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RPL34 Gene

protein-coding   GIFtS: 62
GCID: GC04P109541

Ribosomal Protein L34

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L341 2
60S Ribosomal Protein L342
L342
Leukemia-Associated Protein2
M5

External Ids:    HGNC: 103401   Entrez Gene: 61642   Ensembl: ENSG000001094757   OMIM: 6118405   UniProtKB: P492073   

Export aliases for RPL34 gene to outside databases

Previous GC identifers: GC04P109969 GC04P109862 GC04P110000 GC04P109899 GC04P109761 GC04P105273


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL34 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family
of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21,
but it has been mapped to 4q. Transcript variants derived from alternative splicing, alternative transcription
initiation sites, and/or alternative polyadenylation exist; these variants encode the same protein. As is typical
for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through
the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL34 Gene:
RPL34 (ribosomal protein L34) is a protein-coding gene. Diseases associated with RPL34 include mhc class i deficiency, and alcohol dependence. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL34 gene promoter:
         TBP   AREB6   Sox5   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL34 promoter sequence
   Search Chromatin IP Primers for RPL34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

RPL34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL34 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P109541:  view genomic region     (about GC identifiers)

Start:
109,541,722 bp from pter      End:
109,551,640 bp from pter
Size:
9,919 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL34_HUMAN, P49207 (See protein sequence)
Recommended Name: 60S ribosomal protein L34  
Size: 117 amino acids; 13293 Da
1 PDB 3D structure from and Proteopedia for RPL34:
3J3B (3D)    
Secondary accessions: Q6FG66 Q9BUZ2

Explore the universe of human proteins at neXtProt for RPL34: NX_P49207

Explore proteomics data for RPL34 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys43, Lys62, Lys85, Lys101, Lys105
  • Modification sites at PhosphoSitePlus

  • See RPL34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000986.2  NP_296374.1  

    ENSEMBL proteins: 
     ENSP00000378162   ENSP00000423983   ENSP00000378160   ENSP00000423316   ENSP00000378163  
    Reactome Protein details: P49207

    RPL34 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    2 InterPro protein domains:
     IPR018065 Ribosomal_L34e_CS
     IPR008195 Ribosomal_L34Ae

    Graphical View of Domain Structure for InterPro Entry P49207

    ProtoNet protein and cluster: P49207

    1 Blocks protein domain: IPB008196 Ribosomal protein L34e

    UniProtKB/Swiss-Prot: RL34_HUMAN, P49207
    Similarity: Belongs to the ribosomal protein L34e family


    RPL34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL34:
    60S ribosomal protein L34

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7490091
    GO:0003735structural constituent of ribosome NAS12962325
         
    RPL34 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPL34:
     Decreased viability  Increased S DNA content  Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL34
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPL34
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPL34

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPL34:
    hsa-mir-331-3p (MIRT043342)

    Block miRNA regulation of human, mouse, rat RPL34 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate RPL34:
    hsa-miR-3163 hsa-miR-3613-3p hsa-miR-616* hsa-miR-551b* hsa-miR-888 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidRPL34 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPL34
    Predesigned siRNA for gene silencing in human, mouse, rat RPL34

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPL34

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPL34 (NM_000995)
    Sino Biological Human cDNA Clone for RPL34
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL34

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----

    RPL34 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL34 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL34
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL34
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL34 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL34):
        Ribosome


    RPL34 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL34
    Interactions:

        Search GeneGlobe Interaction Network for RPL34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL34 (P492071, 3 ENSP000003781604) via UniProtKB, MINT, STRING, and/or I2D (see all 278)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNBPP626331, 3EBI-1051893,EBI-1047529 I2D: score=4 
    ENSG00000096150P622693, ENSP000002113724I2D: score=1 STRING: ENSP00000211372
    ENSG00000226225P622693, ENSP000004031754I2D: score=1 STRING: ENSP00000403175
    RPS18P622693, ENSP000003932414I2D: score=1 STRING: ENSP00000393241
    ENSG00000223367P622693, ENSP000004125834I2D: score=1 STRING: ENSP00000412583
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL34 (RL34)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL34 gene (2 alternative transcripts): 
    NM_000995.3  NM_033625.2  

    Unigene Cluster for RPL34:

    Ribosomal protein L34
    Hs.438227  [show with all ESTs]
    Unigene Representative Sequence: BG112770
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394667 ENST00000502534 ENST00000394665 ENST00000503574 ENST00000506397
    ENST00000394668(uc003hyz.3 uc003hza.3) ENST00000504231
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPL34 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate RPL34:
    hsa-miR-3163 hsa-miR-3613-3p hsa-miR-616* hsa-miR-551b* hsa-miR-888 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidRPL34 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPL34
    Predesigned siRNA for gene silencing in human, mouse, rat RPL34
    Clone
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    OriGene clones in human, mouse for RPL34 (see all 11)
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPL34 (NM_000995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPL34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPL34
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPL34
    OriGene qSTAR qPCR primer pairs in human, mouse for RPL34
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL34
      QuantiTect SYBR Green Assays in human, mouse, rat RPL34
      QuantiFast Probe-based Assays in human, mouse, rat RPL34

    Additional mRNA sequence: 

    AF147334.1 AY762981.1 BC001773.1 BC070208.1 BC106009.1 CR542232.1 CR542242.1 L38941.1 

    Selected DOTS entries (see all 49):

    DT.100870560  DT.91672056  DT.87018067  DT.100045525  DT.95377235  DT.100720576  DT.121232342  DT.100045515 
    DT.121468188  DT.100718700  DT.100851492  DT.121232330  DT.121232368  DT.121232377  DT.121403617  DT.100045516 
    DT.91665872  DT.100873735  DT.95315759  DT.40123870  DT.100720571  DT.100720575  DT.70102125  DT.121232344 

    Selected AceView cDNA sequences (see all 1147):

    CD243325 BE744721 AA514483 AF147334 BM772310 BM674123 AA775136 BG292247 
    AI074436 CR542242 AI709292 H89483 F34274 BE745551 AI626040 BQ933525 
    AA181285 BM738781 AA985525 AA320632 BE378595 F29941 BM784535 F31092 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL34 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                    -           -                 -     -               
    SP2:                                -                 -     -               
    SP3:              -     -           -                 -     -               
    SP4:                                -                                       
    SP5:                                -                                       


    ECgene alternative splicing isoforms for RPL34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCTAAAT
    RPL34 Expression
    About this image


    RPL34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RPL34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438227
        Custom PCR Arrays for RPL34
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPL34
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPL34 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm64041 , 5 predicted gene 64041, 5 90.6(n)1
    94.02(a)1
      13 (64.81 cM)5
    6231741  XM_006517804.11  XP_006517867.11 
     1161537815 
    chicken
    (Gallus gallus)
    Aves RPL346
    ribosomal protein L34
    98(a)
    1 ↔ 1
    AADN03014594.1(21-1390)
    African clawed frog
    (Xenopus laevis)
    Amphibia XL342 ribosomal protein L34 82.09(n)    BC053809.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290712 Transcribed sequence with strong similarity to protein more 99.06(n)    CK139409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL34a6
    RpL34b6
    Ribosomal protein L34b
    41(a)
    40(a)
    many → 1
    many → 1
    3R(21884142-21884989)
    3R(5226033-5226978)
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-346
    Protein RPL-34 (rpl-34) mRNA, complete cds
    52(a)
    1 ↔ 1
    IV(12268776-12269533) WBGene00004448
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL34B6
    RPL34A6
    Protein component of the large (60S) ribosomal sub...
    Protein component of the large (60S) ribosomal sub...
    50(a)
    50(a)
    many → 1
    many → 1
    IX(256226-257063) YIL052C
    V(269423-270185) YER056C-A


    ENSEMBL Gene Tree for RPL34 (if available)
    TreeFam Gene Tree for RPL34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL34 gene

    RPL34 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL34 (see all 43)
    PGOHUM00000238603 PGOHUM00000238715 PGOHUM00000238969 PGOHUM00000242178 PGOHUM00000242484


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL34 (see all 186)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007896021,2
    C--109543638(+) TAAAGC/TATCAC 2 -- int10--------
    rs131119811,2
    C,H--109543642(+) GCATCA/CCAAAA 2 -- int14Minor allele frequency- C:0.00NS EA 400
    rs1922385661,2
    --109543946(+) AAAGTA/GATAAT 2 -- int10--------
    rs1409780511,2
    --109544056(+) ATGGAC/GTGTGG 2 -- int10--------
    rs1834354271,2
    C--109544152(+) TTCTCA/TTGAGC 2 -- int10--------
    rs801466231,2
    F--109544186(+) CAACAA/GAGGTA 2 -- int11Minor allele frequency- G:0.03EA 120
    rs1878049361,2
    --109544254(+) GAGGCA/GGAGGC 2 -- int10--------
    rs1911549091,2
    --109544290(+) TGAGAC/GCAGGC 2 -- int10--------
    rs1837036021,2
    --109544439(+) GCTGCA/GATTGC 2 -- int10--------
    rs1881839531,2
    C--109544498(+) AAAAAA/TGGGAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for RPL34 (109541722 - 109551640 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPL34: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL34
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611840    OMIM disorders: --

    5 diseases for RPL34:    
    About MalaCards
    mhc class i deficiency    alcohol dependence    influenza    leukemia
    malaria

    1 disease from the University of Copenhagen DISEASES database for RPL34:
    MHC class I deficiency

    RPL34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPL34
    Human Genome Epidemiology (HuGE) Navigator: RPL34 (2 documents)

    Export disorders for RPL34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL34 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with RPL34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. (PubMed id 7490091)1, 2, 3, 9 Rommens J.M.... Simard J. (Genomics 1995)
    2. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    7. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    8. Identification of ribosomal protein L34 as a novel Cdk5 inhibitor. (PubMed id 10049762)1, 9 Moorthamer M. and Chaudhuri B. (Biochem. Biophys. Res. Commun. 1999)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6164 HGNC: 10340 AceView: RPL34 Ensembl:ENSG00000109475 euGenes: HUgn6164
    ECgene: RPL34 Kegg: 6164 H-InvDB: RPL34

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPL34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL34 gene:
    Search GeneIP for patents involving RPL34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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