Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL38 Gene

Aliases for RPL38 Gene

  • Ribosomal Protein L38 2 3
  • 60S Ribosomal Protein L38 3
  • L38 3

External Ids for RPL38 Gene

Previous GeneCards Identifiers for RPL38 Gene

  • GC17P072221
  • GC17P075257
  • GC17P072663
  • GC17P072796
  • GC17P069711
  • GC17P067610
  • GC17P072202

Summaries for RPL38 Gene

Entrez Gene Summary for RPL38 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL38 Gene

RPL38 (Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL38 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL38 Gene

Genomics for RPL38 Gene

Regulatory Elements for RPL38 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL38 Gene

Start:
74,203,582 bp from pter
End:
74,210,655 bp from pter
Size:
7,074 bases
Orientation:
Plus strand

Genomic View for RPL38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL38 Gene

Proteins for RPL38 Gene

  • Protein details for RPL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63173-RL38_HUMAN
    Recommended name:
    60S ribosomal protein L38
    Protein Accession:
    P63173
    Secondary Accessions:
    • B2R5A8
    • P23411

    Protein attributes for RPL38 Gene

    Size:
    70 amino acids
    Molecular mass:
    8218 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL38 Gene

neXtProt entry for RPL38 Gene

Proteomics data for RPL38 Gene at MOPED

Post-translational modifications for RPL38 Gene

  • Ubiquitination at Lys4, Lys9, Lys55, Lys57, and Lys67
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL38 Gene

No data available for DME Specific Peptides for RPL38 Gene

Domains for RPL38 Gene

Gene Families for RPL38 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPL38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63173

UniProtKB/Swiss-Prot:

RL38_HUMAN :
  • P63173
Family:
  • Belongs to the ribosomal protein L38e family.
genes like me logo Genes that share domains with RPL38: view

Function for RPL38 Gene

Molecular function for RPL38 Gene

GENATLAS Biochemistry: 60S ribosomal protein L38

Gene Ontology (GO) - Molecular Function for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9375793
GO:0003735 structural constituent of ribosome NAS 12962325
genes like me logo Genes that share ontologies with RPL38: view
genes like me logo Genes that share phenotypes with RPL38: view

Animal Models for RPL38 Gene

MGI Knock Outs for RPL38:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL38

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RPL38 Gene

Localization for RPL38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL38 Gene COMPARTMENTS Subcellular localization image for RPL38 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0005925 focal adhesion IDA 21423176
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL38 Gene

Pathways for RPL38 Gene

genes like me logo Genes that share pathways with RPL38: view

Pathways by source for RPL38 Gene

1 KEGG pathway for RPL38 Gene
1 GeneGo (Thomson Reuters) pathway for RPL38 Gene

Gene Ontology (GO) - Biological Process for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL38: view

Transcripts for RPL38 Gene

Unigene Clusters for RPL38 Gene

Ribosomal protein L38:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL38

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: -
SP9:

Relevant External Links for RPL38 Gene

GeneLoc Exon Structure for
RPL38
ECgene alternative splicing isoforms for
RPL38

Expression for RPL38 Gene

mRNA expression in normal human tissues for RPL38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL38 Gene

SOURCE GeneReport for Unigene cluster for RPL38 Gene Hs.380953

genes like me logo Genes that share expressions with RPL38: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL38 Gene

Orthologs for RPL38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL38 35
  • 100 (n)
  • 100 (a)
RPL38 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL38 35
  • 92.38 (n)
  • 98.57 (a)
RPL38 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL38 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl38 35
  • 89.52 (n)
  • 98.57 (a)
Rpl38 16
Rpl38 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPL38 35
  • 84.76 (n)
  • 100 (a)
RPL38 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL38 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl38 35
  • 83.81 (n)
  • 97.14 (a)
Str.3048 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8403 35
zebrafish
(Danio rerio)
Actinopterygii rpl38 35
  • 84.76 (n)
  • 100 (a)
rpl38 36
  • 100 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RL38_ANOGA 35
  • 69.52 (n)
  • 75.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL38 35
  • 65.24 (n)
  • 72.86 (a)
RpL38 36
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-38 35
  • 74.29 (n)
  • 78.57 (a)
rpl-38 36
  • 77 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL38 36
  • 49 (a)
OneToOne
RPL38 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2465 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43460 35
  • 71.98 (n)
  • 78.26 (a)
rice
(Oryza sativa)
Liliopsida Os05g0507200 35
  • 70.05 (n)
  • 75.36 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.912 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4751 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6016 36
  • 86 (a)
OneToOne
Species with no ortholog for RPL38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL38 Gene

ENSEMBL:
Gene Tree for RPL38 (if available)
TreeFam:
Gene Tree for RPL38 (if available)

Paralogs for RPL38 Gene

genes like me logo Genes that share paralogs with RPL38: view

No data available for Paralogs for RPL38 Gene

Variants for RPL38 Gene

Sequence variations from dbSNP and Humsavar for RPL38 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14601 -- 74,209,276(+) AAGAG(A/G/T)AGGCA reference, missense, stop-gained
rs1870985 -- 74,206,011(+) CGAGA(C/G)TGTCT intron-variant
rs2126694 -- 74,207,636(+) CCTCA(A/G)CCTCC intron-variant
rs2382649 -- 74,207,622(-) gagaa(A/C)atggg intron-variant
rs2382838 -- 74,206,483(-) atggg(C/T)ggtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL38 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
nsv509673 CNV Insertion 20534489
nsv833538 CNV Gain 17160897

Relevant External Links for RPL38 Gene

HapMap Linkage Disequilibrium report
RPL38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL38 Gene

Disorders for RPL38 Gene

(1) University of Copenhagen DISEASES for RPL38 Gene

genes like me logo Genes that share disorders with RPL38: view

No data available for UniProtKB/Swiss-Prot for RPL38 Gene

Publications for RPL38 Gene

  1. Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. (PMID: 9375793) Espinosa L. … Navarro E. (Biochim. Biophys. Acta 1997) 3 4 23
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PMID: 16730941) Tsang H.T.H. … Sanderson C.M. (Genomics 2006) 3

Products for RPL38 Gene

Sources for RPL38 Gene

Back to Top

Content