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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPL3 Gene

protein-coding   GIFtS: 60
GCID: GC22M039728

ribosomal protein L3
 Explore 11 diseases affiliated with
RPL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPL3    

Aliases
for RPL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein L31 2     60S Ribosomal Protein L32
L31 2     ASC-12
TARBP-B2 3     Hypothetical Protein2
HIV-1 TAR RNA-Binding Protein B2 3     

External Ids:    HGNC: 103321   Entrez Gene: 61222   Ensembl: ENSG000001003167   OMIM: 6041635   UniProtKB: P390233   

Export aliases for RPL3 gene to outside databases

Previous GC identifers: GC22M036323 GC22M037951 GC22M038033 GC22M038046 GC22M039710 GC22M039717 GC22M039719 GC22M039721 GC22M039723


Summaries
for RPL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPL3:
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal
proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested
that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar
RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple
processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RL3_HUMAN, P39023
Function: The L3 protein is a component of the large subunit of cytoplasmic ribosomes

Gene Wiki entry for RPL3


Genomic Views
for RPL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL3 gene promoter:
         ER-alpha   STAT1   AML1a   Bach2   STAT1beta   CUTL1   STAT1alpha   STAT2   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13

RPL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039728:  view genomic region     (about GC identifiers)

Start:
 39,708,887 bp from pter      End:
 39,716,394 bp from pter
Size:
 7,508 bases      Orientation:
 minus strand

Proteins
for RPL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RL3_HUMAN, P39023 (See protein sequence)
Recommended Name: 60S ribosomal protein L3  
Size: 403 amino acids; 46109 Da
Subcellular location: Nucleus, nucleolus. Cytoplasm
Secondary accessions: B2RDV9 Q15548 Q5I0G0

Explore the universe of human proteins at neXtProt for RPL3: NX_P39023

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P39023

    • RPL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000958.1  NP_001029025.1  

    ENSEMBL proteins: 
     ENSP00000386101   ENSP00000346001   ENSP00000385762   ENSP00000415198   ENSP00000412713  
     ENSP00000416273  
    Reactome Protein details: P39023
    Human Recombinant Protein Products: 
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    Uscn Proteins for RPL3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022625cytosolic large ribosomal subunit IDA12962325


    RPL3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RPL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPL3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019926 Ribosomal_L3_CS
     IPR000597 Ribosomal_L3
     IPR009000 Transl_elong_init/rib_B-barrel

    Graphical View of Domain Structure for InterPro Entry P39023

    ProtoNet protein and cluster: P39023

    1 Blocks protein family: IPB000597 Ribosomal protein L3

    UniProtKB/Swiss-Prot: RL3_HUMAN, P39023
    Similarity: Belongs to the ribosomal protein L3P family


    Function
    for RPL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RL3_HUMAN, P39023
    Function: The L3 protein is a component of the large subunit of cytoplasmic ribosomes

         Genatlas biochemistry entry for RPL3:
    60S ribosomal protein L3

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS2891103
    GO:0003735structural constituent of ribosome NAS12962325


    RPL3 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RPL3:
     Decreased viability of wild-ty  Increased S DNA content  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 


    Pathways & Interactions
    for RPL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Disease
    		Disease1.00
    4Generic Transcription Pathway
    		Gene Expression0.46
    5Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPL3
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPL3 
        Cytoplasmic Ribosomal Proteins

    5/28        Reactome Pathways for RPL3 (see all 28)
        Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Eukaryotic Translation Initiation


    1         Kegg Pathway  (Kegg details for RPL3):
        Ribosome


    RPL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/992 Interacting proteins for RPL3 (P390232, 3 ENSP000003460014) via UniProtKB, MINT, STRING, and/or I2D (see all 992)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL4P365782, 3, ENSP000003114304MINT-7945693 MINT-6489539 MINT-6489355 I2D: score=4 STRING: ENSP00000311430
    RPL8P629172, 3, ENSP000002625844MINT-7945693 MINT-6489539 MINT-6489355 I2D: score=4 STRING: ENSP00000262584
    RPS3P233962, 3, ENSP000002785724MINT-7945693 MINT-6489539 MINT-6489355 I2D: score=2 STRING: ENSP00000278572
    RPL12P300502, 3, ENSP000003547394MINT-7945693 MINT-6489539 I2D: score=4 STRING: ENSP00000354739
    RPL11P629132, 3, ENSP000003636764MINT-6489539 MINT-6489355 I2D: score=3 STRING: ENSP00000363676
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RPL3

    3 DrugBank Compounds for RPL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about RPL3 / RL3 

    Transcripts
    for RPL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPL3 gene (2 alternative transcripts): 
    NM_000967.3  NM_001033853.1  

    Unigene Cluster for RPL3:

    Ribosomal protein L3
    Hs.119598  [show with all ESTs]
    Unigene Representative Sequence: BC036582
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401609 ENST00000464182 ENST00000473638 ENST00000216146(uc003axh.3 uc003axi.3)
    ENST00000465618(uc003axj.3) ENST00000467105 ENST00000402527 ENST00000481985
    ENST00000471290 ENST00000453303 ENST00000484358 ENST00000427905 ENST00000420536
    ENST00000484615(uc011aoj.1) ENST00000460589 ENST00000461967 ENST00000498462
    ENST00000459859

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB062291.1 AB266619.1 AK092695.1 AK297711.1 AK315693.1 AY320405.1 BC002408.2 BC004323.1 
    BC006483.1 BC008003.1 BC008492.1 BC012146.1 BC012786.2 BC013674.1 BC013861.1 BC014017.2 
    BC015032.1 BC015767.1 BC022790.1 BC033296.1 BC036582.1 BC063662.1 BC071666.1 BC088373.1 
    BC107711.1 BC127794.1 CR456566.1 L22453.1 M90054.1 X73460.1 

    24/214 DOTS entries (see all 214):

    DT.91791365  DT.100745912  DT.91934015  DT.91791316  DT.100746000  DT.100745921  DT.91734430  DT.100745995 
    DT.95170875  DT.100746030  DT.95170752  DT.100868906  DT.91791719  DT.100745913  DT.92035812  DT.91794327 
    DT.100745971  DT.100853619  DT.100745975  DT.97869865  DT.100745952  DT.100745876  DT.92008395  DT.100745979 

    24/98 AceView cDNA sequences (see all 98):

    CR601189 CR605531 CR615390 CR590820 NR_000027 BC033296 CR609557 CR602004 
    CR621177 CR597745 CR625577 CR601663 CR595116 CR616722 CR612126 CR597737 
    CR607725 CR608723 BC014017 CR608886 BC012786 CR596802 CR595509 CR590654 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPL3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^
    SP1:        -     -     -     -     -     -                                                                                                                     
    SP2:                                                                          -                                                                                 
    SP3:                                -     -                                   -                                                                                 
    SP4:                    -     -     -     -                                   -                                                                                 
    SP5:                                                                          -                 -                                                               

    ExUns: 12a · 12b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RPL3

    Expression
    for RPL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACCACTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)

    See RPL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPL3

    SOURCE GeneReport for Unigene cluster: Hs.119598
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    In Situ
    Assay Products:     
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    Orthologs
    for RPL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPL3 gene from 9/41 species (see all 41)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RPL31 ribosomal protein L3 84.62(n)
    95.78(a)    		   418016  NM_001006241.1  NP_001006241.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPL36
    		 --
    		 95(a)
    		 1 ↔ 1
    		 5(24634980-24642645)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rpl3-prov2 ribosomal protein L3 81.85(n)    BC042242.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rpl31 ribosomal protein L3 80.31(n)
    89.58(a)    		   322571  NM_001001590.1  NP_001001590.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpL31 , 3 protein biosynthesis structural constituent
    of more3
    Ribosomal protein L31    		 74(a)3
    72.04(n)1
    74.69(a)1    		   413471  NM_079592.31  NP_524316.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rpl-31 Protein RPL-3 69.26(n)
    72.11(a)    		   175501  NM_001026083.3  NP_001021254.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPL3(YOR063W)4
    RPL31    		 Protein component of the large (60S) ribosomal subunit, more4
    Rpl3p1    		 62.86(n)1
    68.57(a)1    		   15(444686-445849)4
    8542291, 4  NP_014706.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RPL3B1 60S ribosomal protein L3-2 65.28(n)
    67.97(a)    		   842454  NM_104840.4  NP_176352.1 
    rice
    (Oryza sativa)    		 Liliopsida AK073392.12   -- 76.37(n)    AK073392.1 


    ENSEMBL Gene Tree for RPL3 (if available)
    TreeFam Gene Tree for RPL3 (if available) 

    Paralogs
    for RPL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPL3 gene
    RPL3L2  
    2 SIMAP similar genes for RPL3 using alignment to 10 protein entries:     RL3_HUMAN (see all proteins):
    rpl3    RPL3L

    RPL3 for paralogs           About GeneDecksing


    5/19 Pseudogenes.org Pseudogenes for RPL3 (see all 19)
    PGOHUM00000238641 PGOHUM00000247890 PGOHUM00000248264 PGOHUM00000239076 PGOHUM00000240567


    Genomic Variants
    for RPL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in RPL3 are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs622283801,2
    		C,--39708525(+) CGGTCT/AGCCTG 2 -- ds50012Minor allele frequency- A:0.03NA NS 138
    rs1841058131,2
    		--39708635(+) CCAGCA/TGCCTC 2 -- ds50010--------
    rs1892578511,2
    		--39708663(+) TTGCAC/GAATGC 2 -- ds50010--------
    rs1403209891,2
    		C,--39708702(+) TCAGCT/GGCAGA 2 -- ds50011Minor allele frequency- G:0.01NS 148
    rs747250331,2
    		C,--39708799(+) AAGGAG/AGGCAG 2 -- ds50014Minor allele frequency- A:0.08CSA WA NS 267
    rs1382924261,2
    		C,F,--39708825(+) CAAGGC/TACCTC 2 -- ds50011Minor allele frequency- T:0.01NS 146
    rs734123111,2
    		C,--39708899(+) GGAAAA/GTAACT 2 -- ut312Minor allele frequency- G:0.04WA 120
    rs1819356271,2
    		C,--39708926(+) CAACTA/GCAAAA 2 -- ut310--------
    rs1412362651,2
    		C,F,--39708965(+) CTTTGC/TAATTC 4 T A mis12Minor allele frequency- T:0.00NS NA 4700
    rs1865820611,2
    		C,--39709003(+) AGAGAC/GGCAGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for RPL3 (39708887 - 39716394 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPL3
         1 Indel: 40501

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    Disorders / Diseases
    for RPL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPL3 for disorders           About GeneDecksing

    OMIM gene information: 604163    OMIM disorders: --

    11 diseases for RPL3:    About MalaCards
    treacher collins syndrome    polycystic kidney disease    kidney disease    esophageal carcinoma
    ovarian carcinoma    esophagitis    colon cancer    prostate cancer
    carcinoma    prostatitis    malaria


    Export disorders for RPL3 gene to outside databases

    Publications
    for RPL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPL3 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with RPL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    2. Molecular cloning and characterization of a TAR-binding nuclear factor from T cells. (PubMed id 7576925)1, 2, 9 Reddy T.R....Wong-Staal F. (1995)
    3. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)1, 2 Sekiguchi T....Nishimoto T. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    9. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (PubMed id 2891103)1, 3 Ou J.-H.... Rutter W. (1987)
    10. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PubMed id 16364039)1, 9 Bergqvist M....Paulsson-Karlsson Y. (2006)

    External Searches for RPL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6122 HGNC: 10332 AceView: RPL3 Ensembl:ENSG00000100316 euGenes: HUgn6122
    ECgene: RPL3 Kegg: 6122 H-InvDB: RPL3

    Other Databases showing RPL3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPL3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPL3 gene:
    Search GeneIP for patents involving RPL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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