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Aliases for RPL3L Gene

Aliases for RPL3L Gene

  • Ribosomal Protein L3-Like 2 3

External Ids for RPL3L Gene

Previous GeneCards Identifiers for RPL3L Gene

  • GC16M002011
  • GC16M001934
  • GC16M001919
  • GC16M001993

Summaries for RPL3L Gene

Entrez Gene Summary for RPL3L Gene

  • This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL3L Gene

RPL3L (Ribosomal Protein L3-Like) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL3L Gene

Genomics for RPL3L Gene

Regulatory Elements for RPL3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL3L Gene

1,943,974 bp from pter
1,957,606 bp from pter
13,633 bases
Minus strand

Genomic View for RPL3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL3L Gene

Proteins for RPL3L Gene

  • Protein details for RPL3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L3-like
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RPL3L Gene

    407 amino acids
    Molecular mass:
    46296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL3L Gene

Proteomics data for RPL3L Gene at MOPED

Post-translational modifications for RPL3L Gene

  • Ubiquitination at Lys250 and Lys373
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL3L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL3L Gene

Domains for RPL3L Gene

Gene Families for RPL3L Gene

  • RPL :L ribosomal proteins

Protein Domains for RPL3L Gene

Suggested Antigen Peptide Sequences for RPL3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92901
  • Belongs to the ribosomal protein L3P family.
genes like me logo Genes that share domains with RPL3L: view

Function for RPL3L Gene

Molecular function for RPL3L Gene

GENATLAS Biochemistry:
60S ribosomal protein 3-like,46kDa

Gene Ontology (GO) - Molecular Function for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8921388
GO:0003735 structural constituent of ribosome NAS 12962325
genes like me logo Genes that share ontologies with RPL3L: view

Phenotypes for RPL3L Gene

GenomeRNAi human phenotypes for RPL3L:
genes like me logo Genes that share phenotypes with RPL3L: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL3L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPL3L Gene

Localization for RPL3L Gene

Subcellular locations from

Jensen Localization Image for RPL3L Gene COMPARTMENTS Subcellular localization image for RPL3L gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 8921388
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL3L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL3L Gene

Pathways for RPL3L Gene

genes like me logo Genes that share pathways with RPL3L: view

Pathways by source for RPL3L Gene

1 KEGG pathway for RPL3L Gene

Gene Ontology (GO) - Biological Process for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL3L: view

Transcripts for RPL3L Gene

mRNA/cDNA for RPL3L Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL3L Gene

Ribosomal protein L3-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL3L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL3L Gene

No ASD Table

Relevant External Links for RPL3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL3L Gene

mRNA expression in normal human tissues for RPL3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL3L Gene

This gene is overexpressed in Muscle - Skeletal (32.3) and Heart - Left Ventricle (16.1).

Protein differential expression in normal tissues for RPL3L Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL3L Gene

SOURCE GeneReport for Unigene cluster for RPL3L Gene Hs.657266

genes like me logo Genes that share expressions with RPL3L: view

Expression partners for RPL3L Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RPL3L Gene

Orthologs for RPL3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL3L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL3L 35
  • 91.73 (n)
  • 97.3 (a)
RPL3L 36
  • 97 (a)
(Canis familiaris)
Mammalia RPL3L 35
  • 88.94 (n)
  • 93.12 (a)
RPL3 36
  • 77 (a)
(Mus musculus)
Mammalia Rpl3l 35
  • 87.71 (n)
  • 95.58 (a)
Rpl3l 16
Rpl3l 36
  • 96 (a)
(Pan troglodytes)
Mammalia RPL3L 35
  • 99.18 (n)
  • 99.51 (a)
RPL3L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl3l 35
  • 87.31 (n)
  • 96.56 (a)
(Monodelphis domestica)
Mammalia RPL3L 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia RPL3L 36
  • 83 (a)
(Gallus gallus)
Aves RPL3L 35
  • 76.99 (n)
  • 84.77 (a)
RPL3L 36
  • 84 (a)
(Anolis carolinensis)
Reptilia RPL3L 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl3l 35
  • 76.09 (n)
  • 83.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL3 37
  • 69 (a)
RpL3 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea rpl-3 36
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL3 36
  • 64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
Species with no ortholog for RPL3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPL3L Gene

Gene Tree for RPL3L (if available)
Gene Tree for RPL3L (if available)

Paralogs for RPL3L Gene

Paralogs for RPL3L Gene

Selected SIMAP similar genes for RPL3L Gene using alignment to 2 proteins: Pseudogenes for RPL3L Gene

genes like me logo Genes that share paralogs with RPL3L: view

Variants for RPL3L Gene

Sequence variations from dbSNP and Humsavar for RPL3L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs30251 -- 1,955,828(+) aggca(C/T)gagcc upstream-variant-2KB
rs30252 -- 1,955,981(+) tgtgt(C/T)ttgtt upstream-variant-2KB
rs30253 -- 1,955,997(+) ggcgg(A/G)cgtct upstream-variant-2KB
rs30254 -- 1,956,098(+) cacag(C/T)acctg upstream-variant-2KB
rs338777 -- 1,951,535(+) GCCAC(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL3L Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
nsv519366 CNV Loss 19592680
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
nsv905053 CNV Gain 21882294
dgv2546n71 CNV Loss 21882294
nsv905055 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
esv1003583 CNV Deletion 20482838

Relevant External Links for RPL3L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL3L Gene

Disorders for RPL3L Gene

Relevant External Links for RPL3L

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RPL3L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RPL3L Gene

Publications for RPL3L Gene

  1. A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region. (PMID: 8921388) van Raay T.J. … Burn T.C. (Genomics 1996) 2 3 4 23
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for RPL3L Gene

Sources for RPL3L Gene

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