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Aliases for RPL37 Gene

Aliases for RPL37 Gene

  • Ribosomal Protein L37 2 3
  • 60S Ribosomal Protein L37a 2 3
  • G1.16 3 4
  • 60S Ribosomal Protein L37 3
  • L37 3

External Ids for RPL37 Gene

Summaries for RPL37 Gene

Entrez Gene Summary for RPL37 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL37 Gene

RPL37 (Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot for RPL37 Gene

  • Binds to the 23S rRNA.

Gene Wiki entry for RPL37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL37 Gene

Genomics for RPL37 Gene

Genomic Location for RPL37 Gene

Start:
40,825,262 bp from pter
End:
40,835,335 bp from pter
Size:
10,074 bases
Orientation:
Minus strand

Genomic View for RPL37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL37 Gene

Regulatory Elements for RPL37 Gene

Proteins for RPL37 Gene

  • Protein details for RPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61927-RL37_HUMAN
    Recommended name:
    60S ribosomal protein L37
    Protein Accession:
    P61927
    Secondary Accessions:
    • B2R4H2
    • P02403
    • Q6IBB4
    • Q99883

    Protein attributes for RPL37 Gene

    Size:
    97 amino acids
    Molecular mass:
    11078 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL37 Gene

neXtProt entry for RPL37 Gene

Proteomics data for RPL37 Gene at MOPED

Post-translational modifications for RPL37 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys31

Other Protein References for RPL37 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL37 Gene

Domains for RPL37 Gene

Gene Families for RPL37 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL37 Gene

UniProtKB/Swiss-Prot:

RL37_HUMAN
Family:
  • Belongs to the ribosomal protein L37e family.:
    • P61927
genes like me logo Genes that share domains with RPL37: view

Function for RPL37 Gene

Molecular function for RPL37 Gene

GENATLAS Biochemistry: 60S ribosomal protein L37,11kDa,overexpressed in colon cancer
UniProtKB/Swiss-Prot Function: Binds to the 23S rRNA.

Gene Ontology (GO) - Molecular Function for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7545944
GO:0003735 structural constituent of ribosome TAS 7545944
GO:0019843 rRNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPL37: view
genes like me logo Genes that share phenotypes with RPL37: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL37 Gene

Localization for RPL37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL37 Gene COMPARTMENTS Subcellular localization image for RPL37 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0022625 cytosolic large ribosomal subunit TAS 7545944
genes like me logo Genes that share ontologies with RPL37: view

Pathways for RPL37 Gene

genes like me logo Genes that share pathways with RPL37: view

Pathways by source for RPL37 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL37 Gene
1 BioSystems pathway for RPL37 Gene

Gene Ontology (GO) - Biological Process for RPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS 7545944
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL37: view

Compounds for RPL37 Gene

(5) Drugbank Compounds for RPL37 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target
PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE
target
Virginiamycin factor S1
  • Virginiamycin factor S
23152-29-6 target
genes like me logo Genes that share compounds with RPL37: view

Transcripts for RPL37 Gene

mRNA/cDNA for RPL37 Gene

Unigene Clusters for RPL37 Gene

Ribosomal protein L37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1:
SP2: - -
SP3: -
SP4: -

Relevant External Links for RPL37 Gene

GeneLoc Exon Structure for
RPL37
ECgene alternative splicing isoforms for
RPL37

Expression for RPL37 Gene

mRNA expression in normal human tissues for RPL37 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL37 Gene

SOURCE GeneReport for Unigene cluster for RPL37 Gene Hs.447582

genes like me logo Genes that share expressions with RPL37: view

Orthologs for RPL37 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL37 36
  • 100 (n)
  • 100 (a)
RPL37 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL37 36
  • 95.53 (n)
  • 100 (a)
RPL37 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
RPL37 36
  • 95.88 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rpl37 36
  • 92.78 (n)
  • 100 (a)
Rpl37 16
Rpl37 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL37 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360841 36
  • 95.19 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL37 36
  • 83.33 (n)
  • 97.73 (a)
RPL37 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL37 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl37 36
  • 86.36 (n)
  • 96.59 (a)
Str.11137 36
zebrafish
(Danio rerio)
Actinopterygii rpl37 36
  • 81.06 (n)
  • 92.05 (a)
rpl37 37
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000952 36
  • 63.26 (n)
  • 73.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL37a 36
  • 68.94 (n)
  • 77.27 (a)
RpL37a 37
  • 74 (a)
OneToMany
RpL37b 37
  • 65 (a)
OneToMany
CG9091 38
  • 75 (a)
CG9873 38
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-37 37
  • 60 (a)
OneToMany
W01D2.1 36
  • 59.39 (n)
  • 64.37 (a)
W01D2.1 37
  • 62 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR688C 36
  • 65.43 (n)
  • 65.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL37A 36
  • 63.18 (n)
  • 65.12 (a)
RPL37A 37
  • 65 (a)
OneToMany
RPL37A 39
RPL37B 37
  • 61 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01870g 36
  • 63.79 (n)
  • 67.9 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52300 36
  • 61.69 (n)
  • 70.11 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12413 36
rice
(Oryza sativa)
Liliopsida Os02g0111700 36
  • 64.02 (n)
  • 69.32 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5687 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01966 36
  • 60.57 (n)
  • 65.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3702 36
  • 63.37 (n)
  • 67.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 67 (a)
OneToOne
Species with no ortholog for RPL37:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL37 Gene

ENSEMBL:
Gene Tree for RPL37 (if available)
TreeFam:
Gene Tree for RPL37 (if available)

Paralogs for RPL37 Gene

genes like me logo Genes that share paralogs with RPL37: view

No data available for Paralogs for RPL37 Gene

Variants for RPL37 Gene

Sequence variations from dbSNP and Humsavar for RPL37 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs29763 -- 40,831,840(-) ATCAA(C/G)TATAA utr-variant-3-prime
rs29764 -- 40,831,822(+) GTCTA(C/G)AAATC utr-variant-3-prime
rs29765 -- 40,831,749(+) AACAC(A/G)GAAAC utr-variant-3-prime
rs42515 -- 40,835,428(-) CCGAC(A/G)AAGAC upstream-variant-2KB
rs154274 -- 40,837,010(-) gtatt(A/C)atccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL37 Gene

Variant ID Type Subtype PubMed ID
nsv880438 CNV Loss 21882294
nsv518711 CNV Loss 19592680

Relevant External Links for RPL37 Gene

HapMap Linkage Disequilibrium report
RPL37

Disorders for RPL37 Gene

No disorders were found for RPL37 Gene.

No data available for UniProtKB/Swiss-Prot for RPL37 Gene

Publications for RPL37 Gene

  1. Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain. (PMID: 7545944) Barnard G.F. … Chen L.B. (Biochim. Biophys. Acta 1994) 2 3 4 23
  2. Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37. (PMID: 7588717) Su S. … Bird R.C. (Eur. J. Biochem. 1995) 3 4 23
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  5. CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism. (PMID: 15485924) Schwartz E.I. … Maraia R.J. (Mol. Cell. Biol. 2004) 3 23

Products for RPL37 Gene

Sources for RPL37 Gene

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