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Aliases for RPL4 Gene

Aliases for RPL4 Gene

  • Ribosomal Protein L4 2 3 5
  • 60S Ribosomal Protein L1 3 4
  • 60S Ribosomal Protein L4 2
  • RPL1 4
  • L4 3

External Ids for RPL4 Gene

Previous GeneCards Identifiers for RPL4 Gene

  • GC15M062584
  • GC15M059890
  • GC15M064370
  • GC15M064507
  • GC15M064578
  • GC15M066790
  • GC15M043627

Summaries for RPL4 Gene

Entrez Gene Summary for RPL4 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL4 Gene

RPL4 (Ribosomal Protein L4) is a Protein Coding gene. Diseases associated with RPL4 include Giant Axonal Neuropathy. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL4 Gene

Genomics for RPL4 Gene

Regulatory Elements for RPL4 Gene

Enhancers for RPL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL4 Gene

66,498,015 bp from pter
66,524,532 bp from pter
26,518 bases
Minus strand

Genomic View for RPL4 Gene

Genes around RPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL4 Gene

Proteins for RPL4 Gene

  • Protein details for RPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L4
    Protein Accession:
    Secondary Accessions:
    • A8K502
    • P39029
    • Q4VBR0
    • Q969Z9

    Protein attributes for RPL4 Gene

    427 amino acids
    Molecular mass:
    47697 Da
    Quaternary structure:
    • May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RPL4 Gene

neXtProt entry for RPL4 Gene

Proteomics data for RPL4 Gene at MOPED

Post-translational modifications for RPL4 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys 20, Lys 29, Lys 46, Lys 106, Lys 140, Lys 157, Lys 165, Lys 175, Lys 219, Lys 234, Lys 239, Lys 259, Lys 274, Lys 283, Lys 327, Lys 333, and Lys 353
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL4 Gene

No data available for DME Specific Peptides for RPL4 Gene

Domains & Families for RPL4 Gene

Gene Families for RPL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L4P family.
  • Belongs to the ribosomal protein L4P family.
genes like me logo Genes that share domains with RPL4: view

Function for RPL4 Gene

Molecular function for RPL4 Gene

GENATLAS Biochemistry:
60S ribosomal protein L4

Gene Ontology (GO) - Molecular Function for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 22720776
genes like me logo Genes that share ontologies with RPL4: view
genes like me logo Genes that share phenotypes with RPL4: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL4 Gene

Localization for RPL4 Gene

Subcellular locations from

Jensen Localization Image for RPL4 Gene COMPARTMENTS Subcellular localization image for RPL4 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 16791210
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL4 Gene

Pathways & Interactions for RPL4 Gene

genes like me logo Genes that share pathways with RPL4: view

Pathways by source for RPL4 Gene

Gene Ontology (GO) - Biological Process for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for SIGNOR curated interactions for RPL4 Gene

Drugs & Compounds for RPL4 Gene

(2) Drugs for RPL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPL4: view

Transcripts for RPL4 Gene

Unigene Clusters for RPL4 Gene

Ribosomal protein L4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP8: - - - -
SP10: -

Relevant External Links for RPL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL4 Gene

mRNA expression in normal human tissues for RPL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL4 Gene

SOURCE GeneReport for Unigene cluster for RPL4 Gene Hs.186350

genes like me logo Genes that share expression patterns with RPL4: view

Protein tissue co-expression partners for RPL4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL4 Gene

Orthologs for RPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL4 35
  • 91.55 (n)
  • 95.97 (a)
-- 36
  • 89 (a)
RPL4 36
  • 96 (a)
(Mus musculus)
Mammalia Rpl4 35
  • 85.52 (n)
  • 92.12 (a)
Rpl4 16
Rpl4 36
  • 94 (a)
(Pan troglodytes)
Mammalia RPL4 35
  • 88.89 (n)
  • 86.76 (a)
RPL4 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Rpl4 35
  • 87.18 (n)
  • 93.27 (a)
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
RPL4 36
  • 96 (a)
RPL4 36
  • 96 (a)
(Monodelphis domestica)
Mammalia RPL4 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
-- 36
  • 97 (a)
-- 36
  • 75 (a)
(Gallus gallus)
Aves RPL4 35
  • 80.73 (n)
  • 90.14 (a)
RPL4 36
  • 81 (a)
(Anolis carolinensis)
Reptilia RPL4 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl4 35
  • 76.58 (n)
  • 89.52 (a)
Str.8811 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64318 35
(Danio rerio)
Actinopterygii rpl4 35
  • 76.15 (n)
  • 85.34 (a)
wufa97a02 35
rpl4 36
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.806 35
fruit fly
(Drosophila melanogaster)
Insecta RpL1 37
  • 62 (a)
RpL4 35
  • 61.88 (n)
  • 68.91 (a)
RpL4 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002306 35
  • 59.62 (n)
  • 65.11 (a)
(Caenorhabditis elegans)
Secernentea rpl-4 37
  • 58 (a)
rpl-4 35
  • 58.59 (n)
  • 60.3 (a)
rpl-4 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR191C 35
  • 61.13 (n)
  • 61.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07139g 35
  • 60.08 (n)
  • 60.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL4A 35
  • 60.59 (n)
  • 61.7 (a)
RPL4A 36
  • 57 (a)
RPL4B 36
  • 57 (a)
RPL4A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09630 35
  • 57.48 (n)
  • 60.23 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1107 35
(Oryza sativa)
Liliopsida Os.8767 35
Os07g0180900 35
  • 55.65 (n)
  • 57.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5831 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03757 35
  • 56.5 (n)
  • 55.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl401 35
  • 60.37 (n)
  • 61.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4071 36
  • 67 (a)
Species with no ortholog for RPL4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL4 Gene

Gene Tree for RPL4 (if available)
Gene Tree for RPL4 (if available)

Paralogs for RPL4 Gene

genes like me logo Genes that share paralogs with RPL4: view

No data available for Paralogs for RPL4 Gene

Variants for RPL4 Gene

Sequence variations from dbSNP and Humsavar for RPL4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1803775 -- 66,500,326(-) GAAAA(C/G/T)CCCAG reference, missense
rs28706938 -- 66,500,423(+) ACCAA(A/G)GAACA intron-variant
rs111585548 -- 66,500,292(+) CTTTA(C/G)CGTGG splice-donor-variant
rs140308009 -- 66,499,880(+) TAGCC(A/G)GACAT intron-variant
rs72752414 -- 66,500,252(+) ATAGT(A/G)TAGGG intron-variant

Variation tolerance for RPL4 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RPL4 Gene

Disorders for RPL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
giant axonal neuropathy
  • gan
- elite association - COSMIC cancer census association via MalaCards
Search RPL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL4 Gene

Publications for RPL4 Gene

  1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PMID: 8268230) Bagni C. … Amaldi F. (Biochim. Biophys. Acta 1993) 2 3 4 23 67
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for RPL4 Gene

Sources for RPL4 Gene