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RPL35A Gene

protein-coding   GIFtS: 65
GCID: GC03P197676

Ribosomal Protein L35a

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L35a1 2
Cell Growth-Inhibiting Gene 33 Protein2 3
DBA52 5
60S Ribosomal Protein L35a2
L35A2

External Ids:    HGNC: 103451   Entrez Gene: 61652   Ensembl: ENSG000001828997   OMIM: 1804685   UniProtKB: P180773   

Export aliases for RPL35A gene to outside databases

Previous GC identifers: GC03U990068 GC03P199076 GC03P199003 GC03P199165 GC03P194979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL35A Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family
of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator
and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene
was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript
variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical
for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through
the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL35A Gene:
RPL35A (ribosomal protein L35a) is a protein-coding gene. Diseases associated with RPL35A include rpl35a-related diamond-blackfan anemia, and diamond-blackfan anemia 5. GO annotations related to this gene include structural constituent of ribosome and tRNA binding.

UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077
Function: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal
subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was
assigned to the P site or P and A site

Gene Wiki entry for RPL35A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL35A gene promoter:
         AhR   AML1a   POU3F1   NRSF form 1   NRSF form 2   Arnt   MEF-2A   AREB6   Zic1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL35A promoter sequence
   Search Chromatin IP Primers for RPL35A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL35A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

RPL35A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL35A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P197676:  view genomic region     (about GC identifiers)

Start:
197,676,858 bp from pter      End:
197,683,481 bp from pter
Size:
6,624 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077 (See protein sequence)
Recommended Name: 60S ribosomal protein L35a  
Size: 110 amino acids; 12538 Da
Miscellaneous: Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased
apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal
subunit rRNA
1 PDB 3D structure from and Proteopedia for RPL35A:
3J3B (3D)    
Secondary accessions: Q08ES9 Q9BVN7

Explore the universe of human proteins at neXtProt for RPL35A: NX_P18077

Explore proteomics data for RPL35A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys45, Lys95
  • Modification sites at PhosphoSitePlus

  • See RPL35A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000987.2  
    ENSEMBL proteins: 
     ENSP00000419117   ENSP00000393393   ENSP00000398058   ENSP00000387688   ENSP00000410683  
    Reactome Protein details: P18077

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR001780 Ribosomal_L35A
     IPR018266 Ribosomal_L35Ae_CS
     IPR009000 Transl_B-barrel

    Graphical View of Domain Structure for InterPro Entry P18077

    ProtoNet protein and cluster: P18077

    1 Blocks protein domain: IPB001780 Ribosomal protein L35Ae

    UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077
    Similarity: Belongs to the ribosomal protein L35Ae family


    RPL35A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL35A_HUMAN, P18077
    Function: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal
    subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was
    assigned to the P site or P and A site

         Genatlas biochemistry entry for RPL35A:
    60S ribosomal protein L35A,12kDa

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0044822poly(A) RNA binding IDA--
         
    RPL35A for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL35A:
     Decreased TP53 protein express  Decreased viability of wild-ty  Increased S DNA content  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325
    GO:0070062extracellular vesicular exosome IDA--

    RPL35A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL35A About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL35A
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL35A
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPL35A (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL35A):
        Ribosome


    RPL35A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL35A
    Interactions:

        Search GeneGlobe Interaction Network for RPL35A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL35A (P180771, 2, 3 ENSP000003933934) via UniProtKB, MINT, STRING, and/or I2D (see all 392)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488590 I2D: score=1 STRING: ENSP00000293842
    SH3GL3Q999632, 3, ENSP000003913724MINT-63524 MINT-8269065 I2D: score=5 STRING: ENSP00000391372
    RPL13P263732, 3, ENSP000003078894MINT-6542674 MINT-6488590 I2D: score=1 STRING: ENSP00000307889
    RPL31P628992, 3, ENSP000003867174MINT-6542674 MINT-6488590 I2D: score=1 STRING: ENSP00000386717
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    RPL35A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL35A (RL35A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL35A gene: 
    NM_000996.2  

    Unigene Cluster for RPL35A:

    Ribosomal protein L35a
    Hs.529631  [show with all ESTs]
    Unigene Representative Sequence: AK021571
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464167(uc003fyr.3) ENST00000485439 ENST00000496582 ENST00000329092
    ENST00000448864(uc003fys.3) ENST00000429437 ENST00000442341 ENST00000439255
    ENST00000474640
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK021571.1 AK026542.1 AK055653.1 BC001037.2 BC010949.1 BC017093.1 BC061890.1 X52966.1 

    Selected DOTS entries (see all 57):

    DT.87011172  DT.100866601  DT.95180425  DT.91943863  DT.100867253  DT.120918921  DT.91773484  DT.99975644 
    DT.100693740  DT.120919145  DT.100649795  DT.100693733  DT.87017877  DT.121156081  DT.100864030  DT.120919004 
    DT.120918815  DT.121330964  DT.120918980  DT.100772897  DT.97824810  DT.100042963  DT.95107187  DT.91773466 

    Selected AceView cDNA sequences (see all 1140):

    BM841046 BM767198 AA314953 AA381826 AA194158 BM841060 BE736169 BE255564 
    F28823 AI749390 BM972808 BM841015 AA187120 CK903246 BF033579 AW328459 
    BQ689128 CD105597 BQ548874 AJ713619 AA777501 BQ688201 AI184962 BG751637 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RPL35A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:              -                                 
    SP2:                                                
    SP3:                                -               


    ECgene alternative splicing isoforms for RPL35A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL35A expression in normal human tissues (normalized intensities)      RPL35A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCGTGCCA
    RPL35A Expression
    About this image


    RPL35A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    RPL35A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL35A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529631
        Custom PCR Arrays for RPL35A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL35A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL35A gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl35a1 , 5 ribosomal protein L35A1, 5 90.91(n)1
    99.09(a)1
      16 (23.59 cM)5
    578081  NM_021338.31  NP_067313.21 
     330564535 
    chicken
    (Gallus gallus)
    Aves RPL35A1 ribosomal protein L35a 81.82(n)
    96.36(a)
      424924  NM_001277457.1  NP_001264386.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL35A6
    ribosomal protein L35a
    94(a)
    1 ↔ 1
    GL343433.1(460102-463164)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rpl35a1 ribosomal protein L35a 81.82(n)
    98.18(a)
      448717  NM_001005134.2  NP_001005134.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl35a1 ribosomal protein L35a 75.45(n)
    90(a)
      436760  NM_001002487.1  NP_001002487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20993
    RpL35A1
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein L35A1
    61(a)3
    61.73(n)1
    62.96(a)1
      83A43
    406541  NM_141282.31  NP_649539.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-331 , 3 60s ribosomal protein L35A3
    rpl-331
    59(a)3
    59.94(n)1
    59.63(a)1
      II(7105425-7106394)3
    1741661  NM_063067.31  NP_495468.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL33B1 RPL33B 53.53(n)
    53.85(a)
      854409   NP_014877.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G742701 AT1G74270 57(n)
    58(a)
      843767  NM_106087.4  NP_177567.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07858001 Os02g0785800 55.88(n)
    57.84(a)
      4330946  NM_001054865.1  NP_001048330.1 


    ENSEMBL Gene Tree for RPL35A (if available)
    TreeFam Gene Tree for RPL35A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL35A gene

    RPL35A for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL35A (see all 41)
    PGOHUM00000238485 PGOHUM00000238787 PGOHUM00000238788 PGOHUM00000242533 PGOHUM00000239733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for RPL35A    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0554474
    Diamond-Blackfan anemia 5 (DBA5)4--see VAR_0554472 V I mis40--------
    rs1168408081,2
    Cpathogenic1197534277(+) AAGGTG/ATTTAC 2 /I /V mis11Minor allele frequency- A:0.01NS 134
    rs1168408091,2
    Cpathogenic1197537175(+) GAATCC/TGAGTG 2 R * stg10--------
    rs1168408071,2
    --pathogenic1197534262(+) CTCTT-/CTTAAAAT 1 -- cds10--------

    HapMap Linkage Disequilibrium report for RPL35A (197676858 - 197683481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RPL35A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv878215CNV Loss21882294
    dgv5379n71CNV Gain21882294
    nsv527527CNV Gain19592680
    esv2751989CNV Gain17911159
    nsv878216CNV Gain21882294
    nsv483023CNV Gain15286789

    Human Gene Mutation Database (HGMD): RPL35A
    Locus Specific Mutation Databases (LSDB): RPL35A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL35A
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL35A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180468   
    OMIM disorders: 612528  
    UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077
  • Diamond-Blackfan anemia 5 (DBA5) [MIM:612528]: A form of Diamond-Blackfan anemia, a congenital
    non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is
    characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.
    30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most
    frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 16 diseases for RPL35A:    About MalaCards
    rpl35a-related diamond-blackfan anemia    diamond-blackfan anemia 5    diamond-blackfan anemia    diamond-blackfan anemia 1
    pure red-cell aplasia    macrocytic anemia    treacher collins syndrome    aplastic anemia
    short stature    cleft palate    influenza    hepatocellular carcinoma
    hiv-1    multiple myeloma    malaria    myeloma

    1 disease from the University of Copenhagen DISEASES database for RPL35A:
    Aplastic anemia

    RPL35A for disorders           About GeneDecksing

    GeneTests: RPL35A
    GeneReviews: RPL35A
    Genetic Association Database (GAD): RPL35A
    Human Genome Epidemiology (HuGE) Navigator: RPL35A (3 documents)

    Export disorders for RPL35A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL35A gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with RPL35A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter. (PubMed id 8786106)1, 2, 3, 9 Colombo P.... Fried M. (Genomics 1996)
    2. cDNA encoding the human homologue of rat ribosomal protein L35a. (PubMed id 2388839)1, 2, 9 Herzog H.... Schweiger M. (Nucleic Acids Res. 1990)
    3. Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. (PubMed id 20378560)1, 4 Konno Y....Ito E. (Haematologica 2010)
    4. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. (PubMed id 19773262)1, 4 Quarello P....Ramenghi U. (Haematologica 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. (PubMed id 18535205)1, 2 Farrar J.E....Arceci R.J. (Blood 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (Genomics 1992)
    9. Inhibition of cell death by ribosomal protein L35a. (PubMed id 12175552)1, 9 Lopez C.D....Naumovski L. (Cancer Lett. 2002)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6165 HGNC: 10345 AceView: RPL35A Ensembl:ENSG00000182899 euGenes: HUgn6165
    ECgene: RPL35A Kegg: 6165 H-InvDB: RPL35A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL35A Pharmacogenomics, SNPs, Pathways
    Diamond-Blackfan Anemia mutation databasehttp://www.dbagenes.unito.it/home.php?select_db=RPL35A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL35A gene:
    Search GeneIP for patents involving RPL35A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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