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Aliases for RPL37A Gene

Aliases for RPL37A Gene

  • Ribosomal Protein L37a 2 3 5
  • L37A 3

External Ids for RPL37A Gene

Previous GeneCards Identifiers for RPL37A Gene

  • GC02P215460
  • GC02P216084
  • GC02P217327
  • GC02P217566
  • GC02P217189
  • GC02P217071
  • GC02P209217

Summaries for RPL37A Gene

Entrez Gene Summary for RPL37A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL37A Gene

RPL37A (Ribosomal Protein L37a) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL37A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL37A Gene

Genomics for RPL37A Gene

Regulatory Elements for RPL37A Gene

Promoters for RPL37A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL37A on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL37A Gene

Chromosome:
2
Start:
216,498,189 bp from pter
End:
216,579,180 bp from pter
Size:
80,992 bases
Orientation:
Plus strand

Genomic View for RPL37A Gene

Genes around RPL37A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL37A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL37A Gene

Proteins for RPL37A Gene

  • Protein details for RPL37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61513-RL37A_HUMAN
    Recommended name:
    60S ribosomal protein L37a
    Protein Accession:
    P61513
    Secondary Accessions:
    • P12751
    • Q6FGF5

    Protein attributes for RPL37A Gene

    Size:
    92 amino acids
    Molecular mass:
    10275 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL37A Gene

neXtProt entry for RPL37A Gene

Proteomics data for RPL37A Gene at MOPED

Post-translational modifications for RPL37A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPL37A Gene

Domains & Families for RPL37A Gene

Gene Families for RPL37A Gene

Protein Domains for RPL37A Gene

Suggested Antigen Peptide Sequences for RPL37A Gene

Graphical View of Domain Structure for InterPro Entry

P61513

UniProtKB/Swiss-Prot:

RL37A_HUMAN :
  • Belongs to the ribosomal protein L37Ae family.
Family:
  • Belongs to the ribosomal protein L37Ae family.
genes like me logo Genes that share domains with RPL37A: view

Function for RPL37A Gene

Gene Ontology (GO) - Molecular Function for RPL37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL37A: view
genes like me logo Genes that share phenotypes with RPL37A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL37A Gene

Localization for RPL37A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL37A Gene COMPARTMENTS Subcellular localization image for RPL37A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for RPL37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL37A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL37A Gene

Pathways & Interactions for RPL37A Gene

genes like me logo Genes that share pathways with RPL37A: view

Pathways by source for RPL37A Gene

1 BioSystems pathway for RPL37A Gene
1 KEGG pathway for RPL37A Gene
1 GeneGo (Thomson Reuters) pathway for RPL37A Gene

Gene Ontology (GO) - Biological Process for RPL37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPL37A: view

No data available for SIGNOR curated interactions for RPL37A Gene

Drugs & Compounds for RPL37A Gene

No Compound Related Data Available

Transcripts for RPL37A Gene

Unigene Clusters for RPL37A Gene

Ribosomal protein L37a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL37A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for RPL37A Gene

GeneLoc Exon Structure for
RPL37A
ECgene alternative splicing isoforms for
RPL37A

Expression for RPL37A Gene

mRNA expression in normal human tissues for RPL37A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL37A Gene

This gene is overexpressed in Tlymphocyte (7.8) and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL37A Gene



SOURCE GeneReport for Unigene cluster for RPL37A Gene Hs.433701

genes like me logo Genes that share expression patterns with RPL37A: view

Protein tissue co-expression partners for RPL37A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL37A Gene

Orthologs for RPL37A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL37A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL37A 35
  • 89.49 (n)
  • 100 (a)
RPL37A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL37A 35
  • 89.13 (n)
  • 100 (a)
-- 36
  • 90 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl37a 35
  • 90.58 (n)
  • 100 (a)
Rpl37a 16
Rpl37a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL37A 35
  • 100 (n)
  • 100 (a)
RPL37A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl37a 35
  • 84.78 (n)
  • 91.3 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL37A 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL37A 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL37A 35
  • 83.7 (n)
  • 98.91 (a)
RPL37A 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl37a 35
  • 84.42 (n)
  • 97.83 (a)
Str.1005 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64282 35
zebrafish
(Danio rerio)
Actinopterygii zgc:171772 35
  • 81.88 (n)
  • 96.74 (a)
RPL37A 36
  • 97 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL37a 37
  • 76 (a)
RpL37A 35
  • 71.38 (n)
  • 76.09 (a)
RpL37A 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009920 35
  • 69.66 (n)
  • 74.16 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-43 35
  • 67.03 (n)
  • 71.43 (a)
rpl-43 36
  • 71 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL310C 35
  • 65.57 (n)
  • 67.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05941g 35
  • 62.64 (n)
  • 63.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL43A 35
  • 64.47 (n)
  • 67.03 (a)
RPL43A 36
  • 66 (a)
OneToMany
RPL43B 36
  • 66 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G10950 35
  • 59.85 (n)
  • 69.32 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2253 35
rice
(Oryza sativa)
Liliopsida Os05g0557000 35
  • 62.5 (n)
  • 71.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07562 35
  • 62.64 (n)
  • 63.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl4302 35
  • 56.41 (n)
  • 59.34 (a)
Species with no ortholog for RPL37A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL37A Gene

ENSEMBL:
Gene Tree for RPL37A (if available)
TreeFam:
Gene Tree for RPL37A (if available)

Paralogs for RPL37A Gene

(1) SIMAP similar genes for RPL37A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL37A: view

No data available for Paralogs for RPL37A Gene

Variants for RPL37A Gene

Sequence variations from dbSNP and Humsavar for RPL37A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs15522 -- 216,501,441(+) CTATA(A/G)TAAAT utr-variant-3-prime
rs1065702 -- 216,501,388(+) GAAGG(A/G)GTTGA reference, missense
rs1804337 -- 216,501,364(+) GGTAA(A/G)GTCCG reference, missense
rs1804342 -- 216,501,365(+) GTAAA(A/C/G)TCCGC reference, synonymous-codon, missense
rs17357806 -- 216,501,462(+) ATGTA(A/G)CAAAA utr-variant-3-prime

Variation tolerance for RPL37A Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL37A Gene

HapMap Linkage Disequilibrium report
RPL37A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL37A Gene

Disorders for RPL37A Gene

Relevant External Links for RPL37A

Genetic Association Database (GAD)
RPL37A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL37A

No disorders were found for RPL37A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL37A Gene

Publications for RPL37A Gene

  1. Primary sequence of the human ribosomal protein L37a. (PMID: 1437567) Hoof T. … Tuemmler B. (Nucleic Acids Res. 1992) 2 3 4 23 67
  2. Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines. (PMID: 8224875) Saha D.P. … Howells R.D. (Gene 1993) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RPL37A Gene

Sources for RPL37A Gene

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