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Aliases for RPL7 Gene

Aliases for RPL7 Gene

  • Ribosomal Protein L7 2 3
  • 60S Ribosomal Protein L7 3
  • HumL7-1 3
  • L7 3

External Ids for RPL7 Gene

Previous GeneCards Identifiers for RPL7 Gene

  • GC08M073255
  • GC08M074143
  • GC08M073920
  • GC08M074252
  • GC08M074365
  • GC08M074202
  • GC08M069693

Summaries for RPL7 Gene

Entrez Gene Summary for RPL7 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL7 Gene

RPL7 (Ribosomal Protein L7) is a Protein Coding gene. Diseases associated with RPL7 include esophagus squamous cell carcinoma and lupus erythematosus. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL7L1.

UniProtKB/Swiss-Prot for RPL7 Gene

  • Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs

Gene Wiki entry for RPL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL7 Gene

Genomics for RPL7 Gene

Regulatory Elements for RPL7 Gene

Genomic Location for RPL7 Gene

Start:
73,290,267 bp from pter
End:
73,295,789 bp from pter
Size:
5,523 bases
Orientation:
Minus strand

Genomic View for RPL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL7 Gene

Proteins for RPL7 Gene

  • Protein details for RPL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18124-RL7_HUMAN
    Recommended name:
    60S ribosomal protein L7
    Protein Accession:
    P18124
    Secondary Accessions:
    • A8K504
    • Q15289
    • Q3KQU0
    • Q5I0X1
    • Q6IBM9

    Protein attributes for RPL7 Gene

    Size:
    248 amino acids
    Molecular mass:
    29226 Da
    Quaternary structure:
    • Homodimer
    SequenceCaution:
    • Sequence=CAA41026.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL7 Gene

neXtProt entry for RPL7 Gene

Proteomics data for RPL7 Gene at MOPED

Post-translational modifications for RPL7 Gene

  • Ubiquitination at Lys40, Lys77, Lys88, Lys107, Lys124, Lys127, Lys148, Lys181, Lys199, Lys202, Lys212, and Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL7 Gene

No data available for DME Specific Peptides for RPL7 Gene

Domains for RPL7 Gene

Gene Families for RPL7 Gene

HGNC:
  • RPL :L ribosomal proteins

Suggested Antigen Peptide Sequences for RPL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18124

UniProtKB/Swiss-Prot:

RL7_HUMAN :
  • P18124
Family:
  • Belongs to the ribosomal protein L30P family.
genes like me logo Genes that share domains with RPL7: view

Function for RPL7 Gene

Molecular function for RPL7 Gene

GENATLAS Biochemistry: 60S ribosomal protein L7
UniProtKB/Swiss-Prot Function: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs

Gene Ontology (GO) - Molecular Function for RPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 8441630
GO:0003723 RNA binding TAS 8441630
GO:0003729 mRNA binding IDA 8441630
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 18274552
genes like me logo Genes that share ontologies with RPL7: view
genes like me logo Genes that share phenotypes with RPL7: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL7 Gene

Localization for RPL7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL7 Gene COMPARTMENTS Subcellular localization image for RPL7 gene
Compartment Confidence
cytosol 5
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL7 Gene

Pathways for RPL7 Gene

genes like me logo Genes that share pathways with RPL7: view

Pathways by source for RPL7 Gene

1 KEGG pathway for RPL7 Gene
1 GeneGo (Thomson Reuters) pathway for RPL7 Gene

Gene Ontology (GO) - Biological Process for RPL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL7: view

Compounds for RPL7 Gene

(1) Novoseek inferred chemical compound relationships for RPL7 Gene

Compound -log(P) Hits PubMed IDs
gtp 38.5 1
genes like me logo Genes that share compounds with RPL7: view

Transcripts for RPL7 Gene

Unigene Clusters for RPL7 Gene

Ribosomal protein L7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5: - - -
SP6:
SP7:

Relevant External Links for RPL7 Gene

GeneLoc Exon Structure for
RPL7
ECgene alternative splicing isoforms for
RPL7

Expression for RPL7 Gene

mRNA expression in normal human tissues for RPL7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RPL7 Gene

SOURCE GeneReport for Unigene cluster for RPL7 Gene Hs.421257

genes like me logo Genes that share expressions with RPL7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL7 Gene

Orthologs for RPL7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL7 35
  • 99.73 (n)
  • 99.6 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
RPL7 35
  • 92.74 (n)
  • 98.79 (a)
RPL7 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL7 35
  • 91.53 (n)
  • 98.39 (a)
RPL7 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl7 35
  • 87.8 (n)
  • 95.93 (a)
Rpl7 16
Rpl7 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl7 35
  • 89.39 (n)
  • 96.69 (a)
chicken
(Gallus gallus)
Aves RPL7 35
  • 76.19 (n)
  • 83.27 (a)
RPL7 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL7 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl7 35
  • 75.61 (n)
  • 79.67 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl7 35
  • 73.8 (n)
  • 79.42 (a)
rpl7 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008916 35
  • 57.18 (n)
  • 54.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL7 35
  • 56.49 (n)
  • 57.32 (a)
RpL7 36
  • 54 (a)
OneToMany
CG5317 37
  • 35 (a)
RpL7 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-7 35
  • 57.46 (n)
  • 56.49 (a)
rpl-7 36
  • 56 (a)
OneToMany
rpl-7 37
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL082W 35
  • 55.18 (n)
  • 52.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL7A 35
  • 54.61 (n)
  • 51.06 (a)
RPL7A 36
  • 51 (a)
ManyToMany
RPL7B 36
  • 51 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03410g 35
  • 56.57 (n)
  • 53.68 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1884 35
soybean
(Glycine max)
eudicotyledons Gma.973 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13580 35
  • 60.73 (n)
  • 61.44 (a)
rice
(Oryza sativa)
Liliopsida Os.4880 35
Os08g0234000 35
  • 61.84 (n)
  • 62.55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07829 35
  • 58.44 (n)
  • 60.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl702 35
  • 57.38 (n)
  • 56.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2360 36
  • 60 (a)
OneToMany
Species with no ortholog for RPL7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL7 Gene

ENSEMBL:
Gene Tree for RPL7 (if available)
TreeFam:
Gene Tree for RPL7 (if available)

Paralogs for RPL7 Gene

Paralogs for RPL7 Gene

Selected SIMAP similar genes for RPL7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPL7: view

Variants for RPL7 Gene

Sequence variations from dbSNP and Humsavar for RPL7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2070764 -- 73,292,418(-) CTGAT(A/T)ATTGG intron-variant
rs4237000 -- 73,292,573(+) TTAGG(G/T)AGCTA intron-variant
rs4394387 -- 73,291,341(+) GAGAT(A/G)AAAAC intron-variant
rs5892404 -- 73,292,188(+) TTTTT(-/T)CCCAT intron-variant
rs12678782 -- 73,290,461(+) CTTTT(G/T)TATAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPL7 Gene

Variant ID Type Subtype PubMed ID
esv2737154 CNV Deletion 23290073
nsv891012 CNV Loss 21882294

Relevant External Links for RPL7 Gene

HapMap Linkage Disequilibrium report
RPL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL7 Gene

Disorders for RPL7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RPL7 Gene including...

Search for RPL7 Gene in MalaCards »

(2) University of Copenhagen DISEASES for RPL7 Gene

(3) Novoseek inferred disease relationships for RPL7 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 38.4 3
rheumatoid arthritis 19.8 1
autoimmune diseases 12.5 1

Relevant External Links for RPL7

Genetic Association Database (GAD)
RPL7
Human Genome Epidemiology (HuGE) Navigator
RPL7
genes like me logo Genes that share disorders with RPL7: view

No data available for UniProtKB/Swiss-Prot for RPL7 Gene

Publications for RPL7 Gene

  1. Structural and functional properties of ribosomal protein L7 from humans and rodents. (PMID: 8441630) Hemmerich P. … Krawinkel U. (Nucleic Acids Res. 1993) 2 3 4 23
  2. Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. (PMID: 8360149) Seshadri T. … Campisi J. (J. Biol. Chem. 1993) 2 3 4
  3. Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. (PMID: 7862521) Neumann F. … Krawinkel U. (Nucleic Acids Res. 1995) 3 4 23
  4. Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function. (PMID: 16797011) Ko J.R. … Lin A. (FEBS Lett. 2006) 3 23
  5. Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association. (PMID: 17258209) Wu W.C. … Lin A. (FEBS Lett. 2007) 3 23

Products for RPL7 Gene

Sources for RPL7 Gene

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