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Aliases for RPL41 Gene

Subcategory (RNA class) for RPL41 Gene

lncRNA

Aliases for RPL41 Gene

  • Ribosomal Protein L41 2 3 5
  • Large Ribosomal Subunit Protein EL41 3 4
  • Homologue Of Yeast Ribosomal Protein YL41 3
  • 60S Ribosomal Protein L41 3
  • HG12 Protein 3
  • HG12 4
  • L41 3

External Ids for RPL41 Gene

ORGUL Members for RPL41 Gene

Previous GeneCards Identifiers for RPL41 Gene

  • GC05P055402
  • GC12M056871
  • GC12P056227
  • GC12P054796
  • GC12P056510
  • GC07P136542

Summaries for RPL41 Gene

Entrez Gene Summary for RPL41 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL41 Gene

RPL41 (Ribosomal Protein L41) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL41 Gene

  • Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

Gene Wiki entry for RPL41 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL41 Gene

Genomics for RPL41 Gene

Regulatory Elements for RPL41 Gene

Enhancers for RPL41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G056298 1.4 ENCODE dbSUPER 22.8 +184.2 184225 4.6 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 NEMP1 BAZ2A ZC3H10 CDK2 RN7SL809P ENSG00000257303 TMEM198B RPL41 RNU6-343P RBMS2
GH12G056045 1.4 Ensembl ENCODE dbSUPER 21.2 -70.1 -70085 2.8 HDGF ATF1 ARID4B ZNF2 GTF3C2 ZNF143 KLF13 ZNF263 REST SMARCA4 PA2G4 RPL41 ZC3H10 BAZ2A PMEL RN7SL809P GDF11 ERBB3 CDK2 IKZF4
GH12G056040 1.7 FANTOM5 ENCODE dbSUPER 13.3 -74.6 -74587 3.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 BAZ2A RN7SL809P ENSG00000258199 STAT2 SUOX RAB5B ENSG00000257740 GDF11 RBMS2 PHC1P1
GH12G056718 1.5 ENCODE dbSUPER 13.1 +606.0 605973 8.9 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 SMARCC2 BAZ2A ENSG00000257740 ANKRD52 TMEM198B ENSG00000224713 NAB2 RN7SL809P STAT2
GH12G057109 1.5 ENCODE dbSUPER 13.1 +994.7 994668 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MCM3 NEMP1 SMARCC2 ENSG00000257740 ANKRD52 BAZ2A NAB2 ENSG00000224713 CTDSP2 LOC283387 RN7SL809P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL41 on UCSC Golden Path with GeneCards custom track

Promoters for RPL41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052478 614 3201 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3

Genomic Location for RPL41 Gene

Chromosome:
12
Start:
56,116,586 bp from pter
End:
56,117,943 bp from pter
Size:
1,358 bases
Orientation:
Plus strand

Genomic View for RPL41 Gene

Genes around RPL41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL41 Gene

Proteins for RPL41 Gene

  • Protein details for RPL41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62945-RL41_HUMAN
    Recommended name:
    60S ribosomal protein L41
    Protein Accession:
    P62945
    Secondary Accessions:
    • A6NG21
    • P28751

    Protein attributes for RPL41 Gene

    Size:
    25 amino acids
    Molecular mass:
    3456 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL41 Gene

neXtProt entry for RPL41 Gene

Post-translational modifications for RPL41 Gene

No Post-translational modifications

Other Protein References for RPL41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL41 Gene

Domains & Families for RPL41 Gene

Gene Families for RPL41 Gene

Protein Domains for RPL41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62945

UniProtKB/Swiss-Prot:

RL41_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL41 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL41 family.
genes like me logo Genes that share domains with RPL41: view

Function for RPL41 Gene

Molecular function for RPL41 Gene

GENATLAS Biochemistry:
60S ribosomal protein L41
UniProtKB/Swiss-Prot Function:
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

Gene Ontology (GO) - Molecular Function for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 1326959
GO:0003730 mRNA 3-UTR binding IDA 16213212
GO:0003735 structural constituent of ribosome TAS,NAS 12962325
GO:0048027 mRNA 5-UTR binding IDA 16213212
genes like me logo Genes that share ontologies with RPL41: view

Phenotypes for RPL41 Gene

genes like me logo Genes that share phenotypes with RPL41: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL41 Gene

Localization for RPL41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL41 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit TAS,IDA 12962325
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL41 Gene

Pathways & Interactions for RPL41 Gene

genes like me logo Genes that share pathways with RPL41: view

Pathways by source for RPL41 Gene

1 KEGG pathway for RPL41 Gene
1 GeneGo (Thomson Reuters) pathway for RPL41 Gene

Gene Ontology (GO) - Biological Process for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,TAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL41: view

No data available for SIGNOR curated interactions for RPL41 Gene

Drugs & Compounds for RPL41 Gene

No Compound Related Data Available

Transcripts for RPL41 Gene

Unigene Clusters for RPL41 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL41 Gene

No ASD Table

Relevant External Links for RPL41 Gene

GeneLoc Exon Structure for
RPL41
ECgene alternative splicing isoforms for
RPL41

Expression for RPL41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RPL41 Gene:

RPL41

SOURCE GeneReport for Unigene cluster for RPL41 Gene:

Hs.112553

Evidence on tissue expression from TISSUES for RPL41 Gene

  • Nervous system(4.9)
  • Muscle(4.8)
  • Blood(4.4)
  • Intestine(4.4)
  • Lung(4.4)
  • Bone(4.3)
  • Eye(4.3)
  • Liver(4.2)
  • Pancreas(4.2)
  • Skin(4.2)
  • Heart(4.1)
  • Stomach(4)
  • Kidney(3.8)
  • Spleen(2.9)
  • Thyroid gland(2.9)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Gall bladder(2.4)
genes like me logo Genes that share expression patterns with RPL41: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL41 Gene

Orthologs for RPL41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPL41 Gene

Organism Taxonomy Gene Similarity Type Details
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17123 34
Species where no ortholog for RPL41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPL41 Gene

ENSEMBL:
Gene Tree for RPL41 (if available)
TreeFam:
Gene Tree for RPL41 (if available)

Paralogs for RPL41 Gene

No data available for Paralogs for RPL41 Gene

Variants for RPL41 Gene

Sequence variations from dbSNP and Humsavar for RPL41 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000210094 -- 56,115,412(+) AATGT(A/C)ATACT upstream-variant-2KB
rs1000303257 -- 56,115,764(+) AATCC(C/T)CACTT upstream-variant-2KB
rs1001181999 -- 56,118,101(+) TGTCG(C/T)GCCTT downstream-variant-500B, upstream-variant-2KB
rs1001226144 -- 56,115,317(+) GTTTC(C/T)TGTAG upstream-variant-2KB
rs1001692193 -- 56,117,959(+) TGGTG(C/T)GGTTT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL41 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832427 CNV loss 17160897
nsv973076 CNV duplication 23825009

Relevant External Links for RPL41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RPL41 Gene

Disorders for RPL41 Gene

Relevant External Links for RPL41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL41

No disorders were found for RPL41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL41 Gene

Publications for RPL41 Gene

  1. Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. (PMID: 1326959) Klaudiny J. … Scheit K.H. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 64
  5. Genomic structure of the human ribosomal protein L41 gene. (PMID: 9891856) Go H. … Taniguchi S. (Biochem. Mol. Biol. Int. 1998) 3 22 64

Products for RPL41 Gene

Sources for RPL41 Gene

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