RPL3L Gene
protein-coding GIFtS: 55
GCID: GC16M001993
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ribosomal protein L3-like
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Aliases
for RPL3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein L3-Like1 2 | | 60S Ribosomal Protein L3-Like2 |
Export aliases for RPL3L gene to outside databasesPrevious GC identifers: GC16M002011 GC16M001934 GC16M001919 |
Summaries
for RPL3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPL3L:
This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3Pfamily of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has atissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is notcurrently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a functionthat is independent of the ribosome. (provided by RefSeq, Jul 2008)
|
Genomic Views
for RPL3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPL3L gene promoter:
SRF NF-1/L NF-1 MAZR Pax-5 SRF (504 AA) MyoD NF-kappaB1 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3RPL3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M001993: view genomic region
(about GC identifiers)
Start:
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1,993,975 bp from pter |
End:
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2,007,607 bp from pter |
Size:
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13,633 bases |
Orientation:
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minus strand |
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Proteins
for RPL3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RL3L_HUMAN, Q92901 (See
protein sequence)Recommended Name: 60S ribosomal protein L3-like Size: 407 amino acids; 46296 DaExplore the universe of human proteins at neXtProt for RPL3L: NX_Q92901
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92901
RPL3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005052.1
ENSEMBL proteins: ENSP00000268661 ENSP00000455856 Reactome Protein details: Q92901
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RPL3L for ontologies About GeneDecksing
RPL3L Antibody Products:
Assay Products for RPL3L: |
Protein
Domains /
Families
for RPL3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL3L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92901ProtoNet protein and cluster: Q92901 1 Blocks protein family: IPB000597 Ribosomal protein L3
UniProtKB/Swiss-Prot: RL3L_HUMAN, Q92901Similarity: Belongs to the ribosomal protein L3P family |
Function
for RPL3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for RPL3L:60S ribosomal protein 3-like,46kDa
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL3L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL3L
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Synthesis Service for RPL3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL3L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL3L |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RPL3L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RPL3L:
|
Pathways & Interactions
for RPL3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Disease | | | 4 | Generic Transcription Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for RPL3L
5/28 
Reactome Pathways for RPL3L (see all 28)
1 
Kegg Pathway (Kegg details for RPL3L):
RPL3L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/246 Interacting proteins for RPL3L (Q929013 ENSP000002686614) via UniProtKB, MINT, STRING, and/or I2D (see all 246)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPL3L for ontologies About GeneDecksing
|
Drugs & Compounds
for RPL3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPL3L
Search CenterWatch for drugs/clinical trials and news about RPL3L / RL3L
|
Transcripts
for RPL3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPL3L gene: NM_005061.2 Unigene Cluster for RPL3L: Ribosomal protein L3-like Hs.657266 [show with all ESTs]Unigene Representative Sequence: BC0504133 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268661(uc002cnh.3) ENST00000565426 ENST00000566484
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL3L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPL3L (NM_005061) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL3L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL3L |
Additional cDNA sequence: AK313162.1 BC050413.1 U65581.1 1 DOTS entry: DT.112155 4 AceView cDNA sequences: NM_005061 U65581 CD619728 BC050413
GeneLoc Exon Structure
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Expression
for RPL3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGCTTCCA
About this image
See RPL3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL3L
SOURCE GeneReport for Unigene cluster: Hs.657266
SABiosciences Custom PCR Arrays for RPL3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL3L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPL3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL3L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL3L |
Orthologs
for RPL3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL3L gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for RPL3L (if available)
TreeFam Gene Tree for RPL3L (if available) |
Paralogs
for RPL3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPL3L gene
- RPL32
2 SIMAP similar genes for RPL3L using alignment to 2 protein entries: RL3L_HUMAN (see all proteins):rpl3 RPL3
RPL3L for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RPL3L
PGOHUM00000248181 PGOHUM00000235967
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Genomic Variants
for RPL3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL3L (1993975 - 2007607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RPL3L
3 CNVs: 5329 29656 4917 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL3L |
|
Disorders
/ Diseases
for RPL3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL3L for disorders About GeneDecksing
8  diseases for RPL3L: About MalaCardstuberous sclerosis, type 2 tuberous sclerosis polycystic kidney disease chronic lymphocytic leukemia
lymphocytic leukemia kidney disease leukemia malaria
Human Genome Epidemiology (HuGE) Navigator: RPL3L (1 document)
Export disorders for RPL3L gene to outside databases
|
Publications
for RPL3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL3L gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with RPL3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region. (PubMed id 8921388)1, 2, 3, 9 van Raay T.J.... Burn T.C. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The molecular mechanics of eukaryotic translation. (PubMed id 15189156)1 Kapp L.D. and Lorsch J.R. (2004)
- Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. (PubMed id 14567916)1 Mazumder B....Fox P.L. (2003)
|
External Searches for RPL3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RPL3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPL3L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RPL3L gene:
Search GeneIP for patents involving RPL3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPL3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPL3L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL3L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPL3L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL3L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RPL3L | | OriGene Custom Protein Services for RPL3L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL3L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL3L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL3L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL3L |
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 |  |  |  | |
| | | | Search Tocris compounds for RPL3L |
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 | | | RPL3L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL3L |
|  |  |  | | | | ThermoFisher Antibodies for RPL3L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL3L |
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