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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL6 Gene

protein-coding   GIFtS: 59
GCID: GC12M112842

ribosomal protein L6


(Previous symbol: TXREB1)
 Explore 17 diseases affiliated with
RPL6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPL6    

Aliases
for RPL6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein L61 2     Tax-Responsive Enhancer Element-Binding Protein 1072 3
TXREB11 2 3     60S Ribosomal Protein L62
L61 2     SHUJUN-22
TAXREB1071 2     DNA-Binding Protein TAXREB1072
Neoplasm-Related Protein C1402 3     TaxREB1073

External Ids:    HGNC: 103621   Entrez Gene: 61282   Ensembl: ENSG000000890097   OMIM: 6037035   UniProtKB: Q028783   

Export aliases for RPL6 gene to outside databases

Previous GC identifers: GC12M111698 GC12M112320 GC12M112621 GC12M111254 GC12M111305 GC07P136752


Summaries
for RPL6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL6:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal
proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer
element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in
tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple
processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878
Function: Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I

Gene Wiki entry for RPL6


Genomic Views
for RPL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL6 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

RPL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M112842:  view genomic region     (about GC identifiers)

Start:
 112,842,994 bp from pter      End:
 112,856,642 bp from pter
Size:
 13,649 bases      Orientation:
 minus strand

1 alternative location:
Chr7+,CRA_TCAG 136,752,100-136,753,021     

Proteins
for RPL6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878 (See protein sequence)
Recommended Name: 60S ribosomal protein L6  
Size: 288 amino acids; 32728 Da
Subunit: May bind IPO9 with low affinity
Secondary accessions: Q2M3Q3 Q8WW97

Explore the universe of human proteins at neXtProt for RPL6: NX_Q02878

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02878

    • RPL6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000961.2  NP_001019833.1  

    ENSEMBL proteins: 
     ENSP00000202773   ENSP00000403172   ENSP00000446708   ENSP00000448570   ENSP00000446883  
     ENSP00000449486   ENSP00000448067   ENSP00000446859   ENSP00000448465  
    Reactome Protein details: Q02878
    Human Recombinant Protein Products: 
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    Novus Biologicals RPL6 Protein
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    Uscn Proteins for RPL6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325


    RPL6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RPL6

    Protein Domains /
    Families
    for RPL6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR014722 Rib_L2_dom2
     IPR005568 Ribosomal_L6_N
     IPR000915 Ribosomal_L6E

    Graphical View of Domain Structure for InterPro Entry Q02878

    ProtoNet protein and cluster: Q02878

    1 Blocks protein family: IPB000915 Ribosomal protein L6E

    UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878
    Similarity: Belongs to the ribosomal protein L6e family


    Function
    for RPL6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RL6_HUMAN, Q02878
    Function: Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I

         Genatlas biochemistry entry for RPL6:
    60S ribosomal protein L6-like,also homologous to TAXREB107 and C140 product from thyroid carcinoma,intracellular
    partner for FGF2,mediating the DNA binding for HLV1 transactivator tax

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8457378
    GO:0003723RNA binding TAS8479925
    GO:0003735structural constituent of ribosome NAS12962325


    RPL6 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RPL6:
     Decreased cell number, increas  Decreased viability  Decreased viability of wild-ty  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 


    Pathways & Interactions
    for RPL6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Disease
    		Disease1.00
    4TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway1.00
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL6
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL6 
        TNF-alpha/NF-kB Signaling Pathway
    Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL6 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL6):
        Ribosome


    RPL6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/494 Interacting proteins for RPL6 (Q028782, 3 ENSP000002027734) via UniProtKB, MINT, STRING, and/or I2D (see all 494)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    RPS15AP622442, 3, ENSP000003186464MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000318646
    RPS2P158802, 3, ENSP000003418854MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000341885
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000278572
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006355regulation of transcription, DNA-dependent TAS8457378
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--


    RPL6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RPL6
    Search CenterWatch for drugs/clinical trials and news about RPL6 / RL6 

    Transcripts
    for RPL6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL6 gene (2 alternative transcripts): 
    NM_000970.3  NM_001024662.1  

    Unigene Clusters for RPL6:

    Ribosomal protein L6
    Hs.528668  [show with all ESTs], Hs.546283  [show with all ESTs]
    Unigene Representative Sequences: BQ050162, BQ055135
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553205 ENST00000202773(uc001ttv.3) ENST00000424576(uc001ttu.3)
    ENST00000549923 ENST00000546368(uc009zwd.1) ENST00000550238 ENST00000551041
    ENST00000552455 ENST00000549847 ENST00000549562 ENST00000553213 ENST00000551291
    ENST00000548343 ENST00000550566 ENST00000549006

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF261087.1 AK298117.1 AK299470.1 AK308469.1 AK308680.1 AY320410.1 BC013863.1 BC022444.1 
    BC031009.1 BC032299.1 BC070195.1 BC071912.1 BC104824.1 BC104826.1 D17554.1 X69391.1 

    24/103 DOTS entries (see all 103):

    DT.91824969  DT.100034401  DT.91826081  DT.100891663  DT.92472963  DT.100891637  DT.86994333  DT.100837228 
    DT.91665193  DT.121153753  DT.100891615  DT.101985673  DT.100891611  DT.121082915  DT.100891634  DT.100891622 
    DT.121082919  DT.121082961  DT.100891623  DT.91940666  DT.100891653  DT.91961957  DT.121082912  DT.95148077 

    24/1484 AceView cDNA sequences (see all 1484):

    BF365510 BF037064 BE886762 AA307193 BM873857 AA382251 BE740256 AW405946 
    BM550524 CD651903 BG289282 W60287 AW059516 BM794666 AA313299 CR605343 
    CB122576 BU160895 BI830346 AV712841 BF102663 BE542112 CD049940 CB131938 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RPL6 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                          -     -     -     -                             -                                 
    SP2:                          -     -     -     -                             -                                 
    SP3:                                                                          -                                 
    SP4:                                                                          -                                 
    SP5:                                                                          -                                 


    ECgene alternative splicing isoforms for RPL6

    Expression
    for RPL6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAAGAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RPL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL6

    SOURCE GeneReport for Unigene clusters: Hs.528668 Hs.546283
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    In Situ
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    Orthologs
    for RPL6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL6 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rpl61 , 5 ribosomal protein L61, 5 83.92(n)1
    89.51(a)1    		   5 (61.72 cM)5
    199881  NM_011290.51  NP_035420.21 
     1212044815 
    chicken
    (Gallus gallus)    		 Aves RPL61 ribosomal protein L6 73.26(n)
    81.27(a)    		   373957  NM_204152.1  NP_989483.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 80(a)
    64(a)
    		 many → 1
    many → 1
    		 GL343282.1(302159-309354)
    2(60772923-60773562)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.259492 Xenopus laevis transcribed sequence with moderate similarity more 76.58(n)    48017641 
    zebrafish
    (Danio rerio)    		 Actinopterygii rpl61 ribosomal protein L6 70.75(n)
    77.47(a)    		   336727  NM_001003844.1  NP_001003844.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG115223
    RpL61    		 Ribosomal protein L61 44(a)3
    50.46(n)1
    49.41(a)1    		   100C73
    437231  NM_143619.21  NP_651876.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-61 , 3 Ribosomal protein ML163
    Protein RPL-61    		 48(a)3
    51.85(n)1
    52.22(a)1    		   III(7279984-7281644)3
    1760151  NM_066183.21  NP_498584.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPL6A(YML073C)4
    RPL6B1    		 N-terminally acetylated protein component of the large more4
    Rpl6bp1    		 51.66(n)1
    48.54(a)1    		   13(124172-123227)4
    8511691  NP_013553.11  8549024 
     NP_013638.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G740601 60S ribosomal protein L6-2 55.81(n)
    54.3(a)    		   843746  NM_106066.5  NP_177546.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g04734001 hypothetical protein 53.77(n)
    50.47(a)    		   4336140  NM_001059600.1  NP_001053065.2 


    ENSEMBL Gene Tree for RPL6 (if available)
    TreeFam Gene Tree for RPL6 (if available) 

    Paralogs
    for RPL6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL6 gene

    RPL6 for paralogs           About GeneDecksing


    5/37 Pseudogenes.org Pseudogenes for RPL6 (see all 37)
    PGOHUM00000238357 PGOHUM00000242663 PGOHUM00000239876 PGOHUM00000246761 PGOHUM00000237084


    Genomic Variants
    for RPL6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/112 NCBI SNPs in RPL6 are shown (see all 112)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1159793431,2
    		--112842504(+) GGAGGA/CTAGCT 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1425026461,2
    		F--112842505(+) GAGGAT/CAGCTA 2 -- ds50011Minor allele frequency- C:0.01NS 138
    rs1440308791,2
    		--112842649(+) GAGCAC/TAGCGG 2 -- ds50010--------
    rs1148140881,2
    		C,F,--112842652(+) CACAGC/TGGGGA 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1136264091,2
    		--112842756(+) AATGCT/CACCAC 2 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1166025451,2
    		--112842952(+) GTAAGA/TATTTT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1996442941,2
    		C,--112843062(+) CATTCG/ATCAGA 4 /T /M mis11Minor allele frequency- A:0.00EU 1295
    rs1411611681,2
    		C,--112843105(+) AGGAAT/CAGCTT 4 /I /V mis11Minor allele frequency- C:0.00NA 2342
    rs1908787621,2
    		--112843249(+) AAGGAA/GTCCTG 2 -- int10--------
    rs775463091,2
    		C,F,--112843338(+) AAACAC/TAACCC 2 -- int11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for RPL6 (112842994 - 112856642 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPL6: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RPL6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPL6 for disorders           About GeneDecksing

    OMIM gene information: 603703    OMIM disorders: --

    17 diseases for RPL6:    About MalaCards
    human t-cell leukemia virus type 1    diamond-blackfan anemia    t-cell leukemia    leukemia
    treacher collins syndrome    esophageal squamous cell carcinoma    systemic lupus erythematosus    squamous cell carcinoma
    lupus erythematosus    noonan syndrome    gastric cancer    thyroid carcinoma
    esophagitis    thyroiditis    carcinoma    anemia
    malaria

    3 diseases from the University of Copenhagen DISEASES database for RPL6:
    Phimosis     Penis carcinoma     Noonan syndrome

    2 Novoseek disease relationships for RPL6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.1 1 8457378 (1)
    gastric cancer 40.7 5 20171175 (2), 15846068 (1), 12678981 (1)


    Export disorders for RPL6 gene to outside databases

    Publications
    for RPL6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL6 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with RPL6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. (PubMed id 8457378)1, 2, 3, 9 Morita T....Shimotohno K. (1993)
    2. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PubMed id 8479925)1, 2, 3, 9 Zaman G.J.R. (1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
    5. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2 Jaekel S.... Goerlich D. (2002)
    6. The human ribosomal protein L6 gene in a critical region for Noonan syndrome. (PubMed id 11043511)1, 2 Kenmochi N.... Tanaka T. (2000)
    7. Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues. (PubMed id 8185817)1, 2 Ohta K.... Onaya T. (1994)
    8. Ribosomal protein L6 promotes growth and cell cycle p rogression through upregulating cyclin E in gastric cancer cells. (PubMed id 20171175)1, 9 Gou Y....Fan D. (2010)
    9. [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance] (PubMed id 12678981)1, 9 Du J.P....Fan D.M. (2003)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for RPL6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing RPL6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6128 HGNC: 10362 AceView: RPL6 Ensembl:ENSG00000089009 euGenes: HUgn6128
    ECgene: RPL6 Kegg: 6128 H-InvDB: RPL6

    Other Databases showing RPL6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RPL6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL6 gene:
    Search GeneIP for patents involving RPL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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