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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPL35A Gene

protein-coding GIFtS: 62
GCID: GC03P197676

ribosomal protein L35a

Explore 9 diseases affiliated with
RPL35A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein L35a¹ ²
L35A¹ ²
Cell Growth-Inhibiting Gene 33 Protein² ³
DBA5² ⁵
60S Ribosomal Protein L35a²

External Ids:	HGNC: 10345¹	Entrez Gene: 6165²	Ensembl: ENSG00000182899⁷	OMIM: 180468⁵	UniProtKB: P18077³

Export aliases for RPL35A gene to outside databases

Previous GC identifers: GC03U990068 GC03P199076 GC03P199003 GC03P199165 GC03P194979

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL35A:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of

ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and

elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was

originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants

utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes

encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077

Function: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit

formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P

site or P and A site

Gene Wiki entry for RPL35A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_029928.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPL35A gene promoter:
AhR AML1a POU3F1 NRSF form 1 NRSF form 2 Arnt MEF-2A AREB6 Zic1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPL35A promoter sequence

Search SABiosciences Chromatin IP Primers for RPL35A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL35A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29

RPL35A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL35A gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P197676: view genomic region (about GC identifiers)

Start:	197,676,858 bp from pter	End:	197,683,481 bp from pter
Size:	6,624 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077 (See protein sequence)

Recommended Name: 60S ribosomal protein L35a

Size: 110 amino acids; 12538 Da

Miscellaneous: Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased

apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal subunit

rRNA

Secondary accessions: Q08ES9 Q9BVN7

Explore the universe of human proteins at neXtProt for RPL35A: NX_P18077

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18077

RPL35A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000987.2

ENSEMBL proteins:

ENSP00000419117 ENSP00000393393 ENSP00000398058 ENSP00000387688 ENSP00000410683

Reactome Protein details: P18077
Human Recombinant Protein Products for RPL35A:

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	Uscn Proteins for RPL35A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0022625	cytosolic large ribosomal subunit	IDA	12962325

RPL35A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPL35A for domains About GeneDecksing

3 InterPro domains/families:

IPR001780 Ribosomal_L35A

IPR018266 Ribosomal_L35Ae_CS

IPR009000 Transl_elong_init/rib_B-barrel

Graphical View of Domain Structure for InterPro Entry P18077

ProtoNet protein and cluster: P18077

1 Blocks protein family: IPB001780 Ribosomal protein L35Ae

UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077

Similarity: Belongs to the ribosomal protein L35Ae family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RL35A_HUMAN, P18077

Function: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit

formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P

site or P and A site

Genatlas biochemistry entry for RPL35A:

60S ribosomal protein L35A,12kDa

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IEA	--
GO:0003735	structural constituent of ribosome	NAS	12962325

RPL35A for ontologies About GeneDecksing

Phenotypes:
6 GenomeRNAi human phenotypes for RPL35A:

Decreased TP53 protein express	Decreased viability of wild-ty	Increased S DNA content	Nuclear 60S biogenesis defects
Nucleolar pre-40S maturation d	S arrest

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPL35A

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPL35A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPL35A

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPL35A

Cytoplasmic Ribosomal Proteins

5/28 Reactome Pathways for RPL35A (see all 28)

	Nonsense Mediated Decay Independent of the Exon Junction Complex
	Nonsense-Mediated Decay
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Eukaryotic Translation Initiation

1 Kegg Pathway (Kegg details for RPL35A):

Ribosome

RPL35A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPL35A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/335 Interacting proteins for RPL35A (P18077^{1, 2, 3} ENSP00000393393⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 335)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6542674 MINT-6489539 MINT-6488590 I2D: score=1 STRING: ENSP00000363676
RPL26	P61254²^,³, ENSP00000293842⁴	MINT-6542674 MINT-6489539 MINT-6488590 I2D: score=1 STRING: ENSP00000293842
RPL6	Q02878²^,³, ENSP00000202773⁴	MINT-6542674 MINT-6489539 MINT-6488590 I2D: score=1 STRING: ENSP00000202773
SH3GL3	Q99963²^,³, ENSP00000391372⁴	MINT-63524 MINT-8269065 I2D: score=5 STRING: ENSP00000391372
RPL13	P26373²^,³, ENSP00000307889⁴	MINT-6542674 MINT-6488590 I2D: score=1 STRING: ENSP00000307889

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006364	rRNA processing	IMP	18697920
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--

RPL35A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPL35A
Search CenterWatch for drugs/clinical trials and news about RPL35A / RL35A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPL35A gene:

NM_000996.2

Unigene Cluster for RPL35A:

Ribosomal protein L35a

Hs.529631 [show with all ESTs]

Unigene Representative Sequence: AK021571

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000464167(uc003fyr.3) ENST00000485439 ENST00000496582 ENST00000329092

ENST00000448864(uc003fys.3) ENST00000429437 ENST00000442341 ENST00000439255

ENST00000474640

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Additional cDNA sequence:

AK021571.1 AK026542.1 AK055653.1 BC001037.2 BC010949.1 BC017093.1 BC061890.1 X52966.1

24/57 DOTS entries (see all 57):

DT.87011172 DT.100866601 DT.95180425 DT.91943863 DT.100867253 DT.120918921 DT.91773484 DT.99975644

DT.100693740 DT.120919145 DT.100649795 DT.100693733 DT.87017877 DT.121156081 DT.100864030 DT.120919004

DT.120918815 DT.121330964 DT.120918980 DT.100772897 DT.97824810 DT.100042963 DT.95107187 DT.91773466

24/1140 AceView cDNA sequences (see all 1140):

W32880 AI184962 F30925 BM781497 BG751637 AA301601 BC061890 BU500748

BQ228063 BM915848 BE392115 AI247929 AW651686 AA329139 AA936021 BM856514

AA654164 BM716139 BM818317 AA365353 F30645 W24086 CA841862 CD108316

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RPL35A About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b
SP1:					-
SP2:
SP3:											-

ECgene alternative splicing isoforms for RPL35A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPL35A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCGTGCCA

About this image

RPL35A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPL35A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL35A

SOURCE GeneReport for Unigene cluster: Hs.529631

SABiosciences Custom PCR Arrays for RPL35A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35A gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rpl35a^{1 , 5}	ribosomal protein L35A^{1, 5}	90.91(n)¹ 99.09(a)¹		16 (23.59 cM)⁵ 57808¹ NM_001130484.1¹ NP_001123956.1¹ 33056453⁵
chicken (Gallus gallus)	Aves	RPL35A¹	ribosomal protein L35a	81.82(n) 96.36(a)		424924 XM_001232254.2 XP_001232255.1
lizard (Anolis carolinensis)	Reptilia	RPL35A⁶	--	94(a)	1 ↔ 1	GL343433.1(460102-463164)
zebrafish (Danio rerio)	Actinopterygii	rpl35a¹	ribosomal protein L35a	75.45(n) 90(a)		436760 NM_001002487.1 NP_001002487.1
fruit fly (Drosophila melanogaster)	Insecta	CG2099³ RpL35A¹	protein biosynthesis structural constituent of more³ Ribosomal protein L35A¹	61(a)³ 61.73(n)¹ 62.96(a)¹		83A4³ 40654¹ NM_141282.2¹ NP_649539.1¹
worm (Caenorhabditis elegans)	Secernentea	rpl-33³	60s ribosomal protein L35A	59(a)		II(7105425-7106394) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G74270⁶ AT1G41880⁶ (see all 4)	60S ribosomal protein L35a-2 (see all 4)	50(a) 50(a) (see all 4)	many → 1 many → 1 (see all 4)	1(27928171-27929497) 1(15651027-15652542)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	60S ribosomal protein L35a-3, putative, expressed (see all 4)	52(a) 52(a) (see all 4)	many → 1 many → 1 (see all 4)	5(27632664-27634880) 5(27578027-27580141)

ENSEMBL Gene Tree for RPL35A (if available)
TreeFam Gene Tree for RPL35A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPL35A gene

RPL35A for paralogs About GeneDecksing

5/41 Pseudogenes.org Pseudogenes for RPL35A (see all 41)
PGOHUM00000238485 PGOHUM00000238787 PGOHUM00000238788 PGOHUM00000242533 PGOHUM00000239733

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116840809^1,2	C	pathogenic	195367704(+)	`GAATCC/TGAGTG`	2	R *	stg¹		0	--	--	--	--
rs116840808^1,2	C	pathogenic	195370602(+)	`AAGGTG/ATTTAC`	2	/I /V	mis¹		1		NS	134
rs74352940^1,2	C,F	--	194978028(+)	`GGGTAG/CTAGGC`	1	--	us2k¹		1		WA	118
rs9835340^1,2	C,F,H	--	194978686(+)	`CTGGCG/ATCCAC`	1	--	us2k¹		20		EA NS NA WA CSA	2118
rs142712955^1,2	C,F	--	194978753(+)	`TAAACG/AAGTTC`	1	--	us2k¹		1		NS	146
rs13318902^1,2	C,F	--	194978901(+)	`atgttG/Acccag`	1	--	us2k¹		7		WA NA CSA NS	392
rs114573631^1,2	C,F	--	194979436(+)	`AGTGCG/AAAGCC`	1	--	us2k¹		2		NA NS	270
rs143337408^1,2	C	--	194979591(+)	`GGTCTG/CCTGCT`	1	--	int¹		1		NS	150
rs78182582^1,2	C,F	--	194979753(+)	`CCCCTG/AACACC`	1	--	int¹		1		NS	122
rs79249954^1,2	C,F	--	194980149(+)	`ATATGG/AATGTT`	1	--	int¹		4		CSA WA NS	248

HapMap Linkage Disequilibrium report for RPL35A (197676858 - 197683481 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RPL35A
2 CNVs: 0044 8440
Human Gene Mutation Database (HGMD): RPL35A

Locus Specific Mutation Databases (LSDB): RPL35A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPL35A for disorders           About GeneDecksing

OMIM gene information: 180468
OMIM disorders: 612528
UniProtKB/Swiss-Prot: RL35A_HUMAN, P18077

Defects in RPL35A are the cause of Diamond-Blackfan anemia type 5 (DBA5) [MIM:612528]. DBA5 is a form of

Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy.

Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an

increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital

anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital

anomalies

9 diseases for RPL35A: About MalaCards

diamond-blackfan anemia treacher collins syndrome macrocytic anemia short stature

aplastic anemia anemia hepatocellular carcinoma carcinoma

malaria

2 diseases from the University of Copenhagen DISEASES database for RPL35A:

Diamond-Blackfan anemia Pure red-cell aplasia

GeneTests: RPL35A

Diamond-Blackfan Anemia

Human Genome Epidemiology (HuGE) Navigator: RPL35A (3 documents)

Export disorders for RPL35A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPL35A gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with RPL35A)

Utopia: connect your pdf to the dynamic
world of online information

The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter. (PubMed id 8786106)^{1, 2, 3, 9} Colombo P....Fried M. (1996)
cDNA encoding the human homologue of rat ribosomal protein L35a. (PubMed id 2388839)^{1, 2, 9} Herzog H.... Schweiger M. (1990)
Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. (PubMed id 18535205)^{1, 2} Farrar J.E....Arceci R.J. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)^{1, 3} Feo S....Fried M. (1992)
Inhibition of cell death by ribosomal protein L35a. (PubMed id 12175552)^{1, 9} Lopez C.D....Naumovski L. (2002)
Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)¹ Zhou J....Liang S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6165	HGNC: 10345	AceView: RPL35A	Ensembl:ENSG00000182899	euGenes: HUgn6165
ECgene: RPL35A	Kegg: 6165	H-InvDB: RPL35A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPL35A	Pharmacogenomics, SNPs, Pathways
Diamond-Blackfan Anemia mutation database	http://www.dbagenes.unito.it/home.php?select_db=RPL35A

Intellectual Property for RPL35A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPL35A gene:
Search GeneIP for patents involving RPL35A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ribosomal protein L35a

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RPL35A Gene

ribosomal protein L35a

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