Aliases for RPL35A Gene
External Ids for RPL35A Gene
Previous GeneCards Identifiers for RPL35A Gene
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Oct 2015]
GeneCards Summary for RPL35A Gene
RPL35A (Ribosomal Protein L35a) is a Protein Coding gene. Diseases associated with RPL35A include Diamond-Blackfan Anemia 5 and Rpl35a-Related Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and tRNA binding.
UniProtKB/Swiss-Prot for RPL35A Gene
Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.