Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPL38 Gene

protein-coding   GIFtS: 58
GCID: GC17P072202

Ribosomal Protein L38

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ribosomal Protein L381 2
60S Ribosomal Protein L382
L382

External Ids:    HGNC: 103491   Entrez Gene: 61692   Ensembl: ENSG000001728097   OMIM: 6041825   UniProtKB: P631733   

Export aliases for RPL38 gene to outside databases

Previous GC identifers: GC17P072221 GC17P075257 GC17P072663 GC17P072796 GC17P069711 GC17P067610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RPL38 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family
of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both
encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1
angiotensin II receptor gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL38 Gene:
RPL38 (ribosomal protein L38) is a protein-coding gene. Diseases associated with RPL38 include diamond-blackfan anemia, and otitis media. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL38 (60S ribosomal protein L38) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL38 gene promoter:
         Max1   Elk-1   Pbx1a   Evi-1   GATA-2   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL38 promoter sequence
   Search Chromatin IP Primers for RPL38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

RPL38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL38 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072202:  view genomic region     (about GC identifiers)

Start:
72,199,721 bp from pter      End:
72,206,794 bp from pter
Size:
7,074 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RL38_HUMAN, P63173 (See protein sequence)
Recommended Name: 60S ribosomal protein L38  
Size: 70 amino acids; 8218 Da
1 PDB 3D structure from and Proteopedia for RPL38:
3J3B (3D)    
Secondary accessions: B2R5A8 P23411

Explore the universe of human proteins at neXtProt for RPL38: NX_P63173

Explore proteomics data for RPL38 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4, Lys9, Lys55, Lys57, Lys67
  • Modification sites at PhosphoSitePlus

  • See RPL38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000990.1  NP_001030335.1  

    ENSEMBL proteins: 
     ENSP00000390279   ENSP00000309830   ENSP00000463312   ENSP00000462837   ENSP00000462580  
     ENSP00000434243  
    Reactome Protein details: P63173

    RPL38 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RPL38
    OriGene Protein Over-expression Lysate for RPL38
    OriGene MassSpec for RPL38
    OriGene Custom Protein Services for RPL38
    GenScript Custom Purified and Recombinant Proteins Services for RPL38
    Novus Biologicals RPL38 Proteins
    Novus Biologicals RPL38 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPL38

    RPL38 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RPL38
    Novus Biologicals RPL38 Antibody
    Search for Antibodies for RPL38 at Abcam
    Cloud-Clone Corp. Antibodies for RPL38
    Search ThermoFisher Antibodies for RPL38
    LSBio Antibodies in human, mouse, rat for RPL38

    RPL38 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPL38
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL38
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPL38
    Cloud-Clone Corp. CLIAs for RPL38


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RPL: L ribosomal proteins

    1 InterPro protein domain:
     IPR002675 Ribosomal_L38e

    Graphical View of Domain Structure for InterPro Entry P63173

    ProtoNet protein and cluster: P63173

    UniProtKB/Swiss-Prot: RL38_HUMAN, P63173
    Similarity: Belongs to the ribosomal protein L38e family


    RPL38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for RPL38:
    60S ribosomal protein L38

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9375793
    GO:0003735structural constituent of ribosome NAS12962325
         
    RPL38 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPL38:
     Decreased cell number, increas  Decreased viability of wild-ty  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 
     S arrest 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rpl38) (see all 19):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  pigmentation 

    RPL38 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rpl38tm1Rugg for RPL38

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL38
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL38

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL38
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL38

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RPL38 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPL38
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL38
    Predesigned siRNA for gene silencing in human, mouse, rat RPL38

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL38

    Clone
    Products:
         
    OriGene clones in human, mouse for RPL38 (see all 15)
    OriGene ORF clones in mouse, rat for RPL38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPL38 (NM_000999)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL38

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPL38
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPL38 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL38


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325
    GO:0033291eukaryotic 80S initiation complex IEA--

    RPL38 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPL38 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL38
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL38
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL38 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL38):
        Ribosome


    RPL38 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL38
    Interactions:

        Search GeneGlobe Interaction Network for RPL38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL38 (P631731, 2, 3 ENSP000003098304) via UniProtKB, MINT, STRING, and/or I2D (see all 425)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223921, 3, ENSP000003655724EBI-359141,EBI-713693 I2D: score=2 STRING: ENSP00000365572
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-6489217 MINT-6488488 I2D: score=1 STRING: ENSP00000221413
    NME1-NME2P223921, 3EBI-359141,EBI-713693 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49445 I2D: score=2 
    RPL23P628292, ENSP000003778654MINT-6489217 MINT-6488590 MINT-6488488 STRING: ENSP00000377865
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0001501skeletal system development IEA--
    GO:0001503ossification IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    RPL38 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL38 (RL38)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPL38 gene (2 alternative transcripts): 
    NM_000999.3  NM_001035258.1  

    Unigene Cluster for RPL38:

    Ribosomal protein L38
    Hs.380953  [show with all ESTs]
    Unigene Representative Sequence: BQ060968
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439590(uc002jka.3) ENST00000311111(uc002jjz.3) ENST00000530646(uc002jjy.1)
    ENST00000529123 ENST00000584577 ENST00000534490 ENST00000528433 ENST00000533498

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPL38 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPL38
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL38
    Predesigned siRNA for gene silencing in human, mouse, rat RPL38
    Clone
    Products:
         
    OriGene clones in human, mouse for RPL38 (see all 15)
    OriGene ORF clones in mouse, rat for RPL38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPL38 (NM_000999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL38
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL38
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RPL38
      QuantiTect SYBR Green Assays in human, mouse, rat RPL38
      QuantiFast Probe-based Assays in human, mouse, rat RPL38

    Additional mRNA sequence: 

    AB055771.1 AK312119.1 BC000603.2 Z26876.1 

    Selected DOTS entries (see all 65):

    DT.92463116  DT.75144110  DT.95119317  DT.100746033  DT.87018371  DT.97868495  DT.120970800  DT.120970760 
    DT.87018407  DT.438387  DT.100060144  DT.100745864  DT.100871490  DT.95119332  DT.95119418  DT.100745933 
    DT.87014732  DT.91835243  DT.87077793  DT.100060138  DT.120970776  DT.120970783  DT.100745931  DT.120970811 

    Selected AceView cDNA sequences (see all 1748):

    AW163639 AI278873 BE467889 AI797106 AA316478 BF718414 AA300768 AA112055 
    BG029368 AI816788 BG942076 BE503123 BC000603 BE219012 AA973670 AA829793 
    BE258386 AW583376 BF718724 BE670851 AW583433 AI278585 AI887842 W95854 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL38 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
    SP1:                                      -     -                 -     -     -     -                 -                           
    SP2:                                            -                 -     -     -     -                 -                           
    SP3:                                            -                 -     -     -     -                 -     -                     
    SP4:                                                              -     -     -     -                 -                           
    SP5:                                            -                 -     -     -     -                                             


    ECgene alternative splicing isoforms for RPL38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPL38 expression in normal human tissues (normalized intensities)      RPL38 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCGGAAAA
    RPL38 Expression
    About this image


    RPL38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    RPL38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380953
        Custom PCR Arrays for RPL38
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPL38
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RPL38
    QuantiTect SYBR Green Assays in human, mouse, rat RPL38
    QuantiFast Probe-based Assays in human, mouse, rat RPL38
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL38 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl381 , 5 ribosomal protein L381, 5 89.52(n)1
    98.57(a)1
      11 (79.82 cM)5
    676711  NM_023372.21  NP_075861.11 
     1146685245 
    chicken
    (Gallus gallus)
    Aves RPL381 ribosomal protein L38 84.76(n)
    100(a)
      771528  NM_001278012.1  NP_001264941.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL386
    ribosomal protein L38
    99(a)
    1 ↔ 1
    2(98102868-98106230)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480146012   -- 83.12(n)    48014601 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl381 ribosomal protein L38 84.76(n)
    100(a)
      436759  NM_001002486.2  NP_001002486.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL381 Ribosomal protein L38 65.24(n)
    72.86(a)
      3355144  NM_001042975.2  NP_001036440.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-381 rpl-38 74.29(n)
    78.57(a)
      180044  NM_074459.4  NP_506860.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL38(YLR325C)4 Protein component of the large (60S) ribosomal subunit, more   --   12(781379-781143) 851035  NP_013429.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G434601 AT2G43460 71.98(n)
    78.26(a)
      818947  NM_129907.2  NP_181874.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05072001 Os05g0507200 70.05(n)
    75.36(a)
      4339261  NM_001062525.1  NP_001055990.1 


    ENSEMBL Gene Tree for RPL38 (if available)
    TreeFam Gene Tree for RPL38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPL38 gene

    RPL38 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RPL38
    PGOHUM00000240476 PGOHUM00000240693 PGOHUM00000237691 PGOHUM00000237808 PGOHUM00000245535


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RPL38 (see all 245)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150499101,2
    F--72197799(+) GAGAGT/GTATCG 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1438253421,2
    --72197876(+) CTGTTA/GTCCTA 2 -- us2k10--------
    rs1141132991,2
    C,F--72197896(+) GGGGCC/TGAGGC 2 -- us2k12Minor allele frequency- T:0.03WA NS 266
    rs285041381,2
    C,F--72197981(+) TAAAAA/CATTAA 2 -- us2k1 tfbs31Minor allele frequency- C:0.01NS 148
    rs1387584491,2
    --72198085(+) GCAACA/GTAAGT 2 -- us2k10--------
    rs1494066031,2
    --72198110(+) CCTGCC/TTGAAA 2 -- us2k10--------
    rs1447691801,2
    C--72198114(+) CCTGAA/TAAAGG 2 -- us2k10--------
    rs739971291,2
    C--72198196(+) AGGGCA/GGAAAG 2 -- us2k14Minor allele frequency- G:0.10WA NA NS 370
    rs1138203281,2
    C,F--72198254(+) AGGAGC/TAGTGG 2 -- us2k13Minor allele frequency- T:0.02CSA WA NS 262
    rs1846872191,2
    --72198313(+) AGCCGC/GGCTCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPL38 (72199721 - 72206794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RPL38:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv12e196CNV Duplication17116639
    nsv509673CNV Insertion20534489
    esv2751770CNV Gain17911159
    dgv372n27CNV Gain19166990
    nsv833538CNV Gain17160897
    nsv517569CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL38
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604182    OMIM disorders: --

    8 diseases for RPL38:    About MalaCards
    diamond-blackfan anemia    otitis media    rhabdomyosarcoma    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    influenza    pancreatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for RPL38:
    Diamond-Blackfan anemia

    RPL38 for disorders           About GeneDecksing


    Export disorders for RPL38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPL38 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with RPL38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. (PubMed id 9375793)1, 2, 9 Espinosa L.... Navarro E. (Biochim. Biophys. Acta 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    6. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6169 HGNC: 10349 AceView: RPL38 Ensembl:ENSG00000172809 euGenes: HUgn6169
    ECgene: RPL38 Kegg: 6169 H-InvDB: RPL38

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPL38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPL38 gene:
    Search GeneIP for patents involving RPL38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RPL38  
     OriGene qPCR primer pairs and template standards for RPL38   OriGene Protein Over-expression Lysate for RPL38  
     OriGene MassSpec something-or-other for RPL38   OriGene clones in human, mouse for RPL38  
     Browse OriGene qSTAR qPCR primer pairs   OriGene Purified Protein for RPL38  
     OriGene ORF clones in mouse, rat for RPL38   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPL38   OriGene Custom Protein Services for RPL38  

     
     
     Block miRNA regulation of human, mouse, rat RPL38 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPL38
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL38 Predesigned siRNA for gene silencing in human, mouse, rat RPL38
     QuantiFast Probe-based Assays in human, mouse, rat RPL38 QuantiTect SYBR Green Assays in human, mouse, rat RPL38
     Custom PCR Arrays for RPL38 Search Chromatin IP Primers for RPL38
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RPL38  Search GeneGlobe Interaction Network for RPL38
     Regulatory tfbs in RPL38 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPL38 GenScript cDNA clones with any tag delivered in your preferred vector for RPL38
     GenScript Custom Assay Services for RPL38 GenScript Custom overexpressing Cell Line Services for RPL38
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RPL38 (RL38)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPL38 antibodies
     RPL38 proteins
     RPL38 lysates
     Search for Antibodies for RPL38 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RPL38
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RPL38
     Antibodies for RPL38
     ELISAs for RPL38
     CLIAs for RPL38



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPL38
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL38
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPL38
     SwitchGear Promoter luciferase reporter plasmids for RPL38
     Search ThermoFisher Antibodies for RPL38
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL38
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL38
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPL38
     LSBio Antibodies in human, mouse, rat for RPL38
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPL38 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4