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RPL4 Gene

protein-coding   GIFtS: 62
GCID: GC15M066790

Ribosomal Protein L4

  See RPL4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L41 2
60S Ribosomal Protein L41 2
60S Ribosomal Protein L12 3
L42
RPL13

External Ids:    HGNC: 103531   Entrez Gene: 61242   Ensembl: ENSG000001744447   OMIM: 1804795   UniProtKB: P365783   

Export aliases for RPL4 gene to outside databases

Previous GC identifers: GC15M062584 GC15M059890 GC15M064370 GC15M064507 GC15M064578 GC15M043627


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL4 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of
ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there
are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL4 Gene:
RPL4 (ribosomal protein L4) is a protein-coding gene. Diseases associated with RPL4 include cat-scratch disease. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL4 (Ribosomal protein L4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL4 gene promoter:
         TBP   FOXF2   TFIID   Meis-1a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL4 promoter sequence
   Search Chromatin IP Primers for RPL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22

RPL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M066790:  view genomic region     (about GC identifiers)

Start:
66,790,355 bp from pter      End:
66,816,870 bp from pter
Size:
26,516 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL4_HUMAN, P36578 (See protein sequence)
Recommended Name: 60S ribosomal protein L4  
Size: 427 amino acids; 47697 Da
Subunit: May bind IPO9 with low affinity. Interacts with RBM3 (By similarity)
1 PDB 3D structure from and Proteopedia for RPL4:
3J3B (3D)    
Secondary accessions: A8K502 P39029 Q4VBR0 Q969Z9

Explore the universe of human proteins at neXtProt for RPL4: NX_P36578

Explore proteomics data for RPL4 at MOPED

Post-translational modifications: 

  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys14, Lys20, Lys29, Lys46, Lys106, Lys140, Lys157, Lys162, Lys165, Lys175,
                                 Lys219, Lys234, Lys239, Lys259, Lys274, Lys283, Lys294, Lys320, Lys327, Lys333 (see all 22)
  • Modification sites at PhosphoSitePlus

  • See RPL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000959.2  
    ENSEMBL proteins: 
     ENSP00000311430   ENSP00000454281   ENSP00000457442   ENSP00000457268  
    Reactome Protein details: P36578

    RPL4 Human Recombinant Protein Products:

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    Novus Biologicals RPL4 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL4

     
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    Search eBioscience for ELISAs for RPL4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    4 InterPro protein domains:
     IPR025755 Ribos_L4_C_dom
     IPR023574 Ribosomal_L4_dom
     IPR002136 Ribosomal_L4/L1e
     IPR013000 Ribosomal_L4/L1e_euk/arc_CS

    Graphical View of Domain Structure for InterPro Entry P36578

    ProtoNet protein and cluster: P36578

    1 Blocks protein domain: IPB002136 Ribosomal protein L4/L1e

    UniProtKB/Swiss-Prot: RL4_HUMAN, P36578
    Similarity: Belongs to the ribosomal protein L4P family


    Find genes that share domains with RPL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL4:
    60S ribosomal protein L4

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8268230
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPL4           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL4:
     Decreased cell number, increas  Increased Salmonella enterica   Nuclear 60S biogenesis defects  Nuclear pre-40S maturation def 
     S arrest  Synthetic lethal with Ras 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL4

    miRNA
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    miRTarBase miRNAs that target RPL4:
    hsa-mir-330-5p (MIRT038237), hsa-mir-1180-3p (MIRT035943), hsa-mir-186-5p (MIRT045063), hsa-mir-423-3p (MIRT042484), hsa-let-7a-5p (MIRT052435), hsa-mir-16-5p (MIRT031387), hsa-mir-1260b (MIRT052730), hsa-mir-454-3p (MIRT039230), hsa-mir-1237-3p (MIRT036248), hsa-mir-744-5p (MIRT037542), hsa-mir-324-3p (MIRT042914), hsa-mir-652-3p (MIRT039546)

    Block miRNA regulation of human, mouse, rat RPL4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPL4:
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    Gene Editing
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----

    Find genes that share ontologies with RPL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL4 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with RPL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL4
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPL4
        TNF-alpha/NF-kB Signaling Pathway
    Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL4 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL4):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL4
    Interactions:

        Search GeneGlobe Interaction Network for RPL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL4 (P365781, 2, 3 ENSP000003114304) via UniProtKB, MINT, STRING, and/or I2D (see all 1248)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404252, 3, ENSP000004039484MINT-62673 MINT-62575 MINT-62749 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62673 MINT-62575 MINT-62749 I2D: score=4 STRING: ENSP00000397177
    ENSG00000206315P404252, 3MINT-62673 MINT-62575 MINT-62749 I2D: score=4 
    ENSG00000224952P404252, 3MINT-62673 MINT-62575 MINT-62749 I2D: score=4 
    ENSG00000232005P404252, 3MINT-62673 MINT-62575 MINT-62749 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL4 (RL4)

    2 Novoseek inferred chemical compound relationships for RPL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythromycin 64.4 6 15561835 (2), 19197244 (1), 2256953 (1)
    azithromycin 56.7 1 17110371 (1)



    Find genes that share compounds with RPL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPL4 gene: 
    NM_000968.3  

    Unigene Clusters for RPL4:

    Ribosomal protein L4
    Hs.186350  [show with all ESTs], Hs.644628  [show with all ESTs]
    Unigene Representative Sequences: AK125772, BC002450
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307961(uc002apv.3) ENST00000567229 ENST00000565723 ENST00000568588(uc002apx.3)
    ENST00000561775 ENST00000569696 ENST00000564744 ENST00000564647 ENST00000563473
    ENST00000566039(uc010ujq.2) ENST00000564439 ENST00000566622 ENST00000569438
    ENST00000566624 ENST00000561554 ENST00000566491 ENST00000564517
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RPL4:
    hsa-miR-4272
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    GenScript: all cDNA clones in your preferred vector: RPL4 (NM_004927)
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    Primer
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    OriGene qPCR primer pairs and template standards for RPL4
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL4
      QuantiFast Probe-based Assays in human, mouse, rat RPL4

    Additional mRNA sequence: 

    AB208977.1 AK130784.1 AK223057.1 AK291117.1 AK291859.1 BC001365.2 BC002450.1 BC005817.2 
    BC007748.2 BC007996.1 BC009888.2 BC010151.2 BC014653.1 BC018840.2 BC040610.1 BC066925.1 
    BC095427.1 D23660.1 L20868.2 

    Selected DOTS entries (see all 159):

    DT.100743615  DT.100743679  DT.80101635  DT.100743721  DT.95377953  DT.95378147  DT.100743611  DT.92324759 
    DT.91912327  DT.65286226  DT.100853932  DT.100743603  DT.92472330  DT.100054121  DT.100743576  DT.92472452 
    DT.92472329  DT.87001093  DT.92472397  DT.97846736  DT.91643443  DT.100638207  DT.121047748  DT.100743720 

    Selected AceView cDNA sequences (see all 108):

    CR590199 CR623277 CR619787 CR624303 CR619963 CR611824 CR618330 BC005817 
    CR598818 CR605656 BC040610 CR604722 CR600624 CR598597 CR611893 CR593486 
    BC014653 CR592894 CR608966 CR606932 CR617258 CR600001 CR593926 CR599223 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:              -           -     -     -                       -                                                                                       
    SP2:                                                                                                  -                                                   
    SP3:              -                 -     -     -                                                                                                         
    SP4:              -                                               -                                                                                       
    SP5:                                -     -     -                                                                                                         


    ECgene alternative splicing isoforms for RPL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCGGAACA
    RPL4 Expression
    About this image


    RPL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RPL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL4 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.186350 Hs.644628
        Custom PCR Arrays for RPL4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL4 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl41 , 5 ribosomal protein L41, 5 85.52(n)1
    92.12(a)1
      9 (34.54 cM)5
    678911  NM_024212.41  NP_077174.11 
     641733875 
    chicken
    (Gallus gallus)
    Aves RPL41 ribosomal protein L4 80.73(n)
    90.14(a)
      415551  NM_001007479.1  NP_001007480.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL46
    ribosomal protein L4
    95(a)
    1 ↔ 1
    GL343467.1(140755-148348)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643182 ribosomal protein 79.7(n)    BC041744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97a022 Danio rerio cDNA clone MGC56659 IMAGE5916329, complete more 79.13(n)    BC049520.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL13
    RpL41
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein L41
    62(a)3
    61.88(n)1
    68.91(a)1
      98B63
    433491  NM_079814.31  NP_524538.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-41 , 3 ribosomal protein L13
    rpl-41
    58(a)3
    58.59(n)1
    60.3(a)1
      I(4645738-4646958)3
    1720741  NM_059015.41  NP_491416.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL4A(YBR031W)4
    RPL4A1
    N-terminally acetylated protein component of the large more4
    RPL4A1
    60.59(n)1
    61.7(a)1
      2(300166-301254)4
    8523191, 4  NP_009587.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G096301 AT3G09630 57.48(n)
    60.23(a)
      820120  NM_001035586.1  NP_001030663.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87672 Oryza sativa (japonica cultivar-group) putative 60S more 71.02(n)    NM_185075.1 


    ENSEMBL Gene Tree for RPL4 (if available)
    TreeFam Gene Tree for RPL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL4 gene

    Find genes that share paralogs with RPL4           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPL4 (see all 10)
    PGOHUM00000248054 PGOHUM00000244334 PGOHUM00000245066 PGOHUM00000263073 PGOHUM00000246349


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RPL4 (see all 35)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454585531,2
    --66792206(+) AAATAC/TAAAAA 1 -- int10--------
    rs1403080091,2
    C--66792218(+) TAGCCA/GGACAT 1 -- int10--------
    rs1890643851,2
    --66792233(+) GCGTGC/TGCCTG 1 -- int10--------
    rs354358141,2
    C,F--66792317(+) GATCAA/C/TGCCAT 1 -- int14NA NS 146
    rs1920881131,2
    --66792322(+) CGCCAC/TTGCAC 1 -- int10--------
    rs1127311821,2
    C--66792517(+) TTGCTA/TTAAAA 1 -- int10--------
    rs727524141,2
    C,F--66792590(+) ATAGTA/GTAGGG 1 -- int11Minor allele frequency- G:0.02NS 140
    rs1115855481,2
    C--66792630(+) CTTTAC/GCGTGG 1 -- spd10--------
    rs787044181,2
    C,F--66792738(+) ACATGT/CACATG 1 -- int12Minor allele frequency- C:0.02WA NS 258
    rs287069381,2
    C,F--66792761(+) ACCAAA/GGAACA 1 -- int17Minor allele frequency- G:0.34NA WA EA NS 494

    HapMap Linkage Disequilibrium report for RPL4 (66790355 - 66816870 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPL4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL4
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180479    OMIM disorders: --

    1 disease for RPL4:    
    About MalaCards
    cat-scratch disease

    1 disease from the University of Copenhagen DISEASES database for RPL4:
    cat-scratch disease

    Find genes that share disorders with RPL4           About GenesLikeMe

    1 Novoseek inferred disease relationship for RPL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 9724090 (1)


    Export disorders for RPL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL4 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with RPL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PubMed id 8268230)1, 2, 3, 9 Bagni C.... Amaldi F. (Biochim. Biophys. Acta 1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2 Jaekel S.... Goerlich D. (EMBO J. 2002)
    4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    5. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    8. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. (PubMed id 22963397)1 Wang B.S....Wang M.R. (Clin. Sci. 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6124 HGNC: 10353 AceView: RPL4 Ensembl:ENSG00000174444 euGenes: HUgn6124
    ECgene: RPL4 Kegg: 6124 H-InvDB: RPL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RPL4 gene:
    Search GeneIP for patents involving RPL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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