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Aliases for RPL35A Gene

Aliases for RPL35A Gene

  • Ribosomal Protein L35a 2 3
  • Cell Growth-Inhibiting Gene 33 Protein 3 4
  • DBA5 3 6
  • 60S Ribosomal Protein L35a 3
  • L35A 3

External Ids for RPL35A Gene

Previous GeneCards Identifiers for RPL35A Gene

  • GC03U990068
  • GC03P199076
  • GC03P199003
  • GC03P199165
  • GC03P197676
  • GC03P194979

Summaries for RPL35A Gene

Entrez Gene Summary for RPL35A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL35A Gene

RPL35A (Ribosomal Protein L35a) is a Protein Coding gene. Diseases associated with RPL35A include diamond-blackfan anemia 5 and rpl35a-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome and tRNA binding.

UniProtKB/Swiss-Prot for RPL35A Gene

  • Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.

Gene Wiki entry for RPL35A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL35A Gene

Genomics for RPL35A Gene

Regulatory Elements for RPL35A Gene

Genomic Location for RPL35A Gene

197,949,987 bp from pter
197,956,610 bp from pter
6,624 bases
Plus strand

Genomic View for RPL35A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL35A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL35A Gene

Proteins for RPL35A Gene

  • Protein details for RPL35A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L35a
    Protein Accession:
    Secondary Accessions:
    • Q08ES9
    • Q9BVN7

    Protein attributes for RPL35A Gene

    110 amino acids
    Molecular mass:
    12538 Da
    Quaternary structure:
    No Data Available
    • Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal subunit rRNA

    Three dimensional structures from OCA and Proteopedia for RPL35A Gene

neXtProt entry for RPL35A Gene

Proteomics data for RPL35A Gene at MOPED

Post-translational modifications for RPL35A Gene

  • Ubiquitination at Lys8, Lys45, and Lys95
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL35A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL35A Gene

Domains for RPL35A Gene

Gene Families for RPL35A Gene

  • RPL :L ribosomal proteins

Protein Domains for RPL35A Gene

Suggested Antigen Peptide Sequences for RPL35A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P18077
  • Belongs to the ribosomal protein L35Ae family.
genes like me logo Genes that share domains with RPL35A: view

Function for RPL35A Gene

Molecular function for RPL35A Gene

GENATLAS Biochemistry: 60S ribosomal protein L35A,12kDa
UniProtKB/Swiss-Prot Function: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.

Gene Ontology (GO) - Molecular Function for RPL35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL35A: view
genes like me logo Genes that share phenotypes with RPL35A: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL35A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL35A Gene

Localization for RPL35A Gene

Subcellular locations from

Jensen Localization Image for RPL35A Gene COMPARTMENTS Subcellular localization image for RPL35A gene
Compartment Confidence
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL35A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL35A Gene

Pathways for RPL35A Gene

genes like me logo Genes that share pathways with RPL35A: view

Pathways by source for RPL35A Gene

1 KEGG pathway for RPL35A Gene
1 GeneGo (Thomson Reuters) pathway for RPL35A Gene

Gene Ontology (GO) - Biological Process for RPL35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL35A: view

Transcripts for RPL35A Gene

Unigene Clusters for RPL35A Gene

Ribosomal protein L35a:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL35A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL35A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP3: -

Relevant External Links for RPL35A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL35A Gene

mRNA expression in normal human tissues for RPL35A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL35A Gene

SOURCE GeneReport for Unigene cluster for RPL35A Gene Hs.529631

genes like me logo Genes that share expressions with RPL35A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL35A Gene

Orthologs for RPL35A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL35A 35
  • 99.7 (n)
  • 100 (a)
RPL35A 36
  • 100 (a)
RPL35A 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 95 (a)
RPL35A 35
  • 91.21 (n)
  • 99.09 (a)
RPL35A 36
  • 99 (a)
(Canis familiaris)
Mammalia RPL35A 35
  • 91.52 (n)
  • 100 (a)
RPL35A 36
  • 87 (a)
(Mus musculus)
Mammalia Rpl35a 35
  • 90.91 (n)
  • 99.09 (a)
Rpl35a 16
Rpl35a 36
  • 99 (a)
(Monodelphis domestica)
Mammalia RPL35A 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RPL35A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rpl35a 35
  • 92.12 (n)
  • 99.09 (a)
(Gallus gallus)
Aves RPL35A 35
  • 81.82 (n)
  • 96.36 (a)
RPL35A 36
  • 73 (a)
(Anolis carolinensis)
Reptilia RPL35A 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl35a 35
  • 81.82 (n)
  • 98.18 (a)
(Danio rerio)
Actinopterygii rpl35a 35
  • 75.45 (n)
  • 90 (a)
rpl35a 36
  • 90 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002754 35
  • 62.35 (n)
  • 65.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL35A 35
  • 61.73 (n)
  • 62.96 (a)
RpL35A 36
  • 43 (a)
CG2099 37
  • 61 (a)
(Caenorhabditis elegans)
Secernentea rpl-33 35
  • 59.94 (n)
  • 59.63 (a)
rpl-33 36
  • 52 (a)
rpl-33 37
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR120C 35
  • 51.92 (n)
  • 51.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL33A 36
  • 51 (a)
RPL33B 35
  • 53.53 (n)
  • 53.85 (a)
RPL33B 36
  • 52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07405g 35
  • 52.24 (n)
  • 50.96 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74270 35
  • 57 (n)
  • 58 (a)
(Oryza sativa)
Liliopsida Os02g0785800 35
  • 55.88 (n)
  • 57.84 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09109 35
  • 52.29 (n)
  • 51.96 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl35b 35
  • 52.29 (n)
  • 50.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
Species with no ortholog for RPL35A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL35A Gene

Gene Tree for RPL35A (if available)
Gene Tree for RPL35A (if available)

Paralogs for RPL35A Gene

genes like me logo Genes that share paralogs with RPL35A: view

No data available for Paralogs for RPL35A Gene

Variants for RPL35A Gene

Sequence variations from dbSNP and Humsavar for RPL35A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_055447 Diamond-Blackfan anemia 5 (DBA5)

Structural Variations from Database of Genomic Variants (DGV) for RPL35A Gene

Variant ID Type Subtype PubMed ID
esv2751989 CNV Gain 17911159
nsv527527 CNV Gain 19592680
dgv5379n71 CNV Gain 21882294
nsv483023 CNV Gain 15286789
nsv878215 CNV Loss 21882294
nsv878216 CNV Gain 21882294

Relevant External Links for RPL35A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL35A Gene

Disorders for RPL35A Gene

(1) OMIM Diseases for RPL35A Gene (180468)


  • Diamond-Blackfan anemia 5 (DBA5) [MIM:612528]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:18535205}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPL35A Gene

Relevant External Links for RPL35A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPL35A: view

Publications for RPL35A Gene

  1. The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter. (PMID: 8786106) Colombo P. … Fried M. (Genomics 1996) 2 3 4 23
  2. cDNA encoding the human homologue of rat ribosomal protein L35a. (PMID: 2388839) Herzog H. … Schweiger M. (Nucleic Acids Res. 1990) 3 4 23
  3. Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. (PMID: 20378560) Konno Y. … Ito E. (Haematologica 2010) 3 48
  4. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. (PMID: 18535205) Farrar J.E. … Arceci R.J. (Blood 2008) 3 4
  5. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. (PMID: 19773262) Quarello P. … Ramenghi U. (Haematologica 2010) 3 48

Products for RPL35A Gene

Sources for RPL35A Gene

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