RPL36AL Gene
protein-coding GIFtS: 55
GCID: GC14M050086
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|
ribosomal protein L36a-like(Previous name: ribosomal protein L36a ) (Previous symbol: RPL36A)
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Aliases for RPL36AL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosomal Protein L36a-Like1 2 | | RPL36A1 2 5 | | Ribosomal Protein L36a1 | | 60S Ribosomal Protein L36a-Like2 | | Ribosomal Protein HL442 |
Export aliases for RPL36AL gene to outside databasesPrevious GC identifers: GC14M047405 GC14M043881 GC14M048073 GC14M048075 GC14M049155 GC14M030202 |
Summaries for RPL36AL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RPL36AL: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60Ssubunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequencesimilarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene andthe human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they aredistinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its officialname is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multipleprocessed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)
|
Genomic Views for RPL36AL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPL36AL gene promoter: TBP Elk-1 Pax-5 AP-1 LCR-F1 C/EBPalpha HEN1 NRF-2 HOXA5 c-Myb Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL36AL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL36AL |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21 Ensembl cytogenetic band: 14q21.3 HGNC cytogenetic band: 14q21RPL36AL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M050086: view genomic region
(about GC identifiers)
Start:
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50,085,237 bp from pter |
End:
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50,087,403 bp from pter |
Size:
|
2,167 bases |
Orientation:
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minus strand |
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Proteins for RPL36AL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0 (See
protein sequence)Recommended Name: 60S ribosomal protein L36a-like Size: 106 amino acids; 12469 Da
Subcellular location: Cytoplasm (Probable)
Miscellaneous: This gene has no introns in its coding regions, and therefore, was most likely produced byretrotransposition of the original X-linked gene during evolution
Secondary accessions: Q3B7A5Explore the universe of human proteins at neXtProt for RPL36AL: NX_Q969Q0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969Q0 RPL36AL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000992.1 ENSEMBL proteins: ENSP00000346012 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005840 | ribosome |
IEA | -- |
RPL36AL for ontologies About GeneDecksing
RPL36AL Antibody Products: Assay Products for RPL36AL: |
Protein
Domains / Families for RPL36AL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL36AL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969Q0ProtoNet protein and cluster: Q969Q0 1 Blocks protein family: IPB000552 Ribosomal protein L44E
UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0Similarity: Belongs to the ribosomal protein L44e family |
Function for RPL36AL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36AL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36AL OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL36AL (NM_001001) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL36AL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
RPL36AL for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RPL36AL:
|
Pathways & Interactions for RPL36AL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for RPL36AL):
RPL36AL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL36AL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/87 Interacting proteins for RPL36AL (Q969Q02, 3 ENSP000003460124) via UniProtKB, MINT, STRING, and/or I2D (see all 87)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
RPL36AL for ontologies About GeneDecksing
|
Drugs & Compounds for RPL36AL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPL36AL Search CenterWatch for drugs/clinical trials and news about RPL36AL / RL36L 
|
Transcripts for RPL36AL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPL36AL gene: NM_001001.4 Unigene Cluster for RPL36AL: Ribosomal protein L36a-like Hs.444749 [show with all ESTs]Unigene Representative Sequence: BU9020701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000298289(uc001wwq.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36AL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36AL OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL36AL (NM_001001) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL36AL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL36AL  |
Additional cDNA sequence: AB063609.1 AK311959.1 BC000741.2 BC003145.1 BC070207.1 BC107716.1 CR542166.1 M15661.1 13 DOTS entries: DT.317891 DT.100034171 DT.95156332 DT.120730038 DT.100806931 DT.100825526 DT.100825531 DT.102824168 DT.120730033 DT.120729904 DT.120729979 DT.120730032 DT.417467 24/361 AceView cDNA sequences (see all 361): BM662362 CD679401 BG940882 AA211585 AA308438 BC003145 AA304119 AA196119 AI199158 AI801282 CB113726 BP872691 M15661 BM560769 BG944543 BM510830 BG112886 BI494273 AA564302 BQ012876 BG944567 BU737939 AI149112 AI863146 GeneLoc Exon Structure
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Expression for RPL36AL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL36AL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTGAAGCCAT
About this image See RPL36AL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPL36AL
SOURCE GeneReport for Unigene cluster: Hs.444749 UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0Tissue specificity: Ubiquitously expressed SABiosciences Custom PCR Arrays for RPL36AL
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL36AL Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPL36AL | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL36AL | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL36AL | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL36AL |
Orthologs for RPL36AL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL36AL gene from 10/38 species (see all 38) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Rpl36al5 Gm131941 |
ribosomal protein L36A-like5 predicted gene 131941 |
81.13(n)1 87.74(a)1 |
  |
12 (28.73 cM)5 3813461 XM_355309.61 XP_355309.51 691827315 |
chicken (Gallus gallus) |
Aves |
F1NIK4_CHICK6 |
Uncharacterized protein |
83(a) |
1 → many |
4(2006692-2008731) |
lizard (Anolis carolinensis) |
Reptilia |
-- |
-- |
96(a) |
1 → many |
GL343451.1(251997-253513) |
African clawed frog (Xenopus laevis) |
Amphibia |
480627542 |
-- |
84.34(n) |
  |
48062754 |
zebrafish (Danio rerio) |
Actinopterygii |
rpl36a1 |
ribosomal protein L36A |
83.02(n) 97.17(a) |
  |
195819 NM_001202510.1 NP_001189439.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG74243 RpL36A1 |
protein biosynthesis structural constituent of more3 Ribosomal protein L36A1 |
76(a)3 70.19(n)1 77.88(a)1 |
  |
28D93 340981 NM_135335.31 NP_609179.21 |
worm (Caenorhabditis elegans) |
Secernentea |
C09H10.23 rpl-411 |
60S ribosomal protein3 Protein RPL-411 |
79(a)3 70.19(n)1 81.73(a)1 |
  |
II(11096040-11097125)3 1746951 NM_063974.61 NP_496375.11 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
RPL42A(YNL162W)4 RPL42A1 |
Protein component of the large (60S) ribosomal subunit, more4 Rpl42ap1 |
69.87(n)1 75(a)1 |
  |
14(331322-332154)4 8555601, 4 NP_014237.21, 4 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT4G143201 |
60S ribosomal protein L36a |
69.7(n) 75.76(a) |
  |
827074 NM_117509.2 NP_193168.1 |
rice (Oryza sativa) |
Liliopsida |
Os.226312 |
Rice mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate more |
79.92(n) |
  |
AK069083.1 |
ENSEMBL Gene Tree for RPL36AL (if available) TreeFam Gene Tree for RPL36AL (if available)  |
Paralogs for RPL36AL gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RPL36AL gene
- RPL36A2 ENSG000002575292
1 SIMAP similar gene for RPL36AL using alignment to 1 protein entry: RL36L_HUMAN:RPL36A
RPL36AL for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for RPL36AL (see all 8) PGOHUM00000239758 PGOHUM00000246783 PGOHUM00000237446 PGOHUM00000243982 PGOHUM00000240032
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Genomic Variants for RPL36AL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 14 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL36AL (50085237 - 50087403 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RPL36AL 1 CNV: 66642  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL36AL |
|
Disorders
/ Diseases for RPL36AL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL36AL for disorders About GeneDecksing
OMIM gene information: 180469
OMIM disorders: --
3 diseases for RPL36AL: About MalaCardsdiamond-blackfan anemia anemia malaria 1 disease from the University of Copenhagen DISEASES database for RPL36AL:Diamond-Blackfan anemia Export disorders for RPL36AL gene to outside databases
|
Publications for RPL36AL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL36AL gene, integrated from 9 sources (see all 15): (articles sorted by number of sources associating them with RPL36AL) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)1, 2 Uechi T.... Kenmochi N. (2002)
- The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (1992)
- Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. (PubMed id 3542712)1, 2 Davies M.S.... Craig R.K. (1986)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
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External Searches for RPL36AL gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPL36AL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL36AL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL36AL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPL36AL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPL36AL gene: Search GeneIP for patents involving RPL36AL
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPL36AL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | RPL36AL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL36AL |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL36AL |
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