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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL7 Gene

protein-coding   GIFtS: 57
GCID: GC08M074202

ribosomal protein L7
 Explore 18 diseases affiliated with
RPL7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPL7    

Aliases
for RPL7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein L71 2
L71 2
HumL7-11
60S Ribosomal Protein L72

External Ids:    HGNC: 103631   Entrez Gene: 61292   Ensembl: ENSG000001476047   OMIM: 6041665   UniProtKB: P181243   

Export aliases for RPL7 gene to outside databases

Previous GC identifers: GC08M073255 GC08M074143 GC08M073920 GC08M074252 GC08M074365 GC08M069693


Summaries
for RPL7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL7:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of
ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus
submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a
preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a
regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an
autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for
genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RL7_HUMAN, P18124
Function: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus;
inhibits cell-free translation of mRNAs

Gene Wiki entry for RPL7


Genomic Views
for RPL7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL7 gene promoter:
         Pax-5   FOXO3   HNF-3beta   FOXO3b   S8   Nkx6-1   FOXO4   FOXO3a   Pax-4a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q13.3

RPL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M074202:  view genomic region     (about GC identifiers)

Start:
 74,202,506 bp from pter      End:
 74,208,024 bp from pter
Size:
 5,519 bases      Orientation:
 minus strand

1 alternative location:
Chr7+,CRA_TCAG 107,517,876-107,518,705     

Proteins
for RPL7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL7_HUMAN, P18124 (See protein sequence)
Recommended Name: 60S ribosomal protein L7  
Size: 248 amino acids; 29226 Da
Subunit: Homodimer
Sequence caution: Sequence=CAA41026.1; Type=Erroneous initiation;
Secondary accessions: A8K504 Q15289 Q3KQU0 Q5I0X1 Q6IBM9

Explore the universe of human proteins at neXtProt for RPL7: NX_P18124

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P18124

    • RPL7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000962.2  
    ENSEMBL proteins: 
     ENSP00000379731   ENSP00000339795   ENSP00000379730   ENSP00000379729   ENSP00000415808  
     ENSP00000401300  
    Reactome Protein details: P18124
    Human Recombinant Protein Products: 
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    Novus Biologicals RPL7 Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPL7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325
    GO:0030529ribonucleoprotein complex IDA18809582


    RPL7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RPL7

    Protein Domains /
    Families
    for RPL7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016082 Ribosomal_L30_ferredoxin-like
     IPR012988 Ribosomal_L30_N
     IPR005998 Ribosomal_L7_euk
     IPR018038 Ribosomal_L30_CS

    Graphical View of Domain Structure for InterPro Entry P18124

    ProtoNet protein and cluster: P18124

    1 Blocks protein family: IPB000517 Ribosomal protein L30

    UniProtKB/Swiss-Prot: RL7_HUMAN, P18124
    Similarity: Belongs to the ribosomal protein L30P family


    Function
    for RPL7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RL7_HUMAN, P18124
    Function: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus;
    inhibits cell-free translation of mRNAs

         Genatlas biochemistry entry for RPL7:
    60S ribosomal protein L7

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RPL7
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for RPL7

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA8441630
    GO:0003723RNA binding TAS8441630
    GO:0003729mRNA binding IDA8441630
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0042803protein homodimerization activity IPI8441630


    RPL7 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RPL7:
     Decreased viability  Decreased viability of wild-ty  Increased S DNA content  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 


    Pathways & Interactions
    for RPL7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Disease
    		Disease1.00
    4Generic Transcription Pathway
    		Gene Expression0.46
    5Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL7
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL7 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL7 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL7):
        Ribosome


    RPL7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/409 Interacting proteins for RPL7 (P181242, 3 ENSP000003397954) via UniProtKB, MINT, STRING, and/or I2D (see all 409)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--


    RPL7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPL7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL7
    1 Novoseek chemical compound relationship for RPL7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 38.5 1 10937868 (1)

    Search CenterWatch for drugs/clinical trials and news about RPL7 / RL7 

    Transcripts
    for RPL7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL7 gene: 
    NM_000971.3  

    Unigene Clusters for RPL7:

    Ribosomal protein L7
    Hs.421257  [show with all ESTs], Hs.571841  [show with all ESTs]
    Unigene Representative Sequences: BM913311, BQ057523
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487500 ENST00000396467 ENST00000352983(uc003xzg.3) ENST00000396466
    ENST00000396465 ENST00000466821 ENST00000435330 ENST00000431653

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPL7
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL7 (see all 7)
    OriGene shRNA RFP: RPL7
    OriGene siRNA: RPL7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL7
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL7

    Additional cDNA sequence: 

    AK225246.1 AK225254.1 AK291119.1 AK313365.1 BC006095.1 BC008850.2 BC009599.1 BC071671.1 
    BC071894.1 BC071895.1 BC087837.1 CR456773.1 L16558.1 X52967.1 X57959.1 

    24/109 DOTS entries (see all 109):

    DT.95161204  DT.121413450  DT.121413461  DT.91780700  DT.100832032  DT.95161241  DT.91780697  DT.91780724 
    DT.100863504  DT.100046013  DT.95161273  DT.95161237  DT.100707520  DT.120845428  DT.100857307  DT.121413464 
    DT.95161223  DT.100707512  DT.100808517  DT.95161209  DT.91900419  DT.91674733  DT.121413418  DT.120884488 

    24/2213 AceView cDNA sequences (see all 2213):

    AA316586 BM822488 BG287736 BU581383 CD639942 CA393968 CA773220 CD520143 
    BE275623 BM799600 AI126813 BU533773 BU581244 BU928180 BG256235 BM760535 
    BM761661 BQ688313 BG259985 BI260423 AA300995 BE205886 C05308 AA233495 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RPL7 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
    SP1:                    -                       -     -                             -                     
    SP2:                    -                 -     -     -     -     -     -           -                     
    SP3:                    -                                                                                 
    SP4:                                                                                                      
    SP5:        -     -     -                                                                                 


    ECgene alternative splicing isoforms for RPL7

    Expression
    for RPL7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATTTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RPL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL7

    SOURCE GeneReport for Unigene clusters: Hs.421257 Hs.571841
        SABiosciences Custom PCR Arrays for RPL7
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    In Situ
    Assay Products:     
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    Orthologs
    for RPL7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL7 gene from 10/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rpl71 , 5 ribosomal protein L71, 5 87.8(n)1
    95.93(a)1    		   1 (4.94 cM)5
    199891  NM_011291.51  NP_035421.21 
     161012955 
    chicken
    (Gallus gallus)    		 Aves RPL71 ribosomal protein L7 76.37(n)
    83.61(a)    		   420182  NM_001006345.2  NP_001006345.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPL76
    		 --
    		 84(a)
    		 1 ↔ 1
    		 4(33461596-33469431)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ630860.12   -- 77.56(n)    BJ630860.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rpl71 ribosomal protein L7 73.8(n)
    79.42(a)    		   336710  NM_213644.1  NP_998809.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpL71 , 3 protein biosynthesis mRNA binding3
    Ribosomal protein L71    		 60(a)
    (best of 2)3
    56.49(n)1
    57.32(a)1    		   31B13
    343521  NM_078807.21  NP_523531.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-71 , 3 ribosomal protein3
    Protein RPL-71    		 56(a)3
    57.46(n)1
    56.49(a)1    		   I(110627-112256)3
    1716021  NM_058275.31  NP_490676.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPL7A1 Rpl7ap 54.84(n)
    51.28(a)    		   852804   NP_011439.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G135801 60S ribosomal protein L7-4 60.71(n)
    61.7(a)    		   820560  NM_202575.1  NP_974304.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.48802 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.05(n)    AK102873.1 


    ENSEMBL Gene Tree for RPL7 (if available)
    TreeFam Gene Tree for RPL7 (if available) 

    Paralogs
    for RPL7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL7 gene
    RPL7L12  
    2 SIMAP similar genes for RPL7 using alignment to 4 protein entries:     RL7_HUMAN (see all proteins):
    RPL7L1    WUGSC

    RPL7 for paralogs           About GeneDecksing


    5/62 Pseudogenes.org Pseudogenes for RPL7 (see all 62)
    PGOHUM00000238576 PGOHUM00000238623 PGOHUM00000238723 PGOHUM00000238904 PGOHUM00000239497


    Genomic Variants
    for RPL7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 NCBI SNPs in RPL7 are shown (see all 117)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1874132871,2
    		--74202383(+) GCACAA/GATTTC 1 -- ds50010--------
    rs1426107961,2
    		C,--74202534(+) AGGCCC/TGAGAA 1 -- ds50011Minor allele frequency- T:0.01NS 148
    rs1141046821,2
    		C,--74202691(+) AAAATA/CTTTTG 1 -- ds50010--------
    rs126787821,2
    		C,F,A,H,--74202696(+) CTTTTG/TTATAG 1 -- ds500117Minor allele frequency- T:0.09NS EA NA 2372
    rs1390320521,2
    		--74202742(+) ACAGAC/GTCGAC 1 -- ds50010--------
    rs1415141661,2
    		--74202761(+) TGCACA/GAAATG 1 -- ds50010--------
    rs1140527091,2
    		--74202853(+) AACAAC/AAAATC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1922313021,2
    		--74202892(+) GAGCAC/GGTACT 1 -- ut310--------
    rs1508815761,2
    		--74203069(+) GACTCC/GCCAAA 1 -- int10--------
    rs1486536201,2
    		C,F,--74203077(+) AAAACA/GGGCTT 1 -- int11Minor allele frequency- G:0.02NS 150

    HapMap Linkage Disequilibrium report for RPL7 (74202506 - 74208024 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPL7: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RPL7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPL7 for disorders           About GeneDecksing

    OMIM gene information: 604166    OMIM disorders: --

    18 diseases for RPL7:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    diamond-blackfan anemia    treacher collins syndrome
    esophagus squamous cell carcinoma    papillary thyroid carcinoma    rheumatoid arthritis    collagen disease
    folliculitis    brucellosis    squamous cell carcinoma    thyroid carcinoma
    arthritis    thyroiditis    carcinoma    breast cancer
    anemia    malaria

    2 diseases from the University of Copenhagen DISEASES database for RPL7:
    Diamond-Blackfan anemia     Esophagus squamous cell carcinoma

    3 Novoseek disease relationships for RPL7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 38.4 3 7856252 (1), 7750987 (1), 10069410 (1)
    rheumatoid arthritis 19.8 1 7856252 (1)
    autoimmune diseases 12.5 1 7743656 (1)

    Human Genome Epidemiology (HuGE) Navigator: RPL7 (2 documents)

    Export disorders for RPL7 gene to outside databases

    Publications
    for RPL7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL7 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with RPL7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional properties of ribosomal protein L7 from humans and rodents. (PubMed id 8441630)1, 2, 3, 9 Hemmerich P....Krawinkel U. (1993)
    2. Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. (PubMed id 8360149)1, 2, 3 Seshadri T.... Campisi J. (1993)
    3. Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. (PubMed id 7862521)1, 2, 9 Neumann F.... Krawinkel U. (1995)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
    7. Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association. (PubMed id 17258209)1, 9 Wu W.C....Lin A. (2007)
    8. Differential expression of ribosomal proteins in human normal and neoplastic colorectum. (PubMed id 12704204)1, 9 Kasai H....Nakayama J. (2003)
    9. Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function. (PubMed id 16797011)1, 9 Ko J.R....Lin A. (2006)
    10. Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. (PubMed id 7750987)1, 9 von Mikecz A....Krawinkel U. (1994)

    External Searches for RPL7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing RPL7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6129 HGNC: 10363 AceView: RPL7 Ensembl:ENSG00000147604 euGenes: HUgn6129
    ECgene: RPL7 Kegg: 6129 H-InvDB: RPL7

    Other Databases showing RPL7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPL7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL7 gene:
    Search GeneIP for patents involving RPL7

    GeneCards and IP:
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