RPL34 Gene
protein-coding GIFtS: 56
GCID: GC04P109541
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ribosomal protein L34
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Aliases
for RPL34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein L341 2 | | L341 2 | | 60S Ribosomal Protein L342 | | Leukemia-Associated Protein2 | | M5 |
Export aliases for RPL34 gene to outside databasesPrevious GC identifers: GC04P109969 GC04P109862 GC04P110000 GC04P109899 GC04P109761 GC04P105273 |
Summaries
for RPL34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPL34:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family ofribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but ithas been mapped to 4q. Transcript variants derived from alternative splicing, alternative transcription initiationsites, and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genesencoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.(provided by RefSeq, Jul 2008)
Gene Wiki entry for RPL34
|
Genomic Views
for RPL34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPL34 gene promoter:
TBP AREB6 Sox5 PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25RPL34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P109541: view genomic region
(about GC identifiers)
Start:
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109,541,722 bp from pter |
End:
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109,551,640 bp from pter |
Size:
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9,919 bases |
Orientation:
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plus strand |
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Proteins
for RPL34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RL34_HUMAN, P49207 (See
protein sequence)Recommended Name: 60S ribosomal protein L34 Size: 117 amino acids; 13293 Da
Secondary accessions: Q6FG66 Q9BUZ2Explore the universe of human proteins at neXtProt for RPL34: NX_P49207
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49207
RPL34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000986.2 NP_296374.1
ENSEMBL proteins: ENSP00000378162 ENSP00000423983 ENSP00000378160 ENSP00000423316 ENSP00000378163 Reactome Protein details: P49207
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RPL34 for ontologies About GeneDecksing
RPL34 Antibody Products:
Assay Products for RPL34: |
Protein
Domains /
Families
for RPL34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL34 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49207ProtoNet protein and cluster: P49207 1 Blocks protein family: IPB008196 Ribosomal protein L34e
UniProtKB/Swiss-Prot: RL34_HUMAN, P49207Similarity: Belongs to the ribosomal protein L34e family |
Function
for RPL34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for RPL34:60S ribosomal protein L34
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL34 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL34 (see all 3)
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RPL34 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RPL34:
|
Pathways & Interactions
for RPL34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Disease | | | 4 | Generic Transcription Pathway | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for RPL34
1  BioSystems Pathway for RPL34
5/28 
Reactome Pathways for RPL34 (see all 28)
1 
Kegg Pathway (Kegg details for RPL34):
RPL34 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL34
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/188 Interacting proteins for RPL34 (P492071, 3 ENSP000003781604) via UniProtKB, MINT, STRING, and/or I2D (see all 188)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPL34 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPL34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPL34
Search CenterWatch for drugs/clinical trials and news about RPL34 / RL34
|
Transcripts
for RPL34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPL34 gene (2 alternative transcripts): NM_000995.3 NM_033625.2 Unigene Cluster for RPL34: Ribosomal protein L34 Hs.438227 [show with all ESTs]Unigene Representative Sequence: BG1127707 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394667 ENST00000502534 ENST00000394665 ENST00000503574 ENST00000506397
ENST00000394668(uc003hyz.3 uc003hza.3) ENST00000504231
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPL34 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPL34 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RPL34 (NM_000995) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPL34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL34 |
Additional cDNA sequence: AF147334.1 AY762981.1 BC001773.1 BC070208.1 BC106009.1 CR542232.1 CR542242.1 L38941.1 24/49 DOTS entries (see all 49): DT.100870560 DT.91672056 DT.87018067 DT.100045525 DT.95377235 DT.100720576 DT.121232342 DT.100045515 DT.121468188 DT.100718700 DT.100851492 DT.121232330 DT.121232368 DT.121232377 DT.121403617 DT.100045516 DT.91665872 DT.100873735 DT.95315759 DT.40123870 DT.100720571 DT.100720575 DT.70102125 DT.121232344 24/1147 AceView cDNA sequences (see all 1147): F34274 H89483 AI709292 CR542242 BG292247 AI074436 AA775136 BM674123 BM772310 AF147334 AA514483 BE744721 CD243325 T59609 BU543862 AW327294 T58614 BG109613 T60724 AI523368 AA364620 BG896834 N35541 AA635583
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RPL34 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | | | | | |
| SP3: | | | | | - | | - | | | | - | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RPL34
|
Expression
for RPL34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPL34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGCTAAAT
About this image
See RPL34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPL34
SOURCE GeneReport for Unigene cluster: Hs.438227
SABiosciences Custom PCR Arrays for RPL34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPL34
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL34 |
Orthologs
for RPL34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPL34 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for RPL34 (if available)
TreeFam Gene Tree for RPL34 (if available) |
Paralogs
for RPL34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPL34 gene
RPL34 for paralogs About GeneDecksing
5/43 Pseudogenes.org Pseudogenes for RPL34 (see all 43)
PGOHUM00000238603 PGOHUM00000238715 PGOHUM00000238969 PGOHUM00000242178 PGOHUM00000242484
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Genomic Variants
for RPL34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL34 |
|
Disorders
/ Diseases
for RPL34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL34 for disorders About GeneDecksing
OMIM gene information: 611840
OMIM disorders: --
5  diseases for RPL34: About MalaCardsmhc class i deficiency leukemia alcohol dependence alcoholism
malaria
1 disease from the University of Copenhagen DISEASES database for RPL34:MHC class I deficiency Human Genome Epidemiology (HuGE) Navigator: RPL34 (2 documents)
Export disorders for RPL34 gene to outside databases
|
Publications
for RPL34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPL34 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with RPL34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. (PubMed id 7490091)1, 2, 3, 9 Rommens J.M.... Simard J. (1995)
- A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
- The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
- Identification of ribosomal protein L34 as a novel Cdk5 inhibitor. (PubMed id 10049762)1, 9 Moorthamer M. and Chaudhuri B. (1999)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for RPL34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPL34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RPL34 gene:
Search GeneIP for patents involving RPL34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPL34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPL34 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPL34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPL34 |
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 | | | RPL34 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RPL34 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL34 |
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