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Aliases for RPL39L Gene

Aliases for RPL39L Gene

  • Ribosomal Protein L39 Like 2 3 5
  • Ribosomal Protein L39-Like 1 2 3
  • 60S Ribosomal Protein L39-2 3 4
  • RPL39L1 3 4
  • Ribosomal Protein L39-Like Protein 3
  • Ribosomal Protein L39-Like 2
  • L39-2 3

External Ids for RPL39L Gene

Previous HGNC Symbols for RPL39L Gene

  • RPL39L1

Previous GeneCards Identifiers for RPL39L Gene

  • GC03M183636
  • GC03M188095
  • GC03M188240
  • GC03M188159
  • GC03M188321
  • GC03M186839
  • GC03M184243

Summaries for RPL39L Gene

Entrez Gene Summary for RPL39L Gene

  • This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL39L Gene

RPL39L (Ribosomal Protein L39 Like) is a Protein Coding gene. Diseases associated with RPL39L include lacrimal gland adenoid cystic carcinoma. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL39.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL39L Gene

Genomics for RPL39L Gene

Genomic Location for RPL39L Gene

Chromosome:
3
Start:
187,120,948 bp from pter
End:
187,180,908 bp from pter
Size:
59,961 bases
Orientation:
Minus strand

Genomic View for RPL39L Gene

Genes around RPL39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL39L Gene

No data available for Regulatory Elements for RPL39L Gene

Proteins for RPL39L Gene

  • Protein details for RPL39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EH5-RL39L_HUMAN
    Recommended name:
    60S ribosomal protein L39-like
    Protein Accession:
    Q96EH5
    Secondary Accessions:
    • Q8IUD0

    Protein attributes for RPL39L Gene

    Size:
    51 amino acids
    Molecular mass:
    6293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL39L Gene

Proteomics data for RPL39L Gene at MOPED

Post-translational modifications for RPL39L Gene

No Post-translational modifications

Other Protein References for RPL39L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPL39L Gene

Domains & Families for RPL39L Gene

Gene Families for RPL39L Gene

Protein Domains for RPL39L Gene

Suggested Antigen Peptide Sequences for RPL39L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EH5

UniProtKB/Swiss-Prot:

RL39L_HUMAN :
  • Belongs to the ribosomal protein L39e family.
Family:
  • Belongs to the ribosomal protein L39e family.
genes like me logo Genes that share domains with RPL39L: view

Function for RPL39L Gene

Gene Ontology (GO) - Molecular Function for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL39L: view
genes like me logo Genes that share phenotypes with RPL39L: view

miRNA for RPL39L Gene

miRTarBase miRNAs that target RPL39L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL39L Gene

Localization for RPL39L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL39L Gene COMPARTMENTS Subcellular localization image for RPL39L gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPL39L Gene

Pathways & Interactions for RPL39L Gene

SuperPathways for RPL39L Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPL39L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RPL39L Gene

Drugs & Compounds for RPL39L Gene

No Compound Related Data Available

Transcripts for RPL39L Gene

mRNA/cDNA for RPL39L Gene

Unigene Clusters for RPL39L Gene

Ribosomal protein L39-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL39L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for RPL39L Gene

GeneLoc Exon Structure for
RPL39L
ECgene alternative splicing isoforms for
RPL39L

Expression for RPL39L Gene

mRNA expression in normal human tissues for RPL39L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL39L Gene

This gene is overexpressed in Testis (x16.2).

SOURCE GeneReport for Unigene cluster for RPL39L Gene Hs.647900

mRNA Expression by UniProt/SwissProt for RPL39L Gene

Q96EH5-RL39L_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RPL39L: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RPL39L Gene

Orthologs for RPL39L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL39L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL39L 35
  • 99.35 (n)
  • 98.04 (a)
RPL39L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL39 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl39l 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL39 36
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rpl39 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RpL39 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-39 36
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL39 36
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6039 36
  • 78 (a)
OneToMany
Species with no ortholog for RPL39L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL39L Gene

ENSEMBL:
Gene Tree for RPL39L (if available)
TreeFam:
Gene Tree for RPL39L (if available)

Paralogs for RPL39L Gene

Paralogs for RPL39L Gene

(2) SIMAP similar genes for RPL39L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL39L: view

Variants for RPL39L Gene

Sequence variations from dbSNP and Humsavar for RPL39L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs270155 -- 187,124,657(-) TTCAG(C/T)ATAGA intron-variant
rs1211480 -- 187,140,212(-) CATTA(C/T)TTGGT upstream-variant-2KB
rs1613579 -- 187,133,286(-) ATCCA(A/G)TCACC intron-variant
rs2241176 -- 187,135,895(-) ccatg(C/T)ggcat intron-variant
rs2241177 -- 187,135,745(-) agcaa(C/G)gcaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL39L Gene

Variant ID Type Subtype PubMed ID
nsv4157 CNV Insertion 18451855
nsv878073 CNV Gain 21882294

Variation tolerance for RPL39L Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL39L Gene

HapMap Linkage Disequilibrium report
RPL39L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL39L Gene

Disorders for RPL39L Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL39L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lacrimal gland adenoid cystic carcinoma
  • adenoid cystic carcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPL39L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL39L
genes like me logo Genes that share disorders with RPL39L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL39L Gene

Publications for RPL39L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors. (PMID: 24452241) Wong Q.W. … Vardy L.A. (RNA Biol 2014) 3
  3. Effects of ribosomal protein l39-L on the drug resistance mechanisms of lung cancer A549 cells. (PMID: 24815453) Liu H.S. … Zhu C.L. (Asian Pac. J. Cancer Prev. 2014) 3
  4. Influence of ribosomal protein L39-L in the drug resistance mechanisms of lacrimal gland adenoid cystic carcinoma cells. (PMID: 24998577) Ye Q. … Tan W.B. (Asian Pac. J. Cancer Prev. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RPL39L Gene

Sources for RPL39L Gene

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