Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL32 Gene

Aliases for RPL32 Gene

  • Ribosomal Protein L32 2 3 5
  • 60S Ribosomal Protein L32 3
  • PP9932 3
  • L32 3

External Ids for RPL32 Gene

Previous GeneCards Identifiers for RPL32 Gene

  • GC03M012806
  • GC03M012869
  • GC03M012852
  • GC03M012853
  • GC03M012810
  • GC03M012876
  • GC03M012877

Summaries for RPL32 Gene

Entrez Gene Summary for RPL32 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL32 Gene

RPL32 (Ribosomal Protein L32) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL32 Gene

Genomics for RPL32 Gene

Regulatory Elements for RPL32 Gene

Enhancers for RPL32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F012870 1.3 FANTOM5 Ensembl ENCODE 13.1 -29.6 -29561 0.8 ATF1 CREM ENSG00000250939 RPL32 SNORA7A GC03M014068 PIR43700 PIR59867
GH03F012885 0.9 Ensembl ENCODE 12.9 -44.5 -44454 1.5 MTA2 BHLHE40 MNT TBX21 ZIC2 ZBTB7A POLR2A STAT2 IKZF1 IRF1 ENSG00000250939 RPL32 SNORA7A IQSEC1 LINC02022 PIRC11
GH03F012879 0.7 ENCODE 12.2 -38.0 -37960 0.7 CBX3 ARNT HINFP DDX20 ZNF175 ZNF644 CHAMP1 ELK1 GATA2 POLR2A ENSG00000250939 RPL32 SNORA7A LOC105376956 LINC02022
GH03F012875 1.6 FANTOM5 Ensembl ENCODE 12.2 -34.6 -34609 1.4 CTCF PKNOX1 ESRRA ZNF121 CCNT2 KLF13 RFX1 ZBTB2 HCFC1 RNF2 ENSG00000250939 RPL32 SNORA7A LINC02022 GC03M014040 LOC105376956 PIR48320
GH03F012937 0.9 ENCODE 11.9 -97.0 -96976 2.3 OSR2 HDAC1 ZNF692 ZMYM3 ZBTB33 PRDM10 ZIC2 ZKSCAN1 ENSG00000250939 RPL32 SNORA7A PIR41577 GC03M014072 GC03P013022
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPL32 on UCSC Golden Path with GeneCards custom track

Promoters for RPL32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001357720 388 2001 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1

Genomic Location for RPL32 Gene

Chromosome:
3
Start:
12,834,485 bp from pter
End:
12,841,588 bp from pter
Size:
7,104 bases
Orientation:
Minus strand

Genomic View for RPL32 Gene

Genes around RPL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL32 Gene

Proteins for RPL32 Gene

  • Protein details for RPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62910-RL32_HUMAN
    Recommended name:
    60S ribosomal protein L32
    Protein Accession:
    P62910
    Secondary Accessions:
    • B2R4Q3
    • P02433

    Protein attributes for RPL32 Gene

    Size:
    135 amino acids
    Molecular mass:
    15860 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL32 Gene

neXtProt entry for RPL32 Gene

Post-translational modifications for RPL32 Gene

  • Ubiquitination at Lys 50
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL32 Gene

Domains & Families for RPL32 Gene

Gene Families for RPL32 Gene

Protein Domains for RPL32 Gene

Suggested Antigen Peptide Sequences for RPL32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62910

UniProtKB/Swiss-Prot:

RL32_HUMAN :
  • Belongs to the ribosomal protein L32e family.
Family:
  • Belongs to the ribosomal protein L32e family.
genes like me logo Genes that share domains with RPL32: view

Function for RPL32 Gene

Molecular function for RPL32 Gene

GENATLAS Biochemistry:
60S ribosomal protein L32,15kDa

Gene Ontology (GO) - Molecular Function for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL32: view
genes like me logo Genes that share phenotypes with RPL32: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL32 Gene

Localization for RPL32 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL32 Gene COMPARTMENTS Subcellular localization image for RPL32 gene
Compartment Confidence
cytosol 5
chloroplast 3
cytoskeleton 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL32 Gene

Pathways & Interactions for RPL32 Gene

genes like me logo Genes that share pathways with RPL32: view

Pathways by source for RPL32 Gene

1 KEGG pathway for RPL32 Gene
1 GeneGo (Thomson Reuters) pathway for RPL32 Gene

Gene Ontology (GO) - Biological Process for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL32: view

No data available for SIGNOR curated interactions for RPL32 Gene

Drugs & Compounds for RPL32 Gene

(1) Additional Compounds for RPL32 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL32: view

Transcripts for RPL32 Gene

Unigene Clusters for RPL32 Gene

Ribosomal protein L32:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL32 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RPL32 Gene

GeneLoc Exon Structure for
RPL32
ECgene alternative splicing isoforms for
RPL32

Expression for RPL32 Gene

mRNA expression in normal human tissues for RPL32 Gene

Protein differential expression in normal tissues from HIPED for RPL32 Gene

This gene is overexpressed in Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL32 Gene



Protein tissue co-expression partners for RPL32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL32 Gene:

RPL32

SOURCE GeneReport for Unigene cluster for RPL32 Gene:

Hs.265174
genes like me logo Genes that share expression patterns with RPL32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL32 Gene

Orthologs for RPL32 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC450727 34
  • 100 (n)
RPL32 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
RPL32 34
  • 94.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL32 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL32 34 35
  • 92.1 (n)
mouse
(Mus musculus)
Mammalia Gm6251 34
  • 88.47 (n)
Gm21893 35
  • 45 (a)
OneToMany
Rpl32l 16
rat
(Rattus norvegicus)
Mammalia LOC680959 34
  • 87.16 (n)
chicken
(Gallus gallus)
Aves RPL32 34 35
  • 83.7 (n)
lizard
(Anolis carolinensis)
Reptilia RPL32 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl32 34
  • 79.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26095 34
zebrafish
(Danio rerio)
Actinopterygii rpl32 34 35
  • 80 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL32 36 34 35
  • 69.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002122 34
  • 69.42 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-32 36 34 35
  • 59.9 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL281C 34
  • 62.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06843g 34
  • 60.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL32 34 35 37
  • 59.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18100 34
  • 64.62 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8117 34
rice
(Oryza sativa)
Liliopsida Os08g0524600 34
  • 67.44 (n)
Os.12339 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3202 34
  • 59.56 (n)
Species where no ortholog for RPL32 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL32 Gene

ENSEMBL:
Gene Tree for RPL32 (if available)
TreeFam:
Gene Tree for RPL32 (if available)

Paralogs for RPL32 Gene

genes like me logo Genes that share paralogs with RPL32: view

No data available for Paralogs for RPL32 Gene

Variants for RPL32 Gene

Sequence variations from dbSNP and Humsavar for RPL32 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1064728 -- 12,836,117(-) CCAGG(C/G/T)TGCGC reference, synonymous-codon, missense
rs111488751 -- 12,843,031(+) CACTT(C/T)GGGAA upstream-variant-2KB
rs111983973 -- 12,840,894(+) ACTGG(C/T)CCAGA intron-variant, upstream-variant-2KB
rs112210112 -- 12,842,331(+) TCTCA(C/T)GGCTC upstream-variant-2KB
rs112963126 -- 12,840,754(+) ACACA(C/G)AAAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL32 Gene

Variant ID Type Subtype PubMed ID
dgv763e201 CNV deletion 23290073
dgv850e199 CNV deletion 23128226
esv2751977 CNV gain 17911159
esv3893663 CNV gain 25118596
nsv1112379 CNV deletion 24896259
nsv1147269 CNV deletion 26484159
nsv460435 CNV loss 19166990
nsv589715 CNV loss 21841781
nsv589716 CNV loss 21841781
nsv7351 OTHER inversion 18451855
nsv821995 CNV gain 20364138
nsv963297 CNV duplication 23825009
nsv979805 CNV duplication 23825009

Variation tolerance for RPL32 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL32 Gene

Disorders for RPL32 Gene

Relevant External Links for RPL32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL32

No disorders were found for RPL32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL32 Gene

Publications for RPL32 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  4. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization. (PMID: 9284913) Vorobieva N.V. … Graphodatsky A.S. (Cytogenet. Cell Genet. 1997) 2 3 64
  5. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. (PMID: 3866218) Young J.A.T. … Trowsdale J. (Nucleic Acids Res. 1985) 3 4 64

Products for RPL32 Gene

Sources for RPL32 Gene

Content
Loading form....