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Aliases for RPL3 Gene

Aliases for RPL3 Gene

  • Ribosomal Protein L3 2 3 5
  • HIV-1 TAR RNA-Binding Protein B 3 4
  • TARBP-B 3 4
  • 60S Ribosomal Protein L3 3
  • ASC-1 3
  • L3 3

External Ids for RPL3 Gene

Previous GeneCards Identifiers for RPL3 Gene

  • GC22M036323
  • GC22M037951
  • GC22M038033
  • GC22M038046
  • GC22M039710
  • GC22M039717
  • GC22M039719
  • GC22M039721
  • GC22M039723
  • GC22M039728
  • GC22M039821
  • GC22M040108
  • GC22M039333
  • GC22M039835
  • GC22M039847
  • GC22M039942

Summaries for RPL3 Gene

Entrez Gene Summary for RPL3 Gene

  • Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL3 Gene

RPL3 (Ribosomal Protein L3) is a Protein Coding gene. Diseases associated with RPL3 include Hiv-1 and Diamond-Blackfan Anemia. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL3L.

UniProtKB/Swiss-Prot for RPL3 Gene

  • The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

Gene Wiki entry for RPL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL3 Gene

Genomics for RPL3 Gene

Regulatory Elements for RPL3 Gene

Enhancers for RPL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F039388 1.5 FANTOM5 Ensembl ENCODE 11.2 -68.5 -68476 1.7 HDAC1 ATF1 PKNOX1 DMAP1 KLF7 CREM EGR2 ZNF362 SP3 SP5 SYNGR1 MGAT3 RPL3 MIEF1 CACNA1I CBX7 APOBEC3G APOBEC3D GC22P039386 PIR49666
GH22F039404 1.4 FANTOM5 Ensembl ENCODE 11.3 -85.2 -85209 1.8 HDAC1 TBL1XR1 FEZF1 ZNF335 GATA2 ZNF302 EGR2 CEBPB ZNF488 TSHZ1 SYNGR1 MGAT3 RPL3 MIEF1 GC22M041396 TAB1
GH22F039204 1.4 FANTOM5 Ensembl ENCODE 10.5 +113.5 113472 4.0 PKNOX1 KLF17 ZNF48 RARA ZNF366 FOS EGR2 SMARCC1 ZNF280D JUNB CBX7 FUNDC2P4 PDGFB APOBEC3B-AS1 RPL3 MGAT3 GC22M041371 GC22M040915
GH22F039362 1.2 FANTOM5 Ensembl ENCODE 11.2 -43.6 -43570 3.7 CTCF TAL1 NRF1 MAFG ZBTB8A RAD21 ZIC2 ARID1B GATA2 SMARCA4 CBX7 SYNGR1 RPL3 TAB1 FUNDC2P4 MGAT3 GC22M041392
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL3 on UCSC Golden Path with GeneCards custom track

Promoters for RPL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000618394 989 3200 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for RPL3 Gene

39,312,882 bp from pter
39,320,389 bp from pter
7,508 bases
Minus strand

Genomic View for RPL3 Gene

Genes around RPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL3 Gene

Proteins for RPL3 Gene

  • Protein details for RPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L3
    Protein Accession:
    Secondary Accessions:
    • B2RDV9
    • Q15548
    • Q5I0G0

    Protein attributes for RPL3 Gene

    403 amino acids
    Molecular mass:
    46109 Da
    Quaternary structure:
    • Interacts with METTL18.

    Three dimensional structures from OCA and Proteopedia for RPL3 Gene

neXtProt entry for RPL3 Gene

Post-translational modifications for RPL3 Gene

  • Ubiquitination at Lys 39, Lys 286, Lys 300, and Lys 366
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL3 Gene

No data available for DME Specific Peptides for RPL3 Gene

Domains & Families for RPL3 Gene

Gene Families for RPL3 Gene

Protein Domains for RPL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L3P family.
  • Belongs to the ribosomal protein L3P family.
genes like me logo Genes that share domains with RPL3: view

Function for RPL3 Gene

Molecular function for RPL3 Gene

GENATLAS Biochemistry:
60S ribosomal protein L3
UniProtKB/Swiss-Prot Function:
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

Gene Ontology (GO) - Molecular Function for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2891103
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 24965446
GO:0008097 5S rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL3: view
genes like me logo Genes that share phenotypes with RPL3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL3 Gene

Localization for RPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL3 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
genes like me logo Genes that share ontologies with RPL3: view

Pathways & Interactions for RPL3 Gene

genes like me logo Genes that share pathways with RPL3: view

Pathways by source for RPL3 Gene

1 KEGG pathway for RPL3 Gene
1 GeneGo (Thomson Reuters) pathway for RPL3 Gene

Gene Ontology (GO) - Biological Process for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL3: view

No data available for SIGNOR curated interactions for RPL3 Gene

Drugs & Compounds for RPL3 Gene

(5) Drugs for RPL3 Gene - From: DrugBank and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omacetaxine mepesuccinate Approved Pharma Target, antagonist 0
Synribo Approved October 2012 Pharma 0
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL3: view

Transcripts for RPL3 Gene

Unigene Clusters for RPL3 Gene

Ribosomal protein L3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^
SP1: - - - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11: -

ExUns: 12a · 12b

Relevant External Links for RPL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL3 Gene

Protein differential expression in normal tissues from HIPED for RPL3 Gene

This gene is overexpressed in Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL3 Gene

Protein tissue co-expression partners for RPL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL3 Gene:


SOURCE GeneReport for Unigene cluster for RPL3 Gene:

genes like me logo Genes that share expression patterns with RPL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL3 Gene

Orthologs for RPL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL3 34
  • 99.65 (n)
(Monodelphis domestica)
Mammalia RPL3 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RPL3 35
  • 95 (a)
(Canis familiaris)
Mammalia RPL3 34 35
  • 91.56 (n)
(Bos Taurus)
Mammalia RPL3 34 35
  • 90.49 (n)
(Rattus norvegicus)
Mammalia Rpl3 34
  • 89.74 (n)
(Mus musculus)
Mammalia Rpl3 34 16 35
  • 89.16 (n)
(Gallus gallus)
Aves RPL3 34 35
  • 84.62 (n)
(Anolis carolinensis)
Reptilia RPL3 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl3 34
  • 81.22 (n)
Str.6702 34
African clawed frog
(Xenopus laevis)
Amphibia rpl3-prov 34
(Danio rerio)
Actinopterygii rpl3 34 35
  • 80.31 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8466 34
fruit fly
(Drosophila melanogaster)
Insecta RpL3 36 34 35
  • 72.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003556 34
  • 67.87 (n)
(Caenorhabditis elegans)
Secernentea rpl-3 34 35
  • 69.17 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR206W 34
  • 66.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16511g 34
  • 63.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL3 34 35 37
  • 62.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL3B 34
  • 65.36 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7639 34
(Hordeum vulgare)
Liliopsida Hv.977 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06843 34
  • 68.55 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl302 34
  • 64.59 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3689 34
Species where no ortholog for RPL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL3 Gene

Gene Tree for RPL3 (if available)
Gene Tree for RPL3 (if available)

Paralogs for RPL3 Gene

Variants for RPL3 Gene

Sequence variations from dbSNP and Humsavar for RPL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10676026 -- 39,316,252(+) CTCTA(-/A/AA)AAAAA intron-variant, upstream-variant-2KB
rs11089942 -- 39,317,581(-) GACAC(A/C/T)ACCCA upstream-variant-2KB, reference, missense
rs111498875 -- 39,317,458(+) TCCCT(A/C/T)ACCAA intron-variant, upstream-variant-2KB
rs111921714 -- 39,319,627(+) AGGCC(A/C/G)GTCGG upstream-variant-2KB, utr-variant-5-prime
rs112014594 -- 39,320,812(+) TCTTC(G/T)TTAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL3 Gene

Variant ID Type Subtype PubMed ID
nsv589033 CNV loss 21841781
nsv834198 CNV loss 17160897
nsv964632 CNV duplication 23825009
nsv966110 CNV duplication 23825009
nsv979677 CNV duplication 23825009

Variation tolerance for RPL3 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL3 Gene

Disorders for RPL3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • aids, slow progression to
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL3 Gene

Publications for RPL3 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Molecular cloning and characterization of a TAR-binding nuclear factor from T cells. (PMID: 7576925) Reddy T.R. … Wong-Staal F. (AIDS Res. Hum. Retroviruses 1995) 3 4 22 64
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  4. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PMID: 16364039) Bergqvist M. … Paulsson-Karlsson Y. (Dis. Esophagus 2006) 3 22 64
  5. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T. … Nishimoto T. (Nucleic Acids Res. 2006) 3 4 64

Products for RPL3 Gene

Sources for RPL3 Gene

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