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Aliases for RPL3L Gene

Aliases for RPL3L Gene

  • Ribosomal Protein L3 Like 2 3 5
  • Ribosomal Protein L3-Like 2

External Ids for RPL3L Gene

Previous GeneCards Identifiers for RPL3L Gene

  • GC16M002011
  • GC16M001934
  • GC16M001919
  • GC16M001993

Summaries for RPL3L Gene

Entrez Gene Summary for RPL3L Gene

  • This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL3L Gene

RPL3L (Ribosomal Protein L3 Like) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL3L Gene

Genomics for RPL3L Gene

Regulatory Elements for RPL3L Gene

Enhancers for RPL3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001953 1.3 Ensembl ENCODE 25.6 +3.1 3057 1.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000255513 RPL3L ENSG00000261123 ENSG00000260646 LOC105371049 MSRB1
GH16F001958 1.2 ENCODE 24.1 -2.8 -2833 3.2 HDGF ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000255513 SNHG9 RPL3L ENSG00000260954 TMEM204 ENSG00000260646 ENSG00000261505 ZNF598 SNHG19 TPSG1
GH16F001962 1.2 ENCODE 23.8 -6.6 -6616 4.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS ENSG00000255513 SNHG9 RPL3L ENSG00000261505 LOC105371055 TRAF7 ENSG00000226890 ENSG00000200059 ENSG00000261240 PRSS29P
GH16F001863 0.7 ENCODE 12.2 +93.7 93712 0.2 CTCF ZNF654 KLF4 REST RAD21 RFX5 ZNF121 ZFHX2 GLIS1 KLF9 HS3ST6 MEIOB MSRB1 RPL3L NDUFB10 SYNGR3 GC16M001851 LOC102723890
GH16F001978 0.7 ENCODE 11.9 -22.0 -21977 1.8 CTCF GTF2F1 MAX ZIC2 YY1 E2F1 HIC1 ZFHX2 POLR2A SCRT2 ENSG00000255513 NDUFB10 RPL3L MSRB1 GFER TBL3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL3L on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL3L Gene

1,943,974 bp from pter
1,957,606 bp from pter
13,633 bases
Minus strand

Genomic View for RPL3L Gene

Genes around RPL3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL3L Gene

Proteins for RPL3L Gene

  • Protein details for RPL3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L3-like
    Protein Accession:

    Protein attributes for RPL3L Gene

    407 amino acids
    Molecular mass:
    46296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL3L Gene

Post-translational modifications for RPL3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL3L Gene

Domains & Families for RPL3L Gene

Gene Families for RPL3L Gene

Protein Domains for RPL3L Gene

Suggested Antigen Peptide Sequences for RPL3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L3P family.
  • Belongs to the ribosomal protein L3P family.
genes like me logo Genes that share domains with RPL3L: view

Function for RPL3L Gene

Molecular function for RPL3L Gene

GENATLAS Biochemistry:
60S ribosomal protein 3-like,46kDa

Gene Ontology (GO) - Molecular Function for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8921388
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL3L: view
genes like me logo Genes that share phenotypes with RPL3L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL3L Gene

Localization for RPL3L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL3L gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,TAS 8921388
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL3L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL3L Gene

Pathways & Interactions for RPL3L Gene

genes like me logo Genes that share pathways with RPL3L: view

Pathways by source for RPL3L Gene

Gene Ontology (GO) - Biological Process for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL3L: view

No data available for SIGNOR curated interactions for RPL3L Gene

Transcripts for RPL3L Gene

mRNA/cDNA for RPL3L Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL3L Gene

Ribosomal protein L3-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL3L Gene

No ASD Table

Relevant External Links for RPL3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL3L Gene

This gene is overexpressed in Muscle - Skeletal (x32.3) and Heart - Left Ventricle (x16.1).

Protein differential expression in normal tissues from HIPED for RPL3L Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL3L Gene

Protein tissue co-expression partners for RPL3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL3L Gene:


SOURCE GeneReport for Unigene cluster for RPL3L Gene:

genes like me logo Genes that share expression patterns with RPL3L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RPL3L Gene

Orthologs for RPL3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL3L 34 35
  • 99.18 (n)
(Bos Taurus)
Mammalia RPL3L 34 35
  • 91.73 (n)
(Monodelphis domestica)
Mammalia RPL3L 35
  • 90 (a)
(Canis familiaris)
Mammalia RPL3L 34
  • 88.94 (n)
RPL3 35
  • 77 (a)
(Mus musculus)
Mammalia Rpl3l 34 16 35
  • 87.71 (n)
(Rattus norvegicus)
Mammalia Rpl3l 34
  • 87.31 (n)
(Ornithorhynchus anatinus)
Mammalia RPL3L 35
  • 83 (a)
(Gallus gallus)
Aves RPL3L 34 35
  • 76.99 (n)
(Anolis carolinensis)
Reptilia RPL3L 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl3l 34
  • 76.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL3 36 35
  • 69 (a)
(Caenorhabditis elegans)
Secernentea rpl-3 35
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL3 35
  • 64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 68 (a)
Species where no ortholog for RPL3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPL3L Gene

Gene Tree for RPL3L (if available)
Gene Tree for RPL3L (if available)

Paralogs for RPL3L Gene

Paralogs for RPL3L Gene

(2) SIMAP similar genes for RPL3L Gene using alignment to 2 proteins: Pseudogenes for RPL3L Gene

genes like me logo Genes that share paralogs with RPL3L: view

Variants for RPL3L Gene

Sequence variations from dbSNP and Humsavar for RPL3L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1003904 -- 1,946,074(+) ATCAC(A/G)CCGCC intron-variant
rs111324377 -- 1,948,707(+) TTTTT(G/T)TTTGT intron-variant
rs111510874 -- 1,948,918(+) ACCGC(A/G)TTAGC intron-variant
rs111557422 -- 1,945,122(+) AGGCC(A/G)AGGCG intron-variant, upstream-variant-2KB
rs111684488 -- 1,944,380(+) CCACC(A/G)CCCAG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL3L Gene

Variant ID Type Subtype PubMed ID
nsv952901 CNV deletion 24416366
nsv833120 CNV loss 17160897
nsv571179 CNV loss 21841781
nsv571178 CNV loss 21841781
nsv519366 CNV loss 19592680
nsv471070 CNV gain 18288195
nsv1125113 CNV deletion 24896259
esv3637627 CNV loss 21293372
esv3553005 CNV deletion 23714750
esv2422427 CNV duplication 17116639
esv1003583 CNV deletion 20482838

Variation tolerance for RPL3L Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL3L Gene

Disorders for RPL3L Gene

Relevant External Links for RPL3L

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL3L Gene

Publications for RPL3L Gene

  1. A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region. (PMID: 8921388) van Raay T.J. … Burn T.C. (Genomics 1996) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for RPL3L Gene

Sources for RPL3L Gene

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