me logo Genes that share expressions with RPL7A: view

Orthologs for RPL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL7A 36
  • 99.62 (n)
  • 100 (a)
RPL7A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL7A 36
  • 88.1 (n)
  • 99.62 (a)
RPL7A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL7A 36
  • 89.72 (n)
  • 100 (a)
RPL7A 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm14214 37
  • 92 (a)
OneToMany
Gm16477 37
  • 99 (a)
OneToMany
Gm4877 37
  • 87 (a)
OneToMany
Gm5619 37
  • 99 (a)
OneToMany
Gm8226 37
  • 100 (a)
OneToMany
Rpl7a 36
  • 88.35 (n)
  • 99.62 (a)
Rpl7a 16
Rpl7a 37
  • 100 (a)
OneToMany
Rpl7a-ps10 37
  • 98 (a)
OneToMany
Rpl7a-ps3 37
  • 96 (a)
OneToMany
Rpl7a-ps5 37
  • 97 (a)
OneToMany
Rpl7a-ps8 37
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL7A 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL7A 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl7a 36
  • 89.47 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL7A 36
  • 82.34 (n)
  • 96.41 (a)
RPL7A 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL7A 37
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 36
rpl7a 36
  • 81.81 (n)
  • 92.43 (a)
rpl7a 37
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL7A 37
  • 67 (a)
OneToOne
RpL7A 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-7A 37
  • 62 (a)
OneToMany
Y73B3A.18 37
  • 36 (a)
OneToMany
Y24D9A.4a 38
  • 63 (a)
Y24D9A.4c 38
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL070C 36
  • 60.3 (n)
  • 58.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL8A 37
  • 57 (a)
OneToMany
RPL8B 36
  • 58.79 (n)
  • 57.81 (a)
RPL8B 37
  • 58 (a)
OneToMany
RPL8B 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00573g 36
  • 55.87 (n)
  • 56.97 (a)
rice
(Oryza sativa)
Liliopsida Os.37882 36
bread mold
(Neurospora crassa)
Ascomycetes NCU04779 36
  • 62.26 (n)
  • 63.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl8 36
  • 58.26 (n)
  • 62.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14745 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5318 37
  • 58 (a)
OneToOne
Species with no ortholog for RPL7A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL7A Gene

ENSEMBL:
Gene Tree for RPL7A (if available)
TreeFam:
Gene Tree for RPL7A (if available)

Paralogs for RPL7A Gene

Selected SIMAP similar genes for RPL7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RPL7A Gene

genes like me logo Genes that share paralogs with RPL7A: view

No data available for Paralogs for RPL7A Gene

Variants for RPL7A Gene

Sequence variations from dbSNP and Humsavar for RPL7A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_014721 -

Structural Variations from Database of Genomic Variants (DGV) for RPL7A Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894057 CNV Gain 21882294
dgv8325n71 CNV Loss 21882294
nsv894076 CNV Loss 21882294
nsv894079 CNV Loss 21882294
nsv894080 CNV Loss 21882294

Relevant External Links for RPL7A Gene

HapMap Linkage Disequilibrium report
RPL7A

Disorders for RPL7A Gene

UniProtKB/Swiss-Prot

RL7A_HUMAN
  • Note=Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.

Relevant External Links for RPL7A

Genetic Association Database (GAD)
RPL7A
Human Genome Epidemiology (HuGE) Navigator
RPL7A
genes like me logo Genes that share disorders with RPL7A: view

Publications for RPL7A Gene

  1. The organization and expression of the human L7a ribosomal protein gene. (PMID: 1756182) Colombo P. … Fried M. (Biochim. Biophys. Acta 1991) 3 4 23
  2. Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene. (PMID: 8482538) De Falco S. … Pietropaolo C. (Gene 1993) 3 4 23
  3. Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. (PMID: 2966065) Kozma S.C. … Hynes N.E. (EMBO J. 1988) 2 3 4
  4. Different domains cooperate to target the human ribosomal L7a protein to the nucleus and to the nucleoli. (PMID: 9030593) Russo G. … Pietropaolo C. (J. Biol. Chem. 1997) 3 23
  5. A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors. (PMID: 7568167) Burris T.P. … O'Malley B.W. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23

Products for RPL7A Gene

Sources for RPL7A Gene

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