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RPL30 Gene

protein-coding   GIFtS: 62
GCID: GC08M099037

Ribosomal Protein L30

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 4

Aliases
Ribosomal Protein L301 2
60S Ribosomal Protein L302
L302

External Ids:    HGNC: 103331   Entrez Gene: 61562   Ensembl: ENSG000001564827   OMIM: 1804675   UniProtKB: P628883   
ORGUL members:    fRNAdb10:FR247111      
H-InvDB12:HIT000101267    
NCBI13:D28438    
RNAdb15:HIV2447    

Export aliases for RPL30 gene to outside databases

Previous GC identifers: GC08M098062 GC08M099127 GC08M098713 GC08M099010 GC08M099123 GC08M094257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL30 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family
of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar
RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPL30 Gene:
RPL30 (ribosomal protein L30) is a protein-coding gene. Diseases associated with RPL30 include treacher collins syndrome, and medulloblastoma. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPL30 Gene

fRNAdb sequence ontology for RPL30:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for RPL30

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL30 gene promoter:
         USF1   LHX3b/Lhx3b   Sox5   p53   FOXO3b   FOXJ2 (long isoform)   USF-1   LHX3a/Lhx3a   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPL30 promoter sequence
   Search Chromatin IP Primers for RPL30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22

RPL30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL30 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M099037:  view genomic region     (about GC identifiers)

Start:
99,037,079 bp from pter      End:
99,058,697 bp from pter
Size:
21,619 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL30_HUMAN, P62888 (See protein sequence)
Recommended Name: 60S ribosomal protein L30  
Size: 115 amino acids; 12784 Da
2 PDB 3D structures from and Proteopedia for RPL30:
3J3B (3D)        3VI6 (3D)    
Secondary accessions: B2R591 P04645 Q502Z6

Explore the universe of human proteins at neXtProt for RPL30: NX_P62888

Explore proteomics data for RPL30 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9, Lys26, Lys32, Lys44, Lys57, Lys68, Lys87
  • Modification sites at PhosphoSitePlus

  • See RPL30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000980.1  
    ENSEMBL proteins: 
     ENSP00000428085   ENSP00000379381   ENSP00000430556   ENSP00000287038   ENSP00000430506  
     ENSP00000429483  
    Reactome Protein details: P62888

    RPL30 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RPL30


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
     IPR000231 Ribosomal_L30e
     IPR022991 Ribosomal_L30e_CS

    Graphical View of Domain Structure for InterPro Entry P62888

    ProtoNet protein and cluster: P62888

    1 Blocks protein domain: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45

    UniProtKB/Swiss-Prot: RL30_HUMAN, P62888
    Similarity: Belongs to the ribosomal protein L30e family


    RPL30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPL30:
    60S ribosomal protein L30,12kDa,likely same as D8S1364E

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS1577483
    GO:0003735structural constituent of ribosome TAS1577483
    GO:0044822poly(A) RNA binding IDA--
         
    RPL30 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL30:
     Decreased cell number, increas  Decreased viability of wild-ty  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 
     S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL30
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    miRNA
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    miRTarBase miRNAs that target RPL30:
    hsa-mir-346 (MIRT042716), hsa-mir-320a (MIRT044397), hsa-let-7a-5p (MIRT052419), hsa-mir-20a-5p (MIRT050530), hsa-mir-93-5p (MIRT048773), hsa-mir-16-5p (MIRT031874)

    Block miRNA regulation of human, mouse, rat RPL30 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPL30:
    hsa-miR-4282
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPL30

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL30


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit TAS1577483
    GO:0070062extracellular vesicular exosome IDA--

    RPL30 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL30 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL30
        CFTR translational fidelity (class I mutations)

    3 BioSystems Pathways for RPL30
        Selenium Metabolism and Selenoproteins
    TNF-alpha/NF-kB Signaling Pathway
    Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL30 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL30):
        Ribosome


    RPL30 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL30
    Interactions:

        Search GeneGlobe Interaction Network for RPL30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL30 (P628882, 3 ENSP000002870384) via UniProtKB, MINT, STRING, and/or I2D (see all 462)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS1577483
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL30 (RL30)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for RPL30 gene: 
    NM_000989.3  

    Unigene Cluster for RPL30:

    Ribosomal protein L30
    Hs.400295  [show with all ESTs]
    Unigene Representative Sequence: AK128768
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518164(uc010mbk.2) ENST00000521534 ENST00000521291 ENST00000396070
    ENST00000518850 ENST00000287038(uc003yif.3) ENST00000523172 ENST00000521726
    ENST00000517489 ENST00000517805 ENST00000522156 ENST00000520998 ENST00000521112

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RPL30:
    hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RPL30 (NM_000989)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPL30
      QuantiTect SYBR Green Assays in human, mouse, rat RPL30
      QuantiFast Probe-based Assays in human, mouse, rat RPL30

    Additional mRNA sequence: 

    AK128768.1 AK308890.1 AK312102.1 AL049968.1 BC032700.2 BC095426.1 L05095.1 X79238.1 

    Selected DOTS entries (see all 40):

    DT.100053162  DT.98131958  DT.99986736  DT.91926780  DT.91766348  DT.91828877  DT.121483992  DT.101956114 
    DT.100033047  DT.92014373  DT.100889313  DT.100889293  DT.121483885  DT.100815323  DT.100889311  DT.91766362 
    DT.91797966  DT.121483940  DT.121484008  DT.95263733  DT.121483891  DT.100889299  DT.100889310  DT.121483952 

    Selected AceView cDNA sequences (see all 1523):

    BQ219559 AI360225 AA040535 AA487972 AA773099 F35956 BQ685173 BQ581530 
    AA575995 AI338762 BG032387 T71744 CB138735 BQ950295 BE876924 AI223247 
    BM787143 H83443 BM663191 BQ277631 AA625686 BM760319 NM_000989 BQ055526 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL30 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
    SP1:        -     -     -           -     -           -     -     -                                             
    SP2:                                -     -           -     -     -                                             
    SP3:                                -     -           -     -     -     -                                       
    SP4:                                -     -                       -                                             
    SP5:                                -     -           -     -     -                                             


    ECgene alternative splicing isoforms for RPL30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGAACAGA
    RPL30 Expression
    About this image


    RPL30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
    RPL30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.400295
        Custom PCR Arrays for RPL30
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPL30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL30 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl301 , 5 ribosomal protein L301, 5 94.2(n)1
    100(a)1
      15 (14.33 cM)5
    199461  NM_001163485.11  NP_001156957.11 
     344405055 
    chicken
    (Gallus gallus)
    Aves RPL301 ribosomal protein L30 85.8(n)
    99.13(a)
      425416  NM_001007967.1  NP_001007968.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    96(a)
    many → 1
    many → 1
    4(20652134-20655026)
    LGd(1076898-1077242)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC053758.12   -- 85.59(n)    BC053758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa93d052 wufa93d05 81.61(n)   336713  BC049055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL301 , 3 peripheral nervous system development
    structural more3
    Ribosomal protein L301
    81(a)3
    70.37(n)1
    81.48(a)1
      37B93
    440591  NM_079948.31  NP_524687.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-301 , 3 rpl-301 72(a)3
    63.36(n)1
    72.07(a)1
      I(10443797-10444796)3
    1729211  NM_060327.51  NP_492728.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL30(YGL030W)4
    RPL301
    Protein component of the large (60S) ribosomal subunit, more4
    RPL301
    62(n)1
    61(a)1
      7(439091-439638)4
    8528531, 4  NP_011485.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G362401 AT1G36240 66.67(n)
    72.48(a)
      840530  NM_103317.1  NP_174853.1 
    rice
    (Oryza sativa)
    Liliopsida AK058917.12   -- 74(n)    AK058917.1 


    ENSEMBL Gene Tree for RPL30 (if available)
    TreeFam Gene Tree for RPL30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL30 gene

    RPL30 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL30 (see all 17)
    PGOHUM00000239357 PGOHUM00000239417 PGOHUM00000256711 PGOHUM00000234945 PGOHUM00000244341


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL30 (see all 194)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs607914771,2
    C--99053512(+) AAAAA-/AGAACA 1 -- ds50010--------
    rs1829051701,2
    --99053538(+) AAAAAA/GCCCTG 1 -- ds50010--------
    rs625235951,2
    C--99053590(+) TGAGAC/TGGAGT 1 -- ds50013Minor allele frequency- T:0.17NA WA 6
    rs1404469821,2
    --99053680(+) CGCCAC/TCACGC 1 -- ds50010--------
    rs1504717061,2
    C--99053683(+) CACCAC/TGCCCG 1 -- ds50010--------
    rs1138447361,2
    F--99053732(+) ACTGCA/GTTAGC 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1889019811,2
    --99053733(+) CTGCGC/TTAGCC 1 -- ds50010--------
    rs1425067961,2
    --99053739(+) TAGCCA/TGGATG 1 -- ds50010--------
    rs1468221891,2
    --99053745(+) GGATGA/GTCTCG 1 -- ds50010--------
    rs1930870001,2
    --99053771(+) GATCCA/GCCCGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPL30 (99037079 - 99058697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPL30:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674440CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL30
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180467OMIM information: 148370 606129 606662 609259    
    9 diseases for RPL30:    
    About MalaCards
    treacher collins syndrome    medulloblastoma    influenza    hepatocellular carcinoma
    hiv-1    malaria    hepatitis    prostate cancer
    prostatitis


    RPL30 for disorders           About GeneDecksing


    Export disorders for RPL30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL30 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with RPL30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e. (PubMed id 22139155)1, 2 Kawaguchi A.... Tanaka I. (Acta Crystallogr. F 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    4. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (Genomics 1992)
    5. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. (PubMed id 16968546)1, 9 De Bortoli M....Kim J.Y. (BMC Cancer 2006)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6156 HGNC: 10333 AceView: RPL30 Ensembl:ENSG00000156482 euGenes: HUgn6156
    ECgene: RPL30 Kegg: 6156 H-InvDB: RPL30

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPL30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL30 gene:
    Search GeneIP for patents involving RPL30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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