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Aliases for RPL41 Gene

Subcategory (RNA class) for RPL41 Gene

lncRNA

Aliases for RPL41 Gene

  • Ribosomal Protein L41 2 3
  • Homologue Of Yeast Ribosomal Protein YL41 3
  • HG12 Protein 3
  • HG12 4
  • L41 3

External Ids for RPL41 Gene

ORGUL Members for RPL41 Gene

Previous GeneCards Identifiers for RPL41 Gene

  • GC05P055402
  • GC12M056871
  • GC12P056227
  • GC12P054796
  • GC12P056510
  • GC07P136542

Summaries for RPL41 Gene

Entrez Gene Summary for RPL41 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL41 Gene

RPL41 (Ribosomal Protein L41) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL41 Gene

  • Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII

Gene Wiki entry for RPL41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL41 Gene

Genomics for RPL41 Gene

Regulatory Elements for RPL41 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL41 Gene

Chromosome:
12
Start:
56,116,586 bp from pter
End:
56,117,943 bp from pter
Size:
1,358 bases
Orientation:
Plus strand

Genomic View for RPL41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL41 Gene

Proteins for RPL41 Gene

  • Protein details for RPL41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62945-RL41_HUMAN
    Recommended name:
    60S ribosomal protein L41
    Protein Accession:
    P62945
    Secondary Accessions:
    • A6NG21
    • P28751

    Protein attributes for RPL41 Gene

    Size:
    25 amino acids
    Molecular mass:
    3456 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL41 Gene

neXtProt entry for RPL41 Gene

Proteomics data for RPL41 Gene at MOPED

Post-translational modifications for RPL41 Gene

No Post-translational modifications

Other Protein References for RPL41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL41 Gene

Domains & Families for RPL41 Gene

Gene Families for RPL41 Gene

Protein Domains for RPL41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62945

UniProtKB/Swiss-Prot:

RL41_HUMAN :
  • Belongs to the ribosomal protein L41e family.
Family:
  • Belongs to the ribosomal protein L41e family.
genes like me logo Genes that share domains with RPL41: view

Function for RPL41 Gene

Molecular function for RPL41 Gene

GENATLAS Biochemistry:
60S ribosomal protein L41
UniProtKB/Swiss-Prot Function:
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII

Gene Ontology (GO) - Molecular Function for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 1326959
GO:0003735 structural constituent of ribosome NAS 12962325
genes like me logo Genes that share ontologies with RPL41: view

Phenotypes for RPL41 Gene

GenomeRNAi human phenotypes for RPL41:
genes like me logo Genes that share phenotypes with RPL41: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL41

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL41 Gene

Localization for RPL41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL41 Gene COMPARTMENTS Subcellular localization image for RPL41 gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL41 Gene

Pathways & Interactions for RPL41 Gene

genes like me logo Genes that share pathways with RPL41: view

Pathways by source for RPL41 Gene

1 BioSystems pathway for RPL41 Gene
1 KEGG pathway for RPL41 Gene
1 GeneGo (Thomson Reuters) pathway for RPL41 Gene

Interacting Proteins for RPL41 Gene

Gene Ontology (GO) - Biological Process for RPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL41: view

No data available for SIGNOR curated interactions for RPL41 Gene

Drugs & Compounds for RPL41 Gene

No Compound Related Data Available

Transcripts for RPL41 Gene

Unigene Clusters for RPL41 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL41

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL41 Gene

No ASD Table

Relevant External Links for RPL41 Gene

GeneLoc Exon Structure for
RPL41
ECgene alternative splicing isoforms for
RPL41

Expression for RPL41 Gene

mRNA expression in normal human tissues for RPL41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for RPL41 Gene Hs.112553

genes like me logo Genes that share expression patterns with RPL41: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RPL41 Gene

Orthologs for RPL41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPL41 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rpl41 16
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17123 35
Species with no ortholog for RPL41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPL41 Gene

ENSEMBL:
Gene Tree for RPL41 (if available)
TreeFam:
Gene Tree for RPL41 (if available)

Paralogs for RPL41 Gene

No data available for Paralogs for RPL41 Gene

Variants for RPL41 Gene

Sequence variations from dbSNP and Humsavar for RPL41 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1689513 -- 56,115,602(-) TCATT(C/T)GTTCA upstream-variant-2KB
rs2021843 -- 56,116,184(-) tttct(C/T)tcttt upstream-variant-2KB
rs2452823 -- 56,115,534(+) acctc(A/G)gcctc upstream-variant-2KB
rs2452824 -- 56,115,546(+) caaag(C/T)gctgg upstream-variant-2KB
rs2640569 -- 56,115,037(+) TGGAA(C/T)TGATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL41 Gene

Variant ID Type Subtype PubMed ID
nsv832427 CNV Loss 17160897

Relevant External Links for RPL41 Gene

HapMap Linkage Disequilibrium report
RPL41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RPL41 Gene

Disorders for RPL41 Gene

Relevant External Links for RPL41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL41
genes like me logo Genes that share disorders with RPL41: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL41 Gene

Publications for RPL41 Gene

  1. Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. (PMID: 1326959) Klaudiny J. … Scheit K.H. (Biochem. Biophys. Res. Commun. 1992) 2 23 67
  2. Identification of mutations in protein kinase CKIIbeta subunit that affect its binding to ribosomal protein L41 and homodimerization. (PMID: 12895290) Ahn B.H. … Bae Y.S. (J. Biochem. Mol. Biol. 2003) 23 67
  3. Transcriptional profiling of human mammary carcinoma cell lines reveals PKW, a new tumor-specific gene. (PMID: 10953283) Preiherr J. … Weidle U.H. (Anticancer Res. 2000) 23 67
  4. Genomic structure of the human ribosomal protein L41 gene. (PMID: 9891856) Go H. … Taniguchi S. (Biochem. Mol. Biol. Int. 1998) 23 67
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 67

Products for RPL41 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPL41
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL41
  • Block miRNA regulation of RPL41 using miScript Target Protectors

Sources for RPL41 Gene

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