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Aliases for RPL31 Gene

Aliases for RPL31 Gene

  • Ribosomal Protein L31 2 3
  • 60S Ribosomal Protein L31 3
  • MMRPS32 6
  • MRPL42 6
  • L31 3

External Ids for RPL31 Gene

Summaries for RPL31 Gene

Entrez Gene Summary for RPL31 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL31 Gene

RPL31 (Ribosomal Protein L31) is a Protein Coding gene. Diseases associated with RPL31 include chancroid. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL31 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL31 Gene

Genomics for RPL31 Gene

Genomic Location for RPL31 Gene

Start:
101,001,715 bp from pter
End:
101,024,032 bp from pter
Size:
22,318 bases
Orientation:
Plus strand

Genomic View for RPL31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL31 Gene

Regulatory Elements for RPL31 Gene

Proteins for RPL31 Gene

  • Protein details for RPL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62899-RL31_HUMAN
    Recommended name:
    60S ribosomal protein L31
    Protein Accession:
    P62899
    Secondary Accessions:
    • B7Z4K2
    • D3DVJ4
    • P12947
    • Q53SQ5
    • Q6IRZ0
    • Q6LBJ6

    Protein attributes for RPL31 Gene

    Size:
    125 amino acids
    Molecular mass:
    14463 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL31 Gene

    Alternative splice isoforms for RPL31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL31 Gene

Proteomics data for RPL31 Gene at MOPED

Post-translational modifications for RPL31 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys39, Lys55, Lys70, Lys75, and Lys115

No data available for DME Specific Peptides for RPL31 Gene

Domains for RPL31 Gene

Gene Families for RPL31 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL31 Gene

UniProtKB/Swiss-Prot:

RL31_HUMAN
Family:
  • Belongs to the ribosomal protein L31e family.:
    • P62899
genes like me logo Genes that share domains with RPL31: view

Function for RPL31 Gene

Molecular function for RPL31 Gene

GENATLAS Biochemistry: 60S ribosomal protein L31,14kDa

Gene Ontology (GO) - Molecular Function for RPL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2780320
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL31: view
genes like me logo Genes that share phenotypes with RPL31: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL31 Gene

Localization for RPL31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL31 Gene COMPARTMENTS Subcellular localization image for RPL31 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL31: view

Pathways for RPL31 Gene

genes like me logo Genes that share pathways with RPL31: view

Pathways by source for RPL31 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL31 Gene
1 BioSystems pathway for RPL31 Gene

Gene Ontology (GO) - Biological Process for RPL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL31: view

Transcripts for RPL31 Gene

Unigene Clusters for RPL31 Gene

Ribosomal protein L31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL31 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
SP1: - - -
SP2:
SP3: -

Relevant External Links for RPL31 Gene

GeneLoc Exon Structure for
RPL31
ECgene alternative splicing isoforms for
RPL31

Expression for RPL31 Gene

mRNA expression in normal human tissues for RPL31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL31 Gene

SOURCE GeneReport for Unigene cluster for RPL31 Gene Hs.469473

genes like me logo Genes that share expressions with RPL31: view

Orthologs for RPL31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 77 (a)
OneToMany
RPL31 36
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPL31 36
  • 91.2 (n)
  • 100 (a)
RPL31 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL31 36
  • 93.87 (n)
  • 100 (a)
RPL31 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl31 36
  • 90.93 (n)
  • 100 (a)
Rpl31 16
Rpl31 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL31 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl31 36
  • 92.27 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL31 36
  • 85.07 (n)
  • 98.4 (a)
RPL31 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL31 37
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl31 36
  • 81.07 (n)
  • 95.2 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl31 36
  • 79.76 (n)
  • 92.86 (a)
rpl31 37
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL31 37
  • 70 (a)
OneToOne
RpL31 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-31 36
  • 66.97 (n)
  • 71.82 (a)
rpl-31 37
  • 67 (a)
OneToOne
rpl-31 38
  • 71 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER076C 36
  • 58.48 (n)
  • 56.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL31A 36
  • 58.56 (n)
  • 58.56 (a)
RPL31A 37
  • 57 (a)
OneToMany
RPL31A 39
RPL31B 37
  • 57 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02937g 36
  • 57.96 (n)
  • 57.66 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26230 36
  • 57.41 (n)
  • 58.33 (a)
rice
(Oryza sativa)
Liliopsida Os06g0319700 36
  • 59.88 (n)
  • 60.19 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13683 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08344 36
  • 62.76 (n)
  • 61.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl31 36
  • 60.19 (n)
  • 60.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10412 37
  • 74 (a)
OneToOne
Species with no ortholog for RPL31:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL31 Gene

ENSEMBL:
Gene Tree for RPL31 (if available)
TreeFam:
Gene Tree for RPL31 (if available)

Paralogs for RPL31 Gene

Selected SIMAP similar genes for RPL31 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RPL31: view

No data available for Paralogs for RPL31 Gene

Variants for RPL31 Gene

Sequence variations from dbSNP and Humsavar for RPL31 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3423 -- 101,006,059(-) AGTGG(C/T)AACAG reference, missense
rs3424 -- 101,006,036(-) CCAAA(A/G)TATAT reference, missense
rs3425 -- 101,006,034(-) AAAGT(A/G)TATAG synonymous-codon, reference
rs10934 -- 101,006,266(-) TCTGG(A/G)CATTC intron-variant, utr-variant-3-prime
rs1065719 -- 101,006,003(+) ACGTA(A/C)TGAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RPL31 Gene

Variant ID Type Subtype PubMed ID
nsv834316 CNV Gain 17160897
esv34123 CNV Loss 18971310

Relevant External Links for RPL31 Gene

HapMap Linkage Disequilibrium report
RPL31
Human Gene Mutation Database (HGMD)
RPL31

Disorders for RPL31 Gene

(1) MalaCards Diseases for RPL31 Gene

Search for RPL31 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RPL31 Gene

genes like me logo Genes that share disorders with RPL31: view

No data available for UniProtKB/Swiss-Prot for RPL31 Gene

Publications for RPL31 Gene

  1. cDNA sequence of human ribosomal protein L31. (PMID: 2780320) Nobori T. … Carson D.A. (Nucleic Acids Res. 1989) 2 3 4
  2. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for RPL31 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPL31
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPL31
    • Block miRNA regulation of RPL31 using miScript Target Protectors

    Sources for RPL31 Gene

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