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Aliases for RPL35 Gene

Aliases for RPL35 Gene

  • Ribosomal Protein L35 2 3 5
  • 60S Ribosomal Protein L35 2
  • L35 3

External Ids for RPL35 Gene

Previous GeneCards Identifiers for RPL35 Gene

  • GC09M118734
  • GC09M119266
  • GC09M121073
  • GC09M122996
  • GC09M124699
  • GC09M126659
  • GC09M127620
  • GC09M097233

Summaries for RPL35 Gene

Entrez Gene Summary for RPL35 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL35 Gene

RPL35 (Ribosomal Protein L35) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

Gene Wiki entry for RPL35 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL35 Gene

Genomics for RPL35 Gene

Regulatory Elements for RPL35 Gene

Enhancers for RPL35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL35 on UCSC Golden Path with GeneCards custom track

Promoters for RPL35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL35 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL35 Gene

124,857,879 bp from pter
124,861,981 bp from pter
4,103 bases
Minus strand

Genomic View for RPL35 Gene

Genes around RPL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL35 Gene

Proteins for RPL35 Gene

  • Protein details for RPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L35
    Protein Accession:
    Secondary Accessions:
    • A8K4V7
    • Q4VBY5
    • Q5JTN5
    • Q6IBC7
    • Q96QJ7
    • Q9BYF4

    Protein attributes for RPL35 Gene

    123 amino acids
    Molecular mass:
    14551 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI39638.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPL35 Gene

neXtProt entry for RPL35 Gene

Proteomics data for RPL35 Gene at MOPED

Post-translational modifications for RPL35 Gene

  • Ubiquitination at Lys 25, Lys 66, and Lys 79
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL35 Gene

No data available for DME Specific Peptides for RPL35 Gene

Domains & Families for RPL35 Gene

Gene Families for RPL35 Gene

Protein Domains for RPL35 Gene

Suggested Antigen Peptide Sequences for RPL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L29P family.
  • Belongs to the ribosomal protein L29P family.
genes like me logo Genes that share domains with RPL35: view

Function for RPL35 Gene

Molecular function for RPL35 Gene

GENATLAS Biochemistry:
60S ribosomal protein L35,12kDa

Gene Ontology (GO) - Molecular Function for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding TAS 2891103
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL35: view
genes like me logo Genes that share phenotypes with RPL35: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL35 Gene

Localization for RPL35 Gene

Subcellular locations from

Jensen Localization Image for RPL35 Gene COMPARTMENTS Subcellular localization image for RPL35 gene
Compartment Confidence
cytosol 5
nucleus 4
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus TAS 2891103
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL35 Gene

Pathways & Interactions for RPL35 Gene

genes like me logo Genes that share pathways with RPL35: view

Pathways by source for RPL35 Gene

1 KEGG pathway for RPL35 Gene
1 GeneGo (Thomson Reuters) pathway for RPL35 Gene

Gene Ontology (GO) - Biological Process for RPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL35: view

No data available for SIGNOR curated interactions for RPL35 Gene

Drugs & Compounds for RPL35 Gene

No Compound Related Data Available

Transcripts for RPL35 Gene

Unigene Clusters for RPL35 Gene

Ribosomal protein L35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4

Relevant External Links for RPL35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL35 Gene

mRNA expression in normal human tissues for RPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL35 Gene

This gene is overexpressed in Tlymphocyte (9.6) and Hair follicle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL35 Gene

SOURCE GeneReport for Unigene cluster for RPL35 Gene Hs.182825

genes like me logo Genes that share expression patterns with RPL35: view

Protein tissue co-expression partners for RPL35 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL35 Gene

Orthologs for RPL35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL35 35
  • 91.6 (n)
  • 99.19 (a)
-- 36
  • 98 (a)
RPL35 36
  • 99 (a)
(Canis familiaris)
Mammalia RPL35 35
  • 92.68 (n)
  • 99.19 (a)
RPL35 36
  • 98 (a)
(Mus musculus)
Mammalia Rpl35 35
  • 89.16 (n)
  • 98.37 (a)
Rpl35 16
Gm10269 36
  • 96 (a)
Gm2000 36
  • 98 (a)
Rpl35 36
  • 98 (a)
(Pan troglodytes)
Mammalia RPL35 35
  • 100 (n)
  • 100 (a)
RPL35 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl35 35
  • 89.7 (n)
  • 98.37 (a)
(Monodelphis domestica)
Mammalia RPL35 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPL35 36
  • 98 (a)
(Gallus gallus)
Aves RPL35 35
  • 82.66 (n)
  • 98.37 (a)
RPL35 36
  • 97 (a)
(Anolis carolinensis)
Reptilia RPL35 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76336 35
rpl35 35
  • 77.78 (n)
  • 93.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29067 35
(Danio rerio)
Actinopterygii rpl35 35
  • 80.22 (n)
  • 92.68 (a)
rpl35 36
  • 93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8401 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001408 35
  • 67.21 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL35 35
  • 66.12 (n)
  • 65.85 (a)
RpL35 36
  • 66 (a)
(Caenorhabditis elegans)
Secernentea rpl-35 37
  • 67 (a)
rpl-35 35
  • 63.41 (n)
  • 67.48 (a)
rpl-35 36
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR095W 35
  • 58.33 (n)
  • 57.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05247g 35
  • 55 (n)
  • 55.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL35B 35
  • 54.44 (n)
  • 57.5 (a)
RPL35A 36
  • 58 (a)
RPL35B 36
  • 58 (a)
RPL35B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02610 35
  • 63.96 (n)
  • 64.23 (a)
(Glycine max)
eudicotyledons Gma.9631 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7399 35
(Hordeum vulgare)
Liliopsida Hv.314 35
(Oryza sativa)
Liliopsida Os.37768 35
Os04g0376000 35
  • 67.21 (n)
  • 67.48 (a)
(Triticum aestivum)
Liliopsida Ta.28696 35
(Zea mays)
Liliopsida Zm.878 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3995 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10498 35
  • 60.06 (n)
  • 54.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl35 35
  • 56.11 (n)
  • 55.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4820 36
  • 79 (a)
Species with no ortholog for RPL35:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL35 Gene

Gene Tree for RPL35 (if available)
Gene Tree for RPL35 (if available)

Paralogs for RPL35 Gene

(1) SIMAP similar genes for RPL35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPL35: view

No data available for Paralogs for RPL35 Gene

Variants for RPL35 Gene

Sequence variations from dbSNP and Humsavar for RPL35 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs944953 -- 124,859,726(+) ACACT(A/C)AAGCC intron-variant
rs113700485 -- 124,858,758(+) CCCTT(C/G)AGGAC intron-variant
rs2067553 -- 124,859,794(-) TGAGG(C/T)CTAGA intron-variant
rs115397968 -- 124,859,444(+) GAAGG(C/T)CCGAT intron-variant
rs116090356 -- 124,859,023(+) GGCTG(A/G)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL35 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV Gain 17160897

Variation tolerance for RPL35 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPL35 Gene

Disorders for RPL35 Gene

Relevant External Links for RPL35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL35 Gene

Publications for RPL35 Gene

  1. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. (PMID: 11401437) Uechi T. … Kenmochi N. (Genomics 2001) 2 3 4 67
  2. The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking. (PMID: 18523488) Chen I.J. … Lin A. (Biochem. Cell Biol. 2008) 3 23
  3. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation. (PMID: 26362536) Le Sage V. … Mouland A.J. (Virol. J. 2015) 3

Products for RPL35 Gene

Sources for RPL35 Gene