RPL36A Gene
protein-coding GIFtS: 54
GCID: GC0XP100645
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ribosomal protein L36a(Previous name: ribosomal protein L44 ) (Previous symbol: RPL44)
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Aliases for RPL36A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosomal Protein L36a1 2 | | 60S Ribosomal Protein L36a2 | | RPL441 2 3 | | L44L2 | | L36A1 2 | | MIG62 | | Cell Growth-Inhibiting Gene 15 Protein2 3 | | DJ164F3.3 (Ribosomal Protein L44)2 | | Cell Migration-Inducing Gene 6 Protein2 3 | | L44-Like Ribosomal Protein2 | | 60S Ribosomal Protein L442 3 | | RPL36AL5 | | Ribosomal Protein L441 | | |
Export aliases for RPL36A gene to outside databasesPrevious GC identifers: GC0XP095937 GC0XP097617 GC0XP098681 GC0XP099417 GC0XP100453 GC0XP100532 GC0XP090452 |
Summaries for RPL36A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RPL36A: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60Ssubunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequencesimilarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although thisgene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). Thisgene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins;however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs betweenthis locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. (provided by RefSeq, Jan 2011) Gene Wiki entry for RPL36A
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Genomic Views for RPL36A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPL36A gene promoter: CREB C/EBPbeta Pbx1a AML1a HOXA5 Hand1 ZID E47 Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL36A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL36A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1RPL36A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP100645: view genomic region
(about GC identifiers)
Start:
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100,645,812 bp from pter |
End:
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100,651,105 bp from pter |
Size:
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5,294 bases |
Orientation:
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plus strand |
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Proteins for RPL36A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RL36A_HUMAN, P83881 (See
protein sequence)Recommended Name: 60S ribosomal protein L36a Size: 106 amino acids; 12441 Da
Subcellular location: Cytoplasm
Secondary accessions: P09896 P10661 Q08ES5 Q5J9I6Explore the universe of human proteins at neXtProt for RPL36A: NX_P83881
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P83881 RPL36A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186901.1 NP_066357.2 ENSEMBL proteins: ENSP00000404375 ENSP00000397659 ENSP00000361940 ENSP00000446503 Reactome Protein details: P83881 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPL36A for ontologies About GeneDecksing
RPL36A Antibody Products: Assay Products for RPL36A: |
Protein
Domains / Families for RPL36A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL36A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P83881ProtoNet protein and cluster: P83881 1 Blocks protein family: IPB000552 Ribosomal protein L44E
UniProtKB/Swiss-Prot: RL36A_HUMAN, P83881Similarity: Belongs to the ribosomal protein L44e family |
Function for RPL36A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: Genatlas biochemistry entry for RPL36A:60S ribosomal protein L36A,12kDa
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL36A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 12962325 |
RPL36A for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for RPL36A:
|
Pathways & Interactions for RPL36A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Disease | | | 4 | Generic Transcription Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 GeneGo (Thomson Reuters) Pathway for RPL36A 1 BioSystems Pathway for RPL36A 
5/28
Reactome Pathways for RPL36A (see all 28)
1
Kegg Pathway (Kegg details for RPL36A):
RPL36A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL36A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/115 Interacting proteins for RPL36A (P838811, 3 ENSP000004043754) via UniProtKB, MINT, STRING, and/or I2D (see all 115)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPL36A for ontologies About GeneDecksing
|
Drugs & Compounds for RPL36A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPL36A Search CenterWatch for drugs/clinical trials and news about RPL36A / RL36A 
|
Transcripts for RPL36A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPL36A gene (2 alternative transcripts): NM_001199972.1 NM_021029.5 Unigene Clusters for RPL36A: Ribosomal protein L36a Hs.432485 [show with all ESTs], Hs.655348 [show with all ESTs]Unigene Representative Sequences: NM_001199973, BU5881399 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000427805(uc004ehk.3) ENST00000392994 ENST00000491851 ENST00000465340(uc004ehj.2) ENST00000372849 ENST00000465744 ENST00000471855 ENST00000489407 ENST00000553110
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL36A (NM_001001) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL36A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL36A  |
Additional cDNA sequence: CR542198.1 24/62 DOTS entries (see all 62): DT.75194536 DT.100797602 DT.86996316 DT.91847564 DT.95157200 DT.101987618 DT.121284624 DT.95228466 DT.100892202 DT.86859046 DT.120738394 DT.121284649 DT.95202364 DT.453397 DT.97864753 DT.100809503 DT.97864755 DT.91776149 DT.100832979 DT.120738412 DT.75176399 DT.95291365 DT.95332794 DT.120635770 24/340 AceView cDNA sequences (see all 340): NM_021029 AA603378 BP872108 AA702085 AA722456 AI275128 CB139366 AA191627 BU070182 BF174460 BX328438 BU508366 AA617691 BF381770 BE877885 BX349397 CB112438 AA988304 BP871723 BM782123 F31717 CR612724 AI720389 AI127223 GeneLoc Exon Structure
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Expression for RPL36A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL36A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTTAACGTCC
About this image See RPL36A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPL36A
SOURCE GeneReport for Unigene clusters: Hs.432485 Hs.655348 SABiosciences Custom PCR Arrays for RPL36A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL36A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL36A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL36A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL36A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL36A |
Orthologs for RPL36A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL36A gene from 7/29 species (see all 29) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
LOC1008599141 |
60S ribosomal protein L36a-like |
85.53(n) 97.17(a) |
  |
100859914 XM_003641094.1 XP_003641142.1 |
lizard (Anolis carolinensis) |
Reptilia |
-- |
-- |
97(a) |
1 → many |
GL343451.1(251997-253513) |
zebrafish (Danio rerio) |
Actinopterygii |
rpl36a2 |
ribosomal protein L36A |
84.94(n) |
  |
195819 BC055187.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG74243 |
protein biosynthesis structural constituent of ribosome less |
75(a) |
  |
28D9 -- |
worm (Caenorhabditis elegans) |
Secernentea |
C09H10.23 |
60S ribosomal protein |
78(a) |
  |
II(11096040-11097125) -- |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT3G233906AT4G143206 |
60S ribosomal protein L36a |
73(a)47(a) |
many ↔ manymany ↔ many |
3(8375372-8376392) 4(8241732-8243910) |
rice (Oryza sativa) |
Liliopsida |
----(see all 8) |
60S ribosomal protein L44, putative, expressed(see all 8) |
73(a)73(a)(see all 8) |
many ↔ manymany ↔ many(see all 8) |
7(20303270-20304717) 7(20266831-20268449) |
ENSEMBL Gene Tree for RPL36A (if available) TreeFam Gene Tree for RPL36A (if available)  |
Paralogs for RPL36A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RPL36A gene
- RPL36A-HNRNPH2 RPL36AL2 ENSG000002575292
1 SIMAP similar gene for RPL36A using alignment to 4 protein entries: RL36A_HUMAN (see all proteins):RPL36AL
RPL36A for paralogs About GeneDecksing
5/55 Pseudogenes.org Pseudogenes for RPL36A (see all 55) PGOHUM00000261081 PGOHUM00000261090 PGOHUM00000261109 PGOHUM00000261110 PGOHUM00000261114
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Genomic Variants for RPL36A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL36A (100645812 - 100651105 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPL36A: -- Locus Specific Mutation Databases (LSDB): RPL36A
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL36A |
|
Disorders
/ Diseases for RPL36A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL36A for disorders About GeneDecksing
OMIM gene information: 180469
OMIM disorders: --
4 diseases for RPL36A: About MalaCardspure red-cell aplasia hepatocellular carcinoma carcinoma malaria Export disorders for RPL36A gene to outside databases
|
Publications for RPL36A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL36A gene, integrated from 9 sources (see all 25): (articles sorted by number of sources associating them with RPL36A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. (PubMed id 9110171)1, 2 Oeltjen J.C....Belmont J.W. (1997)
- Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma. (PubMed id 14752831)1, 9 Kim J.H....Kim D.G. (2004)
- Histone deacetylase 6 associates with ribosomes and re gulates de novo protein translation during arsenite stress. (PubMed id 22367689)1 Kappeler K.V....Chen Q.M. (2012)
- Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (2012)
- Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
|
External Searches for RPL36A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPL36A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL36A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL36A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPL36A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPL36A gene: Search GeneIP for patents involving RPL36A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPL36A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | RPL36A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL36A |
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