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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL4 Gene

protein-coding   GIFtS: 60
GCID: GC15M066790

Ribosomal Protein L4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein L41 2
60S Ribosomal Protein L41 2
60S Ribosomal Protein L12 3
L42
RPL13

External Ids:    HGNC: 103531   Entrez Gene: 61242   Ensembl: ENSG000001744447   OMIM: 1804795   UniProtKB: P365783   

Export aliases for RPL4 gene to outside databases

Previous GC identifers: GC15M062584 GC15M059890 GC15M064370 GC15M064507 GC15M064578 GC15M043627


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL4 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of
ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there
are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL4 Gene: 
RPL4 (ribosomal protein L4) is a protein-coding gene. Diseases associated with RPL4 include cat-scratch disease, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Eukaryotic Translation Initiation and Metabolism of RNA. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL4 (Ribosomal protein L4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL4 gene promoter:
         TBP   FOXF2   TFIID   Meis-1a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22

RPL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M066790:  view genomic region     (about GC identifiers)

Start:
66,790,355 bp from pter      End:
66,816,870 bp from pter
Size:
26,516 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL4_HUMAN, P36578 (See protein sequence)
Recommended Name: 60S ribosomal protein L4  
Size: 427 amino acids; 47697 Da
Subunit: May bind IPO9 with low affinity. Interacts with RBM3 (By similarity)
1 PDB 3D structure from and Proteopedia for RPL4:
3J3B (3D)    
Secondary accessions: A8K502 P39029 Q4VBR0 Q969Z9

Explore the universe of human proteins at neXtProt for RPL4: NX_P36578

Explore proteomics data for RPL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36578

  • RPL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPL4 Protein Expression
    REFSEQ proteins: NP_000959.2  
    ENSEMBL proteins: 
     ENSP00000311430   ENSP00000454281   ENSP00000457442   ENSP00000457268  
    Reactome Protein details: P36578
    Human Recombinant Protein Products for RPL4: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----

    RPL4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPL: L ribosomal proteins

    4 InterPro protein domains:
     IPR025755 Ribos_L4_C_dom
     IPR023574 Ribosomal_L4_dom
     IPR002136 Ribosomal_L4/L1e
     IPR013000 Ribosomal_L4/L1e_euk/arc_CS

    Graphical View of Domain Structure for InterPro Entry P36578

    ProtoNet protein and cluster: P36578

    1 Blocks protein domain: IPB002136 Ribosomal protein L4/L1e

    UniProtKB/Swiss-Prot: RL4_HUMAN, P36578
    Similarity: Belongs to the ribosomal protein L4P family


    RPL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPL4:
    60S ribosomal protein L4

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8268230
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI--
         
    RPL4 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL4:
     Decreased cell number, increas  Increased Salmonella enterica   Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 
     S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPL4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPL4 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL4
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL4
        Cytoplasmic Ribosomal Proteins
    TNF-alpha/NF-kB Signaling Pathway

    5/23        Reactome Pathways for RPL4 (see all 23)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL4):
        Ribosome


    RPL4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1169 Interacting proteins for RPL4 (P365781, 2, 3 ENSP000003114304) via UniProtKB, MINT, STRING, and/or I2D (see all 1169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404252, 3, ENSP000004039484MINT-62673 MINT-62575 MINT-62749 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62673 MINT-62575 MINT-62749 I2D: score=4 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-62673 MINT-62575 MINT-62749 I2D: score=4 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-62673 MINT-62575 MINT-62749 I2D: score=4 
    ENSG00000224952P404252, 3MINT-62673 MINT-62575 MINT-62749 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL4 (RL4)

    2 Novoseek inferred chemical compound relationships for RPL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythromycin 64.4 6 15561835 (2), 19197244 (1), 2256953 (1)
    azithromycin 56.7 1 17110371 (1)

    Search CenterWatch for drugs/clinical trials and news about RPL4 / RL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL4 gene: 
    NM_000968.3  

    Unigene Clusters for RPL4:

    Ribosomal protein L4
    Hs.186350  [show with all ESTs], Hs.644628  [show with all ESTs]
    Unigene Representative Sequences: AK125772, BC002450
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307961(uc002apv.3) ENST00000567229 ENST00000565723 ENST00000568588(uc002apx.3)
    ENST00000561775 ENST00000569696 ENST00000564744 ENST00000564647 ENST00000563473
    ENST00000566039(uc010ujq.2) ENST00000564439 ENST00000566622 ENST00000569438
    ENST00000566624 ENST00000561554 ENST00000566491 ENST00000564517
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB208977.1 AK130784.1 AK223057.1 AK291117.1 AK291859.1 BC001365.2 BC002450.1 BC005817.2 
    BC007748.2 BC007996.1 BC009888.2 BC010151.2 BC014653.1 BC018840.2 BC040610.1 BC066925.1 
    BC095427.1 D23660.1 L20868.2 

    24/159 DOTS entries (see all 159):

    DT.100743615  DT.100743679  DT.80101635  DT.100743721  DT.95377953  DT.95378147  DT.100743611  DT.92324759 
    DT.91912327  DT.65286226  DT.100853932  DT.100743603  DT.92472330  DT.100054121  DT.100743576  DT.92472452 
    DT.92472329  DT.87001093  DT.92472397  DT.97846736  DT.91643443  DT.100638207  DT.121047748  DT.100743720 

    24/108 AceView cDNA sequences (see all 108):

    BC009888 NM_000968 CR594668 CR603779 CR590389 CR592916 CR626053 CR609569 
    CR619311 CR623016 BC007748 CR598274 AK125772 CR600936 CR617296 CR615745 
    CR613835 CR619821 CR593700 CR604273 CR611824 CR624900 CR596594 CR597698 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:              -           -     -     -                       -                                                                                       
    SP2:                                                                                                  -                                                   
    SP3:              -                 -     -     -                                                                                                         
    SP4:              -                                               -                                                                                       
    SP5:                                -     -     -                                                                                                         


    ECgene alternative splicing isoforms for RPL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCGGAACA
    RPL4 Expression
    About this image


    See RPL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL4

    SOURCE GeneReport for Unigene clusters: Hs.186350 Hs.644628
        SABiosciences Custom PCR Arrays for RPL4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL4 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl41 , 5 ribosomal protein L41, 5 87.98(n)1
    94.71(a)1
      9 (34.54 cM)5
    678911  NM_024212.41  NP_077174.11 
     641733875 
    chicken
    (Gallus gallus)
    Aves RPL41 ribosomal protein L4 75.86(n)
    83.21(a)
      415551  NM_001007479.1  NP_001007480.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL46
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL343467.1(140755-148348)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643182 ribosomal protein 79.7(n)    BC041744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97a022 Danio rerio cDNA clone MGC56659 IMAGE5916329, complete more 79.13(n)    BC049520.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL13
    RpL41
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein L41
    62(a)3
    60.84(n)1
    66.07(a)1
      98B63
    433491  NM_079814.21  NP_524538.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-41 , 3 ribosomal protein L13
    Protein RPL-41
    58(a)3
    57.49(n)1
    58.68(a)1
      I(4645738-4646958)3
    1720741  NM_059015.31  NP_491416.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL4A(YBR031W)4 N-terminally acetylated protein component of the large more   --   2(300166-301254) 852319  NP_009587.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G096301 60S ribosomal protein L4-1 55.76(n)
    57.91(a)
      820120  NM_111797.2  NP_187574.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87672 Oryza sativa (japonica cultivar-group) putative 60S more 71.02(n)    NM_185075.1 


    ENSEMBL Gene Tree for RPL4 (if available)
    TreeFam Gene Tree for RPL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL4 gene

    RPL4 for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for RPL4 (see all 10)
    PGOHUM00000248054 PGOHUM00000244334 PGOHUM00000245066 PGOHUM00000263073 PGOHUM00000246349


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/35 SNPs in RPL4 are shown (see all 35)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454585531,2
    --66792206(+) AAATAC/TAAAAA 1 -- int10--------
    rs1403080091,2
    C--66792218(+) TAGCCA/GGACAT 1 -- int10--------
    rs1890643851,2
    --66792233(+) GCGTGC/TGCCTG 1 -- int10--------
    rs354358141,2
    C,F--66792317(+) GATCAA/C/TGCCAT 1 -- int14NA NS 146
    rs1920881131,2
    --66792322(+) CGCCAC/TTGCAC 1 -- int10--------
    rs1127311821,2
    C--66792517(+) TTGCTA/TTAAAA 1 -- int10--------
    rs727524141,2
    C,F--66792590(+) ATAGTA/GTAGGG 1 -- int11Minor allele frequency- G:0.02NS 140
    rs1115855481,2
    C--66792630(+) CTTTAC/GCGTGG 1 -- spd10--------
    rs787044181,2
    C,F--66792738(+) ACATGT/CACATG 1 -- int12Minor allele frequency- C:0.02WA NS 258
    rs287069381,2
    C,F--66792761(+) ACCAAA/GGAACA 1 -- int17Minor allele frequency- G:0.34NA WA EA NS 494

    HapMap Linkage Disequilibrium report for RPL4 (66790355 - 66816870 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPL4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL4
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180479    OMIM disorders: --

    11 diseases for RPL4:    About MalaCards
    cat-scratch disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma    pneumonia
    influenza    colon cancer    ovarian cancer    prostate cancer
    alzheimer's disease    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RPL4:
    cat-scratch disease

    RPL4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for RPL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 9724090 (1)


    Export disorders for RPL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL4 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with RPL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PubMed id 8268230)1, 2, 3, 9 Bagni C.... Amaldi F. (1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2 Jaekel S.... Goerlich D. (2002)
    4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    5. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    7. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (2013)
    8. Autophagy negatively regulates cancer cell proliferati on via selectively targeting VPRBP. (PubMed id 22963397)1 Wang B.S....Wang M.R. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6124 HGNC: 10353 AceView: RPL4 Ensembl:ENSG00000174444 euGenes: HUgn6124
    ECgene: RPL4 Kegg: 6124 H-InvDB: RPL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL4 gene:
    Search GeneIP for patents involving RPL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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