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RPL6 Gene

protein-coding   GIFtS: 63
GCID: GC12M112842

Ribosomal Protein L6


(Previous symbol: TXREB1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L61 2     L62
TXREB11 2 3     SHUJUN-22
Neoplasm-Related Protein C1402 3     TAXREB1072
Tax-Responsive Enhancer Element-Binding Protein 1072 3     DNA-Binding Protein TAXREB1072
60S Ribosomal Protein L62     TaxREB1073

External Ids:    HGNC: 103621   Entrez Gene: 61282   Ensembl: ENSG000000890097   OMIM: 6037035   UniProtKB: Q028783   

Export aliases for RPL6 gene to outside databases

Previous GC identifers: GC12M111698 GC12M112320 GC12M112621 GC12M111254 GC12M111305 GC07P136752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL6 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of
ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the
tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein
may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for RPL6 Gene:
RPL6 (ribosomal protein L6) is a protein-coding gene. Diseases associated with RPL6 include human t-cell leukemia virus type 1, and phimosis. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878
Function: Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of
HTLV-I

Gene Wiki entry for RPL6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL6 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL6 promoter sequence
   Search Chromatin IP Primers for RPL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

RPL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M112842:  view genomic region     (about GC identifiers)

Start:
112,842,994 bp from pter      End:
112,856,642 bp from pter
Size:
13,649 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878 (See protein sequence)
Recommended Name: 60S ribosomal protein L6  
Size: 288 amino acids; 32728 Da
Subunit: May bind IPO9 with low affinity
1 PDB 3D structure from and Proteopedia for RPL6:
3J3B (3D)    
Secondary accessions: Q2M3Q3 Q8WW97

Explore the universe of human proteins at neXtProt for RPL6: NX_Q02878

Explore proteomics data for RPL6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys87, Lys94, Lys100, Lys130, Lys207, Lys210, Lys237, Lys239, Lys262, Lys285
  • Modification sites at PhosphoSitePlus

  • See RPL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000961.2  NP_001019833.1  

    ENSEMBL proteins: 
     ENSP00000202773   ENSP00000403172   ENSP00000448570   ENSP00000476161   ENSP00000446883  
     ENSP00000448067   ENSP00000449486   ENSP00000446859  
    Reactome Protein details: Q02878

    RPL6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RPL6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    4 InterPro protein domains:
     IPR014722 Rib_L2_dom2
     IPR000915 60S_ribosomal_L6E
     IPR005568 Ribosomal_L6_N
     IPR008991 Translation_prot_SH3-like

    Graphical View of Domain Structure for InterPro Entry Q02878

    ProtoNet protein and cluster: Q02878

    1 Blocks protein domain: IPB000915 Ribosomal protein L6E

    UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878
    Similarity: Belongs to the ribosomal protein L6e family


    RPL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL6_HUMAN, Q02878
    Function: Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of
    HTLV-I

         Genatlas biochemistry entry for RPL6:
    60S ribosomal protein L6-like,also homologous to TAXREB107 and C140 product from thyroid carcinoma,intracellular
    partner for FGF2,mediating the DNA binding for HLV1 transactivator tax

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8457378
    GO:0003723RNA binding TAS8479925
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0044822poly(A) RNA binding IDA--
         
    RPL6 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL6:
     Decreased cell number, increas  Decreased viability  Decreased viability of wild-ty  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
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    miRNA
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    hsa-mir-26b-5p (MIRT030194), hsa-mir-16-5p (MIRT032025)

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    Sino Biological Human cDNA Clone for RPL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    RPL6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL6 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL6
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL6
        TNF-alpha/NF-kB Signaling Pathway
    Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL6 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL6):
        Ribosome


    RPL6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL6
    Interactions:

        Search GeneGlobe Interaction Network for RPL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL6 (Q028782, 3 ENSP000002027734) via UniProtKB, MINT, STRING, and/or I2D (see all 572)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    RPS15AP622442, 3, ENSP000003186464MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000318646
    RPS2P158802, 3, ENSP000003418854MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000341885
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000278572
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006355regulation of transcription, DNA-templated TAS8457378
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    RPL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL6 (RL6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL6 gene (2 alternative transcripts): 
    NM_000970.3  NM_001024662.1  

    Unigene Cluster for RPL6:

    Ribosomal protein L6
    Hs.546283  [show with all ESTs]
    Unigene Representative Sequence: BQ055135
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553205 ENST00000202773(uc001ttv.3) ENST00000424576(uc001ttu.3)
    ENST00000546368(uc009zwd.1) ENST00000550238 ENST00000551041 ENST00000552455
    ENST00000550566 ENST00000549847 ENST00000551291 ENST00000553213 ENST00000549562
    ENST00000548343
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPL6 (NM_000970)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL6
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      QuantiFast Probe-based Assays in human, mouse, rat RPL6

    Additional mRNA sequence: 

    AF261087.1 AK298117.1 AK299470.1 AK308469.1 AK308680.1 AY320410.1 BC013863.1 BC022444.1 
    BC031009.1 BC032299.1 BC070195.1 BC071912.1 BC104824.1 BC104826.1 D17554.1 X69391.1 

    Selected DOTS entries (see all 85):

    DT.91824969  DT.100034401  DT.91826081  DT.100891663  DT.86994333  DT.92472963  DT.100891637  DT.100837228 
    DT.100891615  DT.121153753  DT.101985673  DT.91665193  DT.100891611  DT.100891634  DT.100891623  DT.91961957 
    DT.95148077  DT.91940666  DT.95078347  DT.100891614  DT.100891624  DT.91656247  DT.92472958  DT.95322633 

    Selected AceView cDNA sequences (see all 1484):

    BM471972 BU526614 BM854650 CR610164 BM794666 BI227225 BM800739 BQ605334 
    BE278100 BQ688395 BG110389 AA382251 BQ787748 D12002 AA341207 AA313712 
    BE877108 AL523602 CD049940 BC004138 CB131938 BE537402 AA167295 BU166358 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL6 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                          -     -     -     -                             -                                 
    SP2:                          -     -     -     -                             -                                 
    SP3:                                                                          -                                 
    SP4:                                                                          -                                 
    SP5:                                                                          -                                 


    ECgene alternative splicing isoforms for RPL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAGAGGA
    RPL6 Expression
    About this image

    RPL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546283
        Custom PCR Arrays for RPL6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPL6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL6 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl61 , 5 ribosomal protein L61, 5 84.03(n)1
    88.81(a)1
      5 (61.72 cM)5
    199881  NM_011290.51  NP_035420.21 
     1212044815 
    chicken
    (Gallus gallus)
    Aves RPL61 ribosomal protein L6 75.88(n)
    84.55(a)
      373957  NM_204152.1  NP_989483.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    73(a)
    68(a)
    many → 1
    many → 1
    GL343282.1(302046-313144)
    2(60772923-60773562)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.259492 Xenopus laevis transcribed sequence with moderate similarity more 76.58(n)    48017641 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl61 ribosomal protein L6 71.82(n)
    78.86(a)
      336727  NM_001003844.1  NP_001003844.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115223
    RpL61
    Ribosomal protein L61 44(a)3
    49.72(n)1
    49.15(a)1
      100C73
    437231  NM_143619.31  NP_651876.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-61 , 3 Ribosomal protein ML163
    rpl-61
    48(a)3
    54.42(n)1
    56.46(a)1
      III(7279984-7281644)3
    1760151  NM_066183.31  NP_498584.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL6A(YML073C)4 N-terminally acetylated protein component of the large more   --   13(124172-123227) 854902  NP_013638.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G740601 AT1G74060 55.41(n)
    54.05(a)
      843746  NM_106066.5  NP_177546.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05917001 Os02g0591700 52.59(n)
    51.46(a)
      4329831  NM_001053823.1  NP_001047288.1 


    ENSEMBL Gene Tree for RPL6 (if available)
    TreeFam Gene Tree for RPL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL6 gene

    RPL6 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL6 (see all 37)
    PGOHUM00000238357 PGOHUM00000242663 PGOHUM00000239876 PGOHUM00000246761 PGOHUM00000237084


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL6 (see all 166)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364374
    A colorectal cancer sample4--see VAR_0364372 K Q mis40--------
    rs1159793431,2
    C,F--112842504(+) GGAGGA/CTAGCT 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1425026461,2
    F--112842505(+) GAGGAT/CAGCTA 2 -- ds50011Minor allele frequency- C:0.01NS 138
    rs1440308791,2
    --112842649(+) GAGCAC/TAGCGG 2 -- ds50010--------
    rs1148140881,2
    C,F--112842652(+) CACAGC/TGGGGA 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1136264091,2
    F--112842756(+) AATGCT/CACCAC 2 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1166025451,2
    F--112842952(+) GTAAGA/TATTTT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1996442941,2
    C--112843062(+) CATTCG/ATCAGA 4 /T /M mis11Minor allele frequency- A:0.00EU 1295
    rs1411611681,2
    C--112843105(+) AGGAAT/CAGCTT 4 /I /V mis11Minor allele frequency- C:0.00NA 2342
    rs1908787621,2
    --112843249(+) AAGGAA/GTCCTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for RPL6 (112842994 - 112856642 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPL6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL6
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603703    OMIM disorders: --

    Selected diseases for RPL6 (see all 21):    
    About MalaCards
    human t-cell leukemia virus type 1    phimosis    t-cell leukemia    noonan syndrome
    diamond-blackfan anemia    treacher collins syndrome    leukemia    esophageal squamous cell carcinoma
    influenza    breast and colorectal cancer    systemic lupus erythematosus    lupus erythematosus
    esophagitis    squamous cell carcinoma    thyroiditis    neuroblastoma
    hiv-1    endotheliitis    colorectal cancer    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for RPL6:
    Phimosis     Penis carcinoma     Noonan syndrome

    RPL6 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPL6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.1 1 8457378 (1)
    gastric cancer 40.7 5 20171175 (2), 15846068 (1), 12678981 (1)


    Export disorders for RPL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL6 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with RPL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. (PubMed id 8457378)1, 2, 3, 9 Morita T....Shimotohno K. (AIDS Res. Hum. Retroviruses 1993)
    2. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PubMed id 8479925)1, 2, 3, 9 Zaman G.J.R. (Nucleic Acids Res. 1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    5. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2 Jaekel S.... Goerlich D. (EMBO J. 2002)
    6. The human ribosomal protein L6 gene in a critical region for Noonan syndrome. (PubMed id 11043511)1, 2 Kenmochi N.... Tanaka T. (J. Hum. Genet. 2000)
    7. Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues. (PubMed id 8185817)1, 2 Ohta K.... Onaya T. (J. Mol. Endocrinol. 1994)
    8. Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells. (PubMed id 20171175)1, 9 Gou Y....Fan D. (Biochem. Biophys. Res. Commun. 2010)
    9. [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance]. (PubMed id 12678981)1, 9 Du J.P....Fan D.M. (Zhonghua Zhong Liu Za Zhi 2003)
    10. Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. (PubMed id 24174547)1 Bai D....Zheng X. (Nucleic Acids Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6128 HGNC: 10362 AceView: RPL6 Ensembl:ENSG00000089009 euGenes: HUgn6128
    ECgene: RPL6 Kegg: 6128 H-InvDB: RPL6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL6 gene:
    Search GeneIP for patents involving RPL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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