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Aliases for RPL34 Gene

Aliases for RPL34 Gene

  • Ribosomal Protein L34 2 3
  • Leukemia-Associated Protein 3
  • L34 3

External Ids for RPL34 Gene

Previous GeneCards Identifiers for RPL34 Gene

  • GC04P109969
  • GC04P109862
  • GC04P110000
  • GC04P109899
  • GC04P109761
  • GC04P109541
  • GC04P105273

Summaries for RPL34 Gene

Entrez Gene Summary for RPL34 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Transcript variants derived from alternative splicing, alternative transcription initiation sites, and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL34 Gene

RPL34 (Ribosomal Protein L34) is a Protein Coding gene. Diseases associated with RPL34 include baastrup's syndrome and supine hypotensive syndrome. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL34 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL34 Gene

Genomics for RPL34 Gene

Regulatory Elements for RPL34 Gene

Genomic Location for RPL34 Gene

Chromosome:
4
Start:
108,620,566 bp from pter
End:
108,630,484 bp from pter
Size:
9,919 bases
Orientation:
Plus strand

Genomic View for RPL34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL34 Gene

Proteins for RPL34 Gene

  • Protein details for RPL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49207-RL34_HUMAN
    Recommended name:
    60S ribosomal protein L34
    Protein Accession:
    P49207
    Secondary Accessions:
    • Q6FG66
    • Q9BUZ2

    Protein attributes for RPL34 Gene

    Size:
    117 amino acids
    Molecular mass:
    13293 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL34 Gene

neXtProt entry for RPL34 Gene

Proteomics data for RPL34 Gene at MOPED

Post-translational modifications for RPL34 Gene

  • Ubiquitination at Lys 19, Lys 43, Lys 62, Lys 85, and Lys 101
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL34 Gene

Antibody Products

No data available for DME Specific Peptides for RPL34 Gene

Domains & Families for RPL34 Gene

Gene Families for RPL34 Gene

Protein Domains for RPL34 Gene

Suggested Antigen Peptide Sequences for RPL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49207

UniProtKB/Swiss-Prot:

RL34_HUMAN :
  • Belongs to the ribosomal protein L34e family.
Family:
  • Belongs to the ribosomal protein L34e family.
genes like me logo Genes that share domains with RPL34: view

Function for RPL34 Gene

Molecular function for RPL34 Gene

GENATLAS Biochemistry:
60S ribosomal protein L34

Gene Ontology (GO) - Molecular Function for RPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7490091
GO:0003735 structural constituent of ribosome NAS 12962325
genes like me logo Genes that share ontologies with RPL34: view
genes like me logo Genes that share phenotypes with RPL34: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL34 Gene

Localization for RPL34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL34 Gene COMPARTMENTS Subcellular localization image for RPL34 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4

Gene Ontology (GO) - Cellular Components for RPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL34 Gene

Pathways & Interactions for RPL34 Gene

genes like me logo Genes that share pathways with RPL34: view

Pathways by source for RPL34 Gene

1 BioSystems pathway for RPL34 Gene
1 KEGG pathway for RPL34 Gene
1 GeneGo (Thomson Reuters) pathway for RPL34 Gene

Gene Ontology (GO) - Biological Process for RPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL34: view

No data available for SIGNOR curated interactions for RPL34 Gene

Drugs & Compounds for RPL34 Gene

No Compound Related Data Available

Transcripts for RPL34 Gene

Unigene Clusters for RPL34 Gene

Ribosomal protein L34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for RPL34 Gene

GeneLoc Exon Structure for
RPL34
ECgene alternative splicing isoforms for
RPL34

Expression for RPL34 Gene

mRNA expression in normal human tissues for RPL34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL34 Gene

This gene is overexpressed in Nasal epithelium (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL34 Gene



SOURCE GeneReport for Unigene cluster for RPL34 Gene Hs.438227

genes like me logo Genes that share expression patterns with RPL34: view

Protein tissue co-expression partners for RPL34 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL34 Gene

Orthologs for RPL34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL34 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100685685 35
  • 91.45 (n)
  • 95.73 (a)
RPL34 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6404 35
  • 90.6 (n)
  • 94.02 (a)
Gm6404 16
Gm2178 36
  • 82 (a)
OneToMany
Rpl34 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPL34 35
  • 100 (n)
  • 100 (a)
RPL34 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl34l1 35
  • 90.8 (n)
  • 94.83 (a)
cow
(Bos Taurus)
Mammalia RPL34 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL34 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL34 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL34 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.573 35
African clawed frog
(Xenopus laevis)
Amphibia XL34 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29071 35
rpl34 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL34a 36
  • 41 (a)
OneToMany
RpL34b 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-34 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL34A 36
  • 50 (a)
OneToMany
RPL34B 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1788 36
  • 65 (a)
OneToOne
Species with no ortholog for RPL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL34 Gene

ENSEMBL:
Gene Tree for RPL34 (if available)
TreeFam:
Gene Tree for RPL34 (if available)

Paralogs for RPL34 Gene

genes like me logo Genes that share paralogs with RPL34: view

No data available for Paralogs for RPL34 Gene

Variants for RPL34 Gene

Variation tolerance for RPL34 Gene

Residual Variation Intolerance Score: 57.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL34 Gene

HapMap Linkage Disequilibrium report
RPL34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for RPL34 Gene

Disorders for RPL34 Gene

MalaCards: The human disease database

(15) MalaCards diseases for RPL34 Gene - From: DISEASES

Disorder Aliases PubMed IDs
baastrup's syndrome
  • kissing spine
supine hypotensive syndrome
  • antepartum maternal hypotension syndrome
neurogenic bowel
sciatic neuropathy
femoral neuropathy
  • femoral nerve lesions
- elite association
Search RPL34 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL34

Genetic Association Database (GAD)
RPL34
Human Genome Epidemiology (HuGE) Navigator
RPL34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL34
genes like me logo Genes that share disorders with RPL34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL34 Gene

Publications for RPL34 Gene

  1. Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. (PMID: 7490091) Rommens J.M. … Simard J. (Genomics 1995) 2 23 67
  2. Ribosomal proteins L34 and S29 of amphioxus Branchiostoma belcheri tsingtauense: cDNAs cloning and gene copy number. (PMID: 16025162) Liu L. … Ma L. (Acta Biochim. Pol. 2005) 23 67
  3. Genes within genes within bacteria. (PMID: 14559179) Ellis J.C. … Brown J.W. (Trends Biochem. Sci. 2003) 23 67
  4. Identification of ribosomal protein L34 as a novel Cdk5 inhibitor. (PMID: 10049762) Moorthamer M. … Chaudhuri B. (Biochem. Biophys. Res. Commun. 1999) 23 67
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 67

Products for RPL34 Gene

Sources for RPL34 Gene

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