RPL36 Gene
protein-coding GIFtS: 57
GCID: GC19P005674
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ribosomal protein L36
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Aliases for RPL36 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosomal Protein L361 2 | | L361 2 | | DKFZp566B0231 | | 60S Ribosomal Protein L362 | | M5 |
Export aliases for RPL36 gene to outside databasesPrevious GC identifers: GC19P005782 GC19P005621 GC19P005641 GC19P005451 |
Summaries for RPL36 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RPL36: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family ofribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; theyencode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenesof this gene dispersed through the genome. (provided by RefSeq, Jul 2008) Gene Wiki entry for RPL36
|
Genomic Views for RPL36 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPL36 gene promoter: STAT5B Sox5 AML1a HOXA3 p300 Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL36
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL36 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.2RPL36 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P005674: view genomic region
(about GC identifiers)
Start:
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5,674,958 bp from pter |
End:
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5,691,887 bp from pter |
Size:
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16,930 bases |
Orientation:
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plus strand |
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Proteins for RPL36 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RL36_HUMAN, Q9Y3U8 (See
protein sequence)Recommended Name: 60S ribosomal protein L36 Size: 105 amino acids; 12254 Da
Secondary accessions: B2R4Y1 D6W634 Q6FIG1 Q9UQF6Explore the universe of human proteins at neXtProt for RPL36: NX_Q9Y3U8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3U8 RPL36 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_056229.2 NP_378669.1 ENSEMBL proteins: ENSP00000462609 ENSP00000464342 ENSP00000252543 ENSP00000462927 ENSP00000464613 ENSP00000378081 Reactome Protein details: Q9Y3U8 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPL36 for ontologies About GeneDecksing
RPL36 Antibody Products: Assay Products for RPL36: |
Protein
Domains / Families for RPL36 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL36 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3U8ProtoNet protein and cluster: Q9Y3U8 1 Blocks protein family: IPB000509 Ribosomal protein L36E
UniProtKB/Swiss-Prot: RL36_HUMAN, Q9Y3U8Similarity: Belongs to the ribosomal protein L36e family |
Function for RPL36 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL36 (NM_001001) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL36 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL36  |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 12962325 |
RPL36 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RPL36: Animal Models: 1 MGI phenotypic allele for Rpl36 (no phenotypes)
RPL36 for phenotypes About GeneDecksing
|
Pathways & Interactions for RPL36 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Disease | | | 4 | Generic Transcription Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 GeneGo (Thomson Reuters) Pathway for RPL36 1 BioSystems Pathway for RPL36 
5/28
Reactome Pathways for RPL36 (see all 28)
1
Kegg Pathway (Kegg details for RPL36):
RPL36 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL36
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/783 Interacting proteins for RPL36 (Q9Y3U82, 3 ENSP000002525434) via UniProtKB, MINT, STRING, and/or I2D (see all 783)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPL36 for ontologies About GeneDecksing
|
Drugs & Compounds for RPL36 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPL36 Search CenterWatch for drugs/clinical trials and news about RPL36 / RL36 
|
Transcripts for RPL36 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPL36 gene (2 alternative transcripts): NM_015414.3 NM_033643.2 Unigene Cluster for RPL36: Ribosomal protein L36 Hs.408018 [show with all ESTs]Unigene Representative Sequence: CD2486948 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579649 ENST00000582380 ENST00000577222 ENST00000347512(uc002mcv.3) ENST00000582463 ENST00000590786 ENST00000579446 ENST00000394580(uc002mcw.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL36 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPL36 (NM_001001) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL36 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL36  |
Additional cDNA sequence: AF077043.1 AK311990.1 AL050273.1 AY590779.1 BC003052.1 BC004971.1 BC091508.1 CR533465.1 24/28 DOTS entries (see all 28): DT.87017359 DT.92450758 DT.100890826 DT.100890867 DT.100795852 DT.100890854 DT.91817839 DT.92450750 DT.92463734 DT.100769294 DT.95099859 DT.95348400 DT.97862634 DT.100890822 DT.121416822 DT.121494773 DT.121494788 DT.121494691 DT.121494776 DT.121494800 DT.91660720 DT.95097632 DT.95167737 DT.100890833 24/786 AceView cDNA sequences (see all 786): AY313896 AA531014 CR607228 BM919203 BE858983 BG108181 BC003052 CD251492 CB112170 BQ052666 AA126459 BG752946 AI761851 BU174273 BQ950113 BM015824 BE048274 CB125474 AJ713612 BM851699 AW162077 AJ714168 BF527622 BM790823 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RPL36 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for RPL36
|
Expression for RPL36 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL36 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGGAAAGCTG
About this image See RPL36 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPL36
SOURCE GeneReport for Unigene cluster: Hs.408018 SABiosciences Custom PCR Arrays for RPL36
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL36 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL36 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL36 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL36 |
Orthologs for RPL36 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL36 gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for RPL36 (if available) TreeFam Gene Tree for RPL36 (if available)  |
Paralogs for RPL36 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RPL36 gene
RPL36 for paralogs About GeneDecksing
5/23 Pseudogenes.org Pseudogenes for RPL36 (see all 23) PGOHUM00000239939 PGOHUM00000248577 PGOHUM00000247852 PGOHUM00000237063 PGOHUM00000250607
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Genomic Variants for RPL36 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPL36 (5674958 - 5691887 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPL36: -- Human Gene Mutation Database (HGMD): RPL36
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL36 |
|
Disorders
/ Diseases for RPL36 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL36 for disorders About GeneDecksing
OMIM gene information: 611842
OMIM disorders: --
7 diseases for RPL36: About MalaCardspure red-cell aplasia diamond-blackfan anemia portal vein thrombosis cleft palate thrombosis anemia malaria 1 disease from the University of Copenhagen DISEASES database for RPL36:Diamond-Blackfan anemia Export disorders for RPL36 gene to outside databases
|
Publications for RPL36 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL36 gene, integrated from 9 sources (see all 41): (articles sorted by number of sources associating them with RPL36) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
- The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for RPL36 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPL36 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL36 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL36 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPL36 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPL36 gene: Search GeneIP for patents involving RPL36
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPL36 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | Search Tocris compounds for RPL36 |
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 | | RPL36 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | ThermoFisher Antibodies for RPL36 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL36 |
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