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RPL7 Gene

protein-coding   GIFtS: 62
GCID: GC08M074202

Ribosomal Protein L7

  See RPL7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L71 2
60S Ribosomal Protein L72
L72
humL7-12

External Ids:    HGNC: 103631   Entrez Gene: 61292   Ensembl: ENSG000001476047   OMIM: 6041665   UniProtKB: P181243   

Export aliases for RPL7 gene to outside databases

Previous GC identifers: GC08M073255 GC08M074143 GC08M073920 GC08M074252 GC08M074365 GC08M069693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL7 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family
of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP
consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and
RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting
that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has
been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus
erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of
this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL7 Gene:
RPL7 (ribosomal protein L7) is a protein-coding gene. Diseases associated with RPL7 include esophagus squamous cell carcinoma, and lupus erythematosus. GO annotations related to this gene include structural constituent of ribosome and RNA binding. An important paralog of this gene is RPL7L1.

UniProtKB/Swiss-Prot: RL7_HUMAN, P18124
Function: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation
apparatus; inhibits cell-free translation of mRNAs

Gene Wiki entry for RPL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL7 gene promoter:
         Pax-5   FOXO3   HNF-3beta   FOXO3b   S8   Nkx6-1   FOXO4   FOXO3a   Pax-4a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL7 promoter sequence
   Search Chromatin IP Primers for RPL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q13.3

RPL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M074202:  view genomic region     (about GC identifiers)

Start:
74,202,506 bp from pter      End:
74,208,024 bp from pter
Size:
5,519 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RL7_HUMAN, P18124 (See protein sequence)
Recommended Name: 60S ribosomal protein L7  
Size: 248 amino acids; 29226 Da
Subunit: Homodimer
Sequence caution: Sequence=CAA41026.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RPL7:
3J3B (3D)    
Secondary accessions: A8K504 Q15289 Q3KQU0 Q5I0X1 Q6IBM9

Explore the universe of human proteins at neXtProt for RPL7: NX_P18124

Explore proteomics data for RPL7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40, Lys77, Lys88, Lys107, Lys124, Lys127, Lys148, Lys181, Lys199, Lys202,
                                 Lys212, Lys223
  • Modification sites at PhosphoSitePlus

  • See RPL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000962.2  
    ENSEMBL proteins: 
     ENSP00000379731   ENSP00000339795   ENSP00000379730   ENSP00000379729   ENSP00000415808  
     ENSP00000401300  
    Reactome Protein details: P18124

    RPL7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RPL7

     
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    antibodies-online proteins for RPL7 (11 products) 

     
    antibodies-online peptides for RPL7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    4 InterPro protein domains:
     IPR016082 Ribosomal_L30_ferredoxin-like
     IPR012988 Ribosomal_L30_N
     IPR005998 Ribosomal_L7_euk
     IPR018038 Ribosomal_L30_CS

    Graphical View of Domain Structure for InterPro Entry P18124

    ProtoNet protein and cluster: P18124

    1 Blocks protein domain: IPB000517 Ribosomal protein L30

    UniProtKB/Swiss-Prot: RL7_HUMAN, P18124
    Similarity: Belongs to the ribosomal protein L30P family


    Find genes that share domains with RPL7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL7_HUMAN, P18124
    Function: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation
    apparatus; inhibits cell-free translation of mRNAs

         Genatlas biochemistry entry for RPL7:
    60S ribosomal protein L7

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA8441630
    GO:0003723RNA binding TAS8441630
    GO:0003729mRNA binding IDA8441630
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI18274552
         
    Find genes that share ontologies with RPL7           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL7:
     Decreased viability  Decreased viability of wild-ty  Increased S DNA content  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPL7

    miRNA
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    miRTarBase miRNAs that target RPL7:
    hsa-mir-106b-5p (MIRT044249), hsa-mir-132-3p (MIRT045839), hsa-mir-17-5p (MIRT050872), hsa-mir-100-5p (MIRT048570), hsa-mir-615-3p (MIRT040053)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0022625cytosolic large ribosomal subunit IDA12962325
    GO:0030529ribonucleoprotein complex IDA18809582

    Find genes that share ontologies with RPL7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL7 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPL7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL7
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL7
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL7 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL7):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL7
    Interactions:

        Search GeneGlobe Interaction Network for RPL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL7 (P181241, 2, 3 ENSP000003397954) via UniProtKB, MINT, STRING, and/or I2D (see all 550)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    Find genes that share ontologies with RPL7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL7 (RL7)

    1 Novoseek inferred chemical compound relationship for RPL7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 38.5 1 10937868 (1)



    Find genes that share compounds with RPL7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPL7 gene: 
    NM_000971.3  

    Unigene Clusters for RPL7:

    Ribosomal protein L7
    Hs.421257  [show with all ESTs], Hs.571841  [show with all ESTs]
    Unigene Representative Sequences: BM913311, BM808571
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487500 ENST00000396467 ENST00000352983(uc003xzg.3) ENST00000396466
    ENST00000396465 ENST00000466821 ENST00000435330 ENST00000431653
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL7
      QuantiFast Probe-based Assays in human, mouse, rat RPL7

    Additional mRNA sequence: 

    AK225246.1 AK225254.1 AK291119.1 AK313365.1 BC006095.1 BC008850.2 BC009599.1 BC071671.1 
    BC071894.1 BC071895.1 BC087837.1 CR456773.1 L16558.1 X52967.1 X57959.1 

    Selected DOTS entries (see all 100):

    DT.95161204  DT.100832032  DT.121413450  DT.91780700  DT.121413461  DT.95161241  DT.91780724  DT.91780697 
    DT.100863504  DT.100046013  DT.100707520  DT.121413464  DT.95161273  DT.95161237  DT.100857307  DT.120845428 
    DT.95161223  DT.100808517  DT.100707512  DT.91674733  DT.91900419  DT.121413418  DT.95161209  DT.92396004 

    Selected AceView cDNA sequences (see all 2213):

    BM016190 CA866496 BQ059783 BM809428 BG505080 BI602333 BE278710 BG623857 
    BQ672409 BG765759 BU858920 BM565448 AA329307 BG623552 BI860680 CB156643 
    BI837192 BF972048 BM917524 BG779801 BU189290 BI856418 BM558211 BQ050361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL7 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
    SP1:                    -                       -     -                             -                     
    SP2:                    -                 -     -     -     -     -     -           -                     
    SP3:                    -                                                                                 
    SP4:                                                                                                      
    SP5:        -     -     -                                                                                 


    ECgene alternative splicing isoforms for RPL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTTTTC
    RPL7 Expression
    About this image

    RPL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL7 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.421257 Hs.571841
        Custom PCR Arrays for RPL7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL7 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl71 , 5 ribosomal protein L71, 5 87.8(n)1
    95.93(a)1
      1 (4.94 cM)5
    199891  NM_011291.51  NP_035421.21 
     161012955 
    chicken
    (Gallus gallus)
    Aves RPL71 ribosomal protein L7 76.19(n)
    83.27(a)
      420182  NM_001006345.2  NP_001006345.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL76
    ribosomal protein L7
    81(a)
    1 ↔ 1
    4(33461591-33472051)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ630860.12   -- 77.56(n)    BJ630860.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl71 ribosomal protein L7 73.8(n)
    79.42(a)
      336710  NM_213644.2  NP_998809.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL71 , 3 protein biosynthesis mRNA binding3
    Ribosomal protein L71
    60(a)
    (best of 2)3
    56.49(n)1
    57.32(a)1
      31B13
    343521  NM_078807.21  NP_523531.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-71 , 3 ribosomal protein3
    rpl-71
    56(a)3
    57.46(n)1
    56.49(a)1
      I(110627-112256)3
    1716021  NM_058275.41  NP_490676.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL7A1 RPL7A 54.61(n)
    51.06(a)
      852804   NP_011439.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G135801 AT3G13580 60.73(n)
    61.44(a)
      820560  NM_202576.1  NP_974305.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48802 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.05(n)    AK102873.1 


    ENSEMBL Gene Tree for RPL7 (if available)
    TreeFam Gene Tree for RPL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL7 gene
    RPL7L12  
    2 SIMAP similar genes for RPL7 using alignment to 4 protein entries:     RL7_HUMAN (see all proteins):
    RPL7L1    WUGSC

    Find genes that share paralogs with RPL7           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL7 (see all 62)
    PGOHUM00000238576 PGOHUM00000238623 PGOHUM00000238723 PGOHUM00000238904 PGOHUM00000239497


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL7 (see all 76)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874132871,2
    C--74202383(+) GCACAA/GATTTC 1 -- ds50010--------
    rs1426107961,2
    C--74202534(+) AGGCCC/TGAGAA 1 -- ds50011Minor allele frequency- T:0.01NS 148
    rs1141046821,2
    C--74202691(+) AAAATA/CTTTTG 1 -- ds50010--------
    rs126787821,2
    C,F,A,H--74202696(+) CTTTTG/TTATAG 1 -- ds500117Minor allele frequency- T:0.09NS EA NA 2372
    rs1390320521,2
    --74202742(+) ACAGAC/GTCGAC 1 -- ds50010--------
    rs1415141661,2
    C--74202761(+) TGCACA/GAAATG 1 -- ds50010--------
    rs1140527091,2
    F--74202853(+) AACAAC/AAAATC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1922313021,2
    --74202892(+) GAGCAC/GGTACT 1 -- ut310--------
    rs1508815761,2
    --74203069(+) GACTCC/GCCAAA 1 -- int10--------
    rs1486536201,2
    C,F--74203077(+) AAAACA/GGGCTT 1 -- int11Minor allele frequency- G:0.02NS 150

    HapMap Linkage Disequilibrium report for RPL7 (74202506 - 74208024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPL7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    nsv891012CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL7
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604166    OMIM disorders: --

    3 diseases for RPL7:    
    About MalaCards
    esophagus squamous cell carcinoma    lupus erythematosus    systemic lupus erythematosus

    2 diseases from the University of Copenhagen DISEASES database for RPL7:
    Diamond-Blackfan anemia     Esophagus squamous cell carcinoma

    Find genes that share disorders with RPL7           About GenesLikeMe

    3 Novoseek inferred disease relationships for RPL7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 38.4 3 7856252 (1), 7750987 (1), 10069410 (1)
    rheumatoid arthritis 19.8 1 7856252 (1)
    autoimmune diseases 12.5 1 7743656 (1)

    Genetic Association Database (GAD): RPL7
    Human Genome Epidemiology (HuGE) Navigator: RPL7 (2 documents)

    Export disorders for RPL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL7 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with RPL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional properties of ribosomal protein L7 from humans and rodents. (PubMed id 8441630)1, 2, 3, 9 Hemmerich P.... Krawinkel U. (Nucleic Acids Res. 1993)
    2. Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. (PubMed id 8360149)1, 2, 3 Seshadri T.... Campisi J. (J. Biol. Chem. 1993)
    3. Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. (PubMed id 7862521)1, 2, 9 Neumann F.... Krawinkel U. (Nucleic Acids Res. 1995)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    8. Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association. (PubMed id 17258209)1, 9 Wu W.C....Lin A. (FEBS Lett. 2007)
    9. Differential expression of ribosomal proteins in human normal and neoplastic colorectum. (PubMed id 12704204)1, 9 Kasai H....Nakayama J. (J. Histochem. Cytochem. 2003)
    10. Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function. (PubMed id 16797011)1, 9 Ko J.R....Lin A. (FEBS Lett. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6129 HGNC: 10363 AceView: RPL7 Ensembl:ENSG00000147604 euGenes: HUgn6129
    ECgene: RPL7 Kegg: 6129 H-InvDB: RPL7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL7 gene:
    Search GeneIP for patents involving RPL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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