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RPL36AL Gene

protein-coding   GIFtS: 57
GCID: GC14M050086

Ribosomal Protein L36a-Like

(Previous name: ribosomal protein L36a)
(Previous symbol: RPL36A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L36a-Like1 2
RPL36A1 2 5
Ribosomal Protein L36a1
60S Ribosomal Protein L36a-Like2
Ribosomal Protein HL442

External Ids:    HGNC: 103461   Entrez Gene: 61662   Ensembl: ENSG000001655027   OMIM: 1804695   UniProtKB: Q969Q03   

Export aliases for RPL36AL gene to outside databases

Previous GC identifers: GC14M047405 GC14M043881 GC14M048073 GC14M048075 GC14M049155 GC14M030202


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL36AL Gene:
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S
subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct
proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares
sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins.
This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins;
however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a
(RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RPL36AL Gene:
RPL36AL (ribosomal protein L36a-like) is a protein-coding gene. Diseases associated with RPL36AL include diamond-blackfan anemia, and malaria. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL36A-HNRNPH2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL36AL gene promoter:
         TBP   Elk-1   Pax-5   AP-1   LCR-F1   C/EBPalpha   HEN1   NRF-2   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL36AL promoter sequence
   Search Chromatin IP Primers for RPL36AL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL36AL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21

RPL36AL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL36AL gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050086:  view genomic region     (about GC identifiers)

Start:
50,085,237 bp from pter      End:
50,087,403 bp from pter
Size:
2,167 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0 (See protein sequence)
Recommended Name: 60S ribosomal protein L36a-like  
Size: 106 amino acids; 12469 Da
Miscellaneous: This gene has no introns in its coding regions, and therefore, was most likely produced by
retrotransposition of the original X-linked gene during evolution
Secondary accessions: Q3B7A5

Explore the universe of human proteins at neXtProt for RPL36AL: NX_Q969Q0

Explore proteomics data for RPL36AL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RPL36AL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000992.1  
    ENSEMBL proteins: 
     ENSP00000346012  

    RPL36AL Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    2 InterPro protein domains:
     IPR000552 Ribosomal_L44e
     IPR011332 Ribosomal_zn-bd

    Graphical View of Domain Structure for InterPro Entry Q969Q0

    ProtoNet protein and cluster: Q969Q0

    1 Blocks protein domain: IPB000552 Ribosomal protein L44E

    UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0
    Similarity: Belongs to the ribosomal protein L44e family


    RPL36AL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
         
    RPL36AL for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPL36AL:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RL36L_HUMAN, Q969Q0: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005840ribosome IEA--

    RPL36AL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL36AL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RPL36AL):
        Ribosome


    RPL36AL for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL36AL
    Interactions:

        Search GeneGlobe Interaction Network for RPL36AL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL36AL (Q969Q02, 3 ENSP000003460124) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf25Q9BPX72, 3MINT-8250087 I2D: score=2 
    GSK3BP498412, 3MINT-8257636 I2D: score=2 
    TAF1DQ9H5J82, 3MINT-8272707 I2D: score=2 
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    RPL36AL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL36AL (RL36L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL36AL gene: 
    NM_001001.4  

    Unigene Cluster for RPL36AL:

    Ribosomal protein L36a-like
    Hs.444749  [show with all ESTs]
    Unigene Representative Sequence: BU902070
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298289(uc001wwq.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL36AL
      QuantiFast Probe-based Assays in human, mouse, rat RPL36AL

    Additional mRNA sequence: 

    AB063609.1 AK311959.1 BC000741.2 BC003145.1 BC070207.1 BC107716.1 M15661.1 

    13 DOTS entries:

    DT.317891  DT.100034171  DT.95156332  DT.120730038  DT.100806931  DT.100825531  DT.102824168  DT.120730033 
    DT.100825526  DT.120729904  DT.120729979  DT.120730032  DT.417467 

    Selected AceView cDNA sequences (see all 361):

    BM910475 CD679401 AI817372 AA580408 BG940882 BG940172 AA564302 NM_001001 
    AA506417 BE562951 BE206116 BQ340264 BG112886 BP872691 CB113726 BU153427 
    AA669012 AA192987 BP873083 BQ012382 BM560769 BE395743 CA430321 AA308438 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL36AL expression in normal human tissues (normalized intensities)      RPL36AL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAGCCAT
    RPL36AL Expression
    About this image


    RPL36AL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    RPL36AL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL36AL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444749

    UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL36AL gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl36al1 , 5 ribosomal protein L36A-like1, 5 92.14(n)1
    99.06(a)1
      12 (28.73 cM)5
    664831  NM_025589.41  NP_079865.11 
     691827315 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    89(a)
    1 → many
    4(2004055-2006369)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    96(a)
    1 → many
    GL343451.1(251997-253513)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480627542   -- 84.34(n)    48062754 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl36a6
    ribosomal protein L36A
    97(a)
    1 → many
    5(24293967-24298514) ENSDARG00000058105
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74243 protein biosynthesis structural
    constituent of more
    76(a)   28D9   --
    worm
    (Caenorhabditis elegans)
    Secernentea C09H10.23 60S ribosomal protein 79(a)   II(11096040-11097125)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL42A(YNL162W)4 Protein component of the large (60S) ribosomal subunit, more   --   14(331322-332154) 855560  NP_014237.2 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.18462 Vitis vinifera transcribed sequence with strong similarity more 77.42(n)    CB918643.1 
    rice
    (Oryza sativa)
    Liliopsida Os.226312 Rice mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate more 79.92(n)    AK069083.1 


    ENSEMBL Gene Tree for RPL36AL (if available)
    TreeFam Gene Tree for RPL36AL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL36AL gene
    RPL36A-HNRNPH22  RPL36A2  
    2 SIMAP similar genes for RPL36AL using alignment to 1 protein entry:     RL36L_HUMAN:
    RPL36A    RPL36A-HNRNPH2

    RPL36AL for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL36AL (see all 8)
    PGOHUM00000239758 PGOHUM00000246783 PGOHUM00000237446 PGOHUM00000243982 PGOHUM00000240032


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL36AL (see all 15)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173150861,2
    C,F--50084969(+) AAGGCC/GACAGT 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1870902861,2
    --50084975(+) ACAGTC/TTCTAA 1 -- ds50010--------
    rs802707061,2
    --50084986(+) CAGTAC/GTGTCC 1 -- ds50010--------
    rs1394781801,2
    C--50085072(+) TAAATC/TTGACT 1 -- ds50010--------
    rs1501845111,2
    C--50085074(+) AATCTG/CACTAG 1 -- ds50011Minor allele frequency- C:0.01NS 124
    rs1496728701,2
    --50085109(+) CTAGCA/GGCCCC 1 -- ds50010--------
    rs1477892071,2
    --50085126(+) ACAGAA/GTATTT 1 -- ds50010--------
    rs1412416401,2
    --50085137(+) GGTCAA/GCTCTT 1 -- ds50010--------
    rs1153481121,2
    C,F--50085198(+) CCTAGC/TGTTAT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs789309731,2
    C--50085339(+) ACTTGC/TTAGTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPL36AL (50085237 - 50087403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPL36AL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28926CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL36AL
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL36AL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180469    OMIM disorders: --

    3 diseases for RPL36AL:    About MalaCards
    diamond-blackfan anemia    malaria    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RPL36AL:
    Diamond-Blackfan anemia

    RPL36AL for disorders           About GeneDecksing


    Export disorders for RPL36AL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL36AL gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RPL36AL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)1, 2 Uechi T.... Kenmochi N. (Nucleic Acids Res. 2002)
    3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (Genomics 1992)
    4. Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. (PubMed id 3542712)1, 2 Davies M.S.... Craig R.K. (Gene 1986)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A large set of estrogen receptor I^-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. (PubMed id 21182203)1 Nassa G....Weisz A. (Proteomics 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6166 HGNC: 10346 AceView: RPL36AL Ensembl:ENSG00000165502 euGenes: HUgn6166
    ECgene: RPL36AL Kegg: 6166 H-InvDB: RPL36AL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL36AL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL36AL gene:
    Search GeneIP for patents involving RPL36AL

    GeneCards and IP:
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