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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL36AL Gene

protein-coding   GIFtS: 55
GCID: GC14M050086

ribosomal protein L36a-like

(Previous name: ribosomal protein L36a )
(Previous symbol: RPL36A)
 Explore 3 diseases affiliated with
RPL36AL via our new
 Human Malady Compendium 
Biological research products
for RPL36AL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal Protein L36a-Like1 2
RPL36A1 2 5
Ribosomal Protein L36a1
60S Ribosomal Protein L36a-Like2
Ribosomal Protein HL442

External Ids:    HGNC: 103461   Entrez Gene: 61662   Ensembl: ENSG000001655027   OMIM: 1804695   UniProtKB: Q969Q03   

Export aliases for RPL36AL gene to outside databases

Previous GC identifers: GC14M047405 GC14M043881 GC14M048073 GC14M048075 GC14M049155 GC14M030202


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL36AL:
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S
subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence
similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and
the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are
distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official
name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple
processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL36AL gene promoter:
         TBP   Elk-1   Pax-5   AP-1   LCR-F1   C/EBPalpha   HEN1   NRF-2   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL36AL promoter sequence
   Search SABiosciences Chromatin IP Primers for RPL36AL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL36AL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21

RPL36AL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL36AL gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050086:  view genomic region     (about GC identifiers)

Start:
50,085,237 bp from pter      End:
50,087,403 bp from pter
Size:
2,167 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0 (See protein sequence)
Recommended Name: 60S ribosomal protein L36a-like  
Size: 106 amino acids; 12469 Da
Subcellular location: Cytoplasm (Probable)
Miscellaneous: This gene has no introns in its coding regions, and therefore, was most likely produced by
retrotransposition of the original X-linked gene during evolution
Secondary accessions: Q3B7A5

Explore the universe of human proteins at neXtProt for RPL36AL: NX_Q969Q0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969Q0

  • RPL36AL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000992.1  
    ENSEMBL proteins: 
     ENSP00000346012  

    Human Recombinant Protein Products: 
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    Uscn Proteins for RPL36AL

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005840ribosome IEA--


    RPL36AL for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPL36AL for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000552 Ribosomal_L44e
     IPR011332 Ribosomal_zn-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q969Q0

    ProtoNet protein and cluster: Q969Q0

    1 Blocks protein family: IPB000552 Ribosomal protein L44E

    UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0
    Similarity: Belongs to the ribosomal protein L44e family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--


    RPL36AL for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RPL36AL:
     Decreased viability of wild-ty  Increased S DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    Ribosome0.87

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for RPL36AL):
        Ribosome


    RPL36AL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL36AL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for RPL36AL (Q969Q02, 3 ENSP000003460124) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf25Q9BPX72, 3MINT-8250087 I2D: score=2 
    GSK3BP498412, 3MINT-8257636 I2D: score=2 
    TAF1DQ9H5J82, 3MINT-8272707 I2D: score=2 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SH3GLB1Q9Y3713, ENSP000002123694I2D: score=1 STRING: ENSP00000212369
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--


    RPL36AL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL36AL
    Search CenterWatch for drugs/clinical trials and news about RPL36AL / RL36L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPL36AL gene: 
    NM_001001.4  

    Unigene Cluster for RPL36AL:

    Ribosomal protein L36a-like
    Hs.444749  [show with all ESTs]
    Unigene Representative Sequence: BU902070
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298289(uc001wwq.1)

    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional cDNA sequence: 

    AB063609.1 AK311959.1 BC000741.2 BC003145.1 BC070207.1 BC107716.1 CR542166.1 M15661.1 

    13 DOTS entries:

    DT.317891  DT.100034171  DT.95156332  DT.120730038  DT.100806931  DT.100825526  DT.100825531  DT.102824168 
    DT.120730033  DT.120729904  DT.120729979  DT.120730032  DT.417467 

    24/361 AceView cDNA sequences (see all 361):

    BM662362 CD679401 BG940882 AA211585 AA308438 BC003145 AA304119 AA196119 
    AI199158 AI801282 CB113726 BP872691 M15661 BM560769 BG944543 BM510830 
    BG112886 BI494273 AA564302 BQ012876 BG944567 BU737939 AI149112 AI863146 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL36AL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGAAGCCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RPL36AL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL36AL

    SOURCE GeneReport for Unigene cluster: Hs.444749

    UniProtKB/Swiss-Prot: RL36L_HUMAN, Q969Q0
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for RPL36AL
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL36AL gene from 10/38 species (see all 38)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl36al5
    Gm131941
    ribosomal protein L36A-like5
    predicted gene 131941
    81.13(n)1
    87.74(a)1
      12 (28.73 cM)5
    3813461  XM_355309.61  XP_355309.51 
     691827315 
    chicken
    (Gallus gallus)
    Aves F1NIK4_CHICK6
    Uncharacterized protein
    83(a)
    1 → many
    4(2006692-2008731)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    96(a)
    1 → many
    GL343451.1(251997-253513)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480627542   -- 84.34(n)    48062754 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl36a1 ribosomal protein L36A 83.02(n)
    97.17(a)
      195819  NM_001202510.1  NP_001189439.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74243
    RpL36A1
    protein biosynthesis structural constituent
    of more3
    Ribosomal protein L36A1
    76(a)3
    70.19(n)1
    77.88(a)1
      28D93
    340981  NM_135335.31  NP_609179.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C09H10.23
    rpl-411
    60S ribosomal protein3
    Protein RPL-411
    79(a)3
    70.19(n)1
    81.73(a)1
      II(11096040-11097125)3
    1746951  NM_063974.61  NP_496375.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL42A(YNL162W)4
    RPL42A1
    Protein component of the large (60S) ribosomal subunit, more4
    Rpl42ap1
    69.87(n)1
    75(a)1
      14(331322-332154)4
    8555601, 4  NP_014237.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G143201 60S ribosomal protein L36a 69.7(n)
    75.76(a)
      827074  NM_117509.2  NP_193168.1 
    rice
    (Oryza sativa)
    Liliopsida Os.226312 Rice mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate more 79.92(n)    AK069083.1 


    ENSEMBL Gene Tree for RPL36AL (if available)
    TreeFam Gene Tree for RPL36AL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL36AL gene
    RPL36A2  ENSG000002575292  
    1 SIMAP similar gene for RPL36AL using alignment to 1 protein entry:     RL36L_HUMAN:
    RPL36A

    RPL36AL for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for RPL36AL (see all 8)
    PGOHUM00000239758 PGOHUM00000246783 PGOHUM00000237446 PGOHUM00000243982 PGOHUM00000240032


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/14 NCBI SNPs in RPL36AL are shown (see all 14    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173150861,2
    F,--50084969(+) AAGGCC/GACAGT 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1870902861,2
    --50084975(+) ACAGTC/TTCTAA 1 -- ds50010--------
    rs802707061,2
    --50084986(+) CAGTAC/GTGTCC 1 -- ds50010--------
    rs1394781801,2
    --50085072(+) TAAATC/TTGACT 1 -- ds50010--------
    rs1501845111,2
    C,--50085074(+) AATCTG/CACTAG 1 -- ds50011Minor allele frequency- C:0.01NS 124
    rs1496728701,2
    --50085109(+) CTAGCA/GGCCCC 1 -- ds50010--------
    rs1477892071,2
    --50085126(+) ACAGAA/GTATTT 1 -- ds50010--------
    rs1412416401,2
    --50085137(+) GGTCAA/GCTCTT 1 -- ds50010--------
    rs1153481121,2
    C,F,--50085198(+) CCTAGC/TGTTAT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs789309731,2
    C--50085339(+) ACTTGC/TTAGTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPL36AL (50085237 - 50087403 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPL36AL
         1 CNV: 66642

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL36AL
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL36AL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPL36AL for disorders           About GeneDecksing

    OMIM gene information: 180469    OMIM disorders: --

    3 diseases for RPL36AL:    About MalaCards
    diamond-blackfan anemia    anemia    malaria

    1 disease from the University of Copenhagen DISEASES database for RPL36AL:
    Diamond-Blackfan anemia

    Export disorders for RPL36AL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL36AL gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RPL36AL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Functional second genes generated by retrotransposition of the X- linked ribosomal protein genes. (PubMed id 12490704)1, 2 Uechi T.... Kenmochi N. (2002)
    3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (1992)
    4. Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein. (PubMed id 3542712)1, 2 Davies M.S.... Craig R.K. (1986)
    5. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    6. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6166 HGNC: 10346 AceView: RPL36AL Ensembl:ENSG00000165502 euGenes: HUgn6166
    ECgene: RPL36AL Kegg: 6166 H-InvDB: RPL36AL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL36AL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPL36AL gene:
    Search GeneIP for patents involving RPL36AL

    GeneCards and IP:
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