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Aliases for RPL37 Gene

Aliases for RPL37 Gene

  • Ribosomal Protein L37 2 3 5
  • 60S Ribosomal Protein L37a 2 3
  • G1.16 3 4
  • L37 3

External Ids for RPL37 Gene

Previous GeneCards Identifiers for RPL37 Gene

  • GC05M041139
  • GC05M041924
  • GC05M040878
  • GC05M040876
  • GC05M040866
  • GC05M040783

Summaries for RPL37 Gene

Entrez Gene Summary for RPL37 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL37 Gene

RPL37 (Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot for RPL37 Gene

  • Binds to the 23S rRNA.

Gene Wiki entry for RPL37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL37 Gene

Genomics for RPL37 Gene

Regulatory Elements for RPL37 Gene

Promoters for RPL37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL37 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL37 Gene

Chromosome:
5
Start:
40,825,262 bp from pter
End:
40,835,335 bp from pter
Size:
10,074 bases
Orientation:
Minus strand

Genomic View for RPL37 Gene

Genes around RPL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL37 Gene

Proteins for RPL37 Gene

  • Protein details for RPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61927-RL37_HUMAN
    Recommended name:
    60S ribosomal protein L37
    Protein Accession:
    P61927
    Secondary Accessions:
    • B2R4H2
    • P02403
    • Q6IBB4
    • Q99883

    Protein attributes for RPL37 Gene

    Size:
    97 amino acids
    Molecular mass:
    11078 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL37 Gene

neXtProt entry for RPL37 Gene

Proteomics data for RPL37 Gene at MOPED

Post-translational modifications for RPL37 Gene

  • Ubiquitination at Lys 31
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL37 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RPL37

No data available for DME Specific Peptides for RPL37 Gene

Domains & Families for RPL37 Gene

Gene Families for RPL37 Gene

Protein Domains for RPL37 Gene

Suggested Antigen Peptide Sequences for RPL37 Gene

Graphical View of Domain Structure for InterPro Entry

P61927

UniProtKB/Swiss-Prot:

RL37_HUMAN :
  • Belongs to the ribosomal protein L37e family.
Family:
  • Belongs to the ribosomal protein L37e family.
genes like me logo Genes that share domains with RPL37: view

Function for RPL37 Gene

Molecular function for RPL37 Gene

GENATLAS Biochemistry:
60S ribosomal protein L37,11kDa,overexpressed in colon cancer
UniProtKB/Swiss-Prot Function:
Binds to the 23S rRNA.
genes like me logo Genes that share phenotypes with RPL37: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPL37

miRNA for RPL37 Gene

miRTarBase miRNAs that target RPL37

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL37 Gene

Localization for RPL37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL37 Gene COMPARTMENTS Subcellular localization image for RPL37 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPL37 Gene

Pathways & Interactions for RPL37 Gene

genes like me logo Genes that share pathways with RPL37: view

Pathways by source for RPL37 Gene

1 BioSystems pathway for RPL37 Gene
1 KEGG pathway for RPL37 Gene
1 GeneGo (Thomson Reuters) pathway for RPL37 Gene

Gene Ontology (GO) - Biological Process for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPL37: view

No data available for SIGNOR curated interactions for RPL37 Gene

Drugs & Compounds for RPL37 Gene

(5) Drugs for RPL37 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE Experimental Pharma Target 0
Virginiamycin factor S1 Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL37: view

Transcripts for RPL37 Gene

Unigene Clusters for RPL37 Gene

Ribosomal protein L37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1:
SP2: - -
SP3: -
SP4: -

Relevant External Links for RPL37 Gene

GeneLoc Exon Structure for
RPL37
ECgene alternative splicing isoforms for
RPL37

Expression for RPL37 Gene

mRNA expression in normal human tissues for RPL37 Gene

Protein differential expression in normal tissues from HIPED for RPL37 Gene

This gene is overexpressed in Lung (32.8), Peripheral blood mononuclear cells (13.1), Cervix (8.9), and Bone (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL37 Gene



SOURCE GeneReport for Unigene cluster for RPL37 Gene Hs.447582

genes like me logo Genes that share expression patterns with RPL37: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RPL37 Gene

Orthologs for RPL37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL37 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL37 35
  • 95.53 (n)
  • 100 (a)
RPL37 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL37 35
  • 95.88 (n)
  • 100 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl37 35
  • 92.78 (n)
  • 100 (a)
Rpl37 16
Rpl37 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL37 35
  • 100 (n)
  • 100 (a)
RPL37 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360841 35
  • 95.19 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL37 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL37 35
  • 83.33 (n)
  • 97.73 (a)
RPL37 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL37 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl37 35
  • 86.36 (n)
  • 96.59 (a)
Str.11137 35
zebrafish
(Danio rerio)
Actinopterygii rpl37 35
  • 81.06 (n)
  • 92.05 (a)
rpl37 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9091 37
  • 75 (a)
CG9873 37
  • 66 (a)
RpL37a 35
  • 68.94 (n)
  • 77.27 (a)
RpL37a 36
  • 74 (a)
OneToMany
RpL37b 36
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000952 35
  • 63.26 (n)
  • 73.86 (a)
worm
(Caenorhabditis elegans)
Secernentea W01D2.1 35
  • 59.39 (n)
  • 64.37 (a)
rpl-37 36
  • 60 (a)
OneToMany
W01D2.1 36
  • 62 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR688C 35
  • 65.43 (n)
  • 65.43 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01870g 35
  • 63.79 (n)
  • 67.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL37A 35
  • 63.18 (n)
  • 65.12 (a)
RPL37A 36
  • 65 (a)
OneToMany
RPL37B 36
  • 61 (a)
OneToMany
RPL37A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52300 35
  • 61.69 (n)
  • 70.11 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12413 35
rice
(Oryza sativa)
Liliopsida Os02g0111700 35
  • 64.02 (n)
  • 69.32 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5687 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01966 35
  • 60.57 (n)
  • 65.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3702 35
  • 63.37 (n)
  • 67.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for RPL37:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL37 Gene

ENSEMBL:
Gene Tree for RPL37 (if available)
TreeFam:
Gene Tree for RPL37 (if available)

Paralogs for RPL37 Gene

genes like me logo Genes that share paralogs with RPL37: view

No data available for Paralogs for RPL37 Gene

Variants for RPL37 Gene

Sequence variations from dbSNP and Humsavar for RPL37 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_014606 -
rs29763 -- 40,831,840(-) ATCAA(A/C/G)TATAA utr-variant-3-prime
rs29764 -- 40,831,822(+) GTCTA(C/G)AAATC utr-variant-3-prime
rs29765 -- 40,831,749(+) AACAC(A/G)GAAAC utr-variant-3-prime
rs154274 -- 40,837,010(-) gtatt(A/C)atccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL37 Gene

Variant ID Type Subtype PubMed ID
nsv880438 CNV Loss 21882294
nsv518711 CNV Loss 19592680

Variation tolerance for RPL37 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL37 Gene

HapMap Linkage Disequilibrium report
RPL37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL37 Gene

Disorders for RPL37 Gene

Relevant External Links for RPL37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL37

No disorders were found for RPL37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL37 Gene

Publications for RPL37 Gene

  1. Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain. (PMID: 7545944) Barnard G.F. … Chen L.B. (Biochim. Biophys. Acta 1994) 2 3 4 23 67
  2. CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism. (PMID: 15485924) Schwartz E.I. … Maraia R.J. (Mol. Cell. Biol. 2004) 3 23
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  4. Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37. (PMID: 7588717) Su S. … Bird R.C. (Eur. J. Biochem. 1995) 3 23
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for RPL37 Gene

Sources for RPL37 Gene

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