RPL37A Gene
protein-coding GIFtS: 56
GCID: GC02P217327
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|
ribosomal protein L37a
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Aliases
for RPL37A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein L37a1 2 | | L37A1 2 | | 60S Ribosomal Protein L37a2 |
Export aliases for RPL37A gene to outside databasesPrevious GC identifers: GC02P215460 GC02P216084 GC02P217566 GC02P217189 GC02P217071 GC02P209217 |
Summaries
for RPL37A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPL37A:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family ofribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As istypical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughthe genome. (provided by RefSeq, Jul 2008)
Gene Wiki entry for RPL37A
|
Genomic Views
for RPL37A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPL37A gene promoter:
STAT1 AML1a STAT1beta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 STAT1alpha MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL37A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL37A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35RPL37A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P217327: view genomic region
(about GC identifiers)
Start:
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217,362,912 bp from pter |
End:
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217,443,903 bp from pter |
Size:
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80,992 bases |
Orientation:
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plus strand |
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Proteins
for RPL37A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RL37A_HUMAN, P61513 (See
protein sequence)Recommended Name: 60S ribosomal protein L37a Size: 92 amino acids; 10275 Da
Secondary accessions: P12751 Q6FGF5Explore the universe of human proteins at neXtProt for RPL37A: NX_P61513
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61513
RPL37A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000989.1
ENSEMBL proteins: ENSP00000418082 ENSP00000388690 ENSP00000410080 ENSP00000410240 Reactome Protein details: P61513
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RPL37A for ontologies About GeneDecksing
RPL37A Antibody Products:
Assay Products for RPL37A: |
Protein
Domains /
Families
for RPL37A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL37A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61513ProtoNet protein and cluster: P61513 1 Blocks protein family: IPB002674 Ribosomal L37ae protein
UniProtKB/Swiss-Prot: RL37A_HUMAN, P61513Similarity: Belongs to the ribosomal protein L37Ae family |
Function
for RPL37A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL37A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL37A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL37A (NM_000998) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL37A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL37A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RPL37A for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RPL37A:
|
Pathways & Interactions
for RPL37A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Disease | | | 4 | Generic Transcription Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for RPL37A
1  BioSystems Pathway for RPL37A
5/28 
Reactome Pathways for RPL37A (see all 28)
1 
Kegg Pathway (Kegg details for RPL37A):
RPL37A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL37A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/351 Interacting proteins for RPL37A (P615131, 2, 3 ENSP000004180824) via UniProtKB, MINT, STRING, and/or I2D (see all 351)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPL37A for ontologies About GeneDecksing
|
Drugs & Compounds
for RPL37A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPL37A
Search CenterWatch for drugs/clinical trials and news about RPL37A / RL37A
|
Transcripts
for RPL37A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPL37A gene: NM_000998.4 Unigene Cluster for RPL37A: Ribosomal protein L37a Hs.433701 [show with all ESTs]Unigene Representative Sequence: BC0677898 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491306(uc002vgf.3) ENST00000478153 ENST00000490649(uc002vgg.3)
ENST00000487233 ENST00000446558 ENST00000420712 ENST00000359681 ENST00000456586
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL37A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL37A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPL37A (NM_000998) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL37A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL37A |
Additional cDNA sequence: AK023419.1 AK289472.1 AK291857.1 BC000555.2 BC014262.2 BC016748.2 BC039030.1 BC047872.1 BC063476.1 BC067789.1 BC082239.1 CR542152.1 L06499.1 L22154.1 X66699.1 24/81 DOTS entries (see all 81): DT.101962931 DT.100763566 DT.102839462 DT.100716458 DT.100742638 DT.95244961 DT.91781656 DT.97868417 DT.100771718 DT.100771498 DT.100716454 DT.91820585 DT.101986819 DT.91781639 DT.100716438 DT.95244944 DT.91859312 DT.100716455 DT.120948430 DT.120948353 DT.100801652 DT.100716448 DT.100716456 DT.87000712 24/2129 AceView cDNA sequences (see all 2129): CD106468 F24717 BE675512 AA885786 F20360 F37261 AJ572906 AA766892 BG481601 F27179 BM887738 BU856831 F15718 BF685714 AA316785 BE907416 AI393885 BG385432 BQ950200 AI718350 BE904009 CD251211 F30048 AJ573250
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RPL37A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for RPL37A
|
Expression
for RPL37A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL37A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGACAGTGG
About this image
See RPL37A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL37A
SOURCE GeneReport for Unigene cluster: Hs.433701
SABiosciences Custom PCR Arrays for RPL37A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL37A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL37A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL37A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL37A |
Orthologs
for RPL37A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL37A gene from 10/36 species (see all 36) About this table
ENSEMBL Gene Tree for RPL37A (if available)
TreeFam Gene Tree for RPL37A (if available) |
Paralogs
for RPL37A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPL37A gene
1 SIMAP similar gene for RPL37A using alignment to 7 protein entries: RL37A_HUMAN (see all proteins):RPL37L
RPL37A for paralogs About GeneDecksing
5/10 Pseudogenes.org Pseudogenes for RPL37A (see all 10)
PGOHUM00000250390 PGOHUM00000242623 PGOHUM00000239355 PGOHUM00000247540 PGOHUM00000245531
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Genomic Variants
for RPL37A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL37A (217362912 - 217443903 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPL37A: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RPL37A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL37A for disorders About GeneDecksing
OMIM gene information: 613314
OMIM disorders: --
1  disease for RPL37A: About MalaCardsmalaria
Export disorders for RPL37A gene to outside databases
|
Publications
for RPL37A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL37A gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with RPL37A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Primary sequence of the human ribosomal protein L37a. (PubMed id 1437567)1, 2, 3, 9 Hoof T.... Tuemmler B. (1992)
- Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines. (PubMed id 8224875)1, 2, 9 Saha D.P.... Howells R.D. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
|
External Searches for RPL37A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPL37A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL37A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL37A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPL37A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPL37A gene:
Search GeneIP for patents involving RPL37A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPL37A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPL37A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPL37A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL37A | | | OriGene Protein Over-expression Lysate for RPL37A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPL37A | | OriGene 3'-UTR Clone for RPL37A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL37A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL37A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL37A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL37A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL37A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL37A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL37A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL37A |
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 | | | RPL37A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for RPL37A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL37A |
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