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RPL3 Gene

protein-coding   GIFtS: 64
GCID: GC22M040108

Ribosomal Protein L3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein L31 2     ASC-12
TARBP-B2 3     L32
HIV-1 TAR RNA-Binding Protein B2 3     Hypothetical Protein2
60S Ribosomal Protein L32     

External Ids:    HGNC: 103321   Entrez Gene: 61222   Ensembl: ENSG000001003167   OMIM: 6041635   UniProtKB: P390233   

Export aliases for RPL3 gene to outside databases

Previous GC identifers: GC22M036323 GC22M037951 GC22M038033 GC22M038046 GC22M039710 GC22M039717 GC22M039719 GC22M039721 GC22M039723 GC22M039728 GC22M039821


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPL3 Gene:
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of
ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has
been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with
several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional
splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RPL3 Gene:
RPL3 (ribosomal protein L3) is a protein-coding gene. Diseases associated with RPL3 include hiv-1, and diamond-blackfan anemia. GO annotations related to this gene include structural constituent of ribosome and RNA binding. An important paralog of this gene is RPL3L.

UniProtKB/Swiss-Prot: RL3_HUMAN, P39023
Function: The L3 protein is a component of the large subunit of cytoplasmic ribosomes

Gene Wiki entry for RPL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPL3 gene promoter:
         ER-alpha   STAT1   AML1a   Bach2   STAT1beta   CUTL1   STAT1alpha   STAT2   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RPL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13

RPL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M040108:  view genomic region     (about GC identifiers)

Start:
39,708,887 bp from pter      End:
39,716,394 bp from pter
Size:
7,508 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL3_HUMAN, P39023 (See protein sequence)
Recommended Name: 60S ribosomal protein L3  
Size: 403 amino acids; 46109 Da
Subunit: Interacts with METTL18
1 PDB 3D structure from and Proteopedia for RPL3:
3J3B (3D)    
Secondary accessions: B2RDV9 Q15548 Q5I0G0

Explore the universe of human proteins at neXtProt for RPL3: NX_P39023

Explore proteomics data for RPL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys39, Lys250, Lys286, Lys294, Lys300, Lys366, Lys373
  • Modification sites at PhosphoSitePlus

  • See RPL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000958.1  NP_001029025.1  

    ENSEMBL proteins: 
     ENSP00000386101   ENSP00000346001   ENSP00000385762   ENSP00000415198   ENSP00000412713  
     ENSP00000416273  
    Reactome Protein details: P39023

    RPL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RPL3

    RPL3 Antibody Products:

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    Cloud-Clone Corp. CLIAs for RPL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPL: L ribosomal proteins

    3 InterPro protein domains:
     IPR019926 Ribosomal_L3_CS
     IPR000597 Ribosomal_L3
     IPR009000 Transl_B-barrel

    Graphical View of Domain Structure for InterPro Entry P39023

    ProtoNet protein and cluster: P39023

    1 Blocks protein domain: IPB000597 Ribosomal protein L3

    UniProtKB/Swiss-Prot: RL3_HUMAN, P39023
    Similarity: Belongs to the ribosomal protein L3P family


    RPL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL3_HUMAN, P39023
    Function: The L3 protein is a component of the large subunit of cytoplasmic ribosomes

         Genatlas biochemistry entry for RPL3:
    60S ribosomal protein L3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS2891103
    GO:0003735structural constituent of ribosome NAS12962325
    GO:0044822poly(A) RNA binding IDA--
         
    RPL3 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPL3:
     Decreased viability of wild-ty  Increased S DNA content  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPL3
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    miRNA
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    miRTarBase miRNAs that target RPL3:
    hsa-mir-1260b (MIRT052681), hsa-mir-92b-3p (MIRT040684), hsa-mir-1914-5p (MIRT035792), hsa-mir-1296-5p (MIRT036120), hsa-mir-204-5p (MIRT047026), hsa-mir-744-5p (MIRT037436), hsa-mir-1229-3p (MIRT036275), hsa-mir-1301-3p (MIRT035991), hsa-let-7c-5p (MIRT051787), hsa-mir-92a-3p (MIRT049123), hsa-mir-125b-5p (MIRT046052), hsa-mir-423-3p (MIRT042530), hsa-mir-671-5p (MIRT039282), hsa-mir-16-5p (MIRT031945), hsa-mir-615-3p (MIRT039771)

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    Sino Biological Human cDNA Clone for RPL3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RL3_HUMAN, P39023: Nucleus, nucleolus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    chloroplast1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    RPL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPL3 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL3
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL3
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPL3 (see all 9)
        Peptide chain elongation
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for RPL3):
        Ribosome


    RPL3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPL3
    Interactions:

        Search GeneGlobe Interaction Network for RPL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPL3 (P390232, 3 ENSP000003460014) via UniProtKB, MINT, STRING, and/or I2D (see all 1149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622692, 3MINT-7945693 I2D: score=2 
    ENSG00000223367P622692, 3MINT-7945693 I2D: score=2 
    ENSG00000226225P622692, 3MINT-7945693 I2D: score=2 
    ENSG00000235650P622692, 3MINT-7945693 I2D: score=2 
    RPS18P622692, 3MINT-7945693 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPL3 (RL3)

    4 DrugBank Compounds for RPL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HomoharringtonineCephalotaxus alkaloid (see all 6)26833-87-4targetantagonist1730056 2583270
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPL3 gene (2 alternative transcripts): 
    NM_000967.3  NM_001033853.1  

    Unigene Cluster for RPL3:

    Ribosomal protein L3
    Hs.119598  [show with all ESTs]
    Unigene Representative Sequence: BC036582
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401609 ENST00000464182 ENST00000473638 ENST00000216146(uc003axh.3 uc003axi.3)
    ENST00000465618(uc003axj.3) ENST00000467105 ENST00000402527 ENST00000481985
    ENST00000471290 ENST00000453303 ENST00000484358 ENST00000427905 ENST00000420536
    ENST00000484615(uc011aoj.1) ENST00000460589 ENST00000461967 ENST00000498462
    ENST00000459859
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RPL3
      QuantiFast Probe-based Assays in human, mouse, rat RPL3

    Additional mRNA sequence: 

    AB062291.1 AB266619.1 AK092695.1 AK297711.1 AK315693.1 AY320405.1 BC002408.2 BC004323.1 
    BC006483.1 BC008003.1 BC008492.1 BC012146.1 BC012786.2 BC013674.1 BC013861.1 BC014017.2 
    BC015032.1 BC015767.1 BC022790.1 BC033296.1 BC036582.1 BC063662.1 BC071666.1 BC088373.1 
    BC107711.1 BC127794.1 CR456566.1 L22453.1 M90054.1 X73460.1 

    Selected DOTS entries (see all 214):

    DT.91791365  DT.100745912  DT.91934015  DT.91791316  DT.100746000  DT.100745921  DT.91734430  DT.100745995 
    DT.95170875  DT.100746030  DT.95170752  DT.100868906  DT.91791719  DT.100745913  DT.92035812  DT.91794327 
    DT.100745971  DT.100853619  DT.100745975  DT.97869865  DT.100745952  DT.100745876  DT.92008395  DT.100745979 

    Selected AceView cDNA sequences (see all 98):

    CR623564 CR604030 CR592120 CR590654 CR616770 BC012146 CR601663 CR596802 
    CR595509 CR613925 CR607725 BC008003 CR612782 CR597498 CR610441 CR609557 
    CR615390 NR_000028 CR617467 CR612126 CR456566 CR594097 NR_000027 CR621177 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPL3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^
    SP1:        -     -     -     -     -     -                                                                                                                     
    SP2:                                                                          -                                                                                 
    SP3:                                -     -                                   -                                                                                 
    SP4:                    -     -     -     -                                   -                                                                                 
    SP5:                                                                          -                 -                                                               

    ExUns: 12a · 12b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RPL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCACTGA
    RPL3 Expression
    About this image


    RPL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    RPL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119598
        Custom PCR Arrays for RPL3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL3 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpl31 , 5 ribosomal protein L31, 5 89.16(n)1
    98.51(a)1
      15 (37.85 cM)5
    273671  NM_013762.21  NP_038790.21 
     800777815 
    chicken
    (Gallus gallus)
    Aves RPL31 ribosomal protein L3 84.62(n)
    95.78(a)
      418016  NM_001006241.1  NP_001006241.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPL36
    ribosomal protein L3
    95(a)
    1 ↔ 1
    5(24633492-24644688)
    African clawed frog
    (Xenopus laevis)
    Amphibia rpl3-prov2 ribosomal protein L3 81.85(n)    BC042242.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpl31 ribosomal protein L3 80.31(n)
    89.58(a)
      322571  NM_001001590.1  NP_001001590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpL31 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein L31
    74(a)3
    72.04(n)1
    74.69(a)1
      413471  NM_169378.21  NP_731548.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rpl-31 rpl-3 69.17(n)
    71.93(a)
      175501  NM_001026083.4  NP_001021254.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL3(YOR063W)4
    RPL31
    Protein component of the large (60S) ribosomal subunit, more4
    RPL31
    62.86(n)1
    68.57(a)1
      15(444686-445849)4
    8542291, 4  NP_014706.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPL3B1 RPL3B 65.36(n)
    67.97(a)
      842454  NM_104840.4  NP_176352.1 
    rice
    (Oryza sativa)
    Liliopsida AK073392.12   -- 76.37(n)    AK073392.1 


    ENSEMBL Gene Tree for RPL3 (if available)
    TreeFam Gene Tree for RPL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPL3 gene
    RPL3L2  
    2 SIMAP similar genes for RPL3 using alignment to 10 protein entries:     RL3_HUMAN (see all proteins):
    rpl3    RPL3L

    RPL3 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPL3 (see all 19)
    PGOHUM00000238641 PGOHUM00000247890 PGOHUM00000248264 PGOHUM00000239076 PGOHUM00000240567


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPL3 (see all 48)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1376311,2
    C,F,H--22683338(+) tgccaC/Ttgtgc 2 -- us2k17Minor allele frequency- T:0.00NA WA CSA 12
    rs622283801,2
    C,F--39708525(+) CGGTCT/AGCCTG 2 -- ds50012Minor allele frequency- A:0.03NA NS 138
    rs1841058131,2
    --39708635(+) CCAGCA/TGCCTC 2 -- ds50010--------
    rs1892578511,2
    --39708663(+) TTGCAC/GAATGC 2 -- ds50010--------
    rs1403209891,2
    C--39708702(+) TCAGCT/GGCAGA 2 -- ds50011Minor allele frequency- G:0.01NS 148
    rs747250331,2
    C,F--39708799(+) AAGGAG/AGGCAG 2 -- ds50014Minor allele frequency- A:0.08CSA WA NS 267
    rs1382924261,2
    C,F--39708825(+) CAAGGC/TACCTC 2 -- ds50011Minor allele frequency- T:0.01NS 146
    rs734123111,2
    C--39708899(+) GGAAAA/GTAACT 2 -- ut312Minor allele frequency- G:0.04WA 120
    rs1819356271,2
    C--39708926(+) CAACTA/GCAAAA 2 -- ut310--------
    rs1412362651,2
    C,F--39708965(+) CTTTGC/TAATTC 4 T A mis12Minor allele frequency- T:0.00NS NA 4700

    HapMap Linkage Disequilibrium report for RPL3 (39708887 - 39716394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834198CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPL3
    DNA2.0 Custom Variant and Variant Library Synthesis for RPL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604163    OMIM disorders: --

    17 diseases for RPL3:    
    About MalaCards
    hiv-1    diamond-blackfan anemia    treacher collins syndrome    polycystic kidney disease
    kidney disease    influenza    esophagitis    tonsillitis
    neuroblastoma    prostatitis    prostate cancer    thyroiditis
    breast cancer    myeloma    multiple myeloma    cerebritis
    malaria


    RPL3 for disorders           About GeneDecksing


    Export disorders for RPL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPL3 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with RPL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. Molecular cloning and characterization of a TAR-binding nuclear factor from T cells. (PubMed id 7576925)1, 2, 9 Reddy T.R....Wong-Staal F. (AIDS Res. Hum. Retroviruses 1995)
    3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    4. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)1, 2 Sekiguchi T.... Nishimoto T. (Nucleic Acids Res. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (J. Protein Chem. 2003)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    10. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (PubMed id 2891103)1, 3 Ou J.-H.... Rutter W. (Nucleic Acids Res. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6122 HGNC: 10332 AceView: RPL3 Ensembl:ENSG00000100316 euGenes: HUgn6122
    ECgene: RPL3 Kegg: 6122 H-InvDB: RPL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPL3 gene:
    Search GeneIP for patents involving RPL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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