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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPL39L Gene

protein-coding GIFtS: 44
GCID: GC03M186839

ribosomal protein L39-like

(Previous name: ribosomal protein L39-like 1 )
(Previous symbol: RPL39L1)

Explore 5 diseases affiliated with
RPL39L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein L39-Like¹ ²		60S Ribosomal Protein L39-Like²
RPL39L1¹ ² ³		L39-2²
Ribosomal Protein L39-Like 1¹ ²		Ribosomal Protein L39-Like Protein²
60S Ribosomal Protein L39-2² ³

External Ids:	HGNC: 17094¹	Entrez Gene: 116832²	Ensembl: ENSG00000163923⁷	OMIM: 607547⁵	UniProtKB: Q96EH5³

Export aliases for RPL39L gene to outside databases

Previous GC identifers: GC03M183636 GC03M188095 GC03M188240 GC03M188159 GC03M188321 GC03M184243

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL39L:

This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene

has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein

L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has

evolved a function that is independent of the ribosome. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for RPL39L
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL39L promoter sequence

Search SABiosciences Chromatin IP Primers for RPL39L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL39L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27.3

RPL39L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL39L gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M186839: view genomic region (about GC identifiers)

Start:	186,838,736 bp from pter	End:	186,898,696 bp from pter
Size:	59,961 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL39L_HUMAN, Q96EH5 (See protein sequence)

Recommended Name: 60S ribosomal protein L39-like

Size: 51 amino acids; 6293 Da

Secondary accessions: Q8IUD0

Explore the universe of human proteins at neXtProt for RPL39L: NX_Q96EH5

RPL39L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443201.1

ENSEMBL proteins:

ENSP00000397240 ENSP00000296277 ENSP00000389356

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0022625	cytosolic large ribosomal subunit	NAS	12490704

RPL39L for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPL39L for domains About GeneDecksing

3 InterPro domains/families:

IPR020083 Ribosomal_L39_CS

IPR000077 Ribosomal_L39

IPR023626 Ribosomal_L39e_dom

Graphical View of Domain Structure for InterPro Entry Q96EH5

ProtoNet protein and cluster: Q96EH5

1 Blocks protein family: IPB000077 Ribosomal protein L39e

UniProtKB/Swiss-Prot: RL39L_HUMAN, Q96EH5

Similarity: Belongs to the ribosomal protein L39e family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003735	structural constituent of ribosome	IEA	--

RPL39L for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RPL39L:

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPL39L

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for RPL39L (ENSP00000296277⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL30	ENSP00000287038⁴	STRING: ENSP00000287038
RPL4	ENSP00000311430⁴	STRING: ENSP00000311430
RPL27A	ENSP00000346015⁴	STRING: ENSP00000346015
RPL5	ENSP00000359345⁴	STRING: ENSP00000359345
SEC61G	ENSP00000341538⁴	STRING: ENSP00000341538

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	IEA	--
GO:0007283	spermatogenesis	IEP	12490704

RPL39L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for RPL39L
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RPL39L gene:

NM_052969.1

Unigene Cluster for RPL39L:

Ribosomal protein L39-like

Hs.647900 [show with all ESTs]

Unigene Representative Sequence: BQ216858

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455270 ENST00000296277(uc003fre.1) ENST00000433055

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Additional cDNA sequence:

AB063610.1 AF548529.1 BC012328.1 L05096.1

6 DOTS entries:

DT.91667170 DT.120840364 DT.100750125 DT.100807522 DT.99984622 DT.100741480

24/49 AceView cDNA sequences (see all 49):

AW571519 AA460213 BQ219675 AF548529 BU543807 AA603655 BI850392 CR603001

BX281758 BQ430980 L05096 AB063610 BP369804 BE895146 CD251962 NM_052969

BP370857 AA383604 BM461539 BG030062 BG339821 BE875914 BG718891 CD248852

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RPL39L About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:					-

ECgene alternative splicing isoforms for RPL39L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPL39L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RPL39L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPL39L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL39L

SOURCE GeneReport for Unigene cluster: Hs.647900

UniProtKB/Swiss-Prot: RL39L_HUMAN, Q96EH5

Tissue specificity: Testis specific

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL39L gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rpl39l^{1 , 5}	ribosomal protein L39-like^{1, 5}	88.24(n)¹ 90.2(a)¹		16 (5.49 cM)⁵ 68172¹ NM_026594.2¹ NP_080870.1¹ 10170226⁵
chicken (Gallus gallus)	Aves	RL39_CHICK⁶	60S ribosomal protein L39	92(a)	1 → many	4(16633035-16635393)
lizard (Anolis carolinensis)	Reptilia	RPL39L⁶	--	90(a)	1 → many	GL343950.1(105218-107398)
zebrafish (Danio rerio)	Actinopterygii	rpl39⁶	ribosomal protein L39	90(a)	possible ortholog	14(34306764-34309051)
fruit fly (Drosophila melanogaster)	Insecta	RpL39⁶	Ribosomal protein L39	65(a)	1 → many	2R(19949376-19949952)
worm (Caenorhabditis elegans)	Secernentea	rpl-39⁶	60S ribosomal protein L39	69(a)	1 → many	V(7775719-7776067)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G02190⁶ AT4G31985⁶ (see all 3)	60S ribosomal protein L39-1 (see all 3)	67(a) 65(a) (see all 3)	many ↔ many many ↔ many (see all 3)	3(405816-406401) 4(15469895-15470559)
rice (Oryza sativa)	Liliopsida	-- --	60S ribosomal protein L39, putative, expressed	71(a) 71(a)	many ↔ many many ↔ many	6(4032796-4033130) 2(33908132-33908773)

ENSEMBL Gene Tree for RPL39L (if available)
TreeFam Gene Tree for RPL39L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPL39L gene

RPL39²

2 SIMAP similar genes for RPL39L using alignment to 1 protein entry: RL39L_HUMAN:

RPL39 RPL39P5

RPL39L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144493177^1,2		--	186838289(+)	`GCTTTA/CTACGC`	1	--	int¹		0	--	--	--	--
rs146674207^1,2		--	186838292(+)	`TTCTAC/TGCTCT`	1	--	int¹		0	--	--	--	--
rs116625175^1,2		--	186838305(+)	`CCAGCT/CCCTTT`	1	--	int¹		1		NA	120
rs139092935^1,2		--	186838309(+)	`CTCCTG/TTCTAT`	1	--	int¹		0	--	--	--	--
rs73888356^1,2	C,	--	186838311(+)	`CCTTTC/TTATGC`	1	--	int¹		2		WA	120
rs186192360^1,2		--	186838432(+)	`TGACTC/TGTGCC`	1	--	int¹		0	--	--	--	--
rs191434297^1,2		--	186838494(+)	`AGTGGG/TTCTCC`	1	--	int¹		0	--	--	--	--
rs183219532^1,2		--	186838576(+)	`TTATAC/TATCTG`	1	--	int¹		0	--	--	--	--
rs144066354^1,2		--	186838601(+)	`CATCTA/CTCCCT`	1	--	int¹		0	--	--	--	--
rs6801553^1,2	C,F,A,H,	--	186838657(+)	`CATTAC/TCCAGG`	1	--	int¹		17		NA EA NS WA CSA	1685

HapMap Linkage Disequilibrium report for RPL39L (186838736 - 186898696 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPL39L: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPL39L for disorders           About GeneDecksing

OMIM gene information: 607547    OMIM disorders: --

5 diseases for RPL39L:    About MalaCards

cervical squamous cell carcinoma squamous cell carcinoma cervicitis carcinoma

malaria

Export disorders for RPL39L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPL39L gene integrated from 9 sources:
(articles sorted by number of sources associating them with RPL39L)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)^{1, 2} Uechi T.... Kenmochi N. (2002)
A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. (PubMed id 12359333)^{1, 2} Nadano D.... Sato T.-A. (2002)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 116832	HGNC: 17094	AceView: RPL39L	Ensembl:ENSG00000163923	euGenes: HUgn116832
ECgene: RPL39L	H-InvDB: RPL39L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPL39L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPL39L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPL39L gene:
Search GeneIP for patents involving RPL39L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL39L
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	GenScript Custom Purified and Recombinant Proteins Services for RPL39L		GenScript cDNA clones with any tag delivered in your preferred vector for RPL39L
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RPL39L gene at Home site.

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RPL39L Gene

ribosomal protein L39-like

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Export list of displayed genes

RPL39L Gene

ribosomal protein L39-like

Aliasesfor RPL39L gene

Summariesfor RPL39L gene

Genomic Viewsfor RPL39L gene

Proteinsfor RPL39L gene

Protein Domains /Familiesfor RPL39L gene

Functionfor RPL39L gene

Pathways & Interactionsfor RPL39L gene

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Genome Databases showing RPL39L gene

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for RPL39L gene

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for RPL39L gene

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for RPL39L gene

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for RPL39L gene

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for RPL39L gene

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for RPL39L gene

Expression
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Orthologs
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for RPL39L gene

Intellectual Property
for RPL39L gene

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for RPL39L gene