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Aliases for RPL38 Gene

Aliases for RPL38 Gene

  • Ribosomal Protein L38 2 3 5
  • 60S Ribosomal Protein L38 3
  • L38 3

External Ids for RPL38 Gene

Previous GeneCards Identifiers for RPL38 Gene

  • GC17P072221
  • GC17P075257
  • GC17P072663
  • GC17P072796
  • GC17P069711
  • GC17P067610
  • GC17P072202

Summaries for RPL38 Gene

Entrez Gene Summary for RPL38 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL38 Gene

RPL38 (Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL38 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL38 Gene

Genomics for RPL38 Gene

Regulatory Elements for RPL38 Gene

Enhancers for RPL38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074295 1.5 FANTOM5 Ensembl ENCODE 12 +92.8 92808 1.5 PKNOX1 ATF1 ARNT CBX5 GATA2 REST CREB3 MEF2D ZNF585B SMARCA4 TTYH2 DNAI2 HID1-AS1 NAT9 MGC16275 RPL38 GGA3 RAB37 ENSG00000266106
GH17F074239 1.2 FANTOM5 Ensembl ENCODE 11.9 +37.1 37058 3.3 PKNOX1 BHLHE40 MAX CEBPB PRDM10 MYC CD300E DNAI2 TTYH2 CD300C CD300LB MGC16275 RPL38 CD300LF CD300A CD300LD
GH17F074234 0.9 Ensembl ENCODE 12 +31.7 31706 2.6 HDAC1 WRNIP1 ZMYM3 ZEB2 EBF1 ZBTB40 IKZF1 SCRT2 ZBTB20 TTYH2 DNAI2 MGC16275 RPL38 CD300A CD300E ENSG00000264272
GH17F074245 0.8 Ensembl ENCODE 11.6 +42.2 42189 1.5 CTCF TEAD4 ZNF223 KDM1A ZIC2 ZNF423 TTYH2 DNAI2 MGC16275 RPL38 ENSG00000264272
GH17F074248 0.8 Ensembl ENCODE 11.6 +46.6 46573 2.4 HDGF POLR2A TARDBP MNT TTYH2 DNAI2 MGC16275 RPL38 ENSG00000264272
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL38 on UCSC Golden Path with GeneCards custom track

Promoters for RPL38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL38 Gene

74,203,582 bp from pter
74,210,655 bp from pter
7,074 bases
Plus strand

Genomic View for RPL38 Gene

Genes around RPL38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL38 Gene

Proteins for RPL38 Gene

  • Protein details for RPL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L38
    Protein Accession:
    Secondary Accessions:
    • B2R5A8
    • P23411

    Protein attributes for RPL38 Gene

    70 amino acids
    Molecular mass:
    8218 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL38 Gene

neXtProt entry for RPL38 Gene

Post-translational modifications for RPL38 Gene

  • Ubiquitination at Lys 9, Lys 55, and Lys 57
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL38 Gene

No data available for DME Specific Peptides for RPL38 Gene

Domains & Families for RPL38 Gene

Gene Families for RPL38 Gene

Protein Domains for RPL38 Gene


Suggested Antigen Peptide Sequences for RPL38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L38e family.
  • Belongs to the ribosomal protein L38e family.
genes like me logo Genes that share domains with RPL38: view

Function for RPL38 Gene

Molecular function for RPL38 Gene

GENATLAS Biochemistry:
60S ribosomal protein L38

Gene Ontology (GO) - Molecular Function for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9375793
GO:0003735 structural constituent of ribosome NAS,TAS 12962325
genes like me logo Genes that share ontologies with RPL38: view
genes like me logo Genes that share phenotypes with RPL38: view

Animal Models for RPL38 Gene

MGI Knock Outs for RPL38:

Animal Model Products

miRNA for RPL38 Gene

miRTarBase miRNAs that target RPL38

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPL38 Gene

Localization for RPL38 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL38 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0022625 cytosolic large ribosomal subunit IDA,TAS 12962325
genes like me logo Genes that share ontologies with RPL38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL38 Gene

Pathways & Interactions for RPL38 Gene

genes like me logo Genes that share pathways with RPL38: view

Pathways by source for RPL38 Gene

1 KEGG pathway for RPL38 Gene
1 GeneGo (Thomson Reuters) pathway for RPL38 Gene

Gene Ontology (GO) - Biological Process for RPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,TAS 12962325
genes like me logo Genes that share ontologies with RPL38: view

No data available for SIGNOR curated interactions for RPL38 Gene

Transcripts for RPL38 Gene

Unigene Clusters for RPL38 Gene

Ribosomal protein L38:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for RPL38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL38 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (14.1) and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL38 Gene

Protein tissue co-expression partners for RPL38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL38 Gene:


SOURCE GeneReport for Unigene cluster for RPL38 Gene:

genes like me logo Genes that share expression patterns with RPL38: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL38 Gene

Orthologs for RPL38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL38 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
-- 35
  • 87 (a)
(Bos Taurus)
Mammalia RPL38 34 35
  • 92.38 (n)
(Mus musculus)
Mammalia Rpl38 34 16 35
  • 89.52 (n)
(Canis familiaris)
Mammalia RPL38 35
  • 71 (a)
(Gallus gallus)
Aves RPL38 34 35
  • 84.76 (n)
(Anolis carolinensis)
Reptilia RPL38 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl38 34
  • 83.81 (n)
Str.3048 34
(Danio rerio)
Actinopterygii rpl38 34 35
  • 84.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8403 34
African malaria mosquito
(Anopheles gambiae)
Insecta RL38_ANOGA 34
  • 69.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL38 34 35
  • 65.24 (n)
(Caenorhabditis elegans)
Secernentea rpl-38 34 35
  • 74.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL38 35 37
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43460 34
  • 71.98 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2465 34
(Oryza sativa)
Liliopsida Os05g0507200 34
  • 70.05 (n)
(Triticum aestivum)
Liliopsida Ta.912 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6016 35
  • 86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4751 34
Species where no ortholog for RPL38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL38 Gene

Gene Tree for RPL38 (if available)
Gene Tree for RPL38 (if available)

Paralogs for RPL38 Gene

genes like me logo Genes that share paralogs with RPL38: view

No data available for Paralogs for RPL38 Gene

Variants for RPL38 Gene

Sequence variations from dbSNP and Humsavar for RPL38 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10646 -- 74,209,819(+) GAAGG(A/T)ACTGA downstream-variant-500B, reference, missense
rs111424997 -- 74,203,709(+) GCTTG(C/T)TGTGA utr-variant-5-prime
rs111582058 -- 74,207,165(+) CGCCA(C/T)CACAC intron-variant
rs111617180 -- 74,207,542(+) TTTTT(G/T)TGAGA intron-variant
rs111676869 -- 74,204,082(+) GCCGG(A/G)AGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL38 Gene

Variant ID Type Subtype PubMed ID
nsv833538 CNV gain 17160897
nsv517569 CNV gain+loss 19592680
nsv509673 CNV insertion 20534489
esv3641230 CNV gain 21293372
esv3573820 CNV gain 25503493
esv2761978 CNV gain 21179565
esv2751770 CNV gain 17911159
dgv587e214 CNV gain 21293372
dgv5768n54 CNV gain 21841781
dgv372n27 CNV gain 19166990
dgv3282n100 CNV gain 25217958
dgv12e196 CNV duplication 17116639

Variation tolerance for RPL38 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL38 Gene

Disorders for RPL38 Gene

Relevant External Links for RPL38

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL38 Gene

Publications for RPL38 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. (PMID: 9375793) Espinosa L. … Navarro E. (Biochim. Biophys. Acta 1997) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for RPL38 Gene

Sources for RPL38 Gene

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