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Aliases for RPL4 Gene

Aliases for RPL4 Gene

  • Ribosomal Protein L4 2 3 5
  • Large Ribosomal Subunit Protein UL4 3 4
  • 60S Ribosomal Protein L4 2 3
  • 60S Ribosomal Protein L1 3 4
  • RPL1 4
  • L4 3

External Ids for RPL4 Gene

Previous GeneCards Identifiers for RPL4 Gene

  • GC15M062584
  • GC15M059890
  • GC15M064370
  • GC15M064507
  • GC15M064578
  • GC15M066790
  • GC15M043627

Summaries for RPL4 Gene

Entrez Gene Summary for RPL4 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL4 Gene

RPL4 (Ribosomal Protein L4) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL4 Gene

Additional gene information for RPL4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL4 Gene

Genomics for RPL4 Gene

Regulatory Elements for RPL4 Gene

Enhancers for RPL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H066495 1.2 ENCODE 19.3 +27.3 27324 3 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000260773 TIPIN SLC24A1 SNAPC5 RPL4 INTS14 ZWILCH HACD3 SNORD16 SMAD3
GH15H065609 1.2 ENCODE 18.9 +913.1 913120 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 INTS14 PARP16 ENSG00000260773 SNORD16 PDCD7 RPL35AP32 ENSG00000264937 ENSG00000259635 SLC24A1 TIPIN
GH15H066400 1.3 Ensembl ENCODE dbSUPER 15.7 +120.9 120871 6 HDGF BMI1 ETS1 ZNF366 SCRT2 ETV6 RUNX3 IKZF2 SMARCA5 YY2 TIPIN DIS3L SNAPC5 RPL4 SNORD18C SNORD18B SNORD18A SNORD16 ZWILCH GC15M066415
GH15H067060 1.7 Ensembl ENCODE dbSUPER 10.1 -541.6 -541622 11 MLX FEZF1 DMAP1 YY1 ZNF416 SP3 MEF2D ZNF610 ZNF585B GLIS1 ENSG00000260773 SKOR1 ENSG00000259202 ENSG00000259410 MAP2K5 SMAD3 IQCH-AS1 PIAS1 RPL4 AAGAB
GH15H066930 1.6 Ensembl ENCODE dbSUPER 10.5 -407.6 -407589 3 HDGF FOXA2 ARNT ARID4B YBX1 FEZF1 ZBTB7B ZNF207 FOS SP3 ENSG00000260773 RPL35AP32 ZWILCH ENSG00000259202 ENSG00000259410 SNORD16 TIPIN RPL4 ENSG00000259437 LINC02206
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL4 Gene

Chromosome:
15
Start:
66,498,015 bp from pter
End:
66,524,532 bp from pter
Size:
26,518 bases
Orientation:
Minus strand

Genomic View for RPL4 Gene

Genes around RPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL4 Gene

Proteins for RPL4 Gene

  • Protein details for RPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36578-RL4_HUMAN
    Recommended name:
    60S ribosomal protein L4
    Protein Accession:
    P36578
    Secondary Accessions:
    • A8K502
    • P39029
    • Q4VBR0
    • Q969Z9

    Protein attributes for RPL4 Gene

    Size:
    427 amino acids
    Molecular mass:
    47697 Da
    Quaternary structure:
    • May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RPL4 Gene

neXtProt entry for RPL4 Gene

Post-translational modifications for RPL4 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys20, isoforms=29, isoforms=46, isoforms=106, Lys140, Lys157, isoforms=165, isoforms=175, isoforms=219, isoforms=234, Lys239, isoforms=259, isoforms=274, isoforms=283, isoforms=327, Lys333, and Lys353
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL4 Gene

No data available for DME Specific Peptides for RPL4 Gene

Domains & Families for RPL4 Gene

Gene Families for RPL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry

P36578

UniProtKB/Swiss-Prot:

RL4_HUMAN :
  • Belongs to the universal ribosomal protein uL4 family.
Family:
  • Belongs to the universal ribosomal protein uL4 family.
genes like me logo Genes that share domains with RPL4: view

Function for RPL4 Gene

Molecular function for RPL4 Gene

GENATLAS Biochemistry:
60S ribosomal protein L4

Phenotypes From GWAS Catalog for RPL4 Gene

Gene Ontology (GO) - Molecular Function for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPL4: view
genes like me logo Genes that share phenotypes with RPL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL4 Gene

Localization for RPL4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL4 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005791 rough endoplasmic reticulum IDA 24454821
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL4 Gene

Pathways & Interactions for RPL4 Gene

genes like me logo Genes that share pathways with RPL4: view

Pathways by source for RPL4 Gene

1 KEGG pathway for RPL4 Gene
1 GeneGo (Thomson Reuters) pathway for RPL4 Gene

Gene Ontology (GO) - Biological Process for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for SIGNOR curated interactions for RPL4 Gene

Drugs & Compounds for RPL4 Gene

(2) Drugs for RPL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPL4: view

Transcripts for RPL4 Gene

Unigene Clusters for RPL4 Gene

Ribosomal protein L4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - -
SP9:
SP10: -

Relevant External Links for RPL4 Gene

GeneLoc Exon Structure for
RPL4
ECgene alternative splicing isoforms for
RPL4

Expression for RPL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL4 Gene



Protein tissue co-expression partners for RPL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL4 Gene:

RPL4

SOURCE GeneReport for Unigene cluster for RPL4 Gene:

Hs.186350

Evidence on tissue expression from TISSUES for RPL4 Gene

  • Blood(5)
  • Liver(5)
  • Muscle(5)
  • Nervous system(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Pancreas(4.8)
  • Kidney(4.7)
  • Stomach(4.6)
  • Bone(4.5)
  • Heart(4)
  • Spleen(3.6)
  • Thyroid gland(3.2)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RPL4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL4 Gene

Orthologs for RPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL4 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL4 34 34
  • 96 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPL4 33 34
  • 91.55 (n)
-- 34
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL4 33 34
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Rpl4 33
  • 87.18 (n)
mouse
(Mus musculus)
Mammalia Rpl4 33 16 34
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL4 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL4 33 34
  • 80.73 (n)
lizard
(Anolis carolinensis)
Reptilia RPL4 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl4 33
  • 76.58 (n)
Str.8811 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64318 33
zebrafish
(Danio rerio)
Actinopterygii rpl4 33 34
  • 76.15 (n)
wufa97a02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.806 33
fruit fly
(Drosophila melanogaster)
Insecta RpL1 35
  • 62 (a)
RpL4 33 34
  • 61.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002306 33
  • 59.62 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-4 35 33 34
  • 58.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR191C 33
  • 61.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL4A 33 34 36
  • 60.59 (n)
RPL4B 34
  • 57 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07139g 33
  • 60.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09630 33
  • 57.48 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1107 33
rice
(Oryza sativa)
Liliopsida Os07g0180900 33
  • 55.65 (n)
Os.8767 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4071 34
  • 67 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl401 33
  • 60.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03757 33
  • 56.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5831 33
Species where no ortholog for RPL4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL4 Gene

ENSEMBL:
Gene Tree for RPL4 (if available)
TreeFam:
Gene Tree for RPL4 (if available)

Paralogs for RPL4 Gene

No data available for Paralogs for RPL4 Gene

Variants for RPL4 Gene

Sequence variations from dbSNP and Humsavar for RPL4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000194503 -- 66,500,899(+) GAATG(C/T)TAATA intron-variant, downstream-variant-500B
rs1000289102 -- 66,505,351(+) AGCGG(A/C/G)TGAAC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000408247 -- 66,503,846(+) TGTCT(A/C)CCCGG intron-variant, upstream-variant-2KB
rs1000482133 -- 66,505,594(+) AAAAC(A/G)TGTAC intron-variant, upstream-variant-2KB
rs1000707260 -- 66,501,605(+) CACAA(G/T)AACTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL4 Gene

Variant ID Type Subtype PubMed ID
nsv974591 CNV duplication 23825009

Variation tolerance for RPL4 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL4 Gene

Disorders for RPL4 Gene

Relevant External Links for RPL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL4

No disorders were found for RPL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL4 Gene

Publications for RPL4 Gene

  1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PMID: 8268230) Bagni C … Amaldi F (Biochimica et biophysica acta 1993) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 60
  4. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 3 4 60
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 60

Products for RPL4 Gene

Sources for RPL4 Gene

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