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Aliases for RPL6 Gene

Aliases for RPL6 Gene

  • Ribosomal Protein L6 2 3
  • Tax-Responsive Enhancer Element-Binding Protein 107 3 4
  • Neoplasm-Related Protein C140 3 4
  • TAXREB107 3 4
  • TXREB1 3 4
  • DNA-Binding Protein TAXREB107 3
  • 60S Ribosomal Protein L6 3
  • SHUJUN-2 3
  • L6 3

External Ids for RPL6 Gene

Previous HGNC Symbols for RPL6 Gene

  • TXREB1

Previous GeneCards Identifiers for RPL6 Gene

  • GC12M111698
  • GC12M112621
  • GC12M111254
  • GC12M111305
  • GC12M112842
  • GC07P136752

Summaries for RPL6 Gene

Entrez Gene Summary for RPL6 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL6 Gene

RPL6 (Ribosomal Protein L6) is a Protein Coding gene. Diseases associated with RPL6 include phimosis and human t-cell leukemia virus type 1. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL6 Gene

  • Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I

Gene Wiki entry for RPL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL6 Gene

Genomics for RPL6 Gene

Genomic Location for RPL6 Gene

Start:
112,405,190 bp from pter
End:
112,418,843 bp from pter
Size:
13,654 bases
Orientation:
Minus strand

Genomic View for RPL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL6 Gene

Proteins for RPL6 Gene

  • Protein details for RPL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02878-RL6_HUMAN
    Recommended name:
    60S ribosomal protein L6
    Protein Accession:
    Q02878
    Secondary Accessions:
    • Q2M3Q3
    • Q8WW97

    Protein attributes for RPL6 Gene

    Size:
    288 amino acids
    Molecular mass:
    32728 Da
    Quaternary structure:
    • May bind IPO9 with low affinity.

    Three dimensional structures from OCA and Proteopedia for RPL6 Gene

neXtProt entry for RPL6 Gene

Proteomics data for RPL6 Gene at MOPED

Post-translational modifications for RPL6 Gene

  • Ubiquitination at Lys87, Lys94, Lys100, Lys130, Lys207, Lys210, Lys237, Lys239, Lys262, and Lys285
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL6 Gene

No data available for DME Specific Peptides for RPL6 Gene

Domains for RPL6 Gene

Gene Families for RPL6 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL6 Gene

Suggested Antigen Peptide Sequences for RPL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q02878

UniProtKB/Swiss-Prot:

RL6_HUMAN :
  • Q02878
Family:
  • Belongs to the ribosomal protein L6e family.
genes like me logo Genes that share domains with RPL6: view

Function for RPL6 Gene

Molecular function for RPL6 Gene

GENATLAS Biochemistry: 60S ribosomal protein L6-like,also homologous to TAXREB107 and C140 product from thyroid carcinoma,intracellular partner for FGF2,mediating the DNA binding for HLV1 transactivator tax
UniProtKB/Swiss-Prot Function: Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I

Gene Ontology (GO) - Molecular Function for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8457378
GO:0003723 RNA binding TAS 8479925
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL6: view
genes like me logo Genes that share phenotypes with RPL6: view

miRNA for RPL6 Gene

miRTarBase miRNAs that target RPL6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL6 Gene

Localization for RPL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL6 Gene COMPARTMENTS Subcellular localization image for RPL6 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL6 Gene

Pathways for RPL6 Gene

genes like me logo Genes that share pathways with RPL6: view

Pathways by source for RPL6 Gene

1 KEGG pathway for RPL6 Gene
1 GeneGo (Thomson Reuters) pathway for RPL6 Gene

Gene Ontology (GO) - Biological Process for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006355 regulation of transcription, DNA-templated TAS 8457378
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL6: view

Transcripts for RPL6 Gene

Unigene Clusters for RPL6 Gene

Ribosomal protein L6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: -
SP10:

Relevant External Links for RPL6 Gene

GeneLoc Exon Structure for
RPL6
ECgene alternative splicing isoforms for
RPL6

Expression for RPL6 Gene

mRNA expression in normal human tissues for RPL6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RPL6 Gene

SOURCE GeneReport for Unigene cluster for RPL6 Gene Hs.546283

genes like me logo Genes that share expressions with RPL6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL6 Gene

Orthologs for RPL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
OneToMany
RPL6 35
  • 86.76 (n)
  • 91.29 (a)
RPL6 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
RPL6 35
  • 90.05 (n)
  • 95.83 (a)
mouse
(Mus musculus)
Mammalia Gm5428 36
  • 83 (a)
OneToMany
Rpl6 35
  • 84.03 (n)
  • 88.81 (a)
Rpl6 16
Rpl6 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL6 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL6 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl6 35
  • 83.68 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves RPL6 35
  • 75.88 (n)
  • 84.55 (a)
RPL6 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25949 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl6 35
  • 71.43 (n)
  • 82.04 (a)
Str.6008 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8548 35
zebrafish
(Danio rerio)
Actinopterygii rpl6 35
  • 71.82 (n)
  • 78.86 (a)
rpl6 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001911 35
  • 52.85 (n)
  • 48.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL6 35
  • 49.72 (n)
  • 49.15 (a)
RpL6 36
  • 48 (a)
OneToOne
CG11522 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-6 35
  • 54.42 (n)
  • 56.46 (a)
rpl-6 36
  • 47 (a)
OneToOne
rpl-6 37
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL6A 36
  • 45 (a)
OneToMany
RPL6A 38
RPL6B 36
  • 46 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74060 35
  • 55.41 (n)
  • 54.05 (a)
rice
(Oryza sativa)
Liliopsida Os02g0591700 35
  • 52.59 (n)
  • 51.46 (a)
Species with no ortholog for RPL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL6 Gene

ENSEMBL:
Gene Tree for RPL6 (if available)
TreeFam:
Gene Tree for RPL6 (if available)

Paralogs for RPL6 Gene

genes like me logo Genes that share paralogs with RPL6: view

No data available for Paralogs for RPL6 Gene

Variants for RPL6 Gene

Sequence variations from dbSNP and Humsavar for RPL6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11981 -- 112,406,302(-) ATTAC(C/T)TGTGA missense, reference
rs12046 -- 112,405,956(-) TATCA(G/T)CAATG reference, missense
rs1804906 -- 112,408,294(-) ACAAA(A/G)CCAGT reference, synonymous-codon, utr-variant-5-prime
rs2233861 -- 112,406,194(-) ACTTA(A/T)TGCCA intron-variant
rs2301723 -- 112,405,559(+) TAAAA(A/G)TAGCT intron-variant

Relevant External Links for RPL6 Gene

HapMap Linkage Disequilibrium report
RPL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL6 Gene

Disorders for RPL6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RPL6 Gene including...

Search for RPL6 Gene in MalaCards »

(3) University of Copenhagen DISEASES for RPL6 Gene

(2) Novoseek inferred disease relationships for RPL6 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 55.1 1
gastric cancer 40.7 4
genes like me logo Genes that share disorders with RPL6: view

No data available for UniProtKB/Swiss-Prot for RPL6 Gene

Publications for RPL6 Gene

  1. Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. (PMID: 8457378) Morita T. … Shimotohno K. (AIDS Res. Hum. Retroviruses 1993) 2 3 4 23
  2. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PMID: 8479925) Zaman G.J.R. (Nucleic Acids Res. 1993) 2 3 4 23
  3. [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance]. (PMID: 12678981) Du J.P. … Fan D.M. (Zhonghua Zhong Liu Za Zhi 2003) 3 23
  4. Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells. (PMID: 20171175) Gou Y. … Fan D. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues. (PMID: 8185817) Ohta K. … Onaya T. (J. Mol. Endocrinol. 1994) 3 4

Products for RPL6 Gene

Sources for RPL6 Gene

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