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Aliases for RPL36AL Gene

Aliases for RPL36AL Gene

  • Ribosomal Protein L36a Like 2 3 5
  • Large Ribosomal Subunit Protein EL42-Like 3 4
  • 60S Ribosomal Protein L36a-Like 3
  • Ribosomal Protein L36a-Like 2
  • Ribosomal Protein L36a 2
  • Ribosomal Protein HL44 3
  • RPL36A 3

External Ids for RPL36AL Gene

Previous HGNC Symbols for RPL36AL Gene

  • RPL36A

Previous GeneCards Identifiers for RPL36AL Gene

  • GC14M047405
  • GC14M043881
  • GC14M048073
  • GC14M048075
  • GC14M049155
  • GC14M050086
  • GC14M030202

Summaries for RPL36AL Gene

Entrez Gene Summary for RPL36AL Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL36AL Gene

RPL36AL (Ribosomal Protein L36a Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL36A.

Additional gene information for RPL36AL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36AL Gene

Genomics for RPL36AL Gene

Regulatory Elements for RPL36AL Gene

Enhancers for RPL36AL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H049618 1.7 FANTOM5 ENCODE dbSUPER 49.2 -1.5 -1501 6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS RPL36AL LRR1 VCPKMT DNAAF2 NEMF RNU6ATAC30P RHOQP1 KLHDC2 ARF6 RPS29
GH14H049594 1.4 Ensembl ENCODE 55.3 +23.2 23165 7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 RPL36AL LRR1 MGAT2 POLE2 VCPKMT RHOQP1 ENSG00000252919
GH14H049632 1.4 ENCODE dbSUPER 45.6 -14.0 -13957 4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 RPL36AL LRR1 RNU6ATAC30P STK16P1 RHOQP1 DNAAF2 PIR31071
GH14H049584 1.1 ENCODE 38.8 +34.9 34879 4 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 FOS LRR1 RPL36AL POLE2 KLHDC1 KLHDC2 VCPKMT NEMF MAP4K5 RHOQP1 RPS29
GH14H049549 0.8 FANTOM5 ENCODE 37.6 +70.4 70418 0 RFX1 CEBPA HLF FOS HNF4A RPL36AL RNA5SP384 GC14P049375
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL36AL on UCSC Golden Path with GeneCards custom track

Promoters for RPL36AL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000274434 -115 2801 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Location for RPL36AL Gene

Chromosome:
14
Start:
49,618,519 bp from pter
End:
49,620,685 bp from pter
Size:
2,167 bases
Orientation:
Minus strand

Genomic View for RPL36AL Gene

Genes around RPL36AL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL36AL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL36AL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL36AL Gene

Proteins for RPL36AL Gene

  • Protein details for RPL36AL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q0-RL36L_HUMAN
    Recommended name:
    60S ribosomal protein L36a-like
    Protein Accession:
    Q969Q0
    Secondary Accessions:
    • Q3B7A5

    Protein attributes for RPL36AL Gene

    Size:
    106 amino acids
    Molecular mass:
    12469 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.

neXtProt entry for RPL36AL Gene

Post-translational modifications for RPL36AL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL36AL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL36AL Gene

Domains & Families for RPL36AL Gene

Gene Families for RPL36AL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL36AL Gene

Suggested Antigen Peptide Sequences for RPL36AL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Q0

UniProtKB/Swiss-Prot:

RL36L_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL42 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL42 family.
genes like me logo Genes that share domains with RPL36AL: view

Function for RPL36AL Gene

Phenotypes From GWAS Catalog for RPL36AL Gene

Gene Ontology (GO) - Molecular Function for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL36AL: view
genes like me logo Genes that share phenotypes with RPL36AL: view

Animal Model Products

CRISPR Products

miRNA for RPL36AL Gene

miRTarBase miRNAs that target RPL36AL

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL36AL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36AL Gene

Localization for RPL36AL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL36AL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL36AL gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 25468996
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL36AL: view

Pathways & Interactions for RPL36AL Gene

genes like me logo Genes that share pathways with RPL36AL: view

Pathways by source for RPL36AL Gene

Gene Ontology (GO) - Biological Process for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RPL36AL: view

No data available for SIGNOR curated interactions for RPL36AL Gene

Drugs & Compounds for RPL36AL Gene

No Compound Related Data Available

Transcripts for RPL36AL Gene

mRNA/cDNA for RPL36AL Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(361) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL36AL Gene

Ribosomal protein L36a-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL36AL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36AL Gene

No ASD Table

Relevant External Links for RPL36AL Gene

GeneLoc Exon Structure for
RPL36AL
ECgene alternative splicing isoforms for
RPL36AL

Expression for RPL36AL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL36AL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL36AL Gene

This gene is overexpressed in Lymph node (11.8), Monocytes (10.5), Pancreas (6.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL36AL Gene



Protein tissue co-expression partners for RPL36AL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL36AL Gene:

RPL36AL

SOURCE GeneReport for Unigene cluster for RPL36AL Gene:

Hs.444749

mRNA Expression by UniProt/SwissProt for RPL36AL Gene:

Q969Q0-RL36L_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for RPL36AL Gene

  • Kidney(4.5)
  • Muscle(4.5)
  • Blood(2.7)
  • Nervous system(2.7)
  • Liver(2.6)
  • Heart(2.4)
  • Spleen(2.4)
  • Lung(2.3)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Intestine(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with RPL36AL: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL36AL Gene

Orthologs for RPL36AL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36AL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL36AL 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia RPL36A 34
  • 99 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl36a 34
  • 99 (a)
ManyToMany
Rpl36al 33 16
  • 92.14 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
ManyToMany
LOC480311 33
  • 94.03 (n)
-- 34
  • 92 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl36al 33
  • 91.82 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1359 33
zebrafish
(Danio rerio)
Actinopterygii rpl36a 34
  • 97 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8630 33
fruit fly
(Drosophila melanogaster)
Insecta RpL36A 34
  • 78 (a)
OneToMany
CG7424 35
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-41 34
  • 80 (a)
OneToMany
C09H10.2 35
  • 79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL42A 34 36
  • 74 (a)
ManyToMany
RPL42B 34
  • 74 (a)
ManyToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1846 33
barley
(Hordeum vulgare)
Liliopsida Hv.4260 33
rice
(Oryza sativa)
Liliopsida Os.22631 33
corn
(Zea mays)
Liliopsida Zm.2895 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6059 34
  • 77 (a)
OneToMany
Species where no ortholog for RPL36AL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL36AL Gene

ENSEMBL:
Gene Tree for RPL36AL (if available)
TreeFam:
Gene Tree for RPL36AL (if available)

Paralogs for RPL36AL Gene

Paralogs for RPL36AL Gene

(2) SIMAP similar genes for RPL36AL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL36AL: view

Variants for RPL36AL Gene

Sequence variations from dbSNP and Humsavar for RPL36AL Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs104894446 Pathogenic 49,622,137(+) TCTCT(C/T)CCTGG upstream-variant-2KB, reference, missense
rs104894447 Pathogenic 49,622,053(+) GGATC(A/G)CTACT upstream-variant-2KB, reference, missense
rs104894448 Pathogenic 49,622,220(+) AGCAC(A/G)ATATG upstream-variant-2KB, reference, missense
rs104894449 Pathogenic 49,622,285(+) TTCTG(A/T)ACTTA upstream-variant-2KB, reference, stop-gained
rs730882218 Pathogenic 49,621,979(+) TGGAA(C/G)CTGCA upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RPL36AL Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv976338 CNV duplication 23825009

Variation tolerance for RPL36AL Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL36AL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL36AL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36AL Gene

Disorders for RPL36AL Gene

Relevant External Links for RPL36AL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL36AL

No disorders were found for RPL36AL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL36AL Gene

Publications for RPL36AL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes. (PMID: 12490704) Uechi T … Kenmochi N (Nucleic acids research 2002) 3 4 60
  3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S … Fried M (Genomics 1992) 2 3 60
  4. Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. (PMID: 3542712) Davies MS … Craig RK (Gene 1986) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RPL36AL Gene

Sources for RPL36AL Gene

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