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Aliases for RPL39L Gene

Aliases for RPL39L Gene

  • Ribosomal Protein L39 Like 2 3 5
  • Large Ribosomal Subunit Protein EL39-Like 3 4
  • Ribosomal Protein L39-Like 1 2 3
  • 60S Ribosomal Protein L39-2 3 4
  • RPL39L1 3 4
  • Ribosomal Protein L39-Like Protein 3
  • 60S Ribosomal Protein L39-Like 3
  • Ribosomal Protein L39-Like 2
  • L39-2 3

External Ids for RPL39L Gene

Previous HGNC Symbols for RPL39L Gene

  • RPL39L1

Previous GeneCards Identifiers for RPL39L Gene

  • GC03M183636
  • GC03M188095
  • GC03M188240
  • GC03M188159
  • GC03M188321
  • GC03M186839
  • GC03M184243

Summaries for RPL39L Gene

Entrez Gene Summary for RPL39L Gene

  • This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL39L Gene

RPL39L (Ribosomal Protein L39 Like) is a Protein Coding gene. Diseases associated with RPL39L include Lacrimal Gland Adenoid Cystic Carcinoma and Lacrimal Gland Adenocarcinoma. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL39.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL39L Gene

Genomics for RPL39L Gene

Regulatory Elements for RPL39L Gene

Enhancers for RPL39L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G187062 2 FANTOM5 Ensembl ENCODE dbSUPER 11 +116.3 116342 5.1 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 SP3 TBX21 MEF2D SSRP1 ZNF610 TBCCD1 ADIPOQ RPL39L ENSG00000200418 ST6GAL1 PIR46786 GC03P186996 GC03P186997
GH03G187129 1.4 FANTOM5 Ensembl ENCODE 11.4 +50.3 50328 2.4 PKNOX1 RAD21 GATA2 CBX5 ZNF143 FOS CREM ZNF654 JUNB USF2 SNORA81 ENSG00000200418 SNORA63 SNORA4 TBCCD1 RPL39L EIF4A2 ADIPOQ RFC4 RTP4
GH03G187113 0.6 ENCODE 11 +67.5 67521 0.2 CTCF KLF16 TRIM22 SMC3 REST RAD21 RPL39L RPL39P19 PIR46786
GH03G187182 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -2.4 -2395 1.5 PKNOX1 NFRKB SCRT2 FOS ELF1 ZNF592 POLR2H ZNF589 SMARCA4 NR2C1 RTP1 RPL39L
GH03G187164 1.5 Ensembl ENCODE dbSUPER 0.4 +15.5 15502 1.4 ATF1 FOXA2 PKNOX1 ZNF766 GATA2 ELK1 ZNF143 FOS NCOA1 MXD4 ADIPOQ ADIPOQ-AS1 RPL39L RPL39P19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL39L on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL39L Gene

187,120,948 bp from pter
187,180,908 bp from pter
59,961 bases
Minus strand

Genomic View for RPL39L Gene

Genes around RPL39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL39L Gene

Proteins for RPL39L Gene

  • Protein details for RPL39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L39-like
    Protein Accession:
    Secondary Accessions:
    • Q8IUD0

    Protein attributes for RPL39L Gene

    51 amino acids
    Molecular mass:
    6293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPL39L Gene

Post-translational modifications for RPL39L Gene

No Post-translational modifications

Other Protein References for RPL39L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL39L Gene

Domains & Families for RPL39L Gene

Gene Families for RPL39L Gene

Protein Domains for RPL39L Gene

Suggested Antigen Peptide Sequences for RPL39L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL39 family.
  • Belongs to the eukaryotic ribosomal protein eL39 family.
genes like me logo Genes that share domains with RPL39L: view

Function for RPL39L Gene

Gene Ontology (GO) - Molecular Function for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL39L: view
genes like me logo Genes that share phenotypes with RPL39L: view

Animal Model Products

miRNA for RPL39L Gene

miRTarBase miRNAs that target RPL39L

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL39L Gene

Localization for RPL39L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL39L gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit NAS 12490704
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPL39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL39L Gene

Pathways & Interactions for RPL39L Gene

genes like me logo Genes that share pathways with RPL39L: view

Gene Ontology (GO) - Biological Process for RPL39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0007283 spermatogenesis IEP 12490704
genes like me logo Genes that share ontologies with RPL39L: view

No data available for SIGNOR curated interactions for RPL39L Gene

Drugs & Compounds for RPL39L Gene

No Compound Related Data Available

Transcripts for RPL39L Gene

mRNA/cDNA for RPL39L Gene

Unigene Clusters for RPL39L Gene

Ribosomal protein L39-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL39L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for RPL39L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL39L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL39L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPL39L Gene

This gene is overexpressed in Testis (x16.2).

NURSA nuclear receptor signaling pathways regulating expression of RPL39L Gene:


SOURCE GeneReport for Unigene cluster for RPL39L Gene:


mRNA Expression by UniProt/SwissProt for RPL39L Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RPL39L: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL39L Gene

Orthologs for RPL39L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL39L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL39L 34 35
  • 99.35 (n)
(Bos Taurus)
Mammalia RPL39 35
  • 92 (a)
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
(Mus musculus)
Mammalia Rpl39l 35
  • 90 (a)
(Gallus gallus)
Aves RPL39 35
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
(Danio rerio)
Actinopterygii rpl39 35
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL39 35
  • 65 (a)
(Caenorhabditis elegans)
Secernentea rpl-39 35
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL39 35
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6039 35
  • 78 (a)
Species where no ortholog for RPL39L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL39L Gene

Gene Tree for RPL39L (if available)
Gene Tree for RPL39L (if available)

Paralogs for RPL39L Gene

Paralogs for RPL39L Gene

(2) SIMAP similar genes for RPL39L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL39L: view

Variants for RPL39L Gene

Sequence variations from dbSNP and Humsavar for RPL39L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000238479 -- 187,130,973(+) ATGAG(A/C)CCAGG intron-variant
rs1000587625 -- 187,137,983(+) TCTTT(A/C)TCTAA intron-variant
rs1000662868 -- 187,125,485(+) AGTTC(C/T)TGCAT intron-variant
rs1001181372 -- 187,125,063(+) GGAAG(A/G)GAGGA intron-variant
rs1001213952 -- 187,132,101(+) TGCAG(A/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL39L Gene

Variant ID Type Subtype PubMed ID
nsv1004008 CNV gain 25217958
nsv1014596 CNV gain 25217958
nsv4157 CNV insertion 18451855
nsv965243 CNV duplication 23825009

Variation tolerance for RPL39L Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL39L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL39L Gene

Disorders for RPL39L Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL39L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lacrimal gland adenoid cystic carcinoma
  • adenoid cystic carcinoma of lacrimal gland
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPL39L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL39L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL39L Gene

Publications for RPL39L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. (PMID: 12359333) Nadano D. … Sato T.-A. (Biochim. Biophys. Acta 2002) 3 4 64
  3. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PMID: 12490704) Uechi T. … Kenmochi N. (Nucleic Acids Res. 2002) 3 4 64
  4. RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors. (PMID: 24452241) Wong Q.W. … Vardy L.A. (RNA Biol 2014) 3 64
  5. Effects of ribosomal protein l39-L on the drug resistance mechanisms of lung cancer A549 cells. (PMID: 24815453) Liu H.S. … Zhu C.L. (Asian Pac. J. Cancer Prev. 2014) 3 64

Products for RPL39L Gene

Sources for RPL39L Gene

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