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RPL36A-HNRNPH2 Gene

protein-coding   GIFtS: 22
GCID: GC0XP100647

RPL36A-HNRNPH2 Readthrough

  Search for RPL36A-HNRNPH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RPL36A-HNRNPH2 Readthrough1 2
RPL36A-HNRNPH2 Protein2

External Ids:    HGNC: 483491   Entrez Gene: 1005290972   Ensembl: ENSG000002575297   UniProtKB: H0Y3V94   UniProtKB: H7BZ114   

Export aliases for RPL36A-HNRNPH2 gene to outside databases

Previous GC identifer: GC0XU901730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL36A-HNRNPH2 Gene:
This locus represents naturally occurring read-through transcription between the neighboring ribosomal protein
L36a and heterogeneous nuclear ribonucleoprotein H2 (H') genes on chromosome X. The read-through transcript
produces a protein with similarity to the protein encoded by the upstream locus, ribosomal protein L36a.
Alternatively spliced transcript variants have been identified. (provided by RefSeq, Jan 2011)

GeneCards Summary for RPL36A-HNRNPH2 Gene:
RPL36A-HNRNPH2 (RPL36A-HNRNPH2 readthrough) is a protein-coding gene. An important paralog of this gene is RPL36A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for RPL36A-HNRNPH2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RPL36A-HNRNPH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL36A-HNRNPH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

RPL36A-HNRNPH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL36A-HNRNPH2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP100647:  view genomic region     (about GC identifiers)

Start:
100,645,878 bp from pter      End:
100,669,128 bp from pter
Size:
23,251 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/TrEMBL: H0Y3V9 (See protein sequence)
Recommended Name: Protein RPL36A-HNRNPH2  
Size: 88 amino acids; 10140 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7BZ11 (See protein sequence)

Recommended Name: Protein RPL36A-HNRNPH2  
Size: 129 amino acids; 14934 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001186902.1  NP_001186903.1  

ENSEMBL proteins: 
 ENSP00000386974   ENSP00000386655  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000552 Ribosomal_L44e
 IPR011332 Ribosomal_zn-bd

Graphical View of Domain Structure for InterPro Entry H0Y3V9
Graphical View of Domain Structure for InterPro Entry H7BZ11

ProtoNet protein and cluster: H0Y3V9

UniProtKB/TrEMBL: H7BZ11
Similarity: Belongs to the ribosomal protein L44e family


RPL36A-HNRNPH2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003735structural constituent of ribosome ----
     
RPL36A-HNRNPH2 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005840ribosome ----

RPL36A-HNRNPH2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RPL36A-HNRNPH2 About    
See pathways by source

SuperPathContained pathways About
1CFTR translational fidelity class I mutations
Cytoplasmic Ribosomal Proteins0.60
Ribosome0.54
2mRNA Splicing - Major Pathway
mRNA processing0.44

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for RPL36A-HNRNPH2
    mRNA processing
Cytoplasmic Ribosomal Proteins


1 Kegg Pathway  (Kegg details for RPL36A-HNRNPH2):
    Ribosome


RPL36A-HNRNPH2 for pathways           About GeneDecksing

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Interactions:

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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation ----

RPL36A-HNRNPH2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for RPL36A-HNRNPH2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RPL36A-HNRNPH2 gene (2 alternative transcripts): 
NM_001199973.1  NM_001199974.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000409338 ENST00000409170
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RPL36A-HNRNPH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RPL36A-HNRNPH2 Expression
About this image

RPL36A-HNRNPH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL36A-HNRNPH2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
86(a)
1 → many
4(2004055-2006369)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
92(a)
1 → many
GL343451.1(251997-253513)
zebrafish
(Danio rerio)
Actinopterygii rpl36a6
ribosomal protein L36A
93(a)
1 → many
5(24293967-24298514) ENSDARG00000058105
fruit fly
(Drosophila melanogaster)
Insecta RpL36A6
Ribosomal protein L36A
73(a)
1 → many
2L(8041880-8042859)
worm
(Caenorhabditis elegans)
Secernentea rpl-416
Protein RPL-41 (rpl-41) mRNA, complete cds
74(a)
1 → many
II(11096571-11097204) WBGene00004454
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL42A6
RPL42B6
Protein component of the large (60S) ribosomal sub...
Protein component of the large (60S) ribosomal sub...
71(a)
71(a)
many ↔ many
many ↔ many
XIV(331322-332154) YNL162W
VIII(381990-382751) YHR141C
        Species with no ortholog for RPL36A-HNRNPH2

ENSEMBL Gene Tree for RPL36A-HNRNPH2 (if available)
TreeFam Gene Tree for RPL36A-HNRNPH2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RPL36A-HNRNPH2 gene
RPL36A2  RPL36AL2  
2 SIMAP similar genes for RPL36A-HNRNPH2 using alignment to 2 protein entries:     H0Y3V9_HUMAN (see all proteins):
RPL36A    RPL36AL

RPL36A-HNRNPH2 for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for RPL36A-HNRNPH2
PGOHUM00000261160 PGOHUM00000234115 PGOHUM00000250427 PGOHUM00000261387 PGOHUM00000262652


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RPL36A-HNRNPH2 (see all 11)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1149350731,2
C--100651649(+) CAGTTA/CCAAAT 2 -- int10--------
rs1478739861,2
F--100651720(+) TGCAAT/CTGGTA 2 -- int11Minor allele frequency- C:0.02NS 142
rs1415002791,2
C--100651904(+) GATCCG/ACCCGA 2 -- int11Minor allele frequency- A:0.01NS 140
rs70511261,2
C--100651910(+) cccgaC/Tttggc 2 -- int10--------
rs1863872391,2
--100652065(+) GGGGTA/GGGTAT 2 -- int10--------
rs59919311,2
C,F,H--100652066(+) GGGTGG/AGTATC 2 -- int17Minor allele frequency- A:0.18NS NA CSA 767
rs25159011,2
C,F,O,A,H--100652086(-) AACCCA/GTATTT 2 -- int118Minor allele frequency- G:0.64NS EA NA WA CSA 1051
rs59919321,2
C,F--100652212(+) cttggC/Gtcact 2 -- int13Minor allele frequency- G:0.00WA CSA 5
rs1138063711,2
C,F--100652225(+) ACCCCC/TCCACT 2 -- int11Minor allele frequency- T:0.50WA 2
rs3692097201,2
----100651684(+) TTTGAA/GTGGAG 2 -- int10--------

HapMap Linkage Disequilibrium report for RPL36A-HNRNPH2 (100645878 - 100669128 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RPL36A-HNRNPH2: --
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RPL36A-HNRNPH2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RPL36A-HNRNPH2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100529097 HGNC: 48349 Ensembl:ENSG00000257529 euGenes: HUgn100529097 ECgene: RPL36A-HNRNPH2 Kegg: 100529097
H-InvDB: RPL36A-HNRNPH2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RPL36A-HNRNPH2 gene:
Search GeneIP for patents involving RPL36A-HNRNPH2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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