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Aliases for RPL36AL Gene

Aliases for RPL36AL Gene

  • Ribosomal Protein L36a Like 2 3 5
  • Ribosomal Protein L36a 2 3
  • 60S Ribosomal Protein L36a-Like 3
  • Ribosomal Protein L36a-Like 2
  • Ribosomal Protein HL44 3
  • RPL36A 3

External Ids for RPL36AL Gene

Previous HGNC Symbols for RPL36AL Gene

  • RPL36A

Previous GeneCards Identifiers for RPL36AL Gene

  • GC14M047405
  • GC14M043881
  • GC14M048073
  • GC14M048075
  • GC14M049155
  • GC14M050086
  • GC14M030202

Summaries for RPL36AL Gene

Entrez Gene Summary for RPL36AL Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL36AL Gene

RPL36AL (Ribosomal Protein L36a Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL36A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36AL Gene

Genomics for RPL36AL Gene

Regulatory Elements for RPL36AL Gene

Enhancers for RPL36AL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPL36AL on UCSC Golden Path with GeneCards custom track

Promoters for RPL36AL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL36AL Gene

49,618,519 bp from pter
49,620,685 bp from pter
2,167 bases
Minus strand

Genomic View for RPL36AL Gene

Genes around RPL36AL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL36AL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL36AL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL36AL Gene

Proteins for RPL36AL Gene

  • Protein details for RPL36AL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L36a-like
    Protein Accession:
    Secondary Accessions:
    • Q3B7A5

    Protein attributes for RPL36AL Gene

    106 amino acids
    Molecular mass:
    12469 Da
    Quaternary structure:
    No Data Available
    • This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution.

neXtProt entry for RPL36AL Gene

Post-translational modifications for RPL36AL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL36AL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL36AL Gene

Domains & Families for RPL36AL Gene

Gene Families for RPL36AL Gene

Protein Domains for RPL36AL Gene

Suggested Antigen Peptide Sequences for RPL36AL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L44e family.
  • Belongs to the ribosomal protein L44e family.
genes like me logo Genes that share domains with RPL36AL: view

Function for RPL36AL Gene

Gene Ontology (GO) - Molecular Function for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL36AL: view
genes like me logo Genes that share phenotypes with RPL36AL: view

Animal Model Products

CRISPR Products

miRNA for RPL36AL Gene

miRTarBase miRNAs that target RPL36AL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36AL Gene

Localization for RPL36AL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL36AL Gene


Subcellular locations from

Jensen Localization Image for RPL36AL Gene COMPARTMENTS Subcellular localization image for RPL36AL gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25468996
GO:0022625 cytosolic large ribosomal subunit IEA,IBA --
genes like me logo Genes that share ontologies with RPL36AL: view

Pathways & Interactions for RPL36AL Gene

SuperPathways for RPL36AL Gene

Superpath Contained pathways
1 Viral mRNA Translation
genes like me logo Genes that share pathways with RPL36AL: view

Pathways by source for RPL36AL Gene

1 KEGG pathway for RPL36AL Gene

Gene Ontology (GO) - Biological Process for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with RPL36AL: view

No data available for SIGNOR curated interactions for RPL36AL Gene

Drugs & Compounds for RPL36AL Gene

No Compound Related Data Available

Transcripts for RPL36AL Gene

mRNA/cDNA for RPL36AL Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(361) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL36AL Gene

Ribosomal protein L36a-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36AL Gene

No ASD Table

Relevant External Links for RPL36AL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL36AL Gene

mRNA expression in normal human tissues for RPL36AL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL36AL Gene

This gene is overexpressed in Lymph node (11.8), Monocytes (10.5), Pancreas (6.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL36AL Gene

Protein tissue co-expression partners for RPL36AL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL36AL Gene:


SOURCE GeneReport for Unigene cluster for RPL36AL Gene:


mRNA Expression by UniProt/SwissProt for RPL36AL Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RPL36AL: view

Primer Products

No data available for mRNA differential expression in normal tissues for RPL36AL Gene

Orthologs for RPL36AL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36AL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC480311 34
  • 94.03 (n)
  • 99.06 (a)
-- 35
  • 98 (a)
-- 35
  • 92 (a)
(Mus musculus)
Mammalia Rpl36al 34
  • 92.14 (n)
  • 99.06 (a)
Rpl36al 16
Rpl36a 35
  • 99 (a)
(Pan troglodytes)
Mammalia RPL36AL 34
  • 100 (n)
  • 100 (a)
RPL36AL 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl36al 34
  • 91.82 (n)
  • 99.06 (a)
(Bos Taurus)
Mammalia RPL36A 35
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
(Gallus gallus)
Aves -- 35
  • 89 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1359 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8630 34
(Danio rerio)
Actinopterygii rpl36a 35
  • 97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7424 36
  • 76 (a)
RpL36A 35
  • 78 (a)
(Caenorhabditis elegans)
Secernentea C09H10.2 36
  • 79 (a)
rpl-41 35
  • 80 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL42A 35
  • 74 (a)
RPL42B 35
  • 74 (a)
RPL42A 37
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1846 34
(Hordeum vulgare)
Liliopsida Hv.4260 34
(Oryza sativa)
Liliopsida Os.22631 34
(Zea mays)
Liliopsida Zm.2895 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6059 35
  • 77 (a)
Species where no ortholog for RPL36AL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL36AL Gene

Gene Tree for RPL36AL (if available)
Gene Tree for RPL36AL (if available)

Paralogs for RPL36AL Gene

Paralogs for RPL36AL Gene

(2) SIMAP similar genes for RPL36AL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL36AL: view

Variants for RPL36AL Gene

Sequence variations from dbSNP and Humsavar for RPL36AL Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_051809 -
rs2985698 -- 49,618,693(-) TCTTA(A/C)GCAAA utr-variant-3-prime
rs115348112 -- 49,618,480(+) CCTAG(C/T)GTTAT downstream-variant-500B
rs139478180 -- 49,618,354(+) TAAAT(C/T)TGACT downstream-variant-500B
rs78930973 -- 49,618,621(+) ACTTG(C/T)TAGTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPL36AL Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv976338 CNV duplication 23825009

Variation tolerance for RPL36AL Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL36AL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36AL Gene

Disorders for RPL36AL Gene

Relevant External Links for RPL36AL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL36AL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL36AL Gene

Publications for RPL36AL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PMID: 12490704) Uechi T. … Kenmochi N. (Nucleic Acids Res. 2002) 3 4 65
  3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S. … Fried M. (Genomics 1992) 2 3 65
  4. Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. (PMID: 3542712) Davies M.S. … Craig R.K. (Gene 1986) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for RPL36AL Gene

Sources for RPL36AL Gene

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