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Aliases for RPL35 Gene

Aliases for RPL35 Gene

  • Ribosomal Protein L35 2 3 5
  • 60S Ribosomal Protein L35 2 3
  • L35 3

External Ids for RPL35 Gene

Previous GeneCards Identifiers for RPL35 Gene

  • GC09M118734
  • GC09M119266
  • GC09M121073
  • GC09M122996
  • GC09M124699
  • GC09M126659
  • GC09M127620
  • GC09M097233

Summaries for RPL35 Gene

Entrez Gene Summary for RPL35 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL35 Gene

RPL35 (Ribosomal Protein L35) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

Gene Wiki entry for RPL35 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL35 Gene

Genomics for RPL35 Gene

Regulatory Elements for RPL35 Gene

Enhancers for RPL35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F124769 1.2 ENCODE 13.5 +91.4 91364 3.4 HDGF ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF207 GOLGA1 WDR38 ARPC5L RPL35 MIR181A2HG ENSG00000236643 NR6A1
GH09F124799 1.3 Ensembl ENCODE 12.1 +60.7 60668 3.3 PKNOX1 SIN3A GLIS2 ZNF766 FOS KDM4B DEK ZNF263 ZNF592 MBD2 WDR38 RPL35 ARPC5L OLFML2A GAPVD1 RNU6-1020P MIR181A2HG PIR55692
GH09F124774 1.1 Ensembl ENCODE 13.6 +87.3 87319 0.7 ELF3 ATF1 KLF17 ARID4B ZNF2 RAD21 RFX5 ZNF366 ZNF143 RCOR1 WDR38 RPL35 ARPC5L MIR181A2HG OLFML2A NR6A1
GH09F124756 1.2 Ensembl ENCODE 11.8 +102.5 102504 5.4 HDAC1 PKNOX1 CBX3 ARNT SIN3A RAD21 CHAMP1 ZNF766 CBX5 SCRT2 WDR38 ARPC5L RPL35 MIR181A2HG ENSG00000236643 GC09P124694
GH09F124795 1.1 Ensembl ENCODE 12.1 +65.2 65246 3.5 ELF3 PKNOX1 SREBF2 ARID4B ZNF48 ZSCAN9 RAD21 RARA ZNF121 MIXL1 WDR38 RPL35 ARPC5L GAPVD1 RNU6-1020P MIR181A2HG PIR55692 OLFML2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL35 on UCSC Golden Path with GeneCards custom track

Promoters for RPL35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001314214 81 2201 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 ZNF207 ZNF263 PAF1 SP3

Genomic Location for RPL35 Gene

124,857,879 bp from pter
124,861,981 bp from pter
4,103 bases
Minus strand

Genomic View for RPL35 Gene

Genes around RPL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL35 Gene

Proteins for RPL35 Gene

  • Protein details for RPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L35
    Protein Accession:
    Secondary Accessions:
    • A8K4V7
    • Q4VBY5
    • Q5JTN5
    • Q6IBC7
    • Q96QJ7
    • Q9BYF4

    Protein attributes for RPL35 Gene

    123 amino acids
    Molecular mass:
    14551 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI39638.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL35 Gene

neXtProt entry for RPL35 Gene

Post-translational modifications for RPL35 Gene

  • Ubiquitination at Lys 25, Lys 66, and Lys 79
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL35 Gene

No data available for DME Specific Peptides for RPL35 Gene

Domains & Families for RPL35 Gene

Gene Families for RPL35 Gene

Protein Domains for RPL35 Gene

Suggested Antigen Peptide Sequences for RPL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L29P family.
  • Belongs to the ribosomal protein L29P family.
genes like me logo Genes that share domains with RPL35: view

Function for RPL35 Gene

Molecular function for RPL35 Gene

GENATLAS Biochemistry:
60S ribosomal protein L35,12kDa

Gene Ontology (GO) - Molecular Function for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding TAS 2891103
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL35: view
genes like me logo Genes that share phenotypes with RPL35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL35 Gene

Localization for RPL35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL35 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005730 nucleolus TAS 2891103
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL35 Gene

Pathways & Interactions for RPL35 Gene

genes like me logo Genes that share pathways with RPL35: view

Pathways by source for RPL35 Gene

1 KEGG pathway for RPL35 Gene
1 GeneGo (Thomson Reuters) pathway for RPL35 Gene

Gene Ontology (GO) - Biological Process for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL35: view

No data available for SIGNOR curated interactions for RPL35 Gene

Transcripts for RPL35 Gene

Unigene Clusters for RPL35 Gene

Ribosomal protein L35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4

Relevant External Links for RPL35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL35 Gene

This gene is overexpressed in Tlymphocyte (9.6) and Hair follicle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL35 Gene

Protein tissue co-expression partners for RPL35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL35 Gene:


SOURCE GeneReport for Unigene cluster for RPL35 Gene:

genes like me logo Genes that share expression patterns with RPL35: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL35 Gene

Orthologs for RPL35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL35 34 35
  • 100 (n)
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
RPL35 34 35
  • 91.6 (n)
(Monodelphis domestica)
Mammalia RPL35 35
  • 98 (a)
(Mus musculus)
Mammalia Gm2000 35
  • 98 (a)
Gm10269 35
  • 96 (a)
Rpl35 34 16 35
  • 89.16 (n)
(Ornithorhynchus anatinus)
Mammalia RPL35 35
  • 98 (a)
(Canis familiaris)
Mammalia RPL35 34 35
  • 92.68 (n)
(Rattus norvegicus)
Mammalia Rpl35 34
  • 89.7 (n)
(Gallus gallus)
Aves RPL35 34 35
  • 82.66 (n)
(Anolis carolinensis)
Reptilia RPL35 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl35 34
  • 77.78 (n)
MGC76336 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29067 34
(Danio rerio)
Actinopterygii rpl35 34 35
  • 80.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8401 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001408 34
  • 67.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL35 34 35
  • 66.12 (n)
(Caenorhabditis elegans)
Secernentea rpl-35 36 34 35
  • 63.41 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR095W 34
  • 58.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL35A 35
  • 58 (a)
RPL35B 34 35 37
  • 54.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05247g 34
  • 55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02610 34
  • 63.96 (n)
(Glycine max)
eudicotyledons Gma.9631 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7399 34
(Oryza sativa)
Liliopsida Os04g0376000 34
  • 67.21 (n)
Os.37768 34
(Hordeum vulgare)
Liliopsida Hv.314 34
(Triticum aestivum)
Liliopsida Ta.28696 34
(Zea mays)
Liliopsida Zm.878 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4820 35
  • 79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10498 34
  • 60.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl35 34
  • 56.11 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3995 34
Species where no ortholog for RPL35 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL35 Gene

Gene Tree for RPL35 (if available)
Gene Tree for RPL35 (if available)

Paralogs for RPL35 Gene

(1) SIMAP similar genes for RPL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPL35: view

No data available for Paralogs for RPL35 Gene

Variants for RPL35 Gene

Sequence variations from dbSNP and Humsavar for RPL35 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10593927 -- 124,858,202(+) CACAC(-/AT)GTCAC intron-variant, downstream-variant-500B
rs10986468 -- 124,862,400(+) GGAGG(A/T)ATTTA upstream-variant-2KB, splice-donor-variant
rs111327108 -- 124,861,850(+) GCACC(A/G)CCTTC intron-variant, upstream-variant-2KB
rs111943505 -- 124,860,265(+) CTCGG(A/C/G)TACAA upstream-variant-2KB, splice-acceptor-variant
rs112226140 -- 124,859,406(+) TCAGG(G/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL35 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897
nsv951760 CNV deletion 24416366

Variation tolerance for RPL35 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL35 Gene

Disorders for RPL35 Gene

Relevant External Links for RPL35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL35 Gene

Publications for RPL35 Gene

  1. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. (PMID: 11401437) Uechi T. … Kenmochi N. (Genomics 2001) 2 3 4 64
  2. The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking. (PMID: 18523488) Chen I.J. … Lin A. (Biochem. Cell Biol. 2008) 3 22 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 64

Products for RPL35 Gene

Sources for RPL35 Gene

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