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Aliases for RPL6 Gene

Aliases for RPL6 Gene

  • Ribosomal Protein L6 2 3 5
  • Tax-Responsive Enhancer Element-Binding Protein 107 3 4
  • Neoplasm-Related Protein C140 3 4
  • TAXREB107 3 4
  • TXREB1 3 4
  • DNA-Binding Protein TAXREB107 3
  • SHUJUN-2 3
  • L6 3

External Ids for RPL6 Gene

Previous HGNC Symbols for RPL6 Gene

  • TXREB1

Previous GeneCards Identifiers for RPL6 Gene

  • GC12M111698
  • GC12M112621
  • GC12M111254
  • GC12M111305
  • GC12M112842
  • GC07P136752

Summaries for RPL6 Gene

Entrez Gene Summary for RPL6 Gene

  • This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RPL6 Gene

RPL6 (Ribosomal Protein L6) is a Protein Coding gene. Diseases associated with RPL6 include t-cell leukemia and noonan syndrome 1. Among its related pathways are Viral mRNA Translation and Infectious disease. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL6 Gene

  • Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

Gene Wiki entry for RPL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL6 Gene

Genomics for RPL6 Gene

Regulatory Elements for RPL6 Gene

Enhancers for RPL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL6 on UCSC Golden Path with GeneCards custom track

Promoters for RPL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL6 Gene

Chromosome:
12
Start:
112,405,190 bp from pter
End:
112,418,838 bp from pter
Size:
13,649 bases
Orientation:
Minus strand

Genomic View for RPL6 Gene

Genes around RPL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL6 Gene

Proteins for RPL6 Gene

  • Protein details for RPL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02878-RL6_HUMAN
    Recommended name:
    60S ribosomal protein L6
    Protein Accession:
    Q02878
    Secondary Accessions:
    • Q2M3Q3
    • Q8WW97

    Protein attributes for RPL6 Gene

    Size:
    288 amino acids
    Molecular mass:
    32728 Da
    Quaternary structure:
    • May bind IPO9 with low affinity.

    Three dimensional structures from OCA and Proteopedia for RPL6 Gene

neXtProt entry for RPL6 Gene

Proteomics data for RPL6 Gene at MOPED

Post-translational modifications for RPL6 Gene

  • Ubiquitination at Lys 87, Lys 94, Lys 100, Lys 130, Lys 207, Lys 210, Lys 237, Lys 262, and Lys 285
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL6 Gene

Domains & Families for RPL6 Gene

Gene Families for RPL6 Gene

Protein Domains for RPL6 Gene

Suggested Antigen Peptide Sequences for RPL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q02878

UniProtKB/Swiss-Prot:

RL6_HUMAN :
  • Belongs to the ribosomal protein L6e family.
Family:
  • Belongs to the ribosomal protein L6e family.
genes like me logo Genes that share domains with RPL6: view

Function for RPL6 Gene

Molecular function for RPL6 Gene

GENATLAS Biochemistry:
60S ribosomal protein L6-like,also homologous to TAXREB107 and C140 product from thyroid carcinoma,intracellular partner for FGF2,mediating the DNA binding for HLV1 transactivator tax
UniProtKB/Swiss-Prot Function:
Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

Gene Ontology (GO) - Molecular Function for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8479925
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL6: view
genes like me logo Genes that share phenotypes with RPL6: view

miRNA for RPL6 Gene

miRTarBase miRNAs that target RPL6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL6 Gene

Localization for RPL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL6 Gene COMPARTMENTS Subcellular localization image for RPL6 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
chloroplast 1

Gene Ontology (GO) - Cellular Components for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL6 Gene

Pathways & Interactions for RPL6 Gene

genes like me logo Genes that share pathways with RPL6: view

Pathways by source for RPL6 Gene

Gene Ontology (GO) - Biological Process for RPL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL6: view

No data available for SIGNOR curated interactions for RPL6 Gene

Drugs & Compounds for RPL6 Gene

No Compound Related Data Available

Transcripts for RPL6 Gene

Unigene Clusters for RPL6 Gene

Ribosomal protein L6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: -
SP10:

Relevant External Links for RPL6 Gene

GeneLoc Exon Structure for
RPL6
ECgene alternative splicing isoforms for
RPL6

Expression for RPL6 Gene

mRNA expression in normal human tissues for RPL6 Gene

Protein differential expression in normal tissues from HIPED for RPL6 Gene

This gene is overexpressed in Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL6 Gene



SOURCE GeneReport for Unigene cluster for RPL6 Gene Hs.546283

genes like me logo Genes that share expression patterns with RPL6: view

Protein tissue co-expression partners for RPL6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL6 Gene

Orthologs for RPL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL6 35
  • 86.76 (n)
  • 91.29 (a)
-- 36
  • 90 (a)
OneToMany
RPL6 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL6 35
  • 90.05 (n)
  • 95.83 (a)
-- 36
  • 96 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl6 35
  • 84.03 (n)
  • 88.81 (a)
Rpl6l 16
Gm5428 36
  • 83 (a)
OneToMany
Rpl6 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl6 35
  • 83.68 (n)
  • 88.89 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL6 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL6 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL6 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL6 35
  • 75.88 (n)
  • 84.55 (a)
RPL6 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl6 35
  • 71.43 (n)
  • 82.04 (a)
Str.6008 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25949 35
zebrafish
(Danio rerio)
Actinopterygii rpl6 35
  • 71.82 (n)
  • 78.86 (a)
rpl6 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8548 35
fruit fly
(Drosophila melanogaster)
Insecta CG11522 37
  • 44 (a)
RpL6 35
  • 49.72 (n)
  • 49.15 (a)
RpL6 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001911 35
  • 52.85 (n)
  • 48.19 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-6 37
  • 48 (a)
rpl-6 35
  • 54.42 (n)
  • 56.46 (a)
rpl-6 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL6A 36
  • 45 (a)
OneToMany
RPL6B 36
  • 46 (a)
OneToMany
RPL6A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74060 35
  • 55.41 (n)
  • 54.05 (a)
rice
(Oryza sativa)
Liliopsida Os02g0591700 35
  • 52.59 (n)
  • 51.46 (a)
Species with no ortholog for RPL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL6 Gene

ENSEMBL:
Gene Tree for RPL6 (if available)
TreeFam:
Gene Tree for RPL6 (if available)

Paralogs for RPL6 Gene

genes like me logo Genes that share paralogs with RPL6: view

No data available for Paralogs for RPL6 Gene

Variants for RPL6 Gene

Sequence variations from dbSNP and Humsavar for RPL6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17851813 - 112,405,887(+) CCTGG(C/T)GTCTG reference, missense
VAR_036437 A colorectal cancer sample
rs16942044 - 112,405,858(+) CTCTT(C/T)TTCTG reference, missense
rs11981 -- 112,406,302(-) ATTAC(C/T)TGTGA reference, missense
rs12046 -- 112,405,956(-) TATCA(G/T)CAATG reference, missense

Variation tolerance for RPL6 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL6 Gene

HapMap Linkage Disequilibrium report
RPL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL6 Gene

Disorders for RPL6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
noonan syndrome 1
  • noonan syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL6
genes like me logo Genes that share disorders with RPL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL6 Gene

Publications for RPL6 Gene

  1. Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. (PMID: 8457378) Morita T. … Shimotohno K. (AIDS Res. Hum. Retroviruses 1993) 2 3 4 23 67
  2. Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. (PMID: 8479925) Zaman G.J.R. (Nucleic Acids Res. 1993) 2 3 23
  3. Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells. (PMID: 20171175) Gou Y. … Fan D. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance]. (PMID: 12678981) Du J.P. … Fan D.M. (Zhonghua Zhong Liu Za Zhi 2003) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for RPL6 Gene

Sources for RPL6 Gene

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