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Aliases for RPL3L Gene

Aliases for RPL3L Gene

  • Ribosomal Protein L3 Like 2 3 5
  • Large Ribosomal Subunit Protein UL3-Like 4
  • Ribosomal Protein L3-Like 2

External Ids for RPL3L Gene

Previous GeneCards Identifiers for RPL3L Gene

  • GC16M002011
  • GC16M001934
  • GC16M001919
  • GC16M001993

Summaries for RPL3L Gene

Entrez Gene Summary for RPL3L Gene

  • This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL3L Gene

RPL3L (Ribosomal Protein L3 Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL3.

Additional gene information for RPL3L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL3L Gene

Genomics for RPL3L Gene

Regulatory Elements for RPL3L Gene

Enhancers for RPL3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001962 1.4 Ensembl ENCODE 23.8 -6.6 -6616 4.1 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ENSG00000255513 ENSG00000261505 ENSG00000260051 TELO2 E4F1 UNKL TSC2 SNHG9 CRAMP1 SRRM2
GH16H001958 1.1 ENCODE 24.1 -2.8 -2833 3.2 HNRNPUL1 HDGF ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000255513 SNHG9 ENSG00000261505 RPL3L SRRM2 ENSG00000260051 TELO2 TSC2 E4F1 NUBP2
GH16H001953 0.7 ENCODE dbSUPER 25.5 +3.1 3057 1.6 ZBTB33 KDM1A BCL11B ENSG00000255513 RPL3L MSRB1
GH16H001976 1.3 Ensembl ENCODE dbSUPER 12 -21.7 -21702 4.9 GTF2F1 FUS MAX EBF1 E2F1 ZFHX2 POLR2A ATF7 KLF8 DEK CRAMP1 UNKL UBE2I TELO2 TSC2 ENSG00000255513 E4F1 RPL3L MSRB1 ENSG00000261207
GH16H001900 0.7 ENCODE 11.6 +57.3 57282 0.2 TFAP4 PKNOX1 ZNF687 SAP130 RNF2 SIN3A MNT ZNF592 FOXA1 ZNF121 FAHD1 HS3ST6 MSRB1 RPL3L NDUFB10 PIR49138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL3L on UCSC Golden Path with GeneCards custom track

Genomic Locations for RPL3L Gene

Genomic Locations for RPL3L Gene
13,633 bases
Minus strand

Genomic View for RPL3L Gene

Genes around RPL3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL3L Gene

Proteins for RPL3L Gene

  • Protein details for RPL3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L3-like
    Protein Accession:

    Protein attributes for RPL3L Gene

    407 amino acids
    Molecular mass:
    46296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL3L Gene

Post-translational modifications for RPL3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL3L Gene

Domains & Families for RPL3L Gene

Gene Families for RPL3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL3L Gene

Suggested Antigen Peptide Sequences for RPL3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL3 family.
  • Belongs to the universal ribosomal protein uL3 family.
genes like me logo Genes that share domains with RPL3L: view

Function for RPL3L Gene

Molecular function for RPL3L Gene

GENATLAS Biochemistry:
60S ribosomal protein 3-like,46kDa

Gene Ontology (GO) - Molecular Function for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8921388
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL3L: view
genes like me logo Genes that share phenotypes with RPL3L: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL3L Gene

Localization for RPL3L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL3L gene
Compartment Confidence
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome TAS,IEA 8921388
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL3L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL3L Gene

Pathways & Interactions for RPL3L Gene

genes like me logo Genes that share pathways with RPL3L: view

Pathways by source for RPL3L Gene

Gene Ontology (GO) - Biological Process for RPL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL3L: view

No data available for SIGNOR curated interactions for RPL3L Gene

Drugs & Compounds for RPL3L Gene

No Compound Related Data Available

Transcripts for RPL3L Gene

mRNA/cDNA for RPL3L Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL3L Gene

Ribosomal protein L3-like:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL3L Gene

No ASD Table

Relevant External Links for RPL3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL3L Gene

This gene is overexpressed in Muscle - Skeletal (x32.3) and Heart - Left Ventricle (x16.1).

Protein differential expression in normal tissues from HIPED for RPL3L Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL3L Gene

Protein tissue co-expression partners for RPL3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL3L Gene:


SOURCE GeneReport for Unigene cluster for RPL3L Gene:


Evidence on tissue expression from TISSUES for RPL3L Gene

  • Muscle(4.8)
  • Heart(4.6)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with RPL3L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL3L Gene

Orthologs for RPL3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL3L 33 34
  • 99.18 (n)
(Bos Taurus)
Mammalia RPL3L 33 34
  • 91.73 (n)
(Monodelphis domestica)
Mammalia RPL3L 34
  • 90 (a)
(Canis familiaris)
Mammalia RPL3L 33
  • 88.94 (n)
RPL3 34
  • 77 (a)
(Mus musculus)
Mammalia Rpl3l 33 16 34
  • 87.71 (n)
(Rattus norvegicus)
Mammalia Rpl3l 33
  • 87.31 (n)
(Ornithorhynchus anatinus)
Mammalia RPL3L 34
  • 83 (a)
(Gallus gallus)
Aves RPL3L 33 34
  • 76.99 (n)
(Anolis carolinensis)
Reptilia RPL3L 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl3l 33
  • 76.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL3 35 34
  • 69 (a)
(Caenorhabditis elegans)
Secernentea rpl-3 34
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL3 34
  • 64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 68 (a)
Species where no ortholog for RPL3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPL3L Gene

Gene Tree for RPL3L (if available)
Gene Tree for RPL3L (if available)

Paralogs for RPL3L Gene

Paralogs for RPL3L Gene

(2) SIMAP similar genes for RPL3L Gene using alignment to 2 proteins: Pseudogenes for RPL3L Gene

genes like me logo Genes that share paralogs with RPL3L: view

Variants for RPL3L Gene

Sequence variations from dbSNP and Humsavar for RPL3L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000011132 -- 1,952,833(+) GTGGT(C/G)CCAGC intron-variant
rs1000252205 -- 1,944,802(+) ACAGT(G/T)CGGTG upstream-variant-2KB, utr-variant-3-prime
rs1000559678 -- 1,957,074(+) AACCC(C/T)GTCTC upstream-variant-2KB
rs1000694775 -- 1,953,443(+) TGCAA(C/T)TCCTG intron-variant
rs1000807983 -- 1,948,161(+) CTGCA(A/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL3L Gene

Variant ID Type Subtype PubMed ID
nsv952901 CNV deletion 24416366
nsv833120 CNV loss 17160897
nsv571179 CNV loss 21841781
nsv571178 CNV loss 21841781
nsv519366 CNV loss 19592680
nsv471070 CNV gain 18288195
nsv1125113 CNV deletion 24896259
esv3637627 CNV loss 21293372
esv3553005 CNV deletion 23714750
esv2422427 CNV duplication 17116639
esv1003583 CNV deletion 20482838

Variation tolerance for RPL3L Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL3L Gene

Disorders for RPL3L Gene

Relevant External Links for RPL3L

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL3L Gene

Publications for RPL3L Gene

  1. A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region. (PMID: 8921388) Van Raay TJ … Burn TC (Genomics 1996) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for RPL3L Gene

Sources for RPL3L Gene

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