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RPL3L Gene

protein-coding   GIFtS: 58
GCID: GC16M001993

Ribosomal Protein L3-Like

  See RPL3L-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L3-Like1 2
60S Ribosomal Protein L3-Like2

External Ids:    HGNC: 103511   Entrez Gene: 61232   Ensembl: ENSG000001409867   UniProtKB: Q929013   

Export aliases for RPL3L gene to outside databases

Previous GC identifers: GC16M002011 GC16M001934 GC16M001919


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL3L Gene:
This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the
L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a
tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is
not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a
function that is independent of the ribosome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL3L Gene:
RPL3L (ribosomal protein L3-like) is a protein-coding gene. Diseases associated with RPL3L include tuberous sclerosis, type 2, and polycystic kidney disease, type 1. GO annotations related to this gene include structural constituent of ribosome and RNA binding. An important paralog of this gene is RPL3.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL3L gene promoter:
         SRF   NF-1/L   NF-1   MAZR   Pax-5   SRF (504 AA)   MyoD   NF-kappaB1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL3L promoter sequence
   Search Chromatin IP Primers for RPL3L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RPL3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL3L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001993:  view genomic region     (about GC identifiers)

Start:
1,993,975 bp from pter      End:
2,007,607 bp from pter
Size:
13,633 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL3L_HUMAN, Q92901 (See protein sequence)
Recommended Name: 60S ribosomal protein L3-like  
Size: 407 amino acids; 46296 Da

Explore the universe of human proteins at neXtProt for RPL3L: NX_Q92901

Explore proteomics data for RPL3L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys250, Lys373
  • Modification sites at PhosphoSitePlus

  • See RPL3L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005052.1  
    ENSEMBL proteins: 
     ENSP00000268661   ENSP00000455856  
    Reactome Protein details: Q92901

    RPL3L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR019926 Ribosomal_L3_CS
     IPR000597 Ribosomal_L3
     IPR009000 Transl_B-barrel

    Graphical View of Domain Structure for InterPro Entry Q92901

    ProtoNet protein and cluster: Q92901

    1 Blocks protein domain: IPB000597 Ribosomal protein L3

    UniProtKB/Swiss-Prot: RL3L_HUMAN, Q92901
    Similarity: Belongs to the ribosomal protein L3P family


    Find genes that share domains with RPL3L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL3L:
    60S ribosomal protein 3-like,46kDa

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8921388
    GO:0003735structural constituent of ribosome NAS12962325
         
    Find genes that share ontologies with RPL3L           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RPL3L:
     Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL3L
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome TAS8921388
    GO:0022625cytosolic large ribosomal subunit IDA12962325

    Find genes that share ontologies with RPL3L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL3L About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    Cytoplasmic Ribosomal Proteins0.60
    Ribosome0.54
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease


    Find genes that share SuperPaths with RPL3L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RPL3L
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL3L (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL3L):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL3L
    Interactions:

        Search GeneGlobe Interaction Network for RPL3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL3L (Q929013 ENSP000002686614) via UniProtKB, MINT, STRING, and/or I2D (see all 376)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    G3BP2Q9UN863, ENSP000003527384I2D: score=2 STRING: ENSP00000352738
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    DDOSTENSP000003641884STRING: ENSP00000364188
    EIF2S1ENSP000002563834STRING: ENSP00000256383
    EIF2S2ENSP000003641194STRING: ENSP00000364119
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with RPL3L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL3L (RL3L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPL3L gene: 
    NM_005061.2  

    Unigene Cluster for RPL3L:

    Ribosomal protein L3-like
    Hs.657266  [show with all ESTs]
    Unigene Representative Sequence: BC050413
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268661(uc002cnh.3) ENST00000565426 ENST00000566484
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL3L
      QuantiFast Probe-based Assays in human, mouse, rat RPL3L

    Additional mRNA sequence: 

    AK313162.1 BC050413.1 U65581.1 

    1 DOTS entry:

    DT.112155 

    4 AceView cDNA sequences:

    NM_005061 U65581 CD619728 BC050413 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCTTCCA
    RPL3L Expression
    About this image


    RPL3L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Heart (Cardiovascular System)
    RPL3L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL3L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657266
        Custom PCR Arrays for RPL3L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPL3L gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl3l1 , 5 ribosomal protein L3-like1, 5 87.71(n)1
    95.58(a)1
      17 (12.52 cM)5
    662111  NM_001163945.11  NP_001157417.11 
     247278205 
    chicken
    (Gallus gallus)
    Aves RPL3L1 ribosomal protein L3-like 76.99(n)
    84.77(a)
      416542  NM_001277559.1  NP_001264488.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL3L6
    ribosomal protein L3-like
    83(a)
    1 ↔ 1
    GL343650.1(223955-243708)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rpl3l1 ribosomal protein L3-like 76.09(n)
    83.54(a)
      595000  NM_001030441.1  NP_001025612.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL33 protein biosynthesis structural
    constituent of more
    69(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-36
    Protein RPL-3, isoform a (rpl-3) mRNA, complete cd...
    66(a)
    1 → many
    III(3867852-3869546) WBGene00004414
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL36
    Protein component of the large (60S) ribosomal sub...
    64(a)
    1 → many
    XV(444686-445849) YOR063W


    ENSEMBL Gene Tree for RPL3L (if available)
    TreeFam Gene Tree for RPL3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL3L gene
    RPL32  
    2 SIMAP similar genes for RPL3L using alignment to 2 protein entries:     RL3L_HUMAN (see all proteins):
    rpl3    RPL3

    Find genes that share paralogs with RPL3L           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RPL3L
    PGOHUM00000248181 PGOHUM00000235967


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL3L (see all 491)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433591611,2
    --1930867(+) AACTCC/TTGACC 1 -- us2k10--------
    rs1885029171,2
    --1930876(+) CCTCAG/TGTGAT 1 -- us2k10--------
    rs1387811911,2
    C--1930887(+) CCACCC/TGCCTC 1 -- us2k11Minor allele frequency- T:0.01NS 132
    rs1816374441,2
    --1930918(+) TTACAA/GGTGTG 1 -- us2k10--------
    rs1403911101,2
    --1930932(+) CACCCC/TGCCCA 1 -- us2k10--------
    rs1498785291,2
    --1930936(+) CCGCCC/TAGCCA 1 -- us2k10--------
    rs734960101,2
    C,F--1930996(+) CATCTC/TTAAGA 1 -- us2k13Minor allele frequency- T:0.14WA NS 252
    rs1160012521,2
    C,F--1931014(+) TTCTTA/CCATCA 1 -- us2k13Minor allele frequency- C:0.04WA NA NS 370
    rs673694901,2
    C,F--1931021(+) ATCAAT/CAGATA 1 -- us2k16Minor allele frequency- C:0.04NA WA NS 376
    rs1156260401,2
    C,F--1931050(+) AAAATG/ATCAAG 1 -- us2k12Minor allele frequency- A:0.01WA NS 250

    HapMap Linkage Disequilibrium report for RPL3L (1993975 - 2007607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPL3L (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003583CNV Deletion20482838
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905048CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2540n71CNV Loss21882294
    nsv905061CNV Loss21882294
    dgv2547n71CNV Loss21882294
    nsv833120CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL3L
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for RPL3L:    
    About MalaCards
    tuberous sclerosis, type 2    polycystic kidney disease, type 1


    Find genes that share disorders with RPL3L           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: RPL3L (1 document)

    Export disorders for RPL3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL3L gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RPL3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region. (PubMed id 8921388)1, 2, 3, 9 van Raay T.J.... Burn T.C. (Genomics 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6123 HGNC: 10351 AceView: RPL3L Ensembl:ENSG00000140986 euGenes: HUgn6123
    ECgene: RPL3L Kegg: 6123 H-InvDB: RPL3L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL3L gene:
    Search GeneIP for patents involving RPL3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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