Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL36AL Gene

Aliases for RPL36AL Gene

  • Ribosomal Protein L36a-Like 2 3
  • Ribosomal Protein L36a 2 3
  • Ribosomal Protein HL44 3
  • RPL36A 3

External Ids for RPL36AL Gene

Previous HGNC Symbols for RPL36AL Gene

  • RPL36A

Previous GeneCards Identifiers for RPL36AL Gene

  • GC14M047405
  • GC14M043881
  • GC14M048073
  • GC14M048075
  • GC14M049155
  • GC14M050086
  • GC14M030202

Summaries for RPL36AL Gene

Entrez Gene Summary for RPL36AL Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL36AL Gene

RPL36AL (Ribosomal Protein L36a-Like) is a Protein Coding gene. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL36A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36AL Gene

Genomics for RPL36AL Gene

Regulatory Elements for RPL36AL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL36AL Gene

Chromosome:
14
Start:
49,618,519 bp from pter
End:
49,620,685 bp from pter
Size:
2,167 bases
Orientation:
Minus strand

Genomic View for RPL36AL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RPL36AL Gene

Proteins for RPL36AL Gene

  • Protein details for RPL36AL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q0-RL36L_HUMAN
    Recommended name:
    60S ribosomal protein L36a-like
    Protein Accession:
    Q969Q0
    Secondary Accessions:
    • Q3B7A5

    Protein attributes for RPL36AL Gene

    Size:
    106 amino acids
    Molecular mass:
    12469 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene has no introns in its coding regions, and therefore, was most likely produced by retrotransposition of the original X-linked gene during evolution

neXtProt entry for RPL36AL Gene

Proteomics data for RPL36AL Gene at MOPED

Post-translational modifications for RPL36AL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL36AL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL36AL Gene

Domains & Families for RPL36AL Gene

Gene Families for RPL36AL Gene

Protein Domains for RPL36AL Gene

Suggested Antigen Peptide Sequences for RPL36AL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Q0

UniProtKB/Swiss-Prot:

RL36L_HUMAN :
  • Belongs to the ribosomal protein L44e family.
Family:
  • Belongs to the ribosomal protein L44e family.
genes like me logo Genes that share domains with RPL36AL: view

Function for RPL36AL Gene

Gene Ontology (GO) - Molecular Function for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RPL36AL: view
genes like me logo Genes that share phenotypes with RPL36AL: view

miRNA for RPL36AL Gene

miRTarBase miRNAs that target RPL36AL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL36AL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36AL Gene

Localization for RPL36AL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL36AL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL36AL Gene COMPARTMENTS Subcellular localization image for RPL36AL gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005840 ribosome --
GO:0022625 cytosolic large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with RPL36AL: view

Pathways & Interactions for RPL36AL Gene

genes like me logo Genes that share pathways with RPL36AL: view

Pathways by source for RPL36AL Gene

1 BioSystems pathway for RPL36AL Gene
1 KEGG pathway for RPL36AL Gene
1 GeneGo (Thomson Reuters) pathway for RPL36AL Gene

Gene Ontology (GO) - Biological Process for RPL36AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RPL36AL: view

No data available for SIGNOR curated interactions for RPL36AL Gene

Drugs & Compounds for RPL36AL Gene

No Compound Related Data Available

Transcripts for RPL36AL Gene

mRNA/cDNA for RPL36AL Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(361) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPL36AL Gene

Ribosomal protein L36a-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL36AL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36AL Gene

No ASD Table

Relevant External Links for RPL36AL Gene

GeneLoc Exon Structure for
RPL36AL
ECgene alternative splicing isoforms for
RPL36AL

Expression for RPL36AL Gene

mRNA expression in normal human tissues for RPL36AL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL36AL Gene

This gene is overexpressed in Lymph node (11.8), Monocytes (10.5), Pancreas (6.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL36AL Gene



SOURCE GeneReport for Unigene cluster for RPL36AL Gene Hs.444749

mRNA Expression by UniProt/SwissProt for RPL36AL Gene

Q969Q0-RL36L_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RPL36AL: view

Protein tissue co-expression partners for RPL36AL Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RPL36AL Gene

Orthologs for RPL36AL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36AL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC480311 35
  • 94.03 (n)
  • 99.06 (a)
-- 36
  • 98 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rpl36al 35
  • 92.14 (n)
  • 99.06 (a)
Rpl36al 16
Rpl36a 36
  • 99 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL36AL 35
  • 100 (n)
  • 100 (a)
RPL36AL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl36al 35
  • 91.82 (n)
  • 99.06 (a)
cow
(Bos Taurus)
Mammalia RPL36A 36
  • 99 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1359 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8630 35
zebrafish
(Danio rerio)
Actinopterygii rpl36a 36
  • 97 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7424 37
  • 76 (a)
RpL36A 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C09H10.2 37
  • 79 (a)
rpl-41 36
  • 80 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL42A 36
  • 74 (a)
ManyToMany
RPL42B 36
  • 74 (a)
ManyToMany
RPL42A 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1846 35
barley
(Hordeum vulgare)
Liliopsida Hv.4260 35
rice
(Oryza sativa)
Liliopsida Os.22631 35
corn
(Zea mays)
Liliopsida Zm.2895 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6059 36
  • 77 (a)
OneToMany
Species with no ortholog for RPL36AL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL36AL Gene

ENSEMBL:
Gene Tree for RPL36AL (if available)
TreeFam:
Gene Tree for RPL36AL (if available)

Paralogs for RPL36AL Gene

Paralogs for RPL36AL Gene

(2) SIMAP similar genes for RPL36AL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL36AL: view

Variants for RPL36AL Gene

Sequence variations from dbSNP and Humsavar for RPL36AL Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2985698 -- 49,618,693(-) TCTTA(A/C)GCAAA utr-variant-3-prime
rs17121611 -- 49,618,645(+) GACTA(C/T)ACTAA downstream-variant-500B
rs78930973 -- 49,618,621(+) ACTTG(C/T)TAGTA downstream-variant-500B
rs80110552 -- 49,618,622(+) CTTGT(G/T)AGTAA downstream-variant-500B
rs80270706 -- 49,618,268(+) CAGTA(C/G)TGTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPL36AL Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545

Variation tolerance for RPL36AL Gene

Residual Variation Intolerance Score: 48.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL36AL Gene

HapMap Linkage Disequilibrium report
RPL36AL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36AL Gene

Disorders for RPL36AL Gene

Relevant External Links for RPL36AL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL36AL
genes like me logo Genes that share disorders with RPL36AL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL36AL Gene

Publications for RPL36AL Gene

  1. The human large subunit ribosomal protein L36A-like contacts the CCA end of P-site bound tRNA. (PMID: 19647033) Baouz S. … Hountondji C. (Biochimie 2009) 23 67
  2. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S. … Fried M. (Genomics 1992) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for RPL36AL Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPL36AL
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPL36AL
    • Block miRNA regulation of RPL36AL using miScript Target Protectors

    Sources for RPL36AL Gene

    Back to Top

    Content